Axon degeneration mechanisms: commonality amid diversity

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420

Axonal transection in the lesions of multiple sclerosis

Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029

Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP

Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042

Axonal damage in acute multiple sclerosis lesions

Ferguson, B. (1997) · Brain · doi:10.1093/brain/120.3.393 · Cited by 1,532

Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

Fischer, L. R., Culver, D. G., Tennant, P., Davis, A. A., Wang, M.-S., Castellano-Sanchez, A. A., Khan, J., Polak, M. A., & Glass, J. D. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2003.10.004 · Cited by 1,383

Death by design: apoptosis, necrosis and autophagy

Edinger, A. L., & Thompson, C. B. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.011 · Cited by 1,362

Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease

Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., et al. (2005) · Science · doi:10.1126/science.1105681 · Cited by 1,214

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

Araki, T., Sasaki, Y., & Milbrandt, J. (2004) · Science · doi:10.1126/science.1098014 · Cited by 1,060

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P. E., Griffiths, I. R., & Nave, K.-A. (2003) · Nature Genetics · doi:10.1038/ng1095 · Cited by 1,036

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

Sirén, A., Fratelli, M., Brines, M. L., Goemans, C. G., Casagrande, S., Lewczuk, P., Keenan, S., Gleiter, C. H., Pasquali, C., Capobianco, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051606598 · Cited by 1,019

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

NAD + /NADH and NADP + /NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

Ying, W. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1672 · Cited by 1,494

The cholinergic system in aging and neuronal degeneration

Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047

Clinical progression in Parkinson disease and the neurobiology of axons

Cheng, H., Ulane, C. M., & Burke, R. E. (2010) · Annals of Neurology · doi:10.1002/ana.21995 · Cited by 1,012

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

Houtkooper, R. H., Cantó, C., Wanders, R. J., & Auwerx, J. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0026 · Cited by 899

‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease

Chan, C. S., Guzmán, J. N., Ilijić, E., Mercer, J. N., Rick, C., Tkatch, T., Meredith, G. E., & Surmeier, D. J. (2007) · Nature · doi:10.1038/nature05865 · Cited by 936

Role of Axonal Transport in Neurodegenerative Diseases

Vos, K. J. D., Grierson, A. J., Ackerley, S., & Miller, C. C. J. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.061307.090711 · Cited by 767

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

Nikić, I., Merkler, D., Sorbara, C., Brinkoetter, M., Kreutzfeldt, M., Bareyre, F. M., Brück, W., Bishop, D., Misgeld, T., & Kerschensteiner, M. (2011) · Nature Medicine · doi:10.1038/nm.2324 · Cited by 713

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

Komatsu, M., Wang, Q. J., Holstein, G. R., Friedrich, V. L., Iwata, J.-I., Kominami, E., Chait, B. T., Tanaka, K., & Yue, Z. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701311104 · Cited by 614

Wallerian degeneration: an emerging axon death pathway linking injury and disease

Conforti, L., Gilley, J., & Coleman, M. P. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3680 · Cited by 630

Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

Howell, G. R., Libby, R. T., Jakobs, T., Smith, R. S., Phalan, F. C., Barter, J. W., Barbay, J. M., Marchant, J. K., Nagaraju, M., Porciatti, V., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706181 · Cited by 601

Axon Physiology

Debanne, D., Campanac, E., Bialowas, A., Carlier, E., & Alcaraz, G. (2011) · Physiological Reviews · doi:10.1152/physrev.00048.2009 · Cited by 633

The Drosophila Cell Corpse Engulfment Receptor Draper Mediates Glial Clearance of Severed Axons

MacDonald, J. M., Beach, M. G., Porpiglia, E., Sheehan, A. E., Watts, R. J., & Freeman, M. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.028 · Cited by 523

Wallerian Degeneration, WldS, and Nmnat

Coleman, M. P., & Freeman, M. R. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153248 · Cited by 473

Axonal Transport Defects in Neurodegenerative Diseases

Morfini, G. A., Burns, M. R., Binder, L. I., Kanaan, N. M., LaPointe, N. E., Bosco, D. A., Brown, R. H., Brown, H. E., Tiwari, A., Hayward, L. J., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3463-09.2009 · Cited by 478

Mitochondrial changes within axons in multiple sclerosis

Mahad, D. J., Ziabreva, I., Campbell, G., Lax, N., White, K., Hanson, P. S., Lassmann, H., & Turnbull, D. M. (2009) · Brain · doi:10.1093/brain/awp046 · Cited by 454

Axon degeneration: Molecular mechanisms of a self-destruction pathway

Wang, J. T., Medress, Z. A., & Barres, B. A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201108111 · Cited by 464

Tumor Necrosis Factor-α Mediates Oligodendrocyte Death and Delayed Retinal Ganglion Cell Loss in a Mouse Model of Glaucoma

Nakazawa, T., Nakazawa, C., Matsubara, A., Noda, K., Hisatomi, T., She, H., Michaud, N. A., Hafezi‐Moghadam, A., Miller, J. W., & Benowitz, L. I. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2801-06.2006 · Cited by 432

A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease

Sexton, C. E., Kalu, U. G., Filippini, N., Mackay, C. E., & Ebmeier, K. P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.019 · Cited by 410

Disorganized Microtubules Underlie the Formation of Retraction Bulbs and the Failure of Axonal Regeneration

Ertürk, A., Hellal, F., Enes, J., & Bradke, F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0612-07.2007 · Cited by 409

Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma

Buckingham, B. P., Inman, D. M., Lambert, W. S., Oglesby, E., Calkins, D. J., Steele, M. R., Vetter, M. L., Marsh‐Armstrong, N., & Horner, P. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4443-07.2008 · Cited by 410

Distal axonopathy with structural persistence in glaucomatous neurodegeneration

Crish, S. D., Sappington, R. M., Inman, D. M., Horner, P. J., & Calkins, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913141107 · Cited by 350

Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain

Andres, R. H., Horie, N., Slikker, W., Keren-Gill, H., Zhan, K., Sun, G., Manley, N. C., Pereira, M. P., Sheikh, L. A., McMillan, E. L., et al. (2011) · Brain · doi:10.1093/brain/awr094 · Cited by 329

Neurofilaments: neurobiological foundations for biomarker applications

Gafson, A., Barthélemy, N. R., Bomont, P., Carare, R. O., Durham, H. D., Julien, J., Kühle, J., Leppert, D., Nixon, R. A., Weller, R. O., et al. (2020) · Brain · doi:10.1093/brain/awaa098 · Cited by 339

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis

Siffrin, V., Radbruch, H., Glumm, R., Niesner, R., Paterka, M., Herz, J., Leuenberger, T., Lehmann, S. M., Luenstedt, S., Rinnenthal, J. L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.018 · Cited by 325

Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment

Skrobot, O. A., Attems, J., Esiri, M. M., Hortobágyi, T., Ironside, J. W., Kalaria, R. N., King, A., Lammie, G. A., Mann, D. M. A., Neal, J., et al. (2016) · Brain · doi:10.1093/brain/aww214 · Cited by 331

Programmed axon degeneration: from mouse to mechanism to medicine

Coleman, M. P., & Höke, A. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0269-3 · Cited by 329

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

Gerdts, J., Summers, D. W., Milbrandt, J., & DiAntonio, A. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.023 · Cited by 330

Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction

Bishop, P., Rocca, D. L., & Henley, J. M. (2016) · Biochemical Journal · doi:10.1042/bcj20160082 · Cited by 328

Mechanisms of acute axonal degeneration in the optic nerve in vivo

Knöferle, J., Koch, J. C., Ostendorf, T., Michel, U., Planchamp, V., Vutova, P., Tönges, L., Stadelmann, C., Brück, W., Bähr, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909794107 · Cited by 310

Decreased white matter integrity in late-myelinating fiber pathways in Alzheimer's disease supports retrogenesis

Stricker, N. H., Schweinsburg, B. C., Delano‐Wood, L., Wierenga, C. E., Bangen, K. J., Haaland, K. Y., Frank, L. R., Salmon, D. P., & Bondi, M. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.027 · Cited by 318

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

Calkins, D. J. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.07.001 · Cited by 305

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

Miller, B. R., Press, C., Daniels, R. W., Sasaki, Y., Milbrandt, J., & DiAntonio, A. (2009) · Nature Neuroscience · doi:10.1038/nn.2290 · Cited by 301

Bodily selves in relation: embodied simulation as second-person perspective on intersubjectivity

Gallese, V. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0177 · Cited by 328

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

Sterky, F. H., Lee, S., Wibom, R., Olson, L., & Larsson, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103295108 · Cited by 300

Calcium Signaling in Neuronal Motility

Zheng, J. Q., & Poo, M.-M. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123221 · Cited by 292

Retinal Ganglion Cells Downregulate Gene Expression and Lose Their Axons within the Optic Nerve Head in a Mouse Glaucoma Model

Soto, I., Oglesby, E., Buckingham, B. P., Son, J. L., Roberson, E. D. O., Steele, M. R., Inman, D. M., Vetter, M. L., Horner, P. J., & Marsh‐Armstrong, N. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3714-07.2008 · Cited by 273

Parietal white matter lesions in Alzheimer’s disease are associated with cortical neurodegenerative pathology, but not with small vessel disease

McAleese, K. E., Walker, L., Graham, S., Moya, E. L. J., Johnson, M. A., Erskine, D., Colloby, S. J., Dey, M., Martin-Ruiz, C. M., Taylor, J., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1738-2 · Cited by 280

Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy

Sasaki, Y., Araki, T., & Milbrandt, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2320-06.2006 · Cited by 269

UCHL1 (PGP 9.5): Neuronal biomarker and ubiquitin system protein

Day, I. N. M., & Thompson, R. J. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.020 · Cited by 271

Pathology of Multiple Sclerosis: Where Do We Stand?

Popescu, B. F. G., Pirko, I., & Lucchinetti, C. F. (2013) · Continuum · doi:10.1212/01.con.0000433291.23091.65 · Cited by 261

Mechanisms of axon degeneration: From development to disease

Saxena, S., & Caroni, P. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.07.007 · Cited by 264

Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation

di Penta, A., Moreno, B., Reix, S., Fernández-Díez, B., Villanueva, M., Errea, O., Escala, N., Vandenbroeck, K., Comella, J. X., & Villoslada, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054722 · Cited by 258

Identification of E2/E3 Ubiquitinating Enzymes and Caspase Activity Regulating Drosophila Sensory Neuron Dendrite Pruning

Kuo, C. T., Zhu, S., Younger, S. H., Jan, L. Y., & Jan, Y. N. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.014 · Cited by 256

New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection

Haque, A., Polcyn, R., Matzelle, D. D., & Banik, N. L. (2018) · Brain Sciences · doi:10.3390/brainsci8020033 · Cited by 249

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Di Stefano, M., Nascimento-Ferreira, I., Orsomando, G., Mori, V, Gilley, J., Brown, R., Janeckova, L., Vargas, M. E., Worrell, L. A., Loreto, A., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.164 · Cited by 246

The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions

Gornstein, E. L., & Schwarz, T. L. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.016 · Cited by 255

The Axon-Myelin Unit in Development and Degenerative Disease

Stassart, R. M., Möbius, W., Nave, K.-A., & Edgar, J. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00467 · Cited by 246

Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide

Sasaki, Y., Vohra, B. P. S., Lund, F. E., & Milbrandt, J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5469-08.2009 · Cited by 253

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.04.004 · Cited by 240

Zebrafish models of human motor neuron diseases: Advantages and limitations

Babin, P. J., Goizet, C., & Raldúa, D. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.03.001 · Cited by 246

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

Pigino, G. F., Morfini, G. A., Atagi, Y., Deshpande, A., Yu, C., Jungbauer, L. M., LaDu, M. J., Busciglio, J. A., & Brady, S. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901229106 · Cited by 233

Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction

Dubový, P. (2011) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2011.02.011 · Cited by 229

Parkinson’s disease as a result of aging

Rodriguez, M., Rodriguez‐Sabate, C., Morales, I., Sanchez, A., & Sabate, M. (2015) · Aging Cell · doi:10.1111/acel.12312 · Cited by 214

The time course of retrograde trans-synaptic degeneration following occipital lobe damage in humans

Jindahra, P., Petrie, A., & Plant, G. T. (2012) · Brain · doi:10.1093/brain/awr324 · Cited by 212

Protective effects and mechanisms of sirtuins in the nervous system

Zhang, F., Wang, S., Gan, L., Vosler, P. S., Gao, Y., Zigmond, M. J., & Chen, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.09.001 · Cited by 211

High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury

Evans, T. A., Barkauskas, D. S., Myers, J., Hare, E. G., You, J., Ransohoff, R. M., Huang, A. Y.-C., & Silver, J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.013 · Cited by 217

Approaches to Peripheral Nerve Repair: Generations of Biomaterial Conduits Yielding to Replacing Autologous Nerve Grafts in Craniomaxillofacial Surgery

Gaudin, R., Knipfer, C., Henningsen, A., Smeets, R., Heiland, M., & Hadlock, T. A. (2016) · BioMed Research International · doi:10.1155/2016/3856262 · Cited by 210

Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore

Barrientos, S. A., Martínez, N. W., Yoo, S., Jara, J. S., Zamorano, S., Hetz, C. A., Twiss, J. L., Álvarez, J., & Court, F. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4065-10.2011 · Cited by 214

Synaptic Vulnerability in Neurodegenerative Disease

Wishart, T. M., Parson, S. H., & Gillingwater, T. H. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000228202.35163.c4 · Cited by 206

Mechanisms of distal axonal degeneration in peripheral neuropathies

Cashman, C. R., & Höke, A. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.01.048 · Cited by 209

Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging

Sun, S., Liang, H., Cross, A. H., & Song, S. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.11.049 · Cited by 204

In vivo imaging of the diseased nervous system

Misgeld, T., & Kerschensteiner, M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1905 · Cited by 198

TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca 2+ with Exposure to Hydrostatic Pressure

Sappington, R. M., Sidorova, T. N., Long, D. J., & Calkins, D. J. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2321 · Cited by 202

Review: Mitochondria and disease progression in multiple sclerosis

Mahad, D., Lassmann, H., & Turnbull, D. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.00987.x · Cited by 193

Mitochondria as a central sensor for axonal degenerative stimuli

Court, F. A., & Coleman, M. P. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.04.001 · Cited by 201

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

Sasaki, Y., Nakagawa, T., Mao, X., DiAntonio, A., & Milbrandt, J. (2016) · eLife · doi:10.7554/elife.19749 · Cited by 192

Mechanisms of white matter damage in multiple sclerosis

Lassmann, H. (2014) · Glia · doi:10.1002/glia.22597 · Cited by 191

Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin

Yang, J. H., Weimer, R. M., Kallop, D. Y., Olsen, O., Wu, Z., Renier, N., Uryu, K., & Tessier‐Lavigne, M. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.034 · Cited by 184

Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders

Salvadores, N., Sanhueza, M., Manque, P., & Court, F. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00451 · Cited by 182

Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

Hughes, R. O., Bosanac, T., Mao, X. R., Engber, T. M., DiAntonio, A., Milbrandt, J., Devraj, R. V., & Krauss, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108588 · Cited by 183

Quantitative analysis by in vivo imaging of the dynamics of vascular and axonal networks in injured mouse spinal cord

Dray, C., Rougon, G., & Debarbieux, F. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900222106 · Cited by 186

Autophagy and Neuronal Cell Death in Neurological DisordersPreprint

Nixon, R. A., & Yang, D.-S. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008839 · Cited by 183

Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies

Adalbert, R., Nogradi, A., Babetto, E., Janeckova, L., Walker, S. A., Kerschensteiner, M., Misgeld, T., & Coleman, M. P. (2009) · Brain · doi:10.1093/brain/awn312 · Cited by 177

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson’s disease

Tonges, L., Frank, T., Tatenhorst, L., Saal, K. A., Koch, J. C., Szego, E. M., Bahr, M., Weishaupt, J. H., & Lingor, P. (2012) · Brain · doi:10.1093/brain/aws254 · Cited by 176

The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases

Yue, Z., Friedman, L. G., Komatsu, M., & Tanaka, K. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.01.016 · Cited by 179

Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis

Vogt, J., Paul, F., Aktas, O., Müller‐Wielsch, K., Dörr, J., Dörr, S., Bharathi, B. S., Glumm, R., Schmitz, C., Steinbusch, H., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21719 · Cited by 157

Diffuse Axonal Injury and Oxidative Stress: A Comprehensive Review

Frati, A., Cerretani, D., Fiaschi, A. I., Frati, P., Gatto, V., Russa, R. L., Pesce, A., Pinchi, E., Santurro, A., Fraschetti, F., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122600 · Cited by 168

Pervasive Axonal Transport Deficits in Multiple Sclerosis Models

Sorbara, C. D., Wagner, N. E., Ladwig, A., Nikić, I., Merkler, D., Kleele, T., Marinković, P., Naumann, R., Godinho, L., Bareyre, F. M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.11.006 · Cited by 173

Multi-system disorders of glycosphingolipid and ganglioside metabolism

Xu, Y.-H., Barnes, S., Sun, Y., & Grabowski, G. A. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r003996 · Cited by 171

Early ultrastructural defects of axons and axon–glia junctions in mice lacking expression of Cnp1

Edgar, J. M., McLaughlin, M., Werner, H. B., McCulloch, M. C., Barrie, J. A., Brown, A. M., Faichney, A. B., Snaidero, N., Nave, K., & Griffiths, I. R. (2009) · Glia · doi:10.1002/glia.20893 · Cited by 173

Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity

Zhai, R. G., Cao, Y., Hiesinger, P. R., Zhou, Y., Mehta, S. Q., Schulze, K. L., Verstreken, P., & Bellen, H. J. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040416 · Cited by 166

Collagenosis of the Deep Medullary Veins: An Underrecognized Pathologic Correlate of White Matter Hyperintensities and Periventricular Infarction?

Keith, J. L., Gao, F., Noor, R., Kiss, A., Balasubramaniam, G., Au, K., Rogaeva, E. A., Masellis, M., & Black, S. E. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx009 · Cited by 166

Cortical tau load is associated with white matter hyperintensities

McAleese, K. E., Firbank, M., Dey, M., Colloby, S. J., Walker, L., Johnson, M., Beverley, J. R., Taylor, J. P., Thomas, A. J., O’Brien, J. T., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0240-0 · Cited by 161

Aberrant Membranes and Double-Membrane Structures Accumulate in the Axons of Atg5-Null Purkinje Cells before Neuronal Death

Nishiyama, J., Miura, E., Mizushima, N., Watanabe, M., & Yuzaki, M. (2007) · Autophagy · doi:10.4161/auto.4964 · Cited by 159

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Tsika, E., Glauser, L., Moser, R., Fiser, A., Daniel, G., Sheerin, U.-M., Lees, A., Troncoso, J. C., Lewis, P. A., Bandopadhyay, R., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu178 · Cited by 159

Protecting Axonal Degeneration by Increasing Nicotinamide Adenine Dinucleotide Levels in Experimental Autoimmune Encephalomyelitis Models

Kaneko, S., Wang, J., Kaneko, M., Yiu, G. C., Hurrell, J., Chitnis, T., Khoury, S. J., & He, Z. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2116-06.2006 · Cited by 161

PLD3 affects axonal spheroids and network defects in Alzheimer’s disease

Yuan, P., Zhang, M., Tong, L., Morse, T. M., McDougal, R. A., Ding, H., Chan, D., Cai, Y., & Grutzendler, J. (2022) · Nature · doi:10.1038/s41586-022-05491-6 · Cited by 155

Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration In Vivo

Sasaki, Y., Vohra, B. P. S., Baloh, R. H., & Milbrandt, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1429-09.2009 · Cited by 152

Methamphetamine Causes Degeneration of Dopamine Cell Bodies and Terminals of the Nigrostriatal Pathway Evidenced by Silver Staining

Ares‐Santos, S., Granado, N., Espadas, I., Martínez‐Murillo, R., & Moratalla, R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.307 · Cited by 151

Tumor Necrosis Factor-α Concentrations in the Aqueous Humor of Patients with Glaucoma

Sawada, H., Fukuchi, T., Tanaka, T., & Abe, H. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4247 · Cited by 151

Axonal Degeneration in Motor Neuron Disease

Fischer, L. R., & Glass, J. D. (2007) · Neurodegenerative Diseases · doi:10.1159/000107704 · Cited by 158

In vivo correlation between axon diameter and conduction velocity in the human brain

Horowitz, A., Barazany, D., Tavor, I., Bernstein, M., Yovel, G., & Assaf, Y. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0871-0 · Cited by 154

Neuronal death: where does the end begin?

Conforti, L., Adalbert, R., & Coleman, M. P. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.02.004 · Cited by 152

New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases

Ryu, K. W., Kim, D.-S., & Kraus, W. L. (2015) · Chemical Reviews · doi:10.1021/cr5004248 · Cited by 151

Novel White Matter Tract Integrity Metrics Sensitive to Alzheimer Disease Progression

Fieremans, E., Benitez, A. M., Jensen, J. H., Falangola, M. F., Tabesh, A., Deardorff, R. L., Spampinato, M. V., Babb, J. S., Novikov, D. S., Ferris, S. H., et al. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3553 · Cited by 147

A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides

Gallardo, G., Schlüter, O. M., & Südhof, T. C. (2008) · Nature Neuroscience · doi:10.1038/nn2058 · Cited by 145

Mechanically-induced membrane poration causes axonal beading and localized cytoskeletal damage

Kilinc, D., Gallo, G., & Barbee, K. A. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.04.025 · Cited by 144

Autophagy in axonal and dendritic degeneration

Yang, Y., Coleman, M. P., Zhang, L., Zheng, X., & Yue, Z. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.001 · Cited by 146

Early Neurodegeneration Progresses Independently of Microglial Activation by Heparan Sulfate in the Brain of Mucopolysaccharidosis IIIB Mice

Ausseil, J., Desmaris, N., Bigou, S., Attali, R., Corbineau, S., Vitry, S., Parent, M., Cheillan, D., Fuller, M., Maire, I., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002296 · Cited by 142

Acquired axonal degeneration and regeneration

Benarroch, E. E. (2015) · Neurology · doi:10.1212/wnl.0000000000001601 · Cited by 24

Axon degeneration: Molecular mechanisms of a self-destruction pathway

Wang, J. T., Medress, Z. A., & Barres, B. A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201108111 · Cited by 464

Axonal degeneration as a therapeutic target in the CNS

Lingor, P., Koch, J. C., Tönges, L., & Bähr, M. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1362-3 · Cited by 119

Wallerian Degeneration in Injury and Diseases: Concepts and Prevention

Mietto, B. S., Rodrigo, M., de Lima, S., Sergio, T., & Martinez, A. M. B. (2011) · InTech eBooks · doi:10.5772/31927 · Cited by 5

Axon degeneration and rescue

Griffin, J. W., Höke, A., & Nguyen, T. T. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545061.020 · Cited by 3