Enriched environments, experience-dependent plasticity and disorders of the nervous system

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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Amyloid plaque core protein in Alzheimer disease and Down syndrome.

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268

Epidemiology of Parkinson's disease

de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110

What is cognitive reserve? Theory and research application of the reserve concept

STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786

The Current Status of Neural Grafting in the Treatment of Huntington?s Disease. A Review

Wijeyekoon, R., & Barker, R. A. (2011) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2011.00078 · Cited by 22

Early postnatal handling and environmental enrichment improve the behavioral responses of 17-month-old 3xTg-AD and non-transgenic mice in the Forced Swim Test in a gender-dependent manner

Torres–Lista, V., & Giménez‐Llort, L. (2015) · Behavioural Processes · doi:10.1016/j.beproc.2015.09.011 · Cited by 22

Enriched Environment Enhances Poststroke Neurological Function Recovery on Rat: Involvement of p-ERK1/2

Jiang, C., Yu, K., Wu, Y., Xie, H., Liu, G., Wu, J., Jia, J., & Kuang, S. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2016.03.004 · Cited by 22

Effects of exercise and enrichment on behaviour in CD-1 mice

Aujnarain, A. B., Luo, O. D., Taylor, N., Lai, J., & Foster, J. A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.01.007 · Cited by 22

RNA-Sequencing Reveals Unique Transcriptional Signatures of Running and Running-Independent Environmental Enrichment in the Adult Mouse Dentate Gyrus

Grégoire, C., Tobin, S. W., Goldenstein, B., Samarut, É., Leclerc, A., Aumont, A., Drapeau, P., Fulton, S., & Fernandes, K. J. L. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00126 · Cited by 24

Experiences from a multimodal rhythm and music-based rehabilitation program in late phase of stroke recovery – A qualitative study

Pohl, P., Carlsson, G. E., Käll, L. B., Nilsson, M., & Blomstrand, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204215 · Cited by 22

Long-term environmental impact on object recognition, spatial memory, and reversal learning capabilities in Cacna1c haploinsufficient rats

Braun, M. D., Kisko, T. M., Witt, S. H., Rietschel, M., Schwarting, R. K. W., & Wöhr, M. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz235 · Cited by 20

Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington's disease: A nine-month pilot study

Bartlett, D. M., D, J. F. D., Lázár, A. S., Kordsachia, C. C., Rankin, T., Lo, J., Govus, A. D., Power, B., Lampit, A., Eastwood, P. R., et al. (2019) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2019.116522 · Cited by 22

Evaluation of study design variables and their impact on food-maintained operant responding in mice

Haluk, D. M., & Wickman, K. D. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.10.025 · Cited by 22

High-Impact, Self-Motivated Training Within an Enriched Environment With Single Animal Tracking Dose-Dependently Promotes Motor Skill Acquisition and Functional Recovery

Starkey, M. L., Bleul, C., Kasper, H., Mosberger, A. C., Zörner, B., Giger, S., Gullo, M., Buschmann, F., & Schwab, M. E. (2014) · Neurorehabilitation and neural repair · doi:10.1177/1545968314520721 · Cited by 23

Synaptic Density in Early Stages of Psychosis and Clinical High Risk

Blasco, M. B., Aji, K. N., Ramos-Jiménez, C., Leppert, I. R., Tardif, C. L., Cohen, J. P., Rusjan, P., & Mizrahi, R. (2024) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2024.3608 · Cited by 22

Does hospital design impact on patient activity levels and time spent alone?

Rosbergen, I. C. M., Tonello, I., Clark, R. A., & Grimley, R. (2020) · Disability and Rehabilitation · doi:10.1080/09638288.2020.1861117 · Cited by 21

Mechanisms Underlying Non-Pharmacological Dementia Prevention Strategies: A Translational Perspective

Alanko, V., Udeh‐Momoh, C. T., Kivipelto, M., & Matton, A. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.9 · Cited by 22

Embodied Prevention

Kempermann, G. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.841393 · Cited by 24

Vagus nerve stimulation in treating depression: A tale of two stories.

Yuan, T., Li, A., Sun, X., Arias-Carrión, Ó., & Machado, S. E. D. C. (2016) · Current Molecular Medicine · doi:10.2174/1566524016666151222143609 · Cited by 21

Environmental enrichment shapes striatal spike-timing-dependent plasticity in vivo

Morera‐Herreras, T., Gioanni, Y., Siaume‐Perez, S., Vignoud, G., & Venance, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-55842-z · Cited by 25

Environmental Enrichment Ameliorates Neonatal Sevoflurane Exposure-Induced Cognitive and Synaptic Plasticity Impairments

Ji, M., Wang, X., Sun, X., Zhang, H., Ju, L.-S., Qiu, L., Yang, J., Jia, M., Wu, J., & 杨建军 (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0627-1 · Cited by 22

Enriched Environment Protects the Optic Nerve from Early Diabetes-Induced Damage in Adult Rats

Dorfman, D., Aranda, M. L., & Rosenstein, R. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136637 · Cited by 21

Environmental enrichment alters structural plasticity of the adolescent brain but does not remediate the effects of prenatal nicotine exposure

Mychasiuk, R., Muhammad, A., & Kolb, B. E. (2014) · Synapse · doi:10.1002/syn.21737 · Cited by 20

The effect of an enriched environment on activity levels in people with stroke in an acute stroke unit: protocol for a before-after pilot study

Rosbergen, I. C. M., Grimley, R., Hayward, K. S., Walker, K. C., Rowley, D., Campbell, A. M., McGufficke, S., Robertson, S. T., Trinder, J., Janssen, H., et al. (2016) · Pilot and Feasibility Studies · doi:10.1186/s40814-016-0081-z · Cited by 20

Prenatal Stress and Peripubertal Stimulation of the Endocannabinoid System Differentially Regulate Emotional Responses and Brain Metabolism in Mice

Macrì, S., Ceci, C., Canese, R., & Laviola, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041821 · Cited by 20

Natural biological variation of white matter microstructure is accentuated in Huntington's disease

Gregory, S., Crawford, H. E., Seunarine, K. K., Leavitt, B. R., Dürr, A., Roos, R. A. C., Scahill, R. I., Tabrizi, S. J., Rees, G. E., Langbehn, D. R., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24191 · Cited by 20

Building your best day for healthy brain aging—The neuroprotective effects of optimal time use

Mellow, M. L., Dumuid, D., Thacker, J. S., Dorrian, J., & Smith, A. E. (2019) · Maturitas · doi:10.1016/j.maturitas.2019.04.204 · Cited by 19

Differential Effects of Short-term Environmental Enrichment in Juvenile and Adult Mice

Chandler, K., Dosso, H., Simard, S., Siddiqi, S., Rudyk, C., & Salmaso, N. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2019.12.028 · Cited by 20

The Pelvic Girdle Pain deadlock: 2. Topics that, so far, have remained out of focus

Meijer, O. G., Barbe, M. F., Prins, M. R., Schipholt, I. J. L., Hu, H., & Daffertshofer, A. (2020) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2020.102166 · Cited by 22

Recovery of motor function after traumatic spinal cord injury by using plasma-synthesized polypyrrole/iodine application in combination with a mixed rehabilitation scheme

Sánchez‐Torres, S., Dı́az-Ruiz, A., Rı́os, C., Olayo, M. G., Cruz, G. J., Olayo, R., Morales, J., Mondragón‐Lozano, R., Fabela-Sánchez, O., Orozco-Barrios, C. E., et al. (2020) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-020-06395-5 · Cited by 21

Early environmental enrichment for autism spectrum disorder Fmr1 mice models has positive behavioral and molecular effects

Chen, Y.-S., Zhang, S., Yue, C., Xiang, P., Li, J., Wei, Z., Xu, L., & Zeng, Y. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114033 · Cited by 21

Environmental enrichment and exercise housing protocols for mice

Love, C. J., Gubert, C., Renoir, T., & Hannan, A. J. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101689 · Cited by 20

Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach

Schmidt, S., Haase, M., Best, L., Groth, M., Lindner, J., Witte, O. W., Kaleta, C., & Frahm, C. (2022) · Cells · doi:10.3390/cells11233864 · Cited by 21

The Black radical imagination: a space of hope and possible futures

Hill‐Jarrett, T. G. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1241922 · Cited by 27

Absence of Ca2+-stimulated adenylyl cyclases leads to reduced synaptic plasticity and impaired experience-dependent fear memory

Wieczorek, L., Majumdar, D., Wills, T. A., Hu, L., Winder, D. G., Webb, D. J., & Muglia, L. J. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.50 · Cited by 21

Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats

Sampedro‐Piquero, P., Arias, J. L., & Begega, A. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.004 · Cited by 20

Physical exercise is required for environmental enrichment to offset the quantitative effects of dark‐rearing on the S‐100β astrocytic density in the rat visual cortex

Argandoña, E., Bengoetxea, H., & Lafuente, J. V. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2009.01103.x · Cited by 20

Transient Receptor Potential-canonical 1 is Essential for Environmental Enrichment-Induced Cognitive Enhancement and Neurogenesis

Du, L., Wang, L., Yang, X., Wang, P., Li, X.-H., Chai, D., Liu, B., Cao, Y., Xu, W., Liu, R., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9758-9 · Cited by 20

Effects of experimental housing conditions on recovery of laboratory mice

Jirkof, P. (2015) · Lab Animal · doi:10.1038/laban.662 · Cited by 20

Cognitive and neurobehavioral benefits of an enriched environment on young adult mice after chronic ethanol consumption during adolescence

Rico‐Barrio, I., Peñasco, S., Puente, N., Ramos, A., Fontaine, C. J., Reguero, L., Giordano, M. E., Salazar, I. B., Irastorza, I. T., Lekunberri, L., et al. (2018) · Addiction Biology · doi:10.1111/adb.12667 · Cited by 20

Enriched environment inhibits breast cancer progression in obese models with intact leptin signaling

Foglesong, G. D., Queen, N. J., Huang, W., Widstrom, K. J., & Cao, L. (2019) · Endocrine Related Cancer · doi:10.1530/erc-19-0075 · Cited by 22

Environmental enrichment improves cognitive symptoms and pathological features in a focal model of cortical damage of multiple sclerosis

Silva, B. A., Leal, M. C., Farías, M. I., Erhardt, B., Galeano, P., Pitossi, F. J., & Ferrari, C. C. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146520 · Cited by 20

Environmental enrichment decreases chronic psychosocial stress-impaired extinction and reinstatement of ethanol conditioned place preference in C57BL/6 male mice

Bahí, A., & Dreyer, J. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05408-8 · Cited by 20

Long‐term environmental enrichment reduces microglia morphological diversity of the molecular layer of dentate gyrus

de Oliveira, T. C. G., Paulo, D. C., de Lima, C. M., de Oliveira, R. B., Filho, C. S., Diniz, D. G., Bento‐Torres, J., & Diniz, C. W. P. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14920 · Cited by 21

Plastic Changes in Striatal Fast-Spiking Interneurons Following Hemicerebellectomy and Environmental Enrichment

Bartolo, P. D., Gelfo, F., Burello, L., Giorgio, A. D., Petrosini, L., & Granato, A. (2011) · The Cerebellum · doi:10.1007/s12311-011-0275-0 · Cited by 20

The importance of nature in coping

Ottosson, J. (2007) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences)) · Cited by 20

Active forgetting and neuropsychiatric diseases

Berry, J. A., Guhle, D. C., & Davis, R. L. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02521-9 · Cited by 21

Through synapses to spatial memory maps via a topological model

Dabaghian, Y. A. (2019) · Scientific Reports · doi:10.1038/s41598-018-36807-0 · Cited by 19

Stroke survivors’ experiences of occupation in hospital-based stroke rehabilitation: a qualitative exploration

Purcell, S., Scott, P., Gustafsson, L. A., & Molineux, M. (2019) · Disability and Rehabilitation · doi:10.1080/09638288.2018.1542460 · Cited by 19

Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment

Odeón, M. M., & Acosta, G. B. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109726 · Cited by 20

Mapping accumulative whole-brain activities during environmental enrichment with manganese-enhanced magnetic resonance imaging

Li, R., Wang, X., Lin, F., Song, T., Zhu, X., & Lei, H. C. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116588 · Cited by 20

Early exposure to environment sounds and the development of cortical auditory evoked potentials of preterm infants during the first 3 months of life

Cavalcanti, H. G., Nunes, A. D. D. S., da Cunha, B. K. S., Alvarenga, K. D. F., Balen, S. A., & Pereira, A. (2020) · BMC Research Notes · doi:10.1186/s13104-020-05129-8 · Cited by 19

Behavioral Engagement With Playable Objects Resolves Stress-Induced Adaptive Changes by Reshaping the Reward System

Park, J., Lee, E.-H., Kwon, H., Baek, I., Seo, J.-S., Kim, K., & Han, P. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.09.027 · Cited by 19

The differential effects of brief environmental enrichment following social isolation in rats

Guven, E. B., Pranic, N. M., & Ünal, G. (2022) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-022-00989-y · Cited by 19

From animal models to human individuality: Integrative approaches to the study of brain plasticity

Hille, M., Kühn, S., Kempermann, G., Bonhoeffer, T., & Lindenberger, U. (2024) · Neuron · doi:10.1016/j.neuron.2024.10.006 · Cited by 23

Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders

Toma, I. D., Manubens-Gil, L., Ossowski, S., & Dierssen, M. (2016) · Neural Plasticity · doi:10.1155/2016/4235898 · Cited by 21

Impact of Enriched Environment on Murine T Cell Differentiation and Gene Expression Profile

Rattazzi, L., Piras, G., Brod, S., Smith, K. E., Ono, M., & D’Acquisto, F. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00381 · Cited by 23

Vascular Endothelial Growth Factor (VEGF) in Neurodevelopmental Disorders

Howell, K. R., & Armstrong, J. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0130-9 · Cited by 19

Fluoxetine Modulates the Activity of Hypothalamic POMC Neurons via mTOR Signaling

Barone, I., Melani, R., Mainardi, M., Scabia, G., Scali, M., Dattilo, A., Ceccarini, G., Vitti, P., Santini, F., Maffei, L., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1052-6 · Cited by 20

Postnatal Ablation of Synaptic Retinoic Acid Signaling Impairs Cortical Information Processing and Sensory Discrimination in Mice

Park, E., Tjia, M., Zuo, Y., & Chen, L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3028-17.2018 · Cited by 18

Enhancing cognition through pharmacological and environmental interventions: Examples from preclinical models of neurodevelopmental disorders

Morè, L., Lauterborn, J. C., Papaleo, F., & Brambilla, R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.02.003 · Cited by 20

Physical activity and environmental enrichment: Behavioural effects of exposure to different housing conditions in mice

Rabadán, R., Ramos‐Campos, M., Redolat, R., & Mesa‐Gresa, P. (2020) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2019-035 · Cited by 19

Enriched Environment Decelerates the Development of Endometriosis in Mouse

Yin, B., Jiang, H., Liu, X., & Guo, S. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00117-1 · Cited by 19

Enriched Environment Procedures for Rodents: Creating a Standardized Protocol for Diverse Enrichment to Improve Consistency across Research Studies

Harland, B. C., & Dalrymple‐Alford, J. C. (2020) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3637 · Cited by 19

EphB2 mediates social isolation-induced memory forgetting

Wu, X., Zhang, Y., Liu, X., Han, W.-B., Xu, N., & Sun, S. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01051-6 · Cited by 19

Integrin-linked Kinase is Essential for Environmental Enrichment Enhanced Hippocampal Neurogenesis and Memory

Xu, X., Li, T., Wang, D.-D., Chen, B., Wang, Y., & Chen, Z.-Y. (2015) · Scientific Reports · doi:10.1038/srep11456 · Cited by 20

Towards New Therapies for Parkinson's Disease

Finkelstein, D. I. (2011) · InTech eBooks · doi:10.5772/954 · Cited by 19

Environmental enrichment reverses memory impairment induced by toluene in mice

Montes, S., Solís-Guillén, R. D. C., García-Jácome, D., & Páez-Martínez, N. (2017) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2017.04.003 · Cited by 19

Enhanced Plasticity in Zincergic, Cortical Circuits after Exposure to Enriched Environments

Nakashima, A. S., & Dyck, R. H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4645-08.2008 · Cited by 19

Spatial memory impairment by TRPC1 depletion is ameliorated by environmental enrichment

Xing, R., Zhang, Y., Xu, H., Luo, X., Chang, R. C., Liu, J., & Yang, X. (2016) · Oncotarget · doi:10.18632/oncotarget.8428 · Cited by 18

Efficacy of Tai Chi-Style Multi-Component Exercise on Frontal-Related Cognition and Physical Health in Elderly With Amnestic Mild Cognitive Impairment

Yang, S.-Y., Lee, H., Huang, C., & Chen, J. J. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.636390 · Cited by 19

Effects of environmental enrichment on recognition memory in zebrafish larvae

Gatto, E., Bruzzone, M., Maschio, M. D., & Dadda, M. (2022) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2022.105552 · Cited by 18

Post-stroke enriched auditory environment induces structural connectome plasticity: secondary analysis from a randomized controlled trial

Sihvonen, A. J., Soinila, S. O., & Särkämö, T. (2022) · Brain Imaging and Behavior · doi:10.1007/s11682-022-00661-6 · Cited by 22

Enriched Environment Attenuates Ferroptosis after Cerebral Ischemia/Reperfusion Injury via the HIF-1α-ACSL4 Pathway

Liu, J., Luo, Q., Ke, J., Zhang, D., Xu, Y., Liao, W., Chen, X., & Zhang, X. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/5157417 · Cited by 18

Functional aspects of the brain lymphatic drainage system in aging and neurodegenerative diseases

Chen, Y., He, X., Cai, J., & Li, Q. (2024) · Journal of Biomedical Research · doi:10.7555/jbr.37.20230264 · Cited by 18

Light and classical music therapies attenuate chronic unpredictable mild stress-induced depression via BDNF signaling pathway in mice

Cheng, H., Xie, H.-X., Tang, Q.-L., Yi, L., & Zhu, J.-X. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34196 · Cited by 18

Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy

Xu, Y.-Q., Chen, Y., Xing, J., & Yao, J. (2025) · Clinical Epigenetics · doi:10.1186/s13148-025-01820-4 · Cited by 21

The effects of extrinsic stress on somatic markers and behavior are dependent on animal housing conditions

Huzard, D., Mumby, D. G., Sandi, C., Poirier, G. L., & van der Kooij, M. A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.07.018 · Cited by 18

Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo

Dringenberg, H. C., Day, L. R. B., & Choi, D. H. (2014) · Neural Plasticity · doi:10.1155/2014/571285 · Cited by 18

Physical enrichment enhances memory function by regulating stress hormone and brain acetylcholinesterase activity in rats exposed to restraint stress

Nawaz, A., Batool, Z., Shazad, S., Rafiq, S., Afzal, A., & Haider, S. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.05.049 · Cited by 20

Early postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats

Burgos, H., Hernández, A., Constandil, L., Ríos, M., Flores, O., Puentes, G. C., Hernández, K., Morgan, C., Valladares, L., Castillo, A., et al. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.001 · Cited by 16

Observations of Activity Levels in a Purpose-Built, Inpatient, Rehabilitation Facility

Scrivener, K., Pocovi, N. C., Jones, T., Dean, B., Gallagher, S., Henrisson, W., Thorburn, M., & Dean, C. M. (2019) · HERD Health Environments Research & Design Journal · doi:10.1177/1937586718823519 · Cited by 18

Enriched Environment Shortens the Duration of Action Potentials in Cerebellar Granule Cells

Eshra, A., Hirrlinger, P. G., & Hallermann, S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00289 · Cited by 18

Cultivating a healthy neuro‐immune network: A health psychology approach

Bower, J. E., Kuhlman, K. R., Haydon, M. D., Boyle, C. C., & Radin, A. S. (2019) · Social and Personality Psychology Compass · doi:10.1111/spc3.12498 · Cited by 21

Enriched Environment Rearing from Birth Reduced Anxiety, Improved Learning and Memory, and Promoted Social Interactions in Adult Male Mice

Zheng, J., Zou, R., Huang, S., Song, T.-J., & Yu, X. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.004 · Cited by 17

Voluntary Physical Exercise Reduces Motor Dysfunction and Hampers Tumor Cell Proliferation in a Mouse Model of Glioma

Tantillo, E., Colistra, A., Baroncelli, L., Costa, M., Caleo, M., & Vannini, E. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17165667 · Cited by 18

An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation

de León‐Guerrero, S. D., Salazar‐León, J., Meza‐Sosa, K. F., Valle‐García, D., Aguilar‐León, D., Pedraza‐Alva, G., & Pérez‐Martínez, L. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.048936 · Cited by 20

Involvement of p38α in Kainate-Induced Seizure and Neuronal Cell Damage

Namiki, K., Nakamura, A., Furuya, M., Mizuhashi, S., MATSUO, Y., Tokuhara, N., SUDO, T., Hama, H., Kuwaki, T., Yano, S., et al. (2007) · Journal of Receptors and Signal Transduction · doi:10.1080/10799890701357855 · Cited by 18

Functional implications of hippocampal adult neurogenesis in intellectual disabilities

Pons‐Espinal, M., de Lagrán, M. M., & Dierssen, M. (2013) · Amino Acids · doi:10.1007/s00726-013-1489-x · Cited by 18

Violated expectancies: Cause and function of exploration, fear, and aggression

KAMPEN, H. S. V. (2014) · Behavioural Processes · doi:10.1016/j.beproc.2014.05.005 · Cited by 18

An Enriched Rearing Environment Calms Adult Male Rat Sexual Activity: Implication for Distinct Serotonergic and Hormonal Responses to Females

Urakawa, S., Mitsushima, D., Shimozuru, M., Sakuma, Y., & Kondo, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087911 · Cited by 18

Sex differences after environmental enrichment and physical exercise in rats when solving a navigation task

Chamizo, V. D., Rodríguez, C. A., Sánchez, J., & Màrmol, F. (2015) · Learning & Behavior · doi:10.3758/s13420-015-0200-3 · Cited by 18

The Effect of Long-Term Environmental Enrichment in Chronic Cerebral Hypoperfusion-Induced Memory Impairment in Rats

Park, J., Seong, H., Jin, H.-B., & Kim, Y. (2016) · Biological Research For Nursing · doi:10.1177/1099800416686179 · Cited by 19

Towards a Virtual Reality Cognitive Training System for Mild Cognitive Impairment and Alzheimer's Disease Patients

Caggianese, G., Chirico, A., Pietro, G. D., Gallo, L., Giordano, A., Predazzi, M., & Neroni, P. (2018) · International Conference on Advanced Information Networking and Applications Workshops (WAINA) · doi:10.1109/waina.2018.00164 · Cited by 18

The Neurobiology of Behavioral Inhibition as a Developmental Mechanism

Blackford, J. U., Clauss, J. A., & Benningfield, M. M. (2018) · Springer eBooks · doi:10.1007/978-3-319-98077-5_6 · Cited by 21

Genetic markers enable the verification and manipulation of the dauer entry decision

Shih, P.-Y., Lee, J. S., & Sternberg, P. W. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.06.009 · Cited by 18

Neural stem cell therapy for neuropsychiatric disorders

Valenzuela, M., Sidhu, K., Dean, S. K., & Sachdev, P. S. (2007) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2007.00176.x · Cited by 19

Tracking the fear memory engram: discrete populations of neurons within amygdala, hypothalamus, and lateral septum are specifically activated by auditory fear conditioningPreprint

Butler, C., Wilson, Y. M., Gunnersen, J. M., & Murphy, M. (2015) · Learning & Memory · doi:10.1101/lm.037663.114 · Cited by 20

Enriching the environment of αCaMKIIT286A mutant mice reveals that LTD occurs in memory processing but must be subsequently reversed by LTPPreprint

Parsley, S. L., Pilgram, S. M., Soto, F., Giese, K.-P., & Edwards, F. A. (2007) · Learning & Memory · doi:10.1101/lm.356607 · Cited by 18

Environmental Enrichment Prevent the Juvenile Hypoxia-Induced Developmental Loss of Parvalbumin-Immunoreactive Cells in the Prefrontal Cortex and Neurobehavioral Alterations Through Inhibition of NADPH Oxidase-2-Derived Oxidative Stress

Zhang, M., Wu, J., Huo, L., Luo, L., Song, X., Fan, F., Lu, Y., & Liang, D. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9656-6 · Cited by 16

Effect of resveratrol and environmental enrichment on biomarkers of oxidative stress in young healthy mice

Muhammad, M. S., Magaji, R. A., Mohammed, A., Isa, A. S., & Magaji, M. G. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9891-1 · Cited by 17

Environmental Enrichment Rescues Oxidative Stress and Behavioral Impairments Induced by Maternal Care Deprivation: Sex- and Developmental-Dependent Differences

Réus, G. Z., Abitante, M. S., Manosso, L. M., de Moura, A. B., Borba, L. A., Botelho, M. E. M., Darabas, A. C., Demo, J. P., Behenck, J. P., Arent, C. O., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02588-3 · Cited by 16

Environmental enrichment and intranasal oxytocin administration reverse maternal separation-induced impairments of prosocial choice behavior

Joushi, S., Taherizadeh, Z., Esmaeilpour, K., & Sheibani, V. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173318 · Cited by 18

Environmental Enrichment Mitigates the Long-Lasting Sequelae of Perinatal Fentanyl Exposure in Mice

Alipio, J. B., Riggs, L. M., Plank, M., & Keller, A. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.2083-21.2022 · Cited by 17

From the editors

(2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2004

Environmental enrichment: Evidence for an unexpected therapeutic influence

Kotloski, R. J., & Sutula, T. P. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.11.012 · Cited by 54

Enviromimetics: exploring gene environment interactions to identify therapeutic targets for brain disorders

McOmish, C. E., & Hannan, A. J. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.7.899 · Cited by 66

Environmental Enrichment and Gene–Environment Interactions in Mouse Models of Brain Disorders

Hannan, A. (2010) · Neuromethods · doi:10.1007/978-1-60761-474-6_11 · Cited by 3

Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders

Laviola, G., Hannan, A. J., Macrì, S., Solinas, M., & Jaber, M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.001 · Cited by 300