Axon degeneration mechanisms: commonality amid diversity

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420

Axonal transection in the lesions of multiple sclerosis

Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029

Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP

Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042

Axonal damage in acute multiple sclerosis lesions

Ferguson, B. (1997) · Brain · doi:10.1093/brain/120.3.393 · Cited by 1,532

Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

Fischer, L. R., Culver, D. G., Tennant, P., Davis, A. A., Wang, M.-S., Castellano-Sanchez, A. A., Khan, J., Polak, M. A., & Glass, J. D. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2003.10.004 · Cited by 1,383

Death by design: apoptosis, necrosis and autophagy

Edinger, A. L., & Thompson, C. B. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.011 · Cited by 1,362

Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease

Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., et al. (2005) · Science · doi:10.1126/science.1105681 · Cited by 1,214

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

Araki, T., Sasaki, Y., & Milbrandt, J. (2004) · Science · doi:10.1126/science.1098014 · Cited by 1,060

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P. E., Griffiths, I. R., & Nave, K.-A. (2003) · Nature Genetics · doi:10.1038/ng1095 · Cited by 1,036

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

Sirén, A., Fratelli, M., Brines, M. L., Goemans, C. G., Casagrande, S., Lewczuk, P., Keenan, S., Gleiter, C. H., Pasquali, C., Capobianco, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051606598 · Cited by 1,019

XX. Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of their primitive fibres

Waller, A. V. (1850) · Philosophical Transactions of the Royal Society of London · doi:10.1098/rstl.1850.0021 · Cited by 889

Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin

Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., et al. (1998) · Science · doi:10.1126/science.280.5369.1610 · Cited by 889

Molecular motors and mechanisms of directional transport in neurons

Hirokawa, N., & Takemura, R. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1624 · Cited by 856

Charcot-Marie-Tooth Disease Type 2A Caused by Mutation in a Microtubule Motor KIF1Bβ

Zhao, C., Takita, J., Tanaka, Y., Setou, M., Nakagawa, T., Takeda, S., Yang, H. W., Terada, S., Nakata, T., Takei, Y., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00363-4 · Cited by 765

Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport

Hafezparast, M., Klocke, R., Ruhrberg, C., Marquardt, A., Ahmad‐Annuar, A., Bowen, S., Lalli, G., Witherden, A. S., Hummerich, H., Nicholson, S. J., et al. (2003) · Science · doi:10.1126/science.1083129 · Cited by 684

Axonal Self-Destruction and Neurodegeneration

Raff, M., Whitmore, A., & Finn, J. (2002) · Science · doi:10.1126/science.1068613 · Cited by 670

Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

Lunn, E. R., Perry, V. H., Brown, M. C., Rosen, H., & Gordon, S. (1989) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1989.tb00771.x · Cited by 646

Toward an understanding of the molecular mechanisms of physiological cell death.

Vaux, D. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.786 · Cited by 615

Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene

Mack, T. G. A., Reiner, M., Beirowski, B., Mi, W., Emanuelli, M., Wagner, D., Thomson, D., Gillingwater, T., Court, F., Conforti, L., et al. (2001) · Nature Neuroscience · doi:10.1038/nn770 · Cited by 611

In vivo imaging of axonal degeneration and regeneration in the injured spinal cord

Kerschensteiner, M., Schwab, M. E., Lichtman, J. W., & Misgeld, T. (2005) · Nature Medicine · doi:10.1038/nm1229 · Cited by 582

β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury

Gentleman, S. M., Nash, M. J., Sweeting, C. J., Graham, D. I., & Roberts, G. W. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90398-5 · Cited by 570

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches

Tsai, J., Grutzendler, J., Duff, K., & Gan, W.-B. (2004) · Nature Neuroscience · doi:10.1038/nn1335 · Cited by 561

A Kinesin Heavy Chain (KIF5A) Mutation in Hereditary Spastic Paraplegia (SPG10)

Reid, E., Kloos, M. T., Ashley‐Koch, A. E., Hughes, L., Bevan, S., Svenson, I. K., Graham, F. L., Gaskell, P. C., Dearlove, A., Pericak‐Vance, M. A., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/344210 · Cited by 540

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

Saigoh, K., Wang, Y., Suh, J., Yamanishi, T., Sakai, Y., Kiyosawa, H., Harada, T., Ichihara, N., Wakana, S., Kikuchi, T., et al. (1999) · Nature Genetics · doi:10.1038/12647 · Cited by 501

Axonal damage: a key predictor of outcome in human CNS diseases

Medana, I. M., & Esiri, M. M. (2003) · Brain · doi:10.1093/brain/awg061 · Cited by 465

Molecular changes in neurons in multiple sclerosis: Altered axonal expression of Na v 1.2 and Na v 1.6 sodium channels and Na + /Ca 2 + exchanger

Craner, M. J., Newcombe, J., Black, J. A., Hartle, C., Cuzner, M. L., & Waxman, S. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402765101 · Cited by 446

Axon pathology in Parkinson’s disease and Lewy body dementia hippocampus contains α-, β-, and γ-synuclein

Galvin, J. E., Uryu, K., Lee, V. M. ‐., & Trojanowski, J. Q. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13450 · Cited by 430

On the degeneration of rat neuromuscular junctions after nerve section

Miledi, R., & Slater, C. R. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009076 · Cited by 425

Axon pathology in neurological disease: a neglected therapeutic target

Coleman, M. P., & Perry, V. H. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02255-5 · Cited by 387

ULTRASTRUCTURAL STUDIES OF THE DYING-BACK PROCESS

Schaumburg, H. H., Wı́sniewski, H. M., & Spencer, P. S. (1974) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197404000-00006 · Cited by 366

Huntingtin Aggregate-Associated Axonal Degeneration is an Early Pathological Event in Huntington's Disease Mice

He, L., Li, S.-H., Yu, Z.-X., Shelbourne, P., & Li, X. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08473.2001 · Cited by 359

Susceptibility to Neurodegeneration in a Glaucoma Is Modified by Bax Gene Dosage

Libby, R. T., Li, Y., Savinova, O. V., Barter, J. W., Smith, R. S., Nickells, R. W., & John, S. W. M. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010004 · Cited by 358

A local mechanism mediates NAD-dependent protection of axon degeneration

Wang, J., Zhai, Q., Chen, Y., Lin, E., Gu, W., McBurney, M. W., & He, Z. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504028 · Cited by 352

Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia

Edgar, J. M., McLaughlin, M., Yool, D., Zhang, S.-C., Fowler, J. H., Montague, P., Barrie, J. A., McCulloch, M. C., Duncan, I. D., Garbern, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312012 · Cited by 328

Involvement of the Ubiquitin-Proteasome System in the Early Stages of Wallerian Degeneration

Zhai, Q., Wang, J., Kim, A., Liu, Q., Watts, R. J., Hoopfer, E. D., Mitchison, T. J., Luo, L., & He, Z. (2003) · Neuron · doi:10.1016/s0896-6273(03)00429-x · Cited by 322

General mechanisms of axonal damage and its prevention

Stys, P. K. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.031 · Cited by 314

The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves

Beirowski, B., Adalbert, R., Wagner, D. A., Grumme, D., Addicks, K., Ribchester, R. R., & Coleman, M. P. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-6 · Cited by 303

Anoxic and Ischemic Injury of Myelinated Axons in CNS White Matter: From Mechanistic Concepts to Therapeutics

Stys, P. K. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199801000-00002 · Cited by 286

Ultrastructural Studies of the Dying-Back Process

Spencer, P. S., & Schaumburg, H. H. (1977) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197703000-00005 · Cited by 272

Blockers of sodium and calcium entry protect axons from nitric oxide‐mediated degeneration

Kapoor, R., Davies, M., Blaker, P. A., Hall, S. M., & Smith, K. J. (2002) · Annals of Neurology · doi:10.1002/ana.10443 · Cited by 252

A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration ( Wld S ) mouse

Conforti, L., Tarlton, A., Mack, T. G. A., Mi, W., Buckmaster, E. A., Wagner, D., Perry, V. H., & Coleman, M. P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11377 · Cited by 251

Erythropoietin both protects from and reverses experimental diabetic neuropathy

Bianchi, R., Büyükakıllı, B., Brines, M. L., Savino, C., Cavaletti, G., Oggioni, N., Lauria, G., Borgna, M., Lombardi, R., Çimen, B., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307823100 · Cited by 247

TRANSIENT, FOCAL ACCUMULATION OF AXONAL MITOCHONDRIA DURING THE EARLY STAGES OF WALLERIAN DEGENERATION

Webster, H. D. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.12.2.361 · Cited by 245

Functional Fluorescent Ca2+ Indicator Proteins in Transgenic Mice under TET Control

Hasan, M. T., Friedrich, R. W., Euler, T., Larkum, M. E., Giese, G., Both, M., Duebel, J., Waters, J., Bujard, H., Griesbeck, O., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020163 · Cited by 242

Evidence That Wallerian Degeneration and Localized Axon Degeneration Induced by Local Neurotrophin Deprivation Do Not Involve Caspases

Finn, J. T., Weil, M., Archer, F., Siman, R., Srinivasan, A. N., & RAFF, M. C. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01333.2000 · Cited by 241

Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE

Craner, M. (2004) · Brain · doi:10.1093/brain/awh032 · Cited by 235

Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage

Adle‐Biassette, Chrétien, Wingertsmann, Hery, H., Ereau, Scaravilli, Tardieu, & Gray (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00167.x · Cited by 233

Traumatic Axonal Injury Induces Proteolytic Cleavage of the Voltage-Gated Sodium Channels Modulated by Tetrodotoxin and Protease Inhibitors

Iwata, A., Stys, P., Wolf, J., Chen, X.-H., Taylor, A. G., Meaney, D., & Smith, D. H. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0515-03.2004 · Cited by 233

Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease

Ferri, A., Sanes, J. R., Coleman, M. P., Cunningham, J. M., & Kato, A. C. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00206-9 · Cited by 221

Calcium-induced degeneration of axoplasm in isolated segments of rat peripheral nerve

Schlaepfer, W. W. (1974) · Brain Research · doi:10.1016/0006-8993(74)90002-x · Cited by 212

Neurofilament functions in health and disease

Julien, J. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00004-5 · Cited by 209

Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease

Sagot, Y., Dubois‐Dauphin, M., Tan, S., de Bilbao, F., Aebischer, P., Martinou, J., & Kato, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07727.1995 · Cited by 201

An 85-kb tandem triplication in the slow Wallerian degeneration ( Wld s ) mouse

Coleman, M. P., Conforti, L., Buckmaster, E. A., Tarlton, A., Ewing, R. M., Brown, M. C., Lyon, M. F., & Perry, V. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9985 · Cited by 193

Early course of wallerian degeneration in myelinated fibres of the rat phrenic nerve

Lubińska, L. (1977) · Brain Research · doi:10.1016/0006-8993(77)90841-1 · Cited by 192

Axonal protection using flecainide in experimental autoimmune encephalomyelitis

Bechtold, D. A., Kapoor, R., & Smith, K. J. (2004) · Annals of Neurology · doi:10.1002/ana.20045 · Cited by 192

Depolarization-Induced Ca2+ Release in Ischemic Spinal Cord White Matter Involves L-type Ca2+ Channel Activation of Ryanodine Receptors

Ouardouz, M., Nikolaeva, M. A., Coderre, E., Zamponi, G. W., McRory, J. E., Trapp, B. D., Yin, X., Wang, W., Woulfe, J., & Stys, P. K. (2003) · Neuron · doi:10.1016/j.neuron.2003.08.016 · Cited by 191

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

Brendza, R. P., Bacskai, B. J., Cirrito, J. R., Simmons, K. A., Skoch, J. M., Klunk, W. E., Mathis, C. A., Bales, K. R., Paul, S. M., Hyman, B. T., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23269 · Cited by 190

Microanatomy of Axon/Glial Signaling during Wallerian Degeneration

Guertin, A. D., Zhang, D. P., Mak, K. S., Alberta, J. A., & Kim, H. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3766-04.2005 · Cited by 188

Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis

Kornek, B. (2001) · Brain · doi:10.1093/brain/124.6.1114 · Cited by 185

Mechanism of Calcium Entry during Axon Injury and Degeneration

LoPachin, R. M., & Lehning, E. J. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1997.8106 · Cited by 162

Evidence that Very Slow Wallerian Degeneration in C57BL/Ola Mice is an Intrinsic Property of the Peripheral Nerve

Perry, V. H., Brown, M. C., Lunn, E. R., Tree, P., & Gordon, S. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00472.x · Cited by 161

A missense mutation in Tbce causes progressive motor neuronopathy in mice

Martín, N., Jaubert, J., Gounon, P., SALIDO, E. C., Haase, G., Szatanik, M., & Guénet, J. (2002) · Nature Genetics · doi:10.1038/ng1016 · Cited by 159

TheWldsMutation Delays Robust Loss of Motor and Sensory Axons in a Genetic Model for Myelin-Related Axonopathy

Samsam, M., Mi, W., Wessig, C., Zielasek, J., Toyka, K. V., Coleman, M. P., & Martini, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02833.2003 · Cited by 153

CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS

Rasband, M. N., Tayler, J. E., Kaga, Y., Yang, Y., Lappe-Siefke, C., Nave, K., & Bansal, R. (2005) · Glia · doi:10.1002/glia.20165 · Cited by 152

Neurites Can Remain Viable after Destruction of the Neuronal Soma by Programmed Cell Death (Apoptosis)

Deckwerth, T. L., & Johnson, E. M. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1234 · Cited by 152

The 'dying back' process. A common denominator in many naturally occurring and toxic neuropathies.

Jb, C. (1979) · PubMed · Cited by 151

Glial cells are increased proportionally in transgenic optic nerves with increased numbers of axons

Burne, J. F., Staple, J., & RAFF, M. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02064.1996 · Cited by 151

A novel endogenous erythropoietin mediated pathway prevents axonal degeneration

Keswani, S. C., Buldanlioğlu, U., Fischer, A., Reed, N., Polley, M., Hong, L. L., Zhou, C., Jack, C., Leitz, G. J., & Höke, A. (2004) · Annals of Neurology · doi:10.1002/ana.20285 · Cited by 150

Wlds mice are resistant to paclitaxel (taxol) neuropathy

Wang, M. S., Davis, A. A., Culver, D. G., & Glass, J. D. (2002) · Annals of Neurology · doi:10.1002/ana.10300 · Cited by 146

Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injury

Stone, J. R., Okonkwo, D. O., Diallo, A. O., Rubin, D. G., Mutlu, L. K., Povlishock, J. T., & Helm, G. A. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.022 · Cited by 145

Wlds-Mediated Protection of Dopaminergic Fibers in an Animal Model of Parkinson Disease

Sajadi, A., Schneider, B. L., & Aebischer, P. (2004) · Current Biology · doi:10.1016/j.cub.2004.01.053 · Cited by 142

Structural alterations of peripheral nerve induced by the calcium ionophore A23187

Schlaepfer, W. W. (1977) · Brain Research · doi:10.1016/0006-8993(77)90126-3 · Cited by 142

Prolonged survival of transected nerve fibres in C57BL/Ola mice is an intrinsic characteristic of the axon

Glass, J. D., Brushart, T. M. E., George, E. B., & Griffin, J. W. (1993) · Journal of Neurocytology · doi:10.1007/bf01195555 · Cited by 140

Drug development for stroke: importance of protecting cerebral white matter

Dewar, D., Yam, P. S., & McCulloch, J. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00280-0 · Cited by 126

Focal Lesions in the Rat Central Nervous System Induced by Endothelin-1

Hughes, P., Anthony, D. C., Rudin, M., Botham, M. S., Rankine, E. L., Sablone, M., Kindler, D., Mir, A. K., & Perry, V. H. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.12.1276 · Cited by 124

Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice

Beirowski, B., Berek, L., Adalbert, R., Wagner, D. A., Grumme, D., Addicks, K., Ribchester, R. R., & Coleman, M. P. (2003) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2003.10.016 · Cited by 122

Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam.

Fern, R. F., Ransom, B. R., Stys, P. K., & Waxman, S. G. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39449-8 · Cited by 118

Calpain inhibition protects against Taxol-induced sensory neuropathy

Wang, M. S. (2003) · Brain · doi:10.1093/brain/awh078 · Cited by 116

The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse

Fischer, L. R., Culver, D. G., Davis, A. A., Tennant, P., Wang, M.-S., Coleman, M. P., Asress, S., Adalbert, R., Alexander, G. M., & Glass, J. D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.008 · Cited by 115

The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice

Mi, W. (2004) · Brain · doi:10.1093/brain/awh368 · Cited by 115

The effect of myelinating Schwann cells on axons

Martini, R. (2001) · Muscle & Nerve · doi:10.1002/mus.1027 · Cited by 113

The spatio-temporal pattern of Wallerian degeneration in mammalian peripheral nerves

Donat, J. R., & ́niewski, H. M. W. (1973) · Brain Research · doi:10.1016/0006-8993(73)90765-8 · Cited by 110

Organophosphorous neuropathy. I. A teased-fiber study of the spatio-temporal spread of axonal degeneraion.

Bouldin, T. W., & Cavanagh, J. (1979) · PubMed · Cited by 108

Non-apoptotic neurite degeneration in apoptotic neuronal death: pivotal role of mitochondrial function in neurites.

Ikegami, K., & Koike, T. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.057 · Cited by 105

Age‐Dependent Synapse Withdrawal at Axotomised Neuromuscular Junctions in Wlds Mutant and Ube4b/Nmnat Transgenic Mice

Gillingwater, T. H., Thomson, D., Mack, T. G. A., Soffin, E. M., Mattison, R. J., Coleman, M. P., & Ribchester, R. R. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.022343 · Cited by 91

Sodium channel blockade with phenytoin protects spinal cord axons, enhances axonal conduction, and improves functional motor recovery after contusion SCI

Hains, B. C., Saab, C. Y., Lo, A., & Waxman, S. G. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.04.001 · Cited by 90

A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses

Adalbert, R., Gillingwater, T. H., Haley, J. E., Bridge, K., Beirowski, B., Berek, L., Wagner, D. A., Grumme, D., Thomson, D., Çelik, A., et al. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03833.x · Cited by 87

The proximo-distal spread of axonal degeneration in the dorsal columns of the rat

George, R., & Griffin, J. W. (1994) · Journal of Neurocytology · doi:10.1007/bf01181641 · Cited by 83

Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis

Lo, A., Black, J. A., & Waxman, S. G. (2002) · Neuroreport · doi:10.1097/00001756-200210280-00015 · Cited by 83

The proapoptotic proteins Bax and Bak are not involved in Wallerian degeneration

Whitmore, A. V., Lindsten, T., RAFF, M. C., & Thompson, C. B. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401147 · Cited by 82

Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis

Berliocchi, L., Fava, E., Leist, M., Horvat, V., Dinsdale, D. D., Read, D., & Nicotera, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200406126 · Cited by 82

The pattern of axonal degeneration in the peripheral nervous system varies with different types of lesion

Lunn, E. R., Brown, M. C., & Perry, V. H. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90130-v · Cited by 81

Cerebral white matter damage in HIV infection demonstrated using β-amyloid precursor protein immunoreactivity

Raja, F., Sherriff, F. E., Morris, C. S., Bridges, L., & Esiri, M. M. (1997) · Acta Neuropathologica · doi:10.1007/s004010050601 · Cited by 78

The gene for slow Wallerian degeneration (Wld(s)) is also protective against vincristine neuropathy.

Wang, M.-S., Wu, Y., Culver, D. G., & Glass, J. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0334 · Cited by 77

The Neuroprotective Factor Wlds Does Not Attenuate Mutant SOD1-Mediated Motor Neuron Disease

Velde, C. V., Garcia, M. L., Yin, X., Trapp, B. D., & Cleveland, D. W. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:3:193 · Cited by 77

Neurites undergoing Wallerian degeneration show an apoptotic-like process with annexin V positive staining and loss of mitochondrial membrane potential

Sievers, C., Platt, N., Perry, V. H., Coleman, M. P., & Conforti, L. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(03)00039-7 · Cited by 76

Changes at the nodes of ranvier during wallerian degeneration: an electron microscope study

Ballin, R. H. M., & Thomas, P. K. (1969) · Acta Neuropathologica · doi:10.1007/bf00685303 · Cited by 75

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Brand‐Schieber, E., & Werner, P. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.023 · Cited by 73

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Bechtold, D. A. (2004) · Brain · doi:10.1093/brain/awh328 · Cited by 73

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Sasaki, S., Warita, H., Abe, K., & Iwata, M. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1021-9 · Cited by 72

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Ichihara, N., Wu, J., Hua Chui, D., Yamazaki, K., Wakabayashi, T., & Kikuchi, T. (1995) · Brain Research · doi:10.1016/0006-8993(95)00729-a · Cited by 70

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Gillingwater, T. H., Haley, J. E., Ribchester, R. R., & Horsburgh, K. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000095798.98378.34 · Cited by 68

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Keswani, S. C., Leitz, G. J., & Höke, A. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.08.080 · Cited by 67

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Ehlers, M. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.10.015 · Cited by 66

The Rate of Wallerian Degeneration in Cultured Neurons from Wild Type and C57BL/WldS Mice Depends on Time in Culture and may be Extended in the Presence of Elevated K+ Levels

Buckmaster, E. A., Perry, V. H., & Brown, M. C. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01155.x · Cited by 59

Neuroaxonal pathology in Creutzfeldt-Jakob disease

Liberski, P. P., & Budka, H. (1999) · Acta Neuropathologica · doi:10.1007/s004010050995 · Cited by 53

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Stys, P. K. (2004) · Annals of Neurology · doi:10.1002/ana.20082 · Cited by 52

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Yamagishi, S., Fujitani, M., Hata, K., Kitajo, K., Mimura, F., Abe, H., & Yamashita, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501945200 · Cited by 42

The Effect of Traumatic Brain Injury on the Visual System: A Morphologic Characterization of Reactive Axonal Change

Cheng, C. L. Y., & Povlishock, J. T. (1988) · Journal of Neurotrauma · doi:10.1089/neu.1988.5.47 · Cited by 42

Evidence of axonal damage in human acute demyelinating diseases

Ghosh, N., DeLuca, G. C., & Esiri, M. M. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.03.032 · Cited by 41

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Coleman, M. P., & Ribchester, R. R. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337436 · Cited by 40

Changes in intra‐axonal calcium distribution following nerve crush

Mata, M. M., Staple, J. K., & Fink, D. J. (1986) · Journal of Neurobiology · doi:10.1002/neu.480170508 · Cited by 40

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Waxman, S. G. (2004) · Brain · doi:10.1093/brain/awh353 · Cited by 34

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Fang, C., Bernardes-Silva, M., Coleman, M. P., & Perry, V. H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.078 · Cited by 27

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Coleman, M. P., Adalbert, R., & Beirowski, B. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.028 · Cited by 24

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Schwab, C., Steele, J. C., & McGeer, P. L. (1997) · Acta Neuropathologica · doi:10.1007/s004010050737 · Cited by 18

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Singer, M., Flinker, D., & Sidman, R. L. (1956) · Journal of Experimental Zoology · doi:10.1002/jez.1401310306 · Cited by 12

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Abrahams, P., Day, A., & Allt, G. (1981) · Acta Neuropathologica · doi:10.1007/bf00689401 · Cited by 12

Untitled work

Nolte (2001) · doi:10.1002/1098-1136(20010101)33:1

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Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

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Ying, W. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1672 · Cited by 1,494

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Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047

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Cheng, H., Ulane, C. M., & Burke, R. E. (2010) · Annals of Neurology · doi:10.1002/ana.21995 · Cited by 1,012

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Houtkooper, R. H., Cantó, C., Wanders, R. J., & Auwerx, J. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0026 · Cited by 899

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Lingor, P., Koch, J. C., Tönges, L., & Bähr, M. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1362-3 · Cited by 119

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Mietto, B. S., Rodrigo, M., de Lima, S., Sergio, T., & Martinez, A. M. B. (2011) · InTech eBooks · doi:10.5772/31927 · Cited by 5

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