Surface-layer protein extracts from Lactobacillus helveticus inhibit enterohaemorrhagic Escherichia coli O157:H7 adhesion to epithelial cells

Johnson-Henry, Kathene C.; Hagen, Karen E.; Gordonpour, Mahsa; Tompkins, Thomas A.; Sherman, Philip M.

doi:10.1111/j.1462-5822.2006.00791.x

Cited by 274Escherichia coli research studiesProbiotics and Fermented FoodsBacterial Genetics and Biotechnology

Surface-layer protein extracts from Lactobacillus helveticus inhibit enterohaemorrhagic Escherichia coli O157:H7 adhesion to epithelial cells

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Johnson-Henry, Kathene C., Hagen, Karen E., Gordonpour, Mahsa, Tompkins, Thomas A., Sherman, Philip M.·2007·Cellular Microbiology

DOI 10.1111/j.1462-5822.2006.00791.x

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Abstract

Adherence of intestinal pathogens, including Escherichia coli O157:H7, to human intestinal epithelial cells is a key step in pathogenesis. Probiotic bacteria, including Lactobacillus helveticus R0052 inhibit the adhesion of E. coli O157:H7 to epithelial cells, a process which may be related to specific components of the bacterial surface. Surface-layer proteins (Slps) are located in a paracrystalline layer outside the bacterial cell wall and are thought to play a role in tissue adherence. However, the ability of S-layer protein extract derived from probiotic bacteria to block adherence of enteric pathogens has not been investigated. Human epithelial (HEp-2 and T84) cells were treated with S-layer protein extract alone, infected with E. coli O157:H7, or pretreated with S-layer protein extract prior to infection to determine their importance in the inhibition of pathogen adherence. The effects of S-layer protein extracts were characterized by phase-contrast and immunofluorescence microscopy and measurement of the transepithelial electrical resistance of polarized monolayers. Pre-treatment of host epithelial cells with S-layer protein extracts prior to E. coli O157:H7 infection decreased pathogen adherence and attaching-effacing lesions in addition to preserving the barrier function of monolayers. These in vitro studies indicate that a non-viable constituent derived from a probiotic strain may prove effective in interrupting the infectious process of an intestinal pathogen.

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The S-layer protein extract of L. helveticus R0052 has been shown to ameliorate the pathogenesis of E coli O157:H7.
“The S-layer protein extract of L. helveticus R0052 has been shown to ameliorate the pathogenesis of E coli O157:H7 (Sherman et al., 2005; Johnson-Henry et al., 2007).”
From Lactobacillus helveticus: the proteolytic system (2013) · cites this paper as Johnson-Henry et al., 2007

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Authors: Johnson-Henry, K. C., Hagen, K. E., Gordonpour, M., Tompkins, T. A., & Sherman, P. M.
Affiliations: Lallemand (Canada) (CA)
University of Toronto (CA)
Corresponding author: Sherman, Philip M.
ORCID: Tompkins, Thomas A.
Sherman, Philip M.
Venue: Cellular Microbiology
Publisher: Hindawi Limited
Published: 2007-02
Volume: 9
Issue: 2
Pages: 356-367
ISSN: 1462-5814 (ISSN-L)
1462-5822
DOI: 10.1111/j.1462-5822.2006.00791.x
OpenAlex: W2151081251
Cited by: 274
References: 55
Citations by year: 2026: 4 · 2025: 11 · 2024: 4 · 2023: 15 · 2022: 19 · 2021: 11 · 2020: 19 · 2019: 14 · 2018: 15 · 2017: 14 · 2016: 15 · 2015: 17 · 2014: 10 · 2013: 17 · 2012: 25
FWCI: 5.94
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3134 d)
Locations: Cellular Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: University of Guelph
Canada Research Chairs
University of Toronto
Hospital for Sick Children
Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Lactobacillus helveticus, Escherichia coli O157:H7, surface layer protein, probiotics, bacterial adhesion inhibition, intestinal epithelial cells, attaching and effacing lesions, epithelial barrier function, transepithelial electrical resistance
MeSH terms: Bacterial Adhesion, Bacterial Outer Membrane Proteins, Bacterial Proteins, Cell Line, Epithelial Cells, Escherichia coli O157, Lactobacillus helveticus

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Surface-layer protein extracts from Lactobacillus helveticus inhibit enterohaemorrhagic Escherichia coli O157:H7 adhesion to epithelial cells

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