Cited by 1,771Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

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Enriched environments, experience-dependent plasticity and disorders of the nervous system

Nithianantharajah, Jess, Hannan, Anthony J.·2006·Nature Reviews Neuroscience

DOI 10.1038/nrn1970

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Abstract

Behavioural, cellular and molecular studies have revealed significant effects of enriched environments on rodents and other species, and provided new insights into mechanisms of experience-dependent plasticity, including adult neurogenesis and synaptic plasticity. The demonstration that the onset and progression of Huntington's disease in transgenic mice is delayed by environmental enrichment has emphasized the importance of understanding both genetic and environmental factors in nervous system disorders, including those with Mendelian inheritance patterns. A range of rodent models of other brain disorders, including Alzheimer's disease and Parkinson's disease, fragile X and Down syndrome, as well as various forms of brain injury, have now been compared under enriched and standard housing conditions. Here, we review these findings on the environmental modulators of pathogenesis and gene-environment interactions in CNS disorders, and discuss their therapeutic implications.

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“Moreover, this enhanced rearing condition has been used to study the mitigative potential of the environment in a variety of animal disease models (Nithianantharajah and Hannan, 2006).”
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Authors: Nithianantharajah, J., & Hannan, A. J.
Affiliations: The University of Melbourne (AU)
Corresponding author: Hannan, Anthony J.
ORCID: Nithianantharajah, Jess
Hannan, Anthony J.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2006-09
Volume: 7
Issue: 9
Pages: 697-709
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1970
OpenAlex: W2054282296
Cited by: 1,771
References: 180
Citations by year: 2026: 61 · 2025: 74 · 2024: 78 · 2023: 89 · 2022: 109 · 2021: 113 · 2020: 113 · 2019: 106 · 2018: 125 · 2017: 82 · 2016: 95 · 2015: 101 · 2014: 95 · 2013: 88 · 2012: 95
FWCI: 3.79
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: environmental enrichment, experience-dependent plasticity, neuroplasticity, adult neurogenesis, synaptic plasticity, Huntington's disease, Alzheimer's disease, Parkinson's disease, fragile X syndrome, Down syndrome, brain injury, gene-environment interaction, central nervous system disorders, treatment options, rodent models
MeSH terms: Animals, Cell Survival, Disease Models, Animal, Environment Design, Humans, Nervous System Malformations, Neuronal Plasticity, Rodentia, Sensory Deprivation, Neurodegenerative Diseases, Recovery of Function

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Enriched environments, experience-dependent plasticity and disorders of the nervous system

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