Regulation of microRNA biogenesis

MicroRNAs: Target Recognition and Regulatory Functions

Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068

Most mammalian mRNAs are conserved targets of microRNAs

Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462

The nuclear RNase III Drosha initiates microRNA processing

Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O., Kim, S., et al. (2003) · Nature · doi:10.1038/nature01957 · Cited by 5,299

miRBase: annotating high confidence microRNAs using deep sequencing data

Kozomara, A., & Griffiths-Jones, S. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1181 · Cited by 5,073

Role for a bidentate ribonuclease in the initiation step of RNA interference

Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001) · Nature · doi:10.1038/35053110 · Cited by 5,018

The widespread regulation of microRNA biogenesis, function and decay

Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672

MicroRNA genes are transcribed by RNA polymerase II

Lee, Y., Kim, M., Han, J., Yeom, K.-H., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,556

miRBase: tools for microRNA genomics

Griffiths‐Jones, S., Saini, H. K., van Dongen, S., & Enright, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm952 · Cited by 4,432

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

Lau, N. C., Lim, L. P., Weinstein, E. G., & Bartel, D. P. (2001) · Science · doi:10.1126/science.1065062 · Cited by 3,345

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsPreprint

Yi, R., Qin, Y., Macara, I. G., & Cullen, B. R. (2003) · Genes & Development · doi:10.1101/gad.1158803 · Cited by 3,158

Asymmetry in the Assembly of the RNAi Enzyme Complex

Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., & Zamore, P. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00759-1 · Cited by 2,922

The Microprocessor complex mediates the genesis of microRNAs

Gregory, R. I., Yan, K.-P., Amuthan, G., Chendrimada, T. P., Doratotaj, B., Cooch, N. S., & Shiekhattar, R. (2004) · Nature · doi:10.1038/nature03120 · Cited by 2,851

Biogenesis of small RNAs in animals

Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814

Argonaute2 is the catalytic engine of mammalian RNAi

Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J.-J., Hammond, S. M., Joshua-Tor, L., & Hannon, G. J. (2004) · Science · doi:10.1126/science.1102513 · Cited by 2,796

Processing of primary microRNAs by the Microprocessor complex

Denli, A. M., Tops, B. B. J., Plasterk, R. H. A., Ketting, R. F., & Hannon, G. J. (2004) · Nature · doi:10.1038/nature03049 · Cited by 2,784

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

Hutvágner, G., McLachlan, J., Pasquinelli, A. E., Bálint, E., Tuschl, T., & Zamore, P. D. (2001) · Science · doi:10.1126/science.1062961 · Cited by 2,781

Nuclear Export of MicroRNA Precursors

Lund, E., Güttinger, S., Calado, Â., Dahlberg, J. E., & Kutay, U. (2003) · Science · doi:10.1126/science.1090599 · Cited by 2,705

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

Pasquinelli, A. E., Reinhart, B. J., Slack, F. J., Martindale, M. Q., Kuroda, M. I., Maller, B., Hayward, D. C., Ball, E. E., Degnan, B. M., Müller, P., et al. (2000) · Nature · doi:10.1038/35040556 · Cited by 2,671

Functional siRNAs and miRNAs exhibit strand bias

Khvorova, A., Reynolds, A., & Jayasena, S. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00801-8 · Cited by 2,645

MicroRNA maturation: stepwise processing and subcellular localization

Lee, Y., Jeon, K., Lee, J., Kim, S., & Kim, V. N. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf476 · Cited by 2,572

Small silencing RNAs: an expanding universe

Ghildiyal, M., & Zamore, P. D. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2504 · Cited by 2,418

A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia

Calin, G. A., Ferracin, M., Cimmino, A., Leva, G. D., Shimizu, M., Wojcik, S. E., Iorio, M. V., Visone, R., Sever, N. İ., Fabbri, M., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050995 · Cited by 2,415

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Huntzinger, E., & Izaurralde, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2936 · Cited by 2,339

Origin, Biogenesis, and Activity of Plant MicroRNAs

Voinnet, O. (2009) · Cell · doi:10.1016/j.cell.2009.01.046 · Cited by 2,251

The Drosha-DGCR8 complex in primary microRNA processingPreprint

Han, J., Lee, Y., Yeom, K.-H., Kim, Y. K., Jin, H., & Kim, V. N. (2004) · Genes & Development · doi:10.1101/gad.1262504 · Cited by 2,208

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

Chendrimada, T. P., Gregory, R. I., Kumaraswamy, E., Norman, J. A., Cooch, N. S., Nishikura, K., & Shiekhattar, R. (2005) · Nature · doi:10.1038/nature03868 · Cited by 2,195

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

Meister, G., Landthaler, M., Patkaniowska, A., Dorsett, Y., Teng, G., & Tuschl, T. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.007 · Cited by 2,052

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

Grishok, A., Pasquinelli, A. E., Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D. L., Fire, A., Ruvkun, G., & Mello, C. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00431-7 · Cited by 1,908

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

Cai, X., Hagedorn, C. H., & Cullen, B. R. (2004) · RNA · doi:10.1261/rna.7135204 · Cited by 1,874

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

Ketting, R. F., Fischer, S. E. J., Bernstein, E., Sijen, T., Hannon, G. J., & Plasterk, R. H. A. (2001) · Genes & Development · doi:10.1101/gad.927801 · Cited by 1,852

Intronic microRNA precursors that bypass Drosha processing

Ruby, J. G., Jan, C. H., & Bartel, D. P. (2007) · Nature · doi:10.1038/nature05983 · Cited by 1,722

Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex

Han, J., Lee, Y., Yeom, K., Nam, J., Heo, I., Rhee, J., Sohn, S. Y., Cho, Y., Zhang, B.-T., & Kim, V. N. (2006) · Cell · doi:10.1016/j.cell.2006.03.043 · Cited by 1,641

Dicer is essential for mouse development

Bernstein, E., Kim, S. Y., Carmell, M. A., Murchison, E. P., Alcorn, H., Li, M. Z., Mills, A. A., Elledge, S. J., Anderson, K. V., & Hannon, G. J. (2003) · Nature Genetics · doi:10.1038/ng1253 · Cited by 1,627

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

Ventura, A., Young, A. G., Winslow, M. M., Lintault, L., Meissner, A., Erkeland, S. J., Newman, J. J., Bronson, R. T., Crowley, D. G., Stone, J. R., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.019 · Cited by 1,627

Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing

Gregory, R. I., Chendrimada, T. P., Cooch, N., & Shiekhattar, R. (2005) · Cell · doi:10.1016/j.cell.2005.10.022 · Cited by 1,617

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

Hammond, S. M., Boettcher, S., Caudy, A. A., Kobayashi, R., & Hannon, G. J. (2001) · Science · doi:10.1126/science.1064023 · Cited by 1,580

Genetic and Functional Diversification of Small RNA Pathways in Plants

Xie, Z., Johansen, L. K., Gustafson, A. M., Kasschau, K. D., Lellis, A. D., Zilberman, D., Jacobsen, S. E., & Carrington, J. C. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020104 · Cited by 1,569

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

Song, J., Smith, S. K., Hannon, G. J., & Joshua‐Tor, L. (2004) · Science · doi:10.1126/science.1102514 · Cited by 1,531

Selective Blockade of MicroRNA Processing by Lin28

Viswanathan, S. R., Daley, G. Q., & Gregory, R. I. (2008) · Science · doi:10.1126/science.1154040 · Cited by 1,449

Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

Bohnsack, M. T., Czaplinski, K., & Görlich, D. (2004) · RNA · doi:10.1261/rna.5167604 · Cited by 1,436

The let-7 family of microRNAs

Roush, S. F., & Slack, F. J. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.07.007 · Cited by 1,371

PIWI-interacting small RNAs: the vanguard of genome defence

Siomi, M. C., Sato, K., Pezic, D., & Aravin, A. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3089 · Cited by 1,319

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

Tabara, H., Sarkissian, M., Kelly, W. G., Fleenor, J., Grishok, A., Timmons, L., Fire, A. Z., & Mello, C. C. (1999) · Cell · doi:10.1016/s0092-8674(00)81644-x · Cited by 1,307

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencingPreprint

Kanellopoulou, C., Muljo, S. A., Kung, A. L., Ganesan, S., Drapkin, R., Jenuwein, T., Livingston, D. M., & Rajewsky, K. (2005) · Genes & Development · doi:10.1101/gad.1248505 · Cited by 1,297

Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways

Lee, Y. S., Nakahara, K., Pham, J. W., Kim, K., He, Z., Sontheimer, E. J., & Carthew, R. W. (2004) · Cell · doi:10.1016/s0092-8674(04)00261-2 · Cited by 1,287

SMAD proteins control DROSHA-mediated microRNA maturation

Davis‐Dusenbery, B. N., Hilyard, A. C., Lagna, G., & Hata, A. (2008) · Nature · doi:10.1038/nature07086 · Cited by 1,286

Genetic variation in microRNA networks: the implications for cancer research

Ryan, B. M., Robles, A. I., & Harris, C. C. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2867 · Cited by 1,269

Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes

Matranga, C., Tomari, Y., Shin, C., Bartel, D. P., & Zamore, P. D. (2005) · Cell · doi:10.1016/j.cell.2005.08.044 · Cited by 1,211

Identification of microRNAs of the herpesvirus family

Pfeffer, S., Sewer, A., Lagos‐Quintana, M., Sheridan, R., Sander, C., Grässer, F. A., van Dyk, L. F., Ho, C. K., Shuman, S., Chien, M., et al. (2005) · Nature Methods · doi:10.1038/nmeth746 · Cited by 1,178

Diversifying microRNA sequence and function

Ameres, S. L., & Zamore, P. D. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3611 · Cited by 1,175

Modulation of microRNA processing by p53

Suzuki, H. I., Yamagata, K., Sugimoto, K., Iwamoto, T., Kato, S., & Miyazono, K. (2009) · Nature · doi:10.1038/nature08199 · Cited by 1,158

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

Cheloufi, S., Dos Santos, C. O., Chong, M. M. W., & Hannon, G. J. (2010) · Nature · doi:10.1038/nature09092 · Cited by 1,149

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

Mourelatos, Z., Dostie, J., Paushkin, S., Sharma, A., Charroux, B., Abel, L., Rappsilber, J., Mann, M., & Dreyfuss, G. (2002) · Genes & Development · doi:10.1101/gad.974702 · Cited by 1,105

The Mirtron Pathway Generates microRNA-Class Regulatory RNAs in Drosophila

Okamura, K., Hagen, J. W., Duan, H., Tyler, D. M., & Lai, E. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.028 · Cited by 1,089

The microcosmos of cancer

Lujambio, A., & Lowe, S. W. (2012) · Nature · doi:10.1038/nature10888 · Cited by 1,084

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal

Wang, Y., Medvid, R., Melton, C. A., Jaenisch, R., & Blelloch, R. H. (2007) · Nature Genetics · doi:10.1038/ng1969 · Cited by 1,073

Argonaute proteins: functional insights and emerging roles

Meister, G. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3462 · Cited by 1,050

Single Processing Center Models for Human Dicer and Bacterial RNase III

Zhang, H., Kolb, F. A., Jaśkiewicz, Ł., Westhof, É., & Filipowicz, W. (2004) · Cell · doi:10.1016/j.cell.2004.06.017 · Cited by 1,043

ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway

Nykänen, A., Haley, B., & Zamore, P. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00547-5 · Cited by 1,025

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

Heo, I., Joo, C., Cho, J., Ha, M., Han, J., & Kim, V. N. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.014 · Cited by 985

Human embryonic stem cells express a unique set of microRNAs

Suh, M. R., Lee, Y., Kim, J. Y., Kim, S.-K., Moon, S., Lee, J. Y., Cha, K., Chung, H., Yoon, H. S., Moon, S. Y., et al. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.02.019 · Cited by 974

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAsPreprint

Babiarz, J., Ruby, J. G., Wang, Y., Bartel, D. P., & Blelloch, R. H. (2008) · Genes & Development · doi:10.1101/gad.1705308 · Cited by 964

Structural Basis for Double-Stranded RNA Processing by Dicer

MacRae, I. J., Zhou, K., Li, F., Repic, A., Brooks, A. N., Cande, W. Z., Adams, P. D., & Doudna, J. A. (2006) · Science · doi:10.1126/science.1121638 · Cited by 963

A Human snoRNA with MicroRNA-Like Functions

Ender, C., Krek, A., Friedländer, M. R., Beitzinger, M., Weinmann, L., Chen, W., Pfeffer, S., Rajewsky, N., & Meister, G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.017 · Cited by 883

The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. melanogaster Homolog Are Required for miRNA Biogenesis

Landthaler, M., Yalçın, A., & Tuschl, T. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.001 · Cited by 877

Extensive post-transcriptional regulation of microRNAs and its implications for cancer

Thomson, J. M., Newman, M., Parker, J. S., Morin-Kensicki, E. M., Wright, T., & Hammond, S. M. (2006) · Genes & Development · doi:10.1101/gad.1444406 · Cited by 877

A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegans

Knight, S. W., & Bass, B. (2001) · Science · doi:10.1126/science.1062039 · Cited by 875

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathwaysPreprint

岡村, 勝., Ishizuka, A., Siomi, H., & Siomi, M. C. (2004) · Genes & Development · doi:10.1101/gad.1210204 · Cited by 866

Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma

Jazdzewski, K., Murray, E. L., Franssila, K., Jarzab, B., Schoenberg, D. R., & de la Chapelle, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802682105 · Cited by 842

A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

Cifuentes, D., Xue, H., Taylor, D. W., Patnode, H., Mishima, Y., Cheloufi, S., Ma, E., Mane, S., Hannon, G. J., Lawson, N. D., et al. (2010) · Science · doi:10.1126/science.1190809 · Cited by 836

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

Chiang, H. R., Schoenfeld, L. W., Ruby, J. G., Auyeung, V. C., Spies, N., Baek, D., Johnston, W. K., Russ, C., Luo, S., Babiarz, J. E., et al. (2010) · Genes & Development · doi:10.1101/gad.1884710 · Cited by 825

Argonaute2 Cleaves the Anti-Guide Strand of siRNA during RISC Activation

Rand, T., Petersen, S., Du, F., & Wang, X. (2005) · Cell · doi:10.1016/j.cell.2005.10.020 · Cited by 822

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

Rybak‐Wolf, A., Fuchs, H. R., Smirnova, L., Brandt, C., Pohl, E. E., Nitsch, R., & Wulczyn, F. G. (2008) · Nature Cell Biology · doi:10.1038/ncb1759 · Cited by 811

Modulation of microRNA processing and expression through RNA editing by ADAR deaminases

Yang, W., Chendrimada, T. P., Wang, Q., Higuchi, M., Seeburg, P. H., Shiekhattar, R., & Nishikura, K. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1041 · Cited by 801

Characterization of Dicer-deficient murine embryonic stem cells

Murchison, E. P., Partridge, J. F., Tam, O. H., Cheloufi, S., & Hannon, G. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505479102 · Cited by 800

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

Heo, I., Joo, C., Kim, Y.-K., Ha, M., Yoon, M.-J., Cho, J., Yeom, K.-H., Han, J., & Kim, V. N. (2009) · Cell · doi:10.1016/j.cell.2009.08.002 · Cited by 798

Mammalian Mirtron Genes

Berezikov, E., Chung, W., Willis, J., Cuppen, E. P. J. G., & Lai, E. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.028 · Cited by 795

Processing of intronic microRNAs

Kim, Y., & Kim, V. N. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601512 · Cited by 754

Evolution and Functional Diversification of MIRNA Genes

Cuperus, J. T., Fahlgren, N., & Carrington, J. C. (2011) · The Plant Cell · doi:10.1105/tpc.110.082784 · Cited by 749

The role of PACT in the RNA silencing pathway

Lee, Y., Hur, I., Park, S. Y., Kim, Y. K., Suh, M. R., & Kim, V. N. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600942 · Cited by 743

Chromatin structure analyses identify miRNA promotersPreprint

Ozsolak, F., Poling, L. L., Wang, Z., Liu, H., Liu, X., Roeder, R. G., Zhang, X., Song, J. S., & Fisher, D. E. (2008) · Genes & Development · doi:10.1101/gad.1706508 · Cited by 736

The Crystal Structure of Human Argonaute2

Schirle, N. T., & MacRae, I. J. (2012) · Science · doi:10.1126/science.1221551 · Cited by 720

Evolution of microRNA diversity and regulation in animals

Berezikov, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3079 · Cited by 712

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

Newman, M. A., Thomson, J. M., & Hammond, S. M. (2008) · RNA · doi:10.1261/rna.1155108 · Cited by 708

Dual Role for Argonautes in MicroRNA Processing and Posttranscriptional Regulation of MicroRNA Expression

Diederichs, S., & Haber, D. A. (2007) · Cell · doi:10.1016/j.cell.2007.10.032 · Cited by 704

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

Frank, F., Sonenberg, N., & Nagar, B. (2010) · Nature · doi:10.1038/nature09039 · Cited by 666

TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing

Haase, A. D. D., Jaśkiewicz, Ł., Zhang, H., Lainé, S., Sack, R., Gatignol, A., & Filipowicz, W. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400509 · Cited by 657

Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

Ma, J., Yuan, Y. A., Meister, G., Pei, Y., Tuschl, T., & Patel, D. J. (2005) · Nature · doi:10.1038/nature03514 · Cited by 649

The dsRNA protein kinase PKR: Virus and cell control

García, M. A., Meurs, E. F., & Esteban, M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.03.001 · Cited by 644

IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

Upton, J.-P., Wang, L., Han, D., Wang, E. S., Huskey, N. E., Lim, L., Truitt, M., McManus, M. T., Ruggero, D., Goga, A., et al. (2012) · Science · doi:10.1126/science.1226191 · Cited by 640

The Structure of Human Argonaute-2 in Complex with miR-20a

Elkayam, E., Kuhn, C., Tocilj, A., Haase, A. D., Greene, E. M., Hannon, G. J., & Joshua‐Tor, L. (2012) · Cell · doi:10.1016/j.cell.2012.05.017 · Cited by 640

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

Zhang, H., Kolb, F. A., Brondani, V., Billy, É., & Filipowicz, W. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf582 · Cited by 631

Target RNA–Directed Trimming and Tailing of Small Silencing RNAs

Ameres, S. L., Horwich, M. D., Hung, J.-H., Xu, J., Ghildiyal, M., Weng, Z., & Zamore, P. D. (2010) · Science · doi:10.1126/science.1187058 · Cited by 628

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

Trabucchi, M., Briata, P., Garcia-Mayoral, M., Haase, A. D., Filipowicz, W., Ramos, A., Gherzi, R., & Rosenfeld, M. G. (2009) · Nature · doi:10.1038/nature08025 · Cited by 607

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature · doi:10.1038/nature09830 · Cited by 601

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex

Wang, Y., Juranek, S., Li, H., Sheng, G., Tuschl, T., & Patel, D. J. (2008) · Nature · doi:10.1038/nature07666 · Cited by 594

Posttranscriptional Regulation of MicroRNA Biogenesis in Animals

Siomi, H., & Siomi, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.013 · Cited by 591

Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha

Zeng, Y., Yi, R., & Cullen, B. R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600491 · Cited by 583

A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

Forman, J. J., Legesse-Miller, A., & Coller, H. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803230105 · Cited by 581

The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a

Guil, S., & Cáceres, J. F. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1250 · Cited by 567

Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex

Parker, J. S., Roe, S. M., & Barford, D. (2005) · Nature · doi:10.1038/nature03462 · Cited by 558

Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein

Förstemann, K., Tomari, Y., Du, T., Vagin, V. V., Denli, A. M., Bratu, D. P., Klattenhoff, C., Theurkauf, W. E., & Zamore, P. D. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030236 · Cited by 556

Structure of the guide-strand-containing argonaute silencing complex

Wang, Y., Sheng, G., Juranek, S., Tuschl, T., & Patel, D. J. (2008) · Nature · doi:10.1038/nature07315 · Cited by 550

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G. S., Tuschl, T., & Patel, D. J. (2009) · Nature · doi:10.1038/nature08434 · Cited by 549

The deep evolution of metazoan microRNAs

Wheeler, B. M., Heimberg, A. M., Moy, V. N., Sperling, E. A., Holstein, T. W., Heber, S., & Peterson, K. J. (2009) · Evolution & Development · doi:10.1111/j.1525-142x.2008.00302.x · Cited by 534

Structural requirements for pre-microRNA binding and nuclear export by Exportin 5

Zeng, Y. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh824 · Cited by 533

Alternative miRNA Biogenesis Pathways and the Interpretation of Core miRNA Pathway Mutants

Yang, J.-S., & Lai, E. C. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.024 · Cited by 526

A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery

岡田, 千., Yamashita, E., Lee, S. J., Shibata, S., Katahira, J., Nakagawa, A., Yoneda, Y., & Tomitake Tsukihara, A. (2009) · Science · doi:10.1126/science.1178705 · Cited by 525

Dicer recognizes the 5′ end of RNA for efficient and accurate processing

Park, J., Heo, I., Tian, Y., Simanshu, D. K., Chang, H., Jee, D. I. H., Patel, D. J., & Kim, V. N. (2011) · Nature · doi:10.1038/nature10198 · Cited by 507

Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes

Iwasaki, S., Kobayashi, M., Yoda, M., Sakaguchi, Y., Katsuma, S., Suzuki, T., & Tomari, Y. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.015 · Cited by 507

Vive la différence: biogenesis and evolution of microRNAs in plants and animals

Axtell, M. J., Westholm, J. O., & Lai, E. C. (2011) · Genome biology · doi:10.1186/gb-2011-12-4-221 · Cited by 496

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells

Hagan, J. P., Piskounova, E., & Gregory, R. I. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1676 · Cited by 491

Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNA

Cazalla, D., Yario, T., & Steitz, J. A. (2010) · Science · doi:10.1126/science.1187197 · Cited by 483

Posttranscriptional Crossregulation between Drosha and DGCR8

Han, J., Pedersen, J. S., Kwon, S. C., Belair, C. D., Kim, Y. K., Yeom, K., Yang, W., Haussler, D. H., Blelloch, R. H., & Kim, V. N. (2009) · Cell · doi:10.1016/j.cell.2008.10.053 · Cited by 482

Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

Yang, J.-S., Maurin, T., Robine, N., Rasmussen, K. D., Jeffrey, K. L., Chandwani, R., Papapetrou, E. P., Sadelain, M., O’Carroll, D., & Lai, E. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006432107 · Cited by 481

Making RISC

Kawamata, T., & Tomari, Y. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.03.009 · Cited by 481

Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs

Krol, J., Busskamp, V., Markiewicz, I., Stadler, M. B., Ribi, S., Richter, J., Duebel, J., Bicker, S., Fehling, H. J., Schübeler, D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.039 · Cited by 470

Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1

Förstemann, K., Horwich, M. D., Wee, L. M., Tomari, Y., & Zamore, P. D. (2007) · Cell · doi:10.1016/j.cell.2007.05.056 · Cited by 468

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

Kawahara, Y., & Mieda-Sato, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112427109 · Cited by 467

Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells

Saito, K., Ishizuka, A., Siomi, H., & Siomi, M. C. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030235 · Cited by 450

A human, ATP-independent, RISC assembly machine fueled by pre-miRNAPreprint

Maniataki, E., & Mourelatos, Z. (2005) · Genes & Development · doi:10.1101/gad.1384005 · Cited by 447

Selective stabilization of mammalian microRNAs by 3′ adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2Preprint

Katoh, T., Sakaguchi, Y., Miyauchi, K., Suzuki, T., Kashiwabara, S., Baba, T., & Suzuki, T. (2009) · Genes & Development · doi:10.1101/gad.1761509 · Cited by 438

Dicer1 functions as a haploinsufficient tumor suppressorPreprint

Kumar, M. S., Pester, R. E., Chen, C. Y., Lane, K. M., Chin, C., Lü, J., Kirsch, D. G., Golub, T. R., & Jacks, T. (2009) · Genes & Development · doi:10.1101/gad.1848209 · Cited by 437

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

Leung, A. K. L., Vyas, S., Rood, J., Bhutkar, A. J., Sharp, P. A., & Chang, P. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.015 · Cited by 436

In vitro reconstitution of the human RISC-loading complex

MacRae, I. J., Ma, E., Zhou, M., Robinson, C. V., & Doudna, J. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710869105 · Cited by 435

Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

Auyeung, V. C., Ulitsky, I., McGeary, S. E., & Bartel, D. P. (2013) · Cell · doi:10.1016/j.cell.2013.01.031 · Cited by 434

Slicer function of Drosophila Argonautes and its involvement in RISC formationPreprint

九十九, 裕., Tsukumo, H., Nagami, T., Siomi, H., & Siomi, M. C. (2005) · Genes & Development · doi:10.1101/gad.1370605 · Cited by 426

A Dicer-2-Dependent 80S Complex Cleaves Targeted mRNAs during RNAi in Drosophila

Pham, J. W., Pellino, J. L., Lee, Y. S., Carthew, R. W., & Sontheimer, E. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00258-2 · Cited by 425

Degradation of microRNAs by a Family of Exoribonucleases in Arabidopsis

Ramachandran, V., & Chen, X. (2008) · Science · doi:10.1126/science.1163728 · Cited by 423

Velo‐cardio‐facial syndrome: A review of 120 patients

Goldberg, R. B., Motzkin, B., Marion, R., Scambler, P. J., & Shprintzen, R. J. (1993) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320450307 · Cited by 422

Cleavage of the siRNA passenger strand during RISC assembly in human cells

Leuschner, P. J. F., Ameres, S. L., Kueng, S., & Martînez, J. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400637 · Cited by 413

Primary microRNA transcripts are processed co-transcriptionally

Morlando, M., Ballarino, M., Gromak, N., Pagano, F., Bozzoni, I., & Proudfoot, N. J. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1475 · Cited by 408

Sorting of Drosophila Small Silencing RNAs

Tomari, Y., Du, T., & Zamore, P. D. (2007) · Cell · doi:10.1016/j.cell.2007.05.057 · Cited by 402

MicroRNAs in neuronal function and dysfunction

Im, H.-I., & Kenny, P. J. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.004 · Cited by 399

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

Davis‐Dusenbery, B. N., Hilyard, A. C., Nguyen, P. H., Lagna, G., & Hata, A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.011 · Cited by 384

RISC Assembly Defects in the Drosophila RNAi Mutant armitage

Tomari, Y., Du, T., Haley, B., Schwarz, D. S., Bennett, R. P., Cook, H. A., Koppetsch, B. S., Theurkauf, W. E., & Zamore, P. D. (2004) · Cell · doi:10.1016/s0092-8674(04)00218-1 · Cited by 383

ATP-dependent human RISC assembly pathways

Yoda, M., Kawamata, T., Paroo, Z., Ye, X., Iwasaki, S., Liu, Q., & Tomari, Y. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1733 · Cited by 380

Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling

Paroo, Z., Ye, X., Chen, S., & Liu, Q. (2009) · Cell · doi:10.1016/j.cell.2009.06.044 · Cited by 380

Structure and function of Zucchini endoribonuclease in piRNA biogenesis

Nishimasu, H., Ishizu, H., Saito, K., Fukuhara, S., Kamatani, M. K., Bonnefond, L., Matsumoto, N., Nishizawa, T., Nakanaga, K., Aoki, J., et al. (2012) · Nature · doi:10.1038/nature11509 · Cited by 377

Molecular Basis for Interaction of let-7 MicroRNAs with Lin28

Nam, Y., Chen, C., Gregory, R. I., Chou, J. J., & Piotr Sliz, A. (2011) · Cell · doi:10.1016/j.cell.2011.10.020 · Cited by 368

Structure and activity of putative intronic miRNA promoters

Monteys, A. M., Spengler, R. M., Wan, J., Tecedor, L., Lennox, K. A., Xing, Y., & Davidson, B. L. (2010) · RNA · doi:10.1261/rna.1731910 · Cited by 367

The expansion of the metazoan microRNA repertoire

Jana Hertel, A., Lindemeyer, M., Kristin Missal, A., Fried, C., Andrea Tanzer, A., Flamm, C., Hofacker, I. L., Stadler, P. F., & 2005, T. S. O. B. C. L. 2. A. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-25 · Cited by 364

Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway

Ghildiyal, M., Xu, J., Seitz, H., Weng, Z., & Zamore, P. D. (2010) · RNA · doi:10.1261/rna.1972910 · Cited by 362

Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlinesPreprint

Ishizu, H., Siomi, H., & Siomi, M. C. (2012) · Genes & Development · doi:10.1101/gad.203786.112 · Cited by 359

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

Shen, J., Xia, W., Khotskaya, Y. B., Huo, L., Nakanishi, K., Lim, S., Du, Y., Wang, Y., Chang, W., Chen, C., et al. (2013) · Nature · doi:10.1038/nature12080 · Cited by 358

Active turnover modulates mature microRNA activity in Caenorhabditis elegans

Chatterjee, S., & Großhans, H. (2009) · Nature · doi:10.1038/nature08349 · Cited by 357

Structure of yeast Argonaute with guide RNA

Nakanishi, K., Weinberg, D. E., Bartel, D. P., & Patel, D. J. (2012) · Nature · doi:10.1038/nature11211 · Cited by 356

Posttranscriptional Regulation of miRNAs Harboring Conserved Terminal Loops

Michlewski, G., Guil, S., Semple, C. A. M., & Cáceres, J. F. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.013 · Cited by 350

RNA editing of the microRNA‐151 precursor blocks cleavage by the Dicer–TRBP complex

Kawahara, Y., Zinshteyn, B., Chendrimada, T. P., Shiekhattar, R., & Nishikura, K. (2007) · The EMBO Reports · doi:10.1038/sj.embor.7401011 · Cited by 348

A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells

Melo, S. A., Moutinho, C., Ropero, S., Calin, G. A., Rossi, S., Spizzo, R., Fernández, A. F., Dávalos, V., Villanueva, A., Montoya, G., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.09.007 · Cited by 347

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

Ipsaro, J. J., Haase, A. D., Knott, S., Joshua‐Tor, L., & Hannon, G. J. (2012) · Nature · doi:10.1038/nature11502 · Cited by 347

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28–let-7 pathway

Chang, H.-M., Triboulet, R., Thornton, J. E., & Gregory, R. I. (2013) · Nature · doi:10.1038/nature12119 · Cited by 341

Structural determinants of RNA recognition and cleavage by Dicer

MacRae, I. J., Zhou, K., & Doudna, J. A. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1293 · Cited by 338

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

Mori, M., Triboulet, R., Mohseni, M., Schlegelmilch, K., Shrestha, K., Camargo, F. D., & Gregory, R. I. (2014) · Cell · doi:10.1016/j.cell.2013.12.043 · Cited by 335

Dicer-1 and R3D1-L catalyze microRNA maturation in DrosophilaPreprint

Jiang, F., Ye, X., Liu, X., Fincher, L., Mckearin, D. M., & Liu, Q. (2005) · Genes & Development · doi:10.1101/gad.1334005 · Cited by 330

Distinct Mechanisms for MicroRNA Strand Selection by Drosophila Argonautes

Okamura, K., Liu, N., & Lai, E. C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.027 · Cited by 324

Structural determinants of miRNAs for RISC loading and slicer-independent unwinding

Kawamata, T., Seitz, H., & Tomari, Y. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1630 · Cited by 318

Mono-Uridylation of Pre-MicroRNA as a Key Step in the Biogenesis of Group II let-7 MicroRNAs

Heo, I., Ha, M., Lim, J., Yoon, M.-J., Park, J., Kwon, S. C., Chang, H., & Kim, V. N. (2012) · Cell · doi:10.1016/j.cell.2012.09.022 · Cited by 316

Mechanisms of control of microRNA biogenesis

Davis‐Dusenbery, B. N., & Hata, A. (2010) · The Journal of Biochemistry · doi:10.1093/jb/mvq096 · Cited by 314

Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing

Yeom, K., Lee, Y., Han, J., Suh, M. R., & Kim, V. N. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl458 · Cited by 309

Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer

Jazdzewski, K., Liyanarachchi, S., Swierniak, M., Pachucki, J., Ringel, M. D., Jarzab, B., & de la Chapelle, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812591106 · Cited by 304

Heme is involved in microRNA processing

Faller, M., Matsunaga, M., Yin, S., Loo, J. A., & Guo, F. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1182 · Cited by 295

The Loop Position of shRNAs and Pre-miRNAs Is Critical for the Accuracy of Dicer Processing In Vivo

Gu, S., Jin, L., Zhang, Y., Huang, Y., Zhang, F., Valdmanis, P. N., & Kay, M. A. (2012) · Cell · doi:10.1016/j.cell.2012.09.042 · Cited by 291

A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptibility of Lung Cancer in Chinese

Tian, T., Shu, Y., Chen, J., Hu, Z., Xu, L., Jin, G., Liang, J., Liu, P., Zhou, X., Miao, R., et al. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0814 · Cited by 286

The contributions of dsRNA structure to Dicer specificity and efficiency

Vermeulen, A., Behlen, L. S., Reynolds, A., Wolfson, A. D., MARSHALL, W. S., Karpilow, J. M., & Khvorova, A. (2005) · RNA · doi:10.1261/rna.7272305 · Cited by 279

Structural insights into RNA processing by the human RISC-loading complex

Wang, H., Noland, C. L., Siridechadilok, B., Taylor, D. W., Ma, E., Felderer, K., Doudna, J. A., & Nogales, E. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1673 · Cited by 272

MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex

Cheng, T.-L., Wang, Z., Liao, Q., Zhu, Y., Zhou, W.-H., Xu, W., & Qiu, Z. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.01.032 · Cited by 270

MicroRNA turnover: when, how, and why

Rüegger, S., & Großhans, H. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.07.002 · Cited by 269

Hierarchical Rules for Argonaute Loading in Drosophila

Czech, B., Zhou, R., Erlich, Y., Brennecke, J., Binari, R. C., Villalta, C., Gordon, A., Perrimon, N., & Hannon, G. J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.028 · Cited by 266

MCPIP1 Ribonuclease Antagonizes Dicer and Terminates MicroRNA Biogenesis through Precursor MicroRNA Degradation

Suzuki, H. I., Arase, M., Matsuyama, H., Choi, Y. L., Ueno, T., Mano, H., Sugimoto, K., & Miyazono, K. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.012 · Cited by 266

Canonical and alternate functions of the microRNA biogenesis machineryPreprint

Chong, M. M. W., Zhang, G., Cheloufi, S., Neubert, T. A., Hannon, G. J., & Littman, D. R. (2010) · Genes & Development · doi:10.1101/gad.1953310 · Cited by 263

Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing

Azuma-Mukai, A., Oguri, H., Mitsuyama, T., Qian, Z. R., Asai, K., Siomi, H., & Siomi, M. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800334105 · Cited by 259

Mammalian 5′-Capped MicroRNA Precursors that Generate a Single MicroRNA

Xie, M., Li, M., Vilborg, A., Lee, N., Shu, M.-D., Yartseva, V., Šestan, N., & STEITZ, J. A. (2013) · Cell · doi:10.1016/j.cell.2013.11.027 · Cited by 256

Essential and overlapping functions for mammalian Argonautes in microRNA silencingPreprint

Su, H. H., Trombly, M. I., Chen, J., & Wang, X. (2009) · Genes & Development · doi:10.1101/gad.1749809 · Cited by 254

RNA Interference Pathways in Fungi: Mechanisms and Functions

Chang, S.-S., Zhang, Z., & Liu, Y. (2012) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092611-150138 · Cited by 252

C3PO, an Endoribonuclease That Promotes RNAi by Facilitating RISC Activation

Liu, Y., Ye, X., Jiang, F., Liang, C., Chen, D., Peng, J., Kinch, L. N., Grishin, N. V., & Liu, Q. (2009) · Science · doi:10.1126/science.1176325 · Cited by 251

Crystallographic and Modeling Studies of RNase III Suggest a Mechanism for Double-Stranded RNA Cleavage

Błaszczyk, J., Tropea, J. E., Bubunenko, M. G., Routzahn, K. M., Waugh, D. S., Court, D. L., & Ji, X. (2001) · Structure · doi:10.1016/s0969-2126(01)00685-2 · Cited by 250

Prolyl 4-hydroxylation regulates Argonaute 2 stability

Qi, H. H., Ongusaha, P. P., Myllyharju, J., Cheng, D., Pakkanen, O., Shi, Y. G., Lee, S. W., Peng, J., & Shi, Y. (2008) · Nature · doi:10.1038/nature07186 · Cited by 248

Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells

Baccarini, A., Chauhan, H., Gardner, T. J., Jayaprakash, A. D., Sachidanandam, R., & Brown, B. D. (2011) · Current Biology · doi:10.1016/j.cub.2011.01.067 · Cited by 247

let-7 regulates Dicer expression and constitutes a negative feedback loop

Tokumaru, S., Suzuki, M., Yamada, H., Nagino, M., & Takahashi, T. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn187 · Cited by 241

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

Zeng, Y., Sankala, H. M., Zhang, X., & Graves, P. R. (2008) · Biochemical Journal · doi:10.1042/bj20080599 · Cited by 233

‘See-saw’ expression of microRNA-198 and FSTL1 from a single transcript in wound healing

Sundaram, G. M., Common, J. E. A., Gopal, F. E., Srikanta, S., Lakshman, K., Lunny, D. P., Lim, T. C., Tanavde, V., Lane, E. B., & Sampath, P. (2013) · Nature · doi:10.1038/nature11890 · Cited by 231

DGCR8 HITS-CLIP reveals novel functions for the Microprocessor

Macías, S., Plass, M., Stajuda, A., Michlewski, G., Eyras, E., & Cáceres, J. F. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2344 · Cited by 228

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

Rybak‐Wolf, A., Fuchs, H. R., Hadian, K., Smirnova, L., Wulczyn, E. A., Michel, G., Nitsch, R., Krappmann, D., & Wulczyn, F. G. (2009) · Nature Cell Biology · doi:10.1038/ncb1987 · Cited by 226

Long-term, efficient inhibition of microRNA function in mice using rAAV vectors

Xie, J., Ameres, S. L., Friedline, R. H., Hung, J., Zhang, Y., Xie, Q., Li, Z., Su, Q., He, R., Li, M., et al. (2012) · Nature Methods · doi:10.1038/nmeth.1903 · Cited by 220

Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals

Fukunaga, R., Han, B., Hung, J., Xu, J. L., Weng, Z., & Zamore, P. D. (2012) · Cell · doi:10.1016/j.cell.2012.09.027 · Cited by 214

A Mammalian Herpesvirus Uses Noncanonical Expression and Processing Mechanisms to Generate Viral MicroRNAs

Bogerd, H. P., Karnowski, H. W., Cai, X., Shin, J., Pohlers, M., & Cullen, B. R. (2010) · Molecular Cell · doi:10.1016/j.molcel.2009.12.016 · Cited by 213

Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

Lee, H., Zhou, K., Smith, A. M., Noland, C. L., & Doudna, J. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt361 · Cited by 210

HSP90 Protein Stabilizes Unloaded Argonaute Complexes and Microscopic P-bodies in Human Cells

Johnston, M. J. G., Geoffroy, M., Sobala, A., Hay, R. T., & Hutvágner, G. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-10-0885 · Cited by 205

Human RNase III Is a 160-kDa Protein Involved in Preribosomal RNA Processing

Wu, H., Xu, H., Miraglia, L. J., & Crooke, S. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005494200 · Cited by 200

microRNAs associated with the different human Argonaute proteins

Dueck, A., Ziegler, C., Eichner, A., Berezikov, E., & Meister, G. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks705 · Cited by 195

Recognition of the pre-miRNA structure by Drosophila Dicer-1

Tsutsumi, A., Kawamata, T., Izumi, N., Seitz, H., & Tomari, Y. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2125 · Cited by 193

Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs

Ustianenko, D., Hroššová, D., Potěšil, D., Chalupníková, K., Hrazdilová, K., Pachernı́k, J., Cetkovská, K., Uldrijan, S., Zdráhal, Z., & Vaňáčová, Š. (2013) · RNA · doi:10.1261/rna.040055.113 · Cited by 191

Reciprocal Inhibition between Intracellular Antiviral Signaling and the RNAi Machinery in Mammalian Cells

Seo, G. J., Kincaid, R. P., Phanaksri, T., Burke, J. M., Pare, J. M., Cox, J. E., Hsiang, T.-Y., Krug, R. M., & Sullivan, C. S. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.09.002 · Cited by 188

Phosphorylation of human Argonaute proteins affects small RNA binding

Rüdel, S., Wang, Y., Lenobel, R., Körner, R., Hsiao, H.-H., Urlaub, H., Patel, D., & Meister, G. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1032 · Cited by 188

Sequence features associated with microRNA strand selection in humans and flies

Hu, H., Zheng, Y., Xu, Y., Hu, H., Menzel, C., Zhou, Y. H., Chen, W., & Khaitovich, P. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-413 · Cited by 187

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire

Bronevetsky, Y., Villarino, A. V., Eisley, C. J., Barbeau, R., Barczak, A. J., Heinz, G. A., Kremmer, E., Heissmeyer, V., McManus, M. T., Erle, D. J., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20111717 · Cited by 187

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

Rupaimoole, R., & Slack, F. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.246 · Cited by 4,741

Metazoan MicroRNAs

Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751

MicroRNA

Lu, T. X., & Rothenberg, M. E. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.08.034 · Cited by 2,425

Regulation of microRNA function in animals

Gebert, L. F. R., & MacRae, I. J. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0045-7 · Cited by 2,284

Regulation of MicroRNAs

Ergin, K., & Çetinkaya, R. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1170-8_1 · Cited by 87

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

Treiber, T., Treiber, N., & Meister, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0059-1 · Cited by 1,299

The biogenesis and regulation of animal microRNAs

Kim, H., Lee, Y.-Y., & Kim, V. N. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00805-0 · Cited by 201

MicroRNAs in Gene Regulation: When the Smallest Governs It All

Ouellet, D. L., Perron, M. P., Gobeil, L.-A., Plante, P., & Provost, P. (2006) · BioMed Research International · doi:10.1155/jbb/2006/69616 · Cited by 116

Versatile microRNA biogenesis in animals and their viruses

Xie, M., & STEITZ, J. A. (2014) · RNA Biology · doi:10.4161/rna.28985 · Cited by 60