Cited by 5,462MicroRNA in disease regulationRNA regulation and diseasePlant Molecular Biology Research

The DOI matches its Crossref record; 271 of the 272 references it cites were found in a registry or an index.

Regulation of microRNA biogenesis

Ha, Minju, Kim, V. Narry·2014·Nature Reviews Molecular Cell Biology

Open this paper in CoChat — free account

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathological processes in animals. The biogenesis of miRNAs is under tight temporal and spatial control, and their dysregulation is associated with many human diseases, particularly cancer. In animals, miRNAs are ∼22 nucleotides in length, and they are produced by two RNase III proteins--Drosha and Dicer. miRNA biogenesis is regulated at multiple levels, including at the level of miRNA transcription; its processing by Drosha and Dicer in the nucleus and cytoplasm, respectively; its modification by RNA editing, RNA methylation, uridylation and adenylation; Argonaute loading; and RNA decay. Non-canonical pathways for miRNA biogenesis, including those that are independent of Drosha or Dicer, are also emerging.

Integrity signals

Registry

Crossref · 10.1038/nrm3838

Cites

271 of 271 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

3 retracted

DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs
Fukuda, T., Yamagata, K., Fujiyama, S., Μatsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Naitou, M., Endoh, H., Nakamura, T., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1577 · Cited by 452
Retracted
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
Melo, S. A., Ropero, S., Moutinho, C., Aaltonen, L. A., Yamamoto, H., Calin, G. A., Rossi, S., Fernández, A. F., Carneiro, F., Oliveíra, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.317 · Cited by 375
Retracted
Retracted: Post‐transcriptional regulation of the let‐7 microRNA during neural cell specification
Wulczyn, F. G., Smirnova, L., Rybak‐Wolf, A., Brandt, C., Kwidzinski, E., Ninnemann, O., Strehle, M., Seiler, A. E. M., Schumacher, S., & Nitsch, R. (2006) · The FASEB Journal · doi:10.1096/fj.06-6130com · Cited by 328
Retracted
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462
The nuclear RNase III Drosha initiates microRNA processing
Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O., Kim, S., et al. (2003) · Nature · doi:10.1038/nature01957 · Cited by 5,299
Self-citation
miRBase: annotating high confidence microRNAs using deep sequencing data
Kozomara, A., & Griffiths-Jones, S. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1181 · Cited by 5,073
Role for a bidentate ribonuclease in the initiation step of RNA interference
Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001) · Nature · doi:10.1038/35053110 · Cited by 5,018
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
MicroRNA genes are transcribed by RNA polymerase II
Lee, Y., Kim, M., Han, J., Yeom, K.-H., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,556
Self-citation

Show all 272 references

Sorted by citations

Items 901–1,000 of 1,021

High-resolution measurement of long-range distances in RNA: pulse EPR spectroscopy with TEMPO-labeled nucleotides
Halbmair, K., Seikowski, J., Tkach, I., Höbartner, C., Sezer, D., & Bennati, M. (2016) · Chemical Science · doi:10.1039/c5sc04631a · Cited by 57
Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study
Iacomino, G., Russo, P., Stillitano, I., Lauria, F., Marena, P., Ahrens, W., Luca, P. D., & Siani, A. (2016) · Genes & Nutrition · doi:10.1186/s12263-016-0525-3 · Cited by 57
miR-196, an Emerging Cancer Biomarker for Digestive Tract Cancers
Lu, Y., Chang, J. T., Chan, E., Chao, Y., Yeh, T., Chen, J., & Cheng, A. (2016) · Journal of Cancer · doi:10.7150/jca.13460 · Cited by 57
MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8
Xu, L., Wen, T., Liu, Z., Xu, F., Yang, L., Liu, J., Feng, G., & An, G. (2016) · Oncotarget · doi:10.18632/oncotarget.9811 · Cited by 58
MicroRNA-153-3p suppress cell proliferation and invasion by targeting SNAI1 in melanoma
Zeng, H., Yan, S., & Wu, S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.04.032 · Cited by 57
Cryopreservation of boar sperm induces differential microRNAs expression
Zhang, Y., Dai, D., Chang, Y., Li, Y., Zhang, M., Zhou, G., Peng, Z., & Zeng, C. (2017) · Cryobiology · doi:10.1016/j.cryobiol.2017.04.013 · Cited by 57
High throughput small RNA and transcriptome sequencing reveal capacitation-related microRNAs and mRNA in boar sperm
Li, Y., Li, R., Ran, M., Zhang, Y., Liang, K., Ren, Y.-N., He, W., Zhang, M., Zhou, G., Qazi, I. H., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-5132-9 · Cited by 57
Prevention of breast cancer by dietary polyphenols—role of cancer stem cells
Gu, H., Mao, X., & Du, ‬. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1551778 · Cited by 57
miR-150-5p represses TP53 tumor suppressor gene to promote proliferation of colon adenocarcinoma
Liu, F., & Wang, X. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-43231-5 · Cited by 59
METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells
Chamorro-Jorganes, A., Sweaad, W., Katare, R., Besnier, M., Anwar, M., Beazley‐Long, N., Sala‐Newby, G. B., de Lara, Í. R.-P., Chandrasekera, D. N. K., Ritchie, A., et al. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316180 · Cited by 57
Enhancing the therapeutic delivery of oligonucleotides by chemical modification and nanoparticle encapsulation
Sun, Y., Zhao, Y., Zhao, X., Lee, R. J., Teng, L., & Zhou, C. (2017) · Molecules · doi:10.3390/molecules22101724 · Cited by 56
MicroRNA-21 promotes TGF-β1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression
Li, C., Song, L., Zhang, Z., Bai, X., Cui, M., & Ma, L. (2016) · Oncotarget · doi:10.18632/oncotarget.11888 · Cited by 57
Retracted
Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism
Burger, K., Ketley, R. F., & Gullerová, M. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00061 · Cited by 58
Modes of action and diagnostic value of miRNAs in sepsis
Antonakos, N., Gilbert, C., Théroude, C., Schrijver, I. T., & Roger, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.951798 · Cited by 57
Runx2 and Nell-1 in dental follicle progenitor cells regulate bone remodeling and tooth eruption
Zeng, L., He, H., Sun, M., Gong, X., Zhou, M., Hong, Y., Wu, Y., Chen, X., & Chen, Q. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03140-3 · Cited by 57
MicroRNAs as clinical tools for diagnosis, prognosis, and therapy in prostate cancer
Ghamlouche, F., Yehya, A., Zeid, Y., Fakhereddine, H., Fawaz, J., Liu, Y., Al‐Sayegh, M., & Abou-Kheir, W. G. (2023) · Translational Oncology · doi:10.1016/j.tranon.2022.101613 · Cited by 56
The potential role of miRNA in regulating macrophage polarization
Khayati, S., Dehnavi, S., Sadeghi, M., Afshari, J. T., Esmaeili, S., & Mohammadi, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21615 · Cited by 60
Up-regulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage
Marcuzzo, S., Bonanno, S., Kapetis, D., Barzago, C., Cavalcante, P., D’Alessandro, S., Mantegazza, R., & Bernasconi, P. (2015) · Molecular Brain · doi:10.1186/s13041-015-0095-0 · Cited by 57
Tumor invasion and metastasis regulated by microRNA-184 and microRNA-574-5p in small-cell lung cancer
Zhou, R., Zhou, X., Yin, Z., Guo, J., Hu, T., Jiang, S., Liu, L., Dong, X., Zhang, S., & Wu, G. (2015) · Oncotarget · doi:10.18632/oncotarget.6338 · Cited by 56
Nucleotide sequence of miRNA precursor contributes to cleavage site selection by Dicer
Staręga‐Rosłan, J., Galka-Marciniak, P., & Krzyżosiak, W. J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv968 · Cited by 56
Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity
Perche, F., Yi, Y., Hespel, L., Mi, P., Dirisala, A., Cabral, H., Miyata, K., & Kataoka, K. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.02.027 · Cited by 56
Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for treating cardiac pathology and other diseases
Ooi, J. Y. Y., Bernardo, B. C., Singla, S., Patterson, N. L., Lin, R. C. Y., & McMullen, J. R. (2016) · RNA Biology · doi:10.1080/15476286.2016.1181251 · Cited by 56
MicroRNA dysregulation in melanoma
Latchana, N., Ganju, A., Howard, J. H., & Carson, W. E. (2016) · Surgical Oncology · doi:10.1016/j.suronc.2016.05.017 · Cited by 56
Stable association of RNAi machinery is conserved between the cytoplasm and nucleus of human cells
Kalantari, R., Hicks, J. A., Li, L., Gagnon, K. T., Sridhara, V., Lemoff, A. S., Mirzaei, H., & Corey, D. R. (2016) · RNA · doi:10.1261/rna.056499.116 · Cited by 61
The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner
Woldemichael, B. T., Jawaid, A., Kremer, E. A., Gaur, N., Krol, J., Marchais, A., & Mansuy, I. M. (2016) · Nature Communications · doi:10.1038/ncomms12594 · Cited by 56
microRNAs in lipoprotein and lipid metabolism: from biological function to clinical application
Desgagné, V., Bouchard, L., & Guérin, R. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0575 · Cited by 57
Circular Concatemers of Ultra-Short DNA Segments Produce Regulatory RNAs
Allen, S. E., Hug, I., Pabian, S., Rzeszutek, I., Hoehener, C., & Nowacki, M. (2017) · Cell · doi:10.1016/j.cell.2017.02.020 · Cited by 56
miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin
Patel, N., Garikapati, K. R., PANDITA, R. K., Singh, D. K., Pandita, T. K., Bhadra, U., & Bhadra, M. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-02800-2 · Cited by 56
MicroRNAs in Sertoli cells: implications for spermatogenesis and fertility
Procópio, M. S., de Avelar, G. F., Costa, G. M. J., Lacerda, S. M. D. S. N., Resende, R. R., & França, L. R. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2667-z · Cited by 56
The Pattern of microRNA Binding Site Distribution
Zhang, F., & Wang, D. (2017) · Genes · doi:10.3390/genes8110296 · Cited by 56
An innovative paradigm of methods in microRNAs detection: highlighting DNAzymes, the illuminators
Mahdiannasser, M., & Karami, Z. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.02.020 · Cited by 56
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
Ramalho-Carvalho, J., Gonçalves, C. S., Graça, I. C. R., Bidarra, D., Pereira-Silva, E., Salta, S., Godinho, M. I., Gómez, A., Esteller, M., Costa, B. M., et al. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0475-2 · Cited by 56
Developments in lncRNA drug discovery: where are we heading?
Blokhin, I. O., Khorkova, O., Hsiao, J. H., & Wahlestedt, C. (2018) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2018.1501024 · Cited by 56
Applications of miRNAs in cardiac development, disease progression and regeneration
Pang, J. K. S., Phua, Q. H., & Soh, B.-S. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1451-2 · Cited by 57
Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
Caria, A. C. I., Nonaka, C. K. V., Cavalcante, B. R. R., Sousa, R. A. L. D., Aras, R., & Souza, B. S. D. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144977 · Cited by 57
Visualizing a protonated RNA state that modulates microRNA-21 maturation
Baisden, J. T., Boyer, J. A., Zhao, B., Hammond, S. M., & Zhang, Q. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-00667-5 · Cited by 56
Tissue and circulating microRNAs as biomarkers of response to obesity treatment strategies
Catanzaro, G., Filardi, T., Sabato, C., Vacca, A., Migliaccio, S., Morano, S., & Ferretti, E. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01453-9 · Cited by 58
Profiling of epididymal small non‐protein‐coding RNA s
Nixon, B., Iuliis, G. N. D., Dun, M. D., Zhou, W., Trigg, N. A., & Eamens, A. L. (2019) · Andrology · doi:10.1111/andr.12640 · Cited by 56
MicroRNAs-Based Nano-Strategies as New Therapeutic Approach in Multiple Myeloma to Overcome Disease Progression and Drug Resistance
Desantis, V., Saltarella, I., Lamanuzzi, A., Melaccio, A., Solimando, A. G., Mariggiò, M. A., Racanelli, V., Paradiso, A., Vacca, A., & Frassanito, M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093084 · Cited by 55
Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression
Briata, P., & Gherzi, R. (2020) · Non-Coding RNA · doi:10.3390/ncrna6030040 · Cited by 55
Contribution of miRNAs in the Pathogenesis of Breast Cancer
Ghafouri‐Fard, S., Sasi, A. K., Abak, A., Shoorei, H., Khoshkar, A., & Taheri, M. N. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.768949 · Cited by 56
Role of MicroRNAs in Malignant Glioma
Wang, B., & Ma, J. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.156141 · Cited by 55
MicroRNAs in lipid metabolism and atherosclerosis
Giral, H., Kratzer, A., & Landmesser, U. (2016) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2016.11.010 · Cited by 56
Nup358 binds to AGO proteins through its SUMO‐interacting motifs and promotes the association of target mRNA with miRISC
Sahoo, M. R., Gaikwad, S., Khuperkar, D., Ashok, M., Helen, M., Yadav, S. K., Singh, A. P., Magre, I., Deshmukh, P., Dhanvijay, S., et al. (2016) · EMBO Reports · doi:10.15252/embr.201642386 · Cited by 57
Role of MicroRNA in Osteoarthritis
Zhang, M.-C., Lygrisse, K. A., & Wang, J.-X. (2017) · Journal of Arthritis · doi:10.4172/2167-7921.1000239 · Cited by 51
Gene suppression approaches to neurodegeneration
Ghosh, R., & Tabrizi, S. J. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0307-1 · Cited by 56
Dysregulated placental microRNAs in Early and Late onset Preeclampsia
Lykoudi, A., Kοlialexi, A., Lambrou, G. Ι., Braoudaki, M., Siristatidis, C. S., Papaioanou, G. K., Tzetis, M., Mavrou, A., & Papantoniou, N. (2017) · Placenta · doi:10.1016/j.placenta.2017.11.005 · Cited by 55
A double-edged function of DDX3, as an oncogene or tumor suppressor, in cancer progression (Review)
He, Y., Zhang, D., Yang, Y., Wang, X., Zhao, X., Zhang, P., Zhu, H., Xu, N., & Liang, S. (2018) · Oncology Reports · doi:10.3892/or.2018.6203 · Cited by 55
Obesity-induced overexpression of miRNA-24 regulates cholesterol uptake and lipid metabolism by targeting SR-B1
Wang, M., Li, L., Liu, R., Song, Y., Zhang, X., Niu, W., Kumar, A. K., Guo, Z., & Hu, Z. (2018) · Gene · doi:10.1016/j.gene.2018.05.072 · Cited by 55
Structural Flexibility Enables Alternative Maturation, ARGONAUTE Sorting and Activities of miR168, a Global Gene Silencing Regulator in Plants
Iki, T., Cléry, A., Bologna, N. G., Sarazin, A., Brosnan, C. A., Pumplin, N., Allain, F. H. ‐., & Voinnet, O. (2018) · Molecular Plant · doi:10.1016/j.molp.2018.05.006 · Cited by 56
The role of miRNAs in regulating adrenal and gonadal steroidogenesis
Azhar, S., Dong, D., Shen, W., Hu, Z., & Kraemer, F. B. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0105 · Cited by 57
A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis
Rosano, S., Corà, D., Parab, S., Zaffuto, S., Isella, C., Porporato, R., Hoza, R. M., Calogero, R., Riganti, C., Bussolino, F., et al. (2020) · eLife · doi:10.7554/elife.48095 · Cited by 55
MicroRNAs in brown and beige fat
Goody, D., & Pfeifer, A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.05.003 · Cited by 54
LncRNAs and miRNAs: potential biomarkers and therapeutic targets for prostate cancer.
Ma, G., Tang, M., Wu, Y., Xu, X., Pan, F., & Xu, R. (2016) · PubMed Central · Cited by 54
MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos
Kasper, D. M., Moro, A., Ristori, E., Narayanan, A., Hill-Terán, G., Fleming, E. S., Moreno-Mateos, M. A., Vejnar, C. E., Zhang, J., Lee, D., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.02.021 · Cited by 54
miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia
Besnier, M., Shantikumar, S., Anwar, M., Dixit, P., Chamorro-Jorganes, A., Sweaad, W., Sala‐Newby, G. B., Madeddu, P. R., Thomas, A. C., Howard, L., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.05.002 · Cited by 54
Genome-wide analysis of CCHC-type zinc finger (ZCCHC) proteins in yeast, Arabidopsis, and humans
Aceituno-Valenzuela, U., Micol‐Ponce, R., & Ponce, M. R. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03518-7 · Cited by 54
Functional Interactions Between lncRNAs/circRNAs and miRNAs: Insights Into Rheumatoid Arthritis
Han, J., Wang, X., & Zhang, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.810317 · Cited by 54
Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD
Su, S., Wang, J., Deng, T., Yuan, X., He, J., Liu, N., Li, X., Huang, Y., Wang, H., & Ma, J. (2022) · Nature · doi:10.1038/s41586-022-04911-x · Cited by 54
The mechanisms of glycolipid metabolism disorder on vascular injury in type 2 diabetes
Chen, X., Shi, C., Wang, Y., Yu, H., Zhang, Y., Zhang, J., Li, P., & Gao, J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.952445 · Cited by 56
The miR-17-92 cluster: Yin and Yang in human cancers
Zhao, W., Gupta, A., Krawczyk, J., & Gupta, S. (2022) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2022.100647 · Cited by 55
Potential miRNA Use as a Biomarker: From Breast Cancer Diagnosis to Metastasis
Jordan‐Alejandre, E., Campos-Parra, A. D., Castro-López, D. L., & Silva-Cázares, M. B. (2023) · Cells · doi:10.3390/cells12040525 · Cited by 54
SmithRNAs: Could Mitochondria “Bend” Nuclear Regulation?
Pozzi, A., Plazzi, F., Milani, L., Ghiselli, F., & Passamonti, M. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx140 · Cited by 58
Visualization and Quantification of MicroRNA in a Single Cell Using Atomic Force Microscopy
Koo, H., Park, I., Lee, Y., Kim, H. J., Jung, J. H., Lee, J. H., Kim, Y., Kim, J., & Park, J. W. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b05048 · Cited by 54
Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells
Kuo, T.-C., Chen, C.-K., Hua, K., Yu, P., Lee, W.-J., Chen, M.-W., Jeng, Y., Chien, M., Kuo, K.-T., Hsiao, M., et al. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.10.012 · Cited by 54
miR-124 suppresses glioblastoma growth and potentiates chemosensitivity by inhibiting AURKA
Qiao, W., Guo, B., Zhou, H., Xu, W., Chen, Y., Liang, Y., & Dong, B. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.120 · Cited by 54
The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis
Wang, F., Song, W., Zhao, H., Ma, Y., Li, Y., Zhai, D., Pi, J., Si, Y., Xu, J., Dong, L., et al. (2017) · Cell Research · doi:10.1038/cr.2017.26 · Cited by 55
Impact of MicroRNAs in the Cellular Response to Hypoxia
Bertero, T., Rezzonico, R., Pottier, N., & Mari, B. P. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.03.006 · Cited by 56
miR-455-3p serves as prognostic factor and regulates the proliferation and migration of non-small cell lung cancer through targeting HOXB5
Gao, X., Zhao, H., Diao, C., Wang, X., Xie, Y., Liu, Y., Han, J., & Zhang, M. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.123 · Cited by 54
Identification and expression analysis of microRNAs in medaka gonads
Qiu, W., Zhu, Y., Wu, Y., Yuan, C., Chen, K., & Li, M. (2018) · Gene · doi:10.1016/j.gene.2017.12.062 · Cited by 54
The Nematode Caenorhabditis elegans as a Model Organism to Study Metabolic Effects of ω-3 Polyunsaturated Fatty Acids in Obesity
Bouyanfif, A., Jayarathne, S., Koboziev, I., & Moustaïd‐Moussa, N. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy059 · Cited by 60
DNA methylation regulates miR-140-5p and miR-146a expression in osteoarthritis
Papathanasiou, I. V., Trachana, V., Mourmoura, E., & Tsezou, A. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.05.018 · Cited by 55
Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism
Putzbach, W., Gao, Q. Q., Patel, M., van Dongen, S., Haluck-Kangas, A., Sarshad, A. A., Bartom, E. T., Kim, K. A., Scholtens, D. M., Hafner, M., et al. (2017) · eLife · doi:10.7554/elife.29702 · Cited by 56
Concepts and functions of small RNA pathways in C. elegans
Ketting, R. F., & Cochella, L. (2020) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.08.002 · Cited by 56
MicroRNA Signature in Renal Cell Carcinoma
Ghafouri‐Fard, S., Shirvani-Farsani, Z., Branicki, W., & Taheri, M. N. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.596359 · Cited by 54
MiRNAs in the Peri-Implantation Period: Contribution to Embryo–Maternal Communication in Pigs
Kaczmarek, M. M., Szuszkiewicz, J., Guzewska, M. M., & Przygrodzka, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062229 · Cited by 53
Dysregulated CD4+ T Cells and microRNAs in Myocarditis
Wang, J., & Han, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00539 · Cited by 55
Modulation of MicroRNA Processing by Dicer via Its Associated dsRNA Binding Proteins
Yoshida, T., Asano, Y., & Ui‐Tei, K. (2021) · Non-Coding RNA · doi:10.3390/ncrna7030057 · Cited by 56
RETRACTED ARTICLE: Exosomal microRNA⁃93⁃3p secreted by bone marrow mesenchymal stem cells downregulates apoptotic peptidase activating factor 1 to promote wound healing
Shen, C., Tao, C., Zhang, A., Li, X., Guo, Y., Wei, H., Yin, Q., Li, Q., & Jin, P. (2021) · Bioengineered · doi:10.1080/21655979.2021.1997077 · Cited by 53
Retracted
MicroRNA-21: A Critical Pathogenic Factor of Diabetic Nephropathy
Liu, S., Wu, W., Liao, J., Tang, F., Gao, G., Peng, J., Fu, X., Zhan, Y., Chen, Z., Xu, W., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.895010 · Cited by 53
Genetic polymorphisms in immune- and inflammation-associated genes and their association with bovine mastitis resistance/susceptibility
Khan, M. Z., Wang, J., Ma, Y., Chen, T., Ma, M., Ullah, Q., Khan, I. M., Khan, A. A., Cao, Z., & Liu, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1082144 · Cited by 56
Variant rs8400 enhances ALKBH5 expression through disrupting miR-186 binding and promotes neuroblastoma progression
Guan, Q., Lin, H., Hua, W., Lin, L., Liu, J., Deng, L., Zhang, J., Cheng, J., Yang, Z., Li, Y., et al. (2023) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2023.02.05 · Cited by 53
Human Gut Microbiota for Diagnosis and Treatment of Depression
Averina, O. V., Poluektova, E. U., Zorkina, Y., Kovtun, A. S., & Даниленко, В. Н. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115782 · Cited by 54
Micro RNA ‐31 is a positive modulator of endothelial–mesenchymal transition and associated secretory phenotype induced by TGF ‐β
Katsura, A., Suzuki, H. I., Ueno, T., Mihira, H., Yamazaki, T., Yasuda, T., Watabe, T., Mano, H., Yamada, Y., & Miyazono, K. (2015) · Genes to Cells · doi:10.1111/gtc.12323 · Cited by 53
MicroRNA Theranostics in Prostate Cancer Precision Medicine
Matin, F., Jeet, V., Clements, J. A., Yousef, G. M., & Batra, J. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2015.242800 · Cited by 53
MicroRNAs in Lung Development and Disease
Ameis, D., Khoshgoo, N., Iwasiow, B. M., Snarr, P., & Keijzer, R. (2016) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2016.12.002 · Cited by 54
Characterizing isomiR variants within the micro RNA ‐34/449 family
Mercey, O., Popa, A., Cavard, A., Paquet, A. C., Chevalier, B., Pons, N., Magnone, V., Zangari, J., Brest, P., Zaragosi, L., et al. (2017) · FEBS Letters · doi:10.1002/1873-3468.12595 · Cited by 53
Colorectal Cancer: From the Genetic Model to Posttranscriptional Regulation by Noncoding RNAs
Lizarbe, M. A., Calle-Espinosa, J., Fernández-Lizarbe, E., Fernández‐Lizarbe, S., Robles-Ramos, M. Á., Olmo, N., & Turnay, J. (2017) · BioMed Research International · doi:10.1155/2017/7354260 · Cited by 55
Bone marrow mesenchymal stem cell-derived vascular endothelial growth factor attenuates cardiac apoptosis via regulation of cardiac miRNA-23a and miRNA-92a in a rat model of myocardial infarction
Song, Y.-S., Joo, H.-W., Park, I.-H., Shen, G.-Y., Lee, Y., Shin, J. H., Kim, H., & Kim, K.-S. (2017) · PLOS ONE · doi:10.1371/journal.pone.0179972 · Cited by 53
miR-99 regulates normal and malignant hematopoietic stem cell self-renewal
Khalaj, M., Woolthuis, C. M., Hu, W., Durham, B. H., Chu, S. H., Qamar, S., Armstrong, S. A., & Park, C. Y. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161595 · Cited by 53
MicroRNAs in mucosal inflammation
Neudecker, V., Yuan, X., Bowser, J. L., & Eltzschig, H. K. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1568-7 · Cited by 53
Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation during Drosophila development
Li, Z., Lim, M. Y. T., Kaur, P., Saj, A., Bortolamiol-Bécet, D., Gopal, V., Tolwinski, N. S., Tucker‐Kellogg, G., & Okamura, K. (2018) · eLife · doi:10.7554/elife.38389 · Cited by 55
Global identification of functional microRNA-mRNA interactions in Drosophila
Wessels, H., Lebedeva, S., Hirsekorn, A., Wurmus, R., Akalin, A., Mukherjee, N., & Ohler, U. (2019) · Nature Communications · doi:10.1038/s41467-019-09586-z · Cited by 53
Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice
Han, T.-S., Voon, D. C., Oshima, H., Nakayama, M., Echizen, K., Sakai, E., Yong, Z. W. E., Murakami, K., Yu, L., Minamoto, T., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.11.059 · Cited by 54
The Clinical Potential of Circulating miRNAs as Biomarkers: Present and Future Applications for Diagnosis and Prognosis of Age-Associated Bone Diseases
Bottani, M., Banfi, G., & Lombardi, G. (2020) · Biomolecules · doi:10.3390/biom10040589 · Cited by 53
Fecal microRNAs as Innovative Biomarkers of Intestinal Diseases and Effective Players in Host-Microbiome Interactions
Sarshar, M., Scribano, D., Ambrosi, C., Palamara, A. T., & Masotti, A. (2020) · Cancers · doi:10.3390/cancers12082174 · Cited by 54
Inhibition of miRNA‑29a regulates intestinal barrier function in diarrhea‑predominant irritable bowel syndrome by upregulating ZO‑1 and CLDN1
Zhu, H., Xiao, X., Shi, Y., Wu, Y., Huang, Y., Li, D., Xiong, F., He, G., Chai, Y., & Tang, H. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9284 · Cited by 53
Single-molecule imaging of microRNA-mediated gene silencing in cells
Kobayashi, H., & Singer, R. H. (2022) · Nature Communications · doi:10.1038/s41467-022-29046-5 · Cited by 59
Epigenetics in bipolar disorder: a critical review of the literature
Legrand, A., Iftimovici, A., Khayachi, A., & Chaumette, B. (2021) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000267 · Cited by 48
MicroRNA-449b-5p suppresses the growth and invasion of breast cancer cells via inhibiting CREPT-mediated Wnt/β-catenin signaling
Jiang, J., Yang, X., He, X., Ma, W., Wang, J., Zhou, Q., Li, M., & Yu, S. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.02.004 · Cited by 52

Authors: Ha, M., & Kim, V. N.
Affiliations: Seoul National University (KR)
Corresponding author: Kim, V. Narry
ORCID: Ha, Minju
Kim, V. Narry
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2014-07-16
Volume: 15
Issue: 8
Pages: 509-524
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm3838
OpenAlex: W2006247279
Cited by: 5,462
References: 272
Citations by year: 2026: 226 · 2025: 296 · 2024: 477 · 2023: 489 · 2022: 572 · 2021: 582 · 2020: 525 · 2019: 496 · 2018: 500 · 2017: 514 · 2016: 430 · 2015: 310 · 2014: 38
FWCI: 42.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: microRNA biogenesis, Drosha, Dicer, RNA processing, RNA editing, RNA methylation, uridylation, adenylylation, RNA degradation, RNA silencing, cancer
MeSH terms: Animals, Cell Nucleus, Gene Expression Regulation, Humans, Plants, RNA Processing, Post-Transcriptional, RNA, Messenger, Transcription, Genetic, Active Transport, Cell Nucleus, RNA Interference, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of microRNA biogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks