Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2

Mechanisms of Alternative Pre-Messenger RNA Splicing

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Ultraconserved Elements in the Human Genome

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CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism

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Messenger-RNA-binding proteins and the messages they carry

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The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing

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HITS-CLIP yields genome-wide insights into brain alternative RNA processing

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Understanding alternative splicing: towards a cellular code

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Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

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Regulation of Alternative Splicing by Histone Modifications

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Sorting out the complexity of SR protein functions

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Functional consequences of developmentally regulated alternative splicing

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U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

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Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations

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A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons

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An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

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Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decayPreprint

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Distinct Binding Specificities and Functions of Higher Eukaryotic Polypyrimidine Tract-Binding Proteins

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An RNA map predicting Nova-dependent splicing regulation

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Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy

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A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart

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Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping

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Structure of PTB Bound to RNA: Specific Binding and Implications for Splicing Regulation

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Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells

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The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

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Autoregulation of Polypyrimidine Tract Binding Protein by Alternative Splicing Leading to Nonsense-Mediated Decay

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Exon Identity Established through Differential Antagonism between Exonic Splicing Silencer-Bound hnRNP A1 and Enhancer-Bound SR Proteins

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Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.

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Polypyrimidine Tract Binding Protein Antagonizes Exon Definition

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Regulation of Fas Alternative Splicing by Antagonistic Effects of TIA-1 and PTB on Exon Definition

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Cloning and characterization of PSF, a novel pre-mRNA splicing factor.Preprint

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SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs

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Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?

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Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.Preprint

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PSF and p54nrb/NonO – multi‐functional nuclear proteins

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Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.Preprint

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Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein

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A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein.

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Crossregulation and Functional Redundancy between the Splicing Regulator PTB and Its Paralogs nPTB and ROD1

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Cooperative Assembly of an hnRNP Complex Induced by a Tissue-Specific Homolog of Polypyrimidine Tract Binding Protein

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hnRNP 1, the polyprimidine tract-binding protein: distinct nuclear localization and association with hnRNAs

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MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development

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Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2

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RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α

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Understanding splicing regulation through RNA splicing maps

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Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB

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RNA and RNA Binding Proteins Participate in Early Stages of Cell Spreading through Spreading Initiation Centers

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PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2

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The Coupling of Alternative Splicing and Nonsense-Mediated mRNA Decay

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hnRNP H Is a Component of a Splicing Enhancer Complex That Activates a c- src Alternative Exon in Neuronal Cells

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Characterization of cDNAs encoding the polypyrimidine tract-binding protein.Preprint

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A Xenopus Protein Related to hnRNP I Has a Role in Cytoplasmic RNA Localization

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Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo.

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A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing

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The splicing regulator TIA‐1 interacts with U1‐C to promote U1 snRNP recruitment to 5′ splice sites

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Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein

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A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart.

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A novel set of spliceosome‐associated proteins and the essential splicing factor PSF bind stably to pre‐mRNA prior to catalytic step II of the splicing reaction.

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The Polypyrimidine Tract Binding Protein Binds Upstream of Neural Cell-Specific c- src Exon N1 To Repress the Splicing of the Intron Downstream

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Regulation of alternative splicing by the core spliceosomal machineryPreprint

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Multisite RNA Binding and Release of Polypyrimidine Tract Binding Protein during the Regulation of c-src Neural-Specific Splicing

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Dynamic Antagonism between ETR-3 and PTB Regulates Cell Type-Specific Alternative Splicing

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Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein

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Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome

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Multiple RRMs Contribute to RNA Binding Specificity and Affinity for Polypyrimidine Tract Binding Protein

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Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro

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A perinucleolar compartment contains several RNA polymerase III transcripts as well as the polypyrimidine tract-binding protein, hnRNP I [published erratum appears in J Cell Biol 1995 Jul;130(2):497-500]

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Polypyrimidine Tract Binding Protein Blocks the 5′ Splice Site-Dependent Assembly of U2AF and the Prespliceosomal E Complex

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Polypyrimidine Tract Binding Protein Regulates IRES-Mediated Gene Expression during Apoptosis

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Polypyrimidine Tract Binding Protein Modulates Efficiency of Polyadenylation

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Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold

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Novel modes of splicing repression by PTB

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Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA.

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An Intronic Splicing Silencer Causes Skipping of the IIIb Exon of Fibroblast Growth Factor Receptor 2 through Involvement of Polypyrimidine Tract Binding Protein

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Global regulation of alternative splicing during myogenic differentiation

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An intron enhancer recognized by splicing factors activates polyadenylation.

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Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines

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Polypyrimidine Tract-Binding Protein Positively Regulates Inclusion of an Alternative 3′-Terminal Exon

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Cross-Regulation between an Alternative Splicing Activator and a Transcription Repressor Controls Neurogenesis

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RNAi-Mediated PTB Depletion Leads to Enhanced Exon Definition

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Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry.Preprint

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Polypyrimidine Tract Binding Protein Functions as a Repressor To Regulate Alternative Splicing of α-Actinin Mutally Exclusive Exons

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ASESORÍAS INNOVADORAS EN RECURSOS HUMANOS PARA LAS PYMES MEDIANTE EL USO DE LA RED DE INTERNET

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Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB)

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Dynamic balance between activation and repression regulates pre‐mRNA alternative splicing during heart development

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Regulation of alternative splicing by PTB and associated factors

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Splicing Regulation in Neurons: Tinkering with Cell-Specific Control

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Sam68 Regulates a Set of Alternatively Spliced Exons during Neurogenesis

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The Dynamic Organization of the Perinucleolar Compartment in the Cell Nucleus

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The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA

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Exon repression by polypyrimidine tract binding protein

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Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins

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The PTB interacting protein raver1 regulates α‐tropomyosin alternative splicing

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Conserved Intron Elements Repress Splicing of a Neuron-Specific c-src Exon In Vitro

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Post-Transcriptional Control of the Hypoxic Response by RNA-Binding Proteins and MicroRNAs

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Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1

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The Polypyrimidine Tract Binding Protein (PTB) Represses Splicing of Exon 6B from the β-Tropomyosin Pre-mRNA by Directly Interfering with the Binding of the U2AF65 Subunit

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Polypyrimidine Tract Binding Protein Stabilizes the Encephalomyocarditis Virus IRES Structure via Binding Multiple Sites in a Unique Orientation

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Conserved Intron Elements Repress Splicing of a Neuron-Specific c- src Exon In Vitro

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Polypyrimidine tract‐binding protein is essential for early mouse development and embryonic stem cell proliferation

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Delineation of a Novel Pathway That Regulates CD154 (CD40 Ligand) Expression

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Regulation of the Mutually Exclusive Exons 8a and 8 in the CaV1.2 Calcium Channel Transcript by Polypyrimidine Tract-binding Protein

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STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivoPreprint

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Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors

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Nucleocytoplasmic Shuttling of Polypyrimidine Tract-binding Protein Is Uncoupled from RNA Export

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Polypyrimidine tract-binding protein inhibits translation of bip mRNA

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Hypoxia May Increase Rat Insulin mRNA Levels by Promoting Binding of the Polypyrimidine Tract-binding Protein (PTB) to the Pyrimidine-rich Insulin mRNA 3′-Untranslated Region

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Conformation of Polypyrimidine Tract Binding Protein in Solution

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Mutations in RRM4 uncouple the splicing repression and RNA-binding activities of polypyrimidine tract binding protein

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A single polypyrimidine tract binding protein (PTB) binding site mediates splicing inhibition at mouse IgM exons M1 and M2

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The polypyrimidine tract binding protein is a monomer

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Relocalization of the polypyrimidine tract-binding protein during PKA-induced neurite growth

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PTBP1 Is Required for Embryonic Development before Gastrulation

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Polypyrimidine Tract-binding Protein (PTB) Differentially Affects Malignancy in a Cell Line-dependent Manner

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Polypyrimidine tract binding protein and Notch1 are independently re-expressed in glioma

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Polypyrimidine Tract Binding Protein 2 Stabilizes Phosphoglycerate Kinase 2 mRNA in Murine Male Germ Cells by Binding to Its 3′UTR1

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PTB/hnRNP I Is Required for RNP Remodeling during RNA Localization in Xenopus Oocytes

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A Splicing Repressor Domain in Polypyrimidine Tract-binding Protein

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Stoichiometry of a regulatory splicing complex revealed by single‐molecule analyses

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A Novel Polypyrimidine Tract-binding Protein Paralog Expressed in Smooth Muscle Cells

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Crystallographic Analysis of Polypyrimidine Tract-Binding Protein-Raver1 Interactions Involved in Regulation of Alternative Splicing

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The Domains of Polypyrimidine Tract Binding Protein Have Distinct RNA Structural Preferences

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Characterization of the Nuclear Export Signal of Polypyrimidine Tract-binding Protein

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Alternative Splicing of Brain-Specific PTB Defines a Tissue-Specific Isoform Pattern That Predicts Distinct Functional Roles

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Drosophila polypyrimidine‐tract binding protein (PTB) functions specifically in the male germline

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Splicing of a Myosin Phosphatase Targeting Subunit 1 Alternative Exon Is Regulated by Intronic Cis-elements and a Novel Bipartite Exonic Enhancer/Silencer Element

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A Role for Polypyrimidine Tract Binding Protein in the Establishment of Focal Adhesions

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Expression of Human nPTB Is Limited by Extreme Suboptimal Codon Content

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Molecular Cloning and Characterization of a New Neuron-Specific Homologue of Rat Polypyrimidine Tract Binding Protein

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Structure and Function of the Perinucleolar Compartment in Cancer CellsPreprint

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Repression of α-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract

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Drosophila polypyrimidine tract-binding protein is necessary for spermatid individualization

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Interactions between PTB RRMs Induce Slow Motions and Increase RNA Binding Affinity

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Identification and cloning of a human urea transporter HUT11, which is downregulated during adipogenesis of explant cultures of human bone

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The Role of PTB in Insulin mRNA Stability Control

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Polypyrimidine Tract-Binding Protein Is Critical for the Turnover and Subcellular Distribution of CD40 Ligand mRNA in CD4+ T Cells

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MSY2 and polypyrimidine tract binding protein 2 stabilize mRNAs in the mammalian testis

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Untitled work

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Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex

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A protein assembly mediates Xist localization and gene silencing

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Long noncoding RNA H19 interacts with polypyrimidine tract‐binding protein 1 to reprogram hepatic lipid homeostasis

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Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB

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A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival

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Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

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The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation

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Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis

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PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing

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Alternative 3′ UTRs direct localization of functionally diverse protein isoforms in neuronal compartments

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Alternative splicing: the pledge, the turn, and the prestige

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New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein

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RNA splicing analysis using heterogeneous and large RNA-seq datasets

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Forging our understanding of lncRNAs in the brain

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Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesisPreprint

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ASCOT identifies key regulators of neuronal subtype-specific splicing

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The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers

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In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactorsPreprint

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PTBP1 Lactylation Promotes Glioma Stem Cell Maintenance through PFKFB4-Driven Glycolysis

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RNA ‐binding proteins, neural development and the addictions

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De Novo Prediction of PTBP1 Binding and Splicing Targets Reveals Unexpected Features of Its RNA Recognition and Function

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Ptbp2 Controls an Alternative Splicing Network Required for Cell Communication during Spermatogenesis

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The role of alternative splicing coupled to nonsense-mediated mRNA decay in human disease

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Regulation of gene expression in mammalian nervous system through alternative pre-mRNA splicing coupled with RNA quality control mechanisms

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PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons

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Discovery of physiological and cancer-related regulators of 3′ UTR processing with KAPAC

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Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon

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RBP–RNA interactions in the control of autoimmunity and autoinflammation

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Uncovering the roles of long noncoding RNAs in neural development and glioma progression

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RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development

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Physiological and pathophysiological role of nonsense-mediated mRNA decay

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RNA processing in skeletal muscle biology and disease

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Poison exons in neurodevelopment and disease

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Alternative splicing and nonsense‐mediated mRNA decay enforce neural specific gene expression

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MBNL expression in autoregulatory feedback loops

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Crucial roles of different RNA-binding hnRNP proteins in Stem Cells

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Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application

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A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1Preprint

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RNA-Binding Protein PTB and MicroRNA-221 Coregulate AdipoR1 Translation and Adiponectin Signaling

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lncRNA ZNF649-AS1 Induces Trastuzumab Resistance by Promoting ATG5 Expression and Autophagy

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Understanding the Role of lncRNAs in Nervous System Development

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Tracking pre-mRNA maturation across subcellular compartments identifies developmental gene regulation through intron retention and nuclear anchoringPreprint

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Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms

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A comprehensive review of long non-coding RNAs in the pathogenesis and development of non-alcoholic fatty liver disease

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The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes

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Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse

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SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity

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HnRNP L represses cryptic exons

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METTL3-modified lncRNA-SNHG8 binds to PTBP1 to regulate ALAS2 expression to increase oxidative stress and promote myocardial infarction

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PTBP1 knockdown promotes neural differentiation of glioblastoma cells through UNC5B receptor

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The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression

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The Emerging Role of the RBM20 and PTBP1 Ribonucleoproteins in Heart Development and Cardiovascular Diseases

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Mechanisms of Long Non-Coding RNAs in the Assembly and Plasticity of Neural Circuitry

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Mechanistic Insights Into MicroRNA-Induced Neuronal Reprogramming of Human Adult Fibroblasts

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LncRNAs and their RBPs: How to influence the fate of stem cells?

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PTBP1 as a potential regulator of disease

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A post-transcriptional mechanism pacing expression of neural genes with precursor cell differentiation status

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Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation

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Viral Evasion and Manipulation of Host RNA Quality Control Pathways

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Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes

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PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells

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Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation

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Multiple determinants of splicing repression activity in the polypyrimidine tract binding proteins, PTBP1 and PTBP2

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Alternative splicing in endothelial cells: novel therapeutic opportunities in cancer angiogenesis

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The role of RNA splicing factor PTBP1 in neuronal development

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A mechanism underlying position-specific regulation of alternative splicing

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Regulation of mRNA Abundance by Polypyrimidine Tract-Binding Protein-Controlled Alternate 5′ Splice Site Choice

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Visualizing cellular machines with colocalization single molecule microscopy

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Long noncoding RNA H19 – a new player in the pathogenesis of liver diseases

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5'-UTR SNP of FGF13 causes translational defect and intellectual disability

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M6A-modified lncRNA FAM83H-AS1 promotes colorectal cancer progression through PTBP1

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Post-Translational Modifications in Polypyrimidine Tract Binding Proteins PTBP1 and PTBP2

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Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins

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Regulation of HNRNP family by post-translational modifications in cancer

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Prenatal arsenic exposure alters REST/NRSF and microRNA regulators of embryonic neural stem cell fate in a sex-dependent manner

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Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.

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Crucial Roles of LncRNAs-Mediated Autophagy in Breast Cancer

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hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer

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RNA-binding proteins RBM20 and PTBP1 regulate the alternative splicing of FHOD3

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PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons

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Recurrent PTBP1::MAML2 fusions in composite hemangioendothelioma with neuroendocrine differentiation: A report of two cases involving neck lymph nodes

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A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart

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Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing

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Zika virus dysregulates the expression of astrocytic genes involved in neurodevelopment

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Human polypyrimidine tract-binding protein interacts with mitochondrial tRNAThrin the cytosol

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Polypyrimidine tract binding proteins PTBP1 and PTBP2 interact with distinct proteins under splicing conditions

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RNA-Binding Proteins in Heart Development

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The latest role of nerve‐specific splicing factor PTBP1 in the transdifferentiation of glial cells into neurons

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Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins

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The organization of RNA contacts by PTB for regulation ofFASsplicing

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Regulation of alternative splicing and polyadenylation in neurons

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PTBP1 controls intestinal epithelial regeneration through post-transcriptional regulation of gene expression

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The role of RNA splicing factor PTBP1 in neuronal development

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Polypyrimidine tract binding proteins PTBP1 and PTBP2 interact with distinct proteins under splicing conditions

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Understanding the Role of Post‐Translational Modifications on the Splicing Activity of RNA Binding Proteins

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RNA-binding proteins switch gears to drive alternative splicing in neurons

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PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing

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