The DOI matches its Crossref record; 271 of the 272 references it cites were found in a registry or an index.
Regulation of microRNA biogenesis
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathological processes in animals. The biogenesis of miRNAs is under tight temporal and spatial control, and their dysregulation is associated with many human diseases, particularly cancer. In animals, miRNAs are ∼22 nucleotides in length, and they are produced by two RNase III proteins--Drosha and Dicer. miRNA biogenesis is regulated at multiple levels, including at the level of miRNA transcription; its processing by Drosha and Dicer in the nucleus and cytoplasm, respectively; its modification by RNA editing, RNA methylation, uridylation and adenylation; Argonaute loading; and RNA decay. Non-canonical pathways for miRNA biogenesis, including those that are independent of Drosha or Dicer, are also emerging.
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In the citing paper
“miRNAs direct translational repression by partial binding to the 3Ј UTR of mRNAs after first being incorporated into an RNA-induced silencing complex containing Argonaute-2 (Ago2) (Gregory et al., 2005;Chekulaeva and Filipowicz, 2009;Ha and Kim, 2014).”
From MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models (2017) · cites this paper as Ha and Kim, 2014
In the citing paper
“Mammalian cells express several classes of small ncRNA, including microRNA (miRNA) (11), small interfering RNAs (siRNA), small nucleolar RNAs (snoRNA) (12), small nuclear RNA (snRNA) (13), PIWI-interacting RNA (piRNA) (14), and tRNA-derived small RNAs (tRFs) (15)”
From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [11]
In the citing paper
“miRNAs are small non-coding RNAs, approximately 22 nucleotides in length, that typically interact with the 3’UTR of their target mRNAs, although interaction with the 5’UTR and coding regions of targets has also been reported45.”
From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [45]
In the citing paper
“miRNA biogenesis starts with the processing of RNA polymerase II/III transcripts post- or co-transcriptionally (14).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [14]
In the citing paper
“In most cases, miRNAs interact with the 3′ untranslated region (3′ UTR) of target mRNAs to induce mRNA degradation and translational repression.”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [14]
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RetractedRetracted: Post‐transcriptional regulation of the let‐7 microRNA during neural cell specification
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Metadata
- Authors
- Ha, M., & Kim, V. N.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Kim, V. Narry
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2014-07-16
- Volume
- 15
- Issue
- 8
- Pages
- 509-524
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2006247279
- Cited by
- 5,462
- References
- 272
- Citations by year
- 2026: 226 · 2025: 296 · 2024: 477 · 2023: 489 · 2022: 572 · 2021: 582 · 2020: 525 · 2019: 496 · 2018: 500 · 2017: 514 · 2016: 430 · 2015: 310 · 2014: 38
- FWCI
- 42.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- microRNA biogenesis, Drosha, Dicer, RNA processing, RNA editing, RNA methylation, uridylation, adenylylation, RNA degradation, RNA silencing, cancer
- MeSH terms
- Animals, Cell Nucleus, Gene Expression Regulation, Humans, Plants, RNA Processing, Post-Transcriptional, RNA, Messenger, Transcription, Genetic, Active Transport, Cell Nucleus, RNA Interference, MicroRNAs
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