Messenger-RNA-binding proteins and the messages they carry

The Skipping of Constitutive Exons in Vivo Induced by Nonsense Mutations

Dietz, H. C., Valle, D., Francomano, C. A., Kendzior, R. J., Pyeritz, R. E., & Cutting, G. A. (1993) · Science · doi:10.1126/science.8430317 · Cited by 417

Binary specification of nonsense codons by splicing and cytoplasmic translation

Thermann, R., Neu‐Yilik, G., Deters, A., Frede, U., Wehr, K., Hagemeier, C., Hentze, M. W., & Kulozik, A. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3484 · Cited by 406

Identification of AUF1 (Heterogeneous Nuclear Ribonucleoprotein D) as a Component of the α-Globin mRNA Stability Complex

Kiledjian, M., DeMaria, C. T., Brewer, G., & Novick, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4870 · Cited by 145

A census of human RNA-binding proteins

Gerstberger, S., Hafner, M., & Tuschl, T. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3813 · Cited by 2,032

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

Liu, N., Dai, Q., Zheng, G., He, C., Parisien, M., & Pan, T. (2015) · Nature · doi:10.1038/nature14234 · Cited by 1,988

A brave new world of RNA-binding proteins

Hentze, M. W., Castello, A., Schwarzl, T., & Preiss, T. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.130 · Cited by 1,821

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

Leppek, K., Das, R., & Barna, M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.103 · Cited by 949

RBPDB: a database of RNA-binding specificities

Cook, K. B., Kazan, H., Zuberi, K., Morris, Q., & Hughes, T. R. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1069 · Cited by 638

U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

Kaida, D., Berg, M. G., Younis, I., Kasim, M., Singh, L. N., Wan, L., & Dreyfuss, G. (2010) · Nature · doi:10.1038/nature09479 · Cited by 638

Inhibiting eukaryotic transcription: which compound to choose? How to evaluate its activity

Bensaude, O. (2011) · Transcription · doi:10.4161/trns.2.3.16172 · Cited by 574

The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a

Guil, S., & Cáceres, J. F. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1250 · Cited by 567

Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

Huelga, S. C., Vu, A. Q., Arnold, J. D., Liang, T. Y., Liu, P. P., Yan, B. Y., Donohue, J. P., Shiue, L., Hoon, S., Brenner, S., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.001 · Cited by 470

RNA Quality Control in Eukaryotes

Doma, M. K., & Parker, R. (2007) · Cell · doi:10.1016/j.cell.2007.10.041 · Cited by 345

Nascent Pre-rRNA sorting via phase separation drives the assembly of dense fibrillar components in the human nucleolus

Yao, R.-W., Xu, G., Wang, Y., Shan, L., Luan, P.-F., Wang, Y., Wu, M., Yang, L.-Z., Xing, Y.-H., Yang, L., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.08.014 · Cited by 327

Tau exon 10 alternative splicing and tauopathies

Liu, F., & Gong, C.-X. (2008) · Molecular Neurodegeneration · doi:10.1186/1750-1326-3-8 · Cited by 323

Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases

Andreadis, A. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.08.010 · Cited by 311

Mechanisms of dendritic mRNA transport and its role in synaptic tagging

Doyle, M., & Kiebler, M. A. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.278 · Cited by 288

Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes

Statello, L., Maugeri, M., Garre, E., Nawaz, M., Wahlgren, J., Papadimitriou, A., Lundqvist, C., Lindfors, L., Collén, A., Sunnerhagen, P., et al. (2018) · PLOS ONE · doi:10.1371/journal.pone.0195969 · Cited by 242

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

Cheng, J. X., Chen, L., Li, Y., Cloe, A., Yue, M., Wei, J., Watanabe, K. A., Shammo, J. M., Anastasi, J., Shen, Q. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03513-4 · Cited by 204

Skeletal muscle gene expression profiles in 20–29 year old and 65–71 year old women

Welle, S., Brooks, A. I., Delehanty, J. M., Needler, N., Bhatt, K., Shah, B., & Thornton, C. A. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.11.011 · Cited by 210

Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2

Keppetipola, N., Sharma, S., Li, Q., & Black, D. L. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.691456 · Cited by 201

Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles

Khandjian, E. W., Huot, M.-E., Tremblay, S., Davidovic, L., Mazroui, R., & Bardoni, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405398101 · Cited by 178

RNA sequence‐ and shape‐dependent recognition by proteins in the ribonucleoprotein particle

Stefl, R., Skrisovska, L., & Allain, F. H. ‐. (2005) · The EMBO Reports · doi:10.1038/sj.embor.7400325 · Cited by 175

Modulation of mRNA stability as a novel therapeutic approach

Eberhardt, W., Doller, A., Akool, E.-S., & Pfeilschifter, J. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.01.002 · Cited by 173

A genome-wide in situhybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain

McKee, A. E., Minet, E., Stern, C., Riahi, S., Stiles, C. D., & Silver, P. A. (2005) · BMC Developmental Biology · doi:10.1186/1471-213x-5-14 · Cited by 166

Regulation of alternative splicing by PTB and associated factors

Spellman, R., Rideau, A., Matlin, A., Gooding, C., Robinson, F., McGlincy, N., Grellscheid, S. N., Southby, J., Wollerton, M., & Smith, C. W. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330457 · Cited by 128

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

Close, P., East, P., Dirac-Svejstrup, A. B., Hartmann, H., Heron, M., Maslen, S., Chariot, A., Söding, J., Skehel, M., & Svejstrup, J. Q. (2012) · Nature · doi:10.1038/nature10925 · Cited by 119

Comparative proteomics reveals a significant bias toward alternative protein isoforms with conserved structure and function

Ezkurdia, I., del Pozo, A., Frankish, A., Rodriguez, J. M., Harrow, J., Ashman, K., Valencia, A., & Tress, M. L. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss100 · Cited by 89

Genome-wide Analysis of Alternative Pre-mRNA Splicing and RNA-Binding Specificities of the Drosophila hnRNP A/B Family Members

Blanchette, M., Green, R. E., MacArthur, S., Brooks, A. N., Brenner, S. E., Eisen, M. B., & Rio, D. C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.022 · Cited by 86

The role of androgens and the androgen receptor in cycling endometrium

Cloke, B., & Christian, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.031 · Cited by 77

Genomic Analyses of the RNA-binding Protein Hu Antigen R (HuR) Identify a Complex Network of Target Genes and Novel Characteristics of Its Binding Sites

Uren, P. J., Burns, S. C., Ruan, J., Singh, K. K., Smith, A. D., & Penalva, L. O. F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.c111.266882 · Cited by 78

Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex

Hamada, N., Ito, H., Iwamoto, I., Morishita, R., Tabata, H., & Nagata, K.-I. (2015) · Molecular Autism · doi:10.1186/s13229-015-0049-5 · Cited by 59

Cellular oxygen sensing, signalling and how to survive translational arrest in hypoxia

Fähling, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01894.x · Cited by 57

Cell-specific posttranscriptional regulation of CFTR gene expression via influence of MAPK cascades on 3′UTR part of transcripts

Baudouin-Legros, M., Hinzpeter, A., Jaulmes, A., Brouillard, F., Costes, B., Fanen, P., & Edelman, A. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00595.2004 · Cited by 39

Leukotriene B4 BLT Receptor Signaling Regulates the Level and Stability of Cyclooxygenase-2 (COX-2) mRNA through Restricted Activation of Ras/Raf/ERK/p42 AUF1 Pathway

Zhai, B., Yang, H., Mancini, A., He, Q., Antoniou, J., & Di Battista, J. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107623 · Cited by 29

Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy

Walsh, M. B., Janzen, E., Wingrove, E., Hosseinibarkooie, S., Muela, N. R., Davidow, L., Dimitriadi, M., Norabuena, E. M., Rubin, L. L., Wirth, B., et al. (2020) · BMC Biology · doi:10.1186/s12915-020-00845-w · Cited by 22

Identification of the specific interactors of the human lariat RNA debranching enzyme 1 protein

Masaki, S., Yoshimoto, R., Kaida, D., Hata, A., Satoh, T., Ohno, M., & Kataoka, N. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023705 · Cited by 21

An atlas of RNA-dependent proteins in cell division reveals the riboregulation of mitotic protein-protein interactions

(2025) · doi:10.1038/s41467-025-57671-3 · Cited by 15

Rie1 and Sgn1 form an RNA-binding complex that enforces the meiotic entry cell fate decision

(2023) · doi:10.1083/jcb.202302074 · Cited by 5