Cited by 1,756Cell death mechanisms and regulationCancer-related Molecular PathwaysUbiquitin and proteasome pathways

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IAP proteins: blocking the road to death's door

Salvesen, Guy S., Duckett, Colin S.·2002·Nature Reviews Molecular Cell Biology

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Abstract

The 'inhibitor of apoptosis' (IAP) gene family, which was discovered less than a decade ago, encodes a group of structurally related proteins that, in addition to their ability to suppress apoptotic cell death, are involved in an increasing number of seemingly unrelated cellular functions. Here, we review the functional and structural properties of this fascinating group of proteins, and of several recently identified IAP-binding factors that regulate IAP function.

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Authors: Salvesen, G. S., & Duckett, C. S.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
University of Michigan (US)
Corresponding author: Duckett, Colin S.
ORCID: Salvesen, Guy S.
Duckett, Colin S.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2002-06
Volume: 3
Issue: 6
Pages: 401-410
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm830
OpenAlex: W1492587973
Semantic Scholar: 37eaa4d6440b014eff358aeee58f3772e77e8934
Cited by: 1,756
References: 157
Citations by year: 2026: 12 · 2025: 8 · 2024: 20 · 2023: 25 · 2022: 26 · 2021: 32 · 2020: 46 · 2019: 48 · 2018: 42 · 2017: 43 · 2016: 43 · 2015: 59 · 2014: 63 · 2013: 90 · 2012: 81
FWCI: 9.92
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: inhibitor of apoptosis proteins, apoptosis, cell death regulation, protein structure
MeSH terms: Animals, Binding Sites, Gene Expression Regulation, Humans, Proteins, Cysteine Proteinase Inhibitors, Apoptosis, Insect Proteins, Inhibitor of Apoptosis Proteins

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IAP proteins: blocking the road to death's door

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