Enriched environments, experience-dependent plasticity and disorders of the nervous system

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268

Epidemiology of Parkinson's disease

de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110

What is cognitive reserve? Theory and research application of the reserve concept

STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786

Qualitative investigation of the perceptions and experiences of nursing and allied health professionals involved in the implementation of an enriched environment in an Australian acute stroke unit

Rosbergen, I. C. M., Brauer, S., Fitzhenry, S., Grimley, R., & Hayward, K. S. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-018226 · Cited by 34

High-resolution CMOS-based biosensor for assessing hippocampal circuit dynamics in experience-dependent plasticity

Emery, B. A., Hu, X., Khanzada, S., Kempermann, G., & Amin, H. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115471 · Cited by 31

Brain heparanase expression is up‐regulated during postnatal development and hypoxia‐induced neovascularization in adult rats

Navarro, F. P., Farès, R., Sanchez, P. E., Nadam, J., Georges, B., Moulin, C., Morales, A., Péquignot, J.-M., & Bezin, L. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05116.x · Cited by 29

Activity Based Therapies to Promote Forelimb use after a Cervical Spinal Cord Injury.

Dai, H., MacArthur, L. H., McAtee, M., Hockenbury, N., Tidwell, J. L., McHugh, B., Mansfield, K., Finn, T., Hamers, F. P. T., & Bregman, B. S. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008-0592 · Cited by 28

Cognitive Impairments in Patients With Hemispatial Neglect From Acute Right Hemisphere Stroke

Lee, B. H., Kim, E. J., Ku, B. D., Choi, K. M., Seo, S. W., Kim, G., Chung, C., Heilman, K. M., & Na, D. L. (2008) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0b013e3181772101 · Cited by 28

Rearing‐environment‐dependent hippocampal local field potential differences in wild‐type and inositol trisphosphate receptor type 2 knockout mice

Tanaka, M., Wang, X., Mikoshiba, K., Hirase, H., & Shinohara, Y. (2017) · The Journal of Physiology · doi:10.1113/jp274573 · Cited by 26

Simply a nest? Effects of different enrichments on stereotypic and anxiety-related behaviour in mice

Gross, A. N.-M., Engel, A. K. J., & Würbel, H. (2011) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2011.06.020 · Cited by 35

Advancing Alzheimer’s Therapeutics: Exploring the Impact of Physical Exercise in Animal Models and Patients

Andrade-Guerrero, J., Rodríguez-Arellano, P., Barron-Leon, N., Orta‐Salazar, E., Ledesma-Alonso, C., Díaz-Cintra, S. Y., & Soto-Rojas, L. O. (2023) · Cells · doi:10.3390/cells12212531 · Cited by 28

Effects of sports experience on children's gross motor coordination level

Biino, V., Giustino, V., Gallotta, M. C., Bellafiore, M., Battaglia, G., Lanza, M., Baldari, C., Giuriato, M., Figlioli, F., Guidetti, L., et al. (2023) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2023.1310074 · Cited by 27

Molecular mechanisms of experience-dependent structural and functional plasticity in the brain

Kondo, M. (2016) · Anatomical Science International · doi:10.1007/s12565-016-0358-6 · Cited by 27

Rehabilitation robotics for the upper extremity: review with new directions for orthopaedic disorders

Hakim, R. M., Tunis, B. G., & Ross, M. D. (2016) · Disability and Rehabilitation Assistive Technology · doi:10.1080/17483107.2016.1269211 · Cited by 27

Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imaging

Gil, R., Fernandes, F. F., & Shemesh, N. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117446 · Cited by 25

Integrated Gait Triggered Mixed Reality and Neurophysiological Monitoring as a Framework for Next-Generation Ambulatory Stroke Rehabilitation

Ko, L., Stevenson, C., Chang, W.-C., Yu, K., Chi, K.-C., Chen, Y., & Chen, C. (2021) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2021.3125946 · Cited by 27

Environmental enrichment for stroke and other non-progressive brain injury

Qin, H., Reid, I., Gorelik, A., & Ng, L. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011879.pub2 · Cited by 26

Efficacy of Multimodal Sensory Therapy in Adult Acquired Brain Injury: A Systematic Review

Norwood, M. F., Lakhani, A., Watling, D. P., Marsh, C. H., & Zeeman, H. (2022) · Neuropsychology Review · doi:10.1007/s11065-022-09560-5 · Cited by 31

A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise

Methi, A., Islam, M. R., Kaurani, L., Sakib, M. S., Krüger, D. M., Pena, T., Burkhardt, S., Liebetanz, D., & Fischer, A. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03869-9 · Cited by 33

Affective dysfunction in a mouse model of R ett syndrome: Therapeutic effects of environmental stimulation and physical activity

Kondo, M., Gray, L. J., Pelka, G. J., Leang, S.-K., Christodoulou, J., Tam, P., & Hannan, A. J. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22308 · Cited by 27

Defensive behaviors and prosencephalic neurogenesis in pigeons (Columba livia) are affected by environmental enrichment in adulthood

Melleu, F. F., Pinheiro, M. V., Lino-de-Oliveira, C., & Marino–Neto, J. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1043-6 · Cited by 27

An enriched environment elevates corticosteroid receptor levels in the hippocampus and restores cognitive function in a rat model of chronic cerebral hypoperfusion

Zhang, L., Zhang, J., Sun, H., Zhu, H., Liu, H., & Yang, Y. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.023 · Cited by 27

Visual depth perception in normal and deprived rats: Effects of environmental enrichment

Baroncelli, L., Braschi, C., & Maffei, L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.036 · Cited by 27

Behavior of Rodents with an Emphasis on Enrichment

Brandão, J., & Mayer, J. (2011) · Journal of Exotic Pet Medicine · doi:10.1053/j.jepm.2011.07.001 · Cited by 27

Novel approaches to alcohol rehabilitation: Modification of stress-responsive brain regions through environmental enrichment

Pang, T. Y., Hannan, A. J., & Lawrence, A. J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.021 · Cited by 27

An Enriched Environment Ameliorates Oxidative Stress and Olfactory Dysfunction in Parkinson’s Disease with α-Synucleinopathy

Wi, S., Lee, J. W., Kim, M., Park, C., & Cho, S. (2018) · Cell Transplantation · doi:10.1177/0963689717742662 · Cited by 27

Transgenic Mouse Models as Tools for Understanding How Increased Cognitive and Physical Stimulation Can Improve Cognition in Alzheimer’s Disease

Shepherd, A. L., Zhang, T. D., Zeleznikow-Johnston, A., Hannan, A. J., & Burrows, E. L. (2018) · Brain Plasticity · doi:10.3233/bpl-180076 · Cited by 28

Activity-Based Therapies To Promote Forelimb Use after a Cervical Spinal Cord Injury

Dai, H., MacArthur, L. H., McAtee, M., Hockenbury, N., Tidwell, J. L., McHugh, B., Mansfield, K., Finn, T. P., Hamers, F. P. T., & Bregman, B. S. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0592 · Cited by 27

Exercise Plus Cognitive Performance Over and Above Exercise Alone in Subjects with Mild Cognitive Impairment

Sacco, G., Caillaud, C., Ben-Sadoun, G., Robert, P. H., David, R., & Brisswalter, J. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150194 · Cited by 32

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

Mohar, B., Michel, G., Wang, Y., Hernandez, V., Grimm, J. B., Park, J.-Y., Patel, R. H., Clarke, M. D., Brown, T. A., Bergmann, C., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01923-4 · Cited by 42

The effects of enrichment novelty versus complexity in cages of group-housed rats (Rattus norvegicus)

Abou-Ismail, U. A., & Mendl, M. (2016) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2016.04.014 · Cited by 26

Late-life environmental enrichment preserves short-term memory and may attenuate microglia in male APP/PS1 mice

Stuart, K. E., King, A. E., King, N. E., Collins, J. M., Vickers, J. C., & Ziebell, J. M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.04.015 · Cited by 27

Environmental Enrichment Attenuates Oxidative Stress and Alters Detoxifying Enzymes in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease

Seo, J. H., Kang, S., Kim, K., Wi, S., Lee, J. W., & Cho, S. (2020) · Antioxidants · doi:10.3390/antiox9100928 · Cited by 26

Microglial Morphology Across Distantly Related Species: Phylogenetic, Environmental and Age Influences on Microglia Reactivity and Surveillance States

Paulo, D. C., Bento‐Torres, J., Filho, C. S., de Oliveira, T. C. G., de Sousa, A. A., dos Reis, R. R., dos Santos, Z. A., de Lima, C. M., Augusto‐Oliveira, M., Said, N. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.683026 · Cited by 28

Development of visual cortex in human neonates is selectively modified by postnatal experience

Li, M., Liu, T., Xu, X., Wen, Q., Zhao, Z., Dang, X., Zhang, Y., & Wu, D. (2022) · eLife · doi:10.7554/elife.78733 · Cited by 27

Environmental Enrichment in Stroke Research: an Update

Neves, L. T., Paz, L. V., Wieck, A., Mestriner, R. G., Monteiro, V. A. C. D. M., & Xavier, L. L. (2023) · Translational Stroke Research · doi:10.1007/s12975-023-01132-w · Cited by 26

Influence of the environment on adult CNS plasticity and repair

Foscarin, S., Rossi, F., & Carulli, D. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1293-4 · Cited by 26

Behavioral effects of combined environmental enrichment and chronic nicotine administration in male NMRI mice

Mesa‐Gresa, P., Pérez‐Martinez, A., & Redolat, R. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.03.010 · Cited by 26

Enriched physical environment reverses spatial cognitive impairment of socially isolated APP swe/ PS 1dE9 transgenic mice before amyloidosis onset

Cao, M., Hu, P., Zhang, Y., Yan, Y., Shields, C. B., Zhang, Y., Hu, G., & Xiao, M. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12790 · Cited by 26

Optimizing brain performance: Identifying mechanisms of adaptive neurobiological plasticity

Lambert, K. G., Eisch, A. J., Galea, L. A. M., Kempermann, G., & Merzenich, M. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.06.033 · Cited by 26

Putative neural consequences of captivity for elephants and cetaceans

Jacobs, B., Rally, H., Doyle, C., O’Brien, L., Tennison, M., & Marino, L. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0100 · Cited by 25

Mechanistic insight of neurodegeneration due to micro/nano-plastic-induced gut dysbiosis

Ghosh, A., & Gorain, B. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03875-3 · Cited by 27

Enduring effects of post-weaning rearing condition on depressive- and anxiety-like behaviors and motor activity in male rats

Mosaferi, B., Babri, S., Ebrahimi, H., & Mohaddes, G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.015 · Cited by 25

Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model

Stuart, K., King, A., Fernandez-Martos, C. M., Summers, M., & Vickers, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-03016-0 · Cited by 22

Postischemic Housing Environment on Cerebral Metabolism and Neuron Apoptosis after Focal Cerebral Ischemia in Rats

Qian, H.-Z., Zhang, H., Yin, L.-L., & Zhang, J. (2018) · Current Medical Science · doi:10.1007/s11596-018-1927-9 · Cited by 25

Environment and early life: Decisive factors for stress-resilience and vulnerability

Hegde, A., & Mitra, R. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2019.12.002 · Cited by 31

Enriched environment ameliorates dexamethasone effects on emotional reactivity and metabolic parameters in mice

Delanogare, E., de Souza, R. M., Rosa, G. K., Guanabara, F. G., Rafacho, A., & Moreira, E. L. G. (2020) · Stress · doi:10.1080/10253890.2020.1735344 · Cited by 26

The beneficial effects of physical exercise on visuospatial working memory in preadolescent children

Serra, L., Raimondi, S., Domenico, C. D., Maffei, S., Lardone, A., Liparoti, M., Sorrentino, P., Caltagirone, C., Petrosini, L., & Mandolesi, L. (2021) · AIMS neuroscience · doi:10.3934/neuroscience.2021026 · Cited by 25

Dance activity interventions targeting cognitive functioning in older adults with mild cognitive impairment: A meta-analysis

Yuan, Y., Li, X., & Liu, W. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.966675 · Cited by 28

Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences

Kaliman, P., Cosín‐Tomás, M., Madrid, A., Roque-López, S., Llanez-Anaya, E., Papale, L. A., Alisch, R. S., & Davidson, R. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-21246-9 · Cited by 29

Environmental housing affects the duration of mechanical allodynia and the spinal astroglial activation in a rat model of chronic inflammatory pain

Gabriel, A. F., Marcus, M. A. E., Honig, W. M. M., Helgers, N., & Joosten, E. A. J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.039 · Cited by 25

Cognitive Improvement Induced by Environment Enrichment in Chronic Cerebral Hypoperfusion Rats: a Result of Upregulated Endogenous Neuroprotection?

Yang, Y., Zhang, J., Xiong, L., Deng, M., Wang, J., Xin, J., & Liu, H. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0529-2 · Cited by 25

Lesion-induced and activity-dependent structural plasticity of Purkinje cell dendritic spines in cerebellar vermis and hemisphere

Gelfo, F., Florenzano, F., Foti, F., Burello, L., Petrosini, L., & Bartolo, P. D. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1109-5 · Cited by 25

Statins Reduce the Risks of Relapse to Addiction in Rats

Chauvet, C., Nicolas, C., Lafay‐Chebassier, C., Jaber, M., Thiriet, N., & Solinas, M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.317 · Cited by 25

Environmental training is beneficial to clinical symptoms and cortical presynaptic defects in mice suffering from experimental autoimmune encephalomyelitis

Bonfiglio, T., Olivero, G., Vergassola, M., Mannelli, L. D. C., Pacini, A., Iannuzzi, F., Summa, M., Bertorelli, R., Feligioni, M., Ghelardini, C., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.026 · Cited by 25

Intergenerational Sex-Specific Transmission of Maternal Social Experience

Faraji, J., Karimi, M., Soltanpour, N., Rouhzadeh, Z., Roudaki, S., Hosseini, S. A., Jafari, S. Y., Abdollahi, A. A., Soltanpour, N., Moeeini, R., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-28729-8 · Cited by 25

A qualitative exploration of post-acute stroke participants’ experiences of a multimodal intervention incorporating horseback riding

Pohl, P., Carlsson, G. E., Käll, L. B., Nilsson, M., & Blomstrand, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203933 · Cited by 26

Motor System Development of the Preterm and Low Birthweight Infant

Pitcher, J. B., Schneider, L. A., Drysdale, J. L., Ridding, M. C., & Owens, J. A. (2011) · Clinics in Perinatology · doi:10.1016/j.clp.2011.08.010 · Cited by 26

Environmental enrichment improves hippocampus-dependent spatial learning in female C57BL/6 mice in novel IntelliCage sweet reward-based behavioral tests

Bramati, G., Stauffer, P., Nigri, M., Wolfer, D. P., & Amrein, I. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1256744 · Cited by 26

Environmental enrichment alleviates hyperalgesia by modulating central sensitization in a nitroglycerin-induced chronic migraine model of mice

Wang, L., Liu, X., Zhu, C., Wu, S., Li, Z., Jing, L., Zhang, Z., Jing, Y., & Wang, Y. (2024) · The Journal of Headache and Pain · doi:10.1186/s10194-024-01779-2 · Cited by 24

Effects of environmental enrichment and stereotypic behavior on maternal behavior and infant viability in a model carnivore, the American mink (Neovison vison)

Díez‐León, M., & Mason, G. J. (2015) · Zoo Biology · doi:10.1002/zoo.21249 · Cited by 26

Environmentally enriched pigs have transcriptional profiles consistent with neuroprotective effects and reduced microglial activity

Brown, S. M., Bush, S. J., SUMMERS, K. M., Hume, D. A., & Lawrence, A. B. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.05.015 · Cited by 24

The downstream effects of forced exercise training and voluntary physical activity in an enriched environment on hippocampal plasticity in preadolescent rats

Rostami, S., Haghparast, A., & Fayazmilani, R. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147373 · Cited by 24

Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice

Xiao, R., Ali, S., Caligiuri, M. A., & Cao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.695859 · Cited by 24

Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity

Hakon, J., Quattromani, M. J., Sjölund, C., Talhada, D., Kim, B., Moyanova, S. G., Mastroiacovo, F., Menna, L. D., Olsson, R., Englund, E. M., et al. (2023) · Brain · doi:10.1093/brain/awad293 · Cited by 25

Neural plasticity after spinal cord injury.

Liu, J., Yang, X., Jiang, L., Wang, C., & Yang, M. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-5374.2012.05.010 · Cited by 25

The impact of enriched environment and transplantation of murine cortical embryonic stem cells on recovery from controlled cortical contusion injury

Peruzzaro, S., Gallagher, J., Dunkerson, J., Fluharty, S., Mudd, D. B., Hoane, M. R., & Smith, J. S. (2013) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-120299 · Cited by 24

Effect of environmental enrichment on physical and psychological dependence signs and voluntary morphine consumption in morphine-dependent and morphine-withdrawn rats

Abadi, A. H.-A., Miladi‐Gorji, H., & Bigdeli, I. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000197 · Cited by 24

Different housing conditions alter the behavioural phenotype of CCK2 receptor-deficient mice

Abramov, U., Raud, S., Innos, J., Lasner, H., Kurrikoff, K., Türna, T., Puussaar, T., Õkva, K., Matsui, T., & Vasar, E. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.04.027 · Cited by 24

Exploring staff experience of an “enriched environment” within stroke rehabilitation: a qualitative sub-study

White, J. H., Alborough, K., Janssen, H., Spratt, N. J., Jordan, L., & Pollack, M. R. P. (2013) · Disability and Rehabilitation · doi:10.3109/09638288.2013.872200 · Cited by 24

Modeling Restricted Repetitive Behavior in Animals

Bechard, A. R. (2012) · Autism - Open Access · doi:10.4172/2165-7890.s1-006 · Cited by 24

Effect of the environmental enrichment on the severity of psychological dependence and voluntary methamphetamine consumption in methamphetamine withdrawn rats

Hajheidari, S., Miladi‐Gorji, H., & Bigdeli, I. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.10.017 · Cited by 24

Effects of environmental enrichment in aged mice on anxiety-like behaviors and neuronal nitric oxide synthase expression in the brain

Tomiga, Y., Ito, A., Sudo, M., Ando, S., Maruyama, A., Nakashima, S., Kawanaka, K., Uehara, Y., Kiyonaga, A., Tanaka, H., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.010 · Cited by 24

Neuroendocrine and neurotrophic signaling in Huntington’s disease: Implications for pathogenic mechanisms and treatment strategies

Bartlett, D. M., Cruickshank, T. M., Hannan, A. J., Eastwood, P. R., Lázár, A. S., & Ziman, M. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.006 · Cited by 27

Enriched Environment Elicits Proangiogenic Mechanisms After Focal Cerebral Ischemia

Xie, H., Yu, K., Zhou, N., Shen, X., Tian, S., Zhang, B., Wang, Y., Wu, J., Liu, G., Jiang, C., et al. (2018) · Translational Stroke Research · doi:10.1007/s12975-018-0629-8 · Cited by 24

The effects of living in an outdoor enclosure on hippocampal plasticity and anxiety‐like behavior in response to nematode infection

Cope, E. C., Opendak, M. M., LaMarca, E. A., Murthy, S. S., Park, C. Y., Olson, L. B., Martinez, S., Leung, J. M., Graham, A. L., & Gould, E. (2018) · Hippocampus · doi:10.1002/hipo.23033 · Cited by 27

The role of the endocannabinoid system in autism spectrum disorders: Evidence from mouse studies

Pietropaolo, S., Bellocchio, L., Bouzón‐Arnáiz, I., & Yee, B. K. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.016 · Cited by 24

Pre and post-injury environmental enrichment effects functional recovery following medial frontal cortical contusion injury in rats

Jacqmain, J., Nudi, E., Fluharty, S., & Smith, J. S. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.056 · Cited by 24

The therapeutic potential of G-protein coupled receptors in Huntington's disease

Dowie, M. J., Scotter, E. L., Molinari, E., & Glass, M. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.07.008 · Cited by 26

Environmental enrichment has minimal effects on behavior in the Shank3 complete knockout model of autism spectrum disorder

Hulbert, S. W., Bey, A. L., & Jiang, Y. (2018) · Brain and Behavior · doi:10.1002/brb3.1107 · Cited by 22

Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer’s Disease

Sharma, V., Singh, T. G., & Singh, S. (2020) · Current Drug Targets · doi:10.2174/1389450121666200727104728 · Cited by 23

Nanoscale 3D EM Reconstructions Reveal Intrinsic Mechanisms of Structural Diversity of Chemical Synapses

Zhu, Y., Uytiepo, M., Bushong, E. A., Haberl, M. G., Beutter, E., Scheiwe, F., Zhang, W., Chang, L., Luu, D., Chui, B., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.108953 · Cited by 22

Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501

Goldberg, M., Islam, M. R., Kerimoglu, C., Lancelin, C., Gisa, V., Burkhardt, S., Krüger, D. M., Marquardt, T., Malchow, B., Schmitt, A., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01627-w · Cited by 24

Effects of short environmental enrichment on early‐life adversity induced cognitive alternations in adolescent rats

Joushi, S., Esmaeilpour, K., Masoumi‐Ardakani, Y., Esmaeili‐Mahani, S., & Sheibani, V. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24974 · Cited by 24

Environmental enrichment recruits activin A to recalibrate neural activity in mouse hippocampus

Dahlmanns, M., Dahlmanns, J. K., Schmidt, C. C., Valero-Aracama, M. J., Zheng, F., & Alzheimer, C. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac092 · Cited by 23

Homeostatic Synaptic Plasticity

Turrigiano, G. G. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_18 · Cited by 25

Unlike Physical Exercise, Modified Environment Increases the Lifespan of SOD1G93A Mice However Both Conditions Induce Cellular Changes

Gerber, Y. N., Sabourin, J.-C., Hugnot, J., & Perrin, F. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045503 · Cited by 26

Seasonal Variation in Cell Proliferation and Cell Migration in the Brain of Adult Red-Sided Garter Snakes (Thamnophis sirtalis parietalis)

Maine, A. R., Powers, S. D., & Lutterschmidt, D. I. (2014) · Brain Behavior and Evolution · doi:10.1159/000364778 · Cited by 23

Enriched environment attenuates nicotine self-administration and induces changes in ΔFosB expression in the rat prefrontal cortex and nucleus accumbens

Venebra-Muñoz, A., Corona-Morales, A. A., Santiago-Garcı́a, J., Melgarejo-Gutiérrez, M. A., Caba, M., & García‐García, F. (2014) · Neuroreport · doi:10.1097/wnr.0000000000000157 · Cited by 23

Environmental Housing and Duration of Exposure Affect Striatal Graft Morphology in a Rodent Model of Huntington's Disease

Döbrössy, M., & Dunnett, S. (2008) · Cell Transplantation · doi:10.3727/096368908787236558 · Cited by 24

Environmental enrichment does not impact on tumor growth in mice

Westwood, J. A., Darcy, P. K., & Kershaw, M. H. (2013) · F1000Research · doi:10.12688/f1000research.2-140.v1 · Cited by 23

Effect of early life housing manipulation on baseline and drug-induced behavioural responses on neurochemistry in the male rat

Simpson, J., Bree, D., & Kelly, J. P. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.008 · Cited by 23

Exercise Effects on Early Vocal Ultrasonic Communication Dysfunction in a PINK1 Knockout Model of Parkinson’s Disease

Kelm‐Nelson, C. A., Yang, K. M., & Ciucci, M. R. (2015) · Journal of Parkinson s Disease · doi:10.3233/jpd-150688 · Cited by 23

Environmental Enrichment Attenuates Traumatic Brain Injury: Induced Neuronal Hyperexcitability in Supragranular Layers of Sensory Cortex

Alwis, D. S., Yan, E. B., Johnstone, V., Carron, S. F., Hellewell, S. C., Morganti-Kossmann, M. C., & Rajan, R. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3774 · Cited by 20

Use of a Virtual Environment to Engage Motor and Postural Abilities in Elderly Subjects With and Without Mild Cognitive Impairment (MAAMI Project)

Bourrelier, J., Ryard, J., Dion, M., Merienne, F., Manckoundia, P., & Mourey, F. (2016) · IRBM · doi:10.1016/j.irbm.2016.02.007 · Cited by 23

Environmental Enrichment Results in Both Brain Connectivity Efficiency and Selective Improvement in Different Behavioral Tasks

Sampedro‐Piquero, P., Álvarez-Suárez, P., Moreno‐Fernández, R. D., Garcia‐Castro, G., Cuesta, M., & Begega, A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.07.036 · Cited by 25

Cholinergic and Dopaminergic Alterations in Nigrostriatal Neurons Are Involved in Environmental Enrichment Motor Protection in a Mouse Model of Parkinson’s Disease

Hilário, W. F., Herlinger, A. L., Areal, L. B., de Moraes, L. S., Ferreira, T. A. A., Andrade, T. E. S., Martins-Silva, C., & Pires, R. G. W. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0831-7 · Cited by 22

A Long-Term Enriched Environment Ameliorates the Accelerated Age-Related Memory Impairment Induced by Gestational Administration of Lipopolysaccharide: Role of Plastic Mitochondrial Quality Control

Zhuang, Z.-Q., Zhang, Z., Zhang, Y., Ge, H.-H., Sun, S., Zhang, P., & Chen, G.-H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.559182 · Cited by 20

Resting‐state language network neuroplasticity in post‐stroke music listening: A randomized controlled trial

Sihvonen, A. J., Pitkäniemi, A., Leo, V., Soinila, S. O., & Särkämö, T. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15524 · Cited by 23

Early environmental enrichment prevents cognitive impairments and developing addictive behaviours in a mouse model of prenatal psychological and physical stress

Razavinasab, M., Parsania, S., Nikootalab, M., Khaleghi, M., Saleki, K., Banazadeh, M., & Shabani, M. (2021) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10161 · Cited by 22

Environmental enrichment: dissociated effects between physical activity and changing environmental complexity on anxiety and neurogenesis in adult male Balb/C mice.

Ramírez-Rodríguez, G. B., Gutiérrez-Vera, B., Ortíz‐López, L., Vega‐Rivera, N. M., Juan, D. M.-S., Granados-Juárez, A., Aquino, D. V. C.-D., Castro-García, M., & Ramos, M. F. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113878 · Cited by 23

Metabolic Syndrome and Vascular-Associated Cognitive Impairment: a Focus on Preclinical Investigations

Jenkins, T. A. (2022) · Current Diabetes Reports · doi:10.1007/s11892-022-01475-y · Cited by 25

Enlarged Interior Built Environment Scale Modulates High-Frequency EEG Oscillations

Bower, I. S., Clark, G. M., Tucker, R., Hill, A. T., Lum, J. A. G., Mortimer, M. A., & Enticott, P. G. (2022) · eNeuro · doi:10.1523/eneuro.0104-22.2022 · Cited by 23

From the editors

(2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2004

Environmental enrichment: Evidence for an unexpected therapeutic influence

Kotloski, R. J., & Sutula, T. P. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.11.012 · Cited by 54

Enviromimetics: exploring gene environment interactions to identify therapeutic targets for brain disorders

McOmish, C. E., & Hannan, A. J. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.7.899 · Cited by 66

Environmental Enrichment and Gene–Environment Interactions in Mouse Models of Brain Disorders

Hannan, A. (2010) · Neuromethods · doi:10.1007/978-1-60761-474-6_11 · Cited by 3

Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders

Laviola, G., Hannan, A. J., Macrì, S., Solinas, M., & Jaber, M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.001 · Cited by 300