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Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

Pillai, Padmini S., Molony, Ryan D., Martinod, Kimberly, Dong, Huiping, Pang, Iris K., Tal, Michal C., Solis, Angel G., Bielecki, Piotr, Mohanty, Subhasis, Trentalange, Mark, Homer, Robert J., Flavell, Richard A., Wagner, Denisa D., Montgomery, Ruth R., Shaw, Albert C., Staeheli, Peter, Iwasaki, Akiko·2016·Science
DOI 10.1126/science.aaf3926PMC PMC5465864
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Abstract

Flu immunity shows its age: As we age, our immune systems change; in many ways not for the better. For instance, the elderly account for 90% of influenza deaths annually. Pillai et al. now report that influenza-infected human monocytes, a type of immune cell, exhibit reduced antiviral activity. In influenza-infected mice, two innate immune sensing pathways work together to promote antiviral immunity to influenza. Mice lacking antiviral immunity (similar to the situation in elderly people) had elevated bacterial burdens in their lungs and increased inflammatory responses, which both contributed to their increased susceptibility to influenza. Science , this issue p. 463

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Metadata

Authors
Pillai, P. S., Molony, R. D., Martinod, K., Dong, H., Pang, I. K., Tal, M. C., Solis, A. G., Bielecki, P., Mohanty, S., Trentalange, M., Homer, R. J., Flavell, R. A., Wagner, D. D., Montgomery, R. R., Shaw, A. C., Staeheli, P., & Iwasaki, A.
Affiliations
  • Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
  • Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA.
  • Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
  • Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
  • Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
  • Section of Rheumatology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
  • Institut für Medizinische Mikrobiologie und Hygiene, Institute of Virology, University Medical Center Freiburg, Hermann-Herder-Strasse 11, 79104 Freiburg, Germany.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2016-04-22
Volume
352
Issue
6284
Pages
463-466
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.aaf3926
PMC
PMC5465864
Cited by
229
References
8
Language
en
Funders
  • NIH (AI081884, AI062428, AI064705, HHSN272201100019C, K24 AG02489, T32 AI007019-36, T32 AI007019-38, T32 AI055403, 5T32HL066987-13, F31 AG039163, R01HL102101, R01HL125501, K24 AG042489, P30 AG21342)
  • Deutsche Forschungsgemeinschaft (DFG) (SFB1160/P13)
  • Howard Hughes Medical Institute

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