Cited by 1,771Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.

Enriched environments, experience-dependent plasticity and disorders of the nervous system

Nithianantharajah, Jess, Hannan, Anthony J.·2006·Nature Reviews Neuroscience

DOI 10.1038/nrn1970

Open this paper in CoChat — free account

Abstract

Behavioural, cellular and molecular studies have revealed significant effects of enriched environments on rodents and other species, and provided new insights into mechanisms of experience-dependent plasticity, including adult neurogenesis and synaptic plasticity. The demonstration that the onset and progression of Huntington's disease in transgenic mice is delayed by environmental enrichment has emphasized the importance of understanding both genetic and environmental factors in nervous system disorders, including those with Mendelian inheritance patterns. A range of rodent models of other brain disorders, including Alzheimer's disease and Parkinson's disease, fragile X and Down syndrome, as well as various forms of brain injury, have now been compared under enriched and standard housing conditions. Here, we review these findings on the environmental modulators of pathogenesis and gene-environment interactions in CNS disorders, and discuss their therapeutic implications.

Integrity signals

Registry

Crossref · 10.1038/nrn1970

Cites

180 of 180 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Epidemiology of Parkinson's disease
de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110
What is cognitive reserve? Theory and research application of the reserve concept
STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786

Flagged first, then by citations

Show all 180 references

Research works printed but not linked: 1

Valenzuela, M. J. & Sachdev, P. Brain reserve and dementia: a systematic review. Psychol. Med. 36, 441–454 (2006). · DOI · Paper page

Sorted by citations

Items 201–300 of 999

Early Social Enrichment Rescues Adult Behavioral and Brain Abnormalities in a Mouse Model of Fragile X Syndrome
Oddi, D., Subashi, E., Middei, S., Bellocchio, L., Lemaire, V., Guzmán, M., Crusio, W. E., D'Amato, F. R., & Pietropaolo, S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.291 · Cited by 107
Epigenetic memory: The Lamarckian brain
Fischer, A. (2014) · The EMBO Journal · doi:10.1002/embj.201387637 · Cited by 107
CBP is required for environmental enrichment‐induced neurogenesis and cognitive enhancement
López‐Atalaya, J. P., Ciccarelli, A., Viosca, J., Valor, L. M., Jimenez-Minchan, M., Canals, S., Giustetto, M., & Barco, Á. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.299 · Cited by 111
The epigenetic bottleneck of neurodegenerative and psychiatric diseases
Sananbenesi, F., & Fischer, A. (2009) · Biological Chemistry · doi:10.1515/bc.2009.131 · Cited by 107
Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice
Goertz, N., Lewejohann, L., Tomm, M., Ambrée, O., Keyvani, K., Paulus, W., & Sachser, N. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.006 · Cited by 115
Exercise mode and executive function in older adults: An ERP study of task-switching
Dai, C.-T., Chang, Y., Huang, C., & Hung, T. (2013) · Brain and Cognition · doi:10.1016/j.bandc.2013.07.007 · Cited by 113
Changes in Brain Size during the Menstrual Cycle
Hagemann, G., Ugur, T., Schleußner, E., Mentzel, H., Fitzek, C., Witte, O. W., & Gaser, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014655 · Cited by 114
Sensory Input Enhances Synaptogenesis of Adult-Born Neurons
Livneh, Y., Feinstein, N., Klein, M. E., & Mizrahi, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4105-08.2009 · Cited by 108
Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF
Choi, S. H., Li, Y., Parada, L. F., & Sisodia, S. S. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-52 · Cited by 106
Role for astroglial α1-adrenoreceptors in gliotransmission and control of synaptic plasticity in the neocortex
Pankratov, Y., & Lalo, U. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00230 · Cited by 104
Environmental factors as modulators of neurodegeneration: Insights from gene–environment interactions in Huntington's disease
Mo, C., Hannan, A. J., & Renoir, T. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.03.003 · Cited by 108
Self-citation
Novelty Determines the Effects of Olfactory Enrichment on Memory and Neurogenesis Through Noradrenergic Mechanisms
Veyrac, A., Sacquet, J., Nguyen, V., Marien, M. R., Jourdan, F., & Didier, A. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.191 · Cited by 105
Glutamate–dopamine–GABA interactions in the aging basal ganglia
Mora, F., Segovia, G., & Arco, A. D. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.10.006 · Cited by 118
REGULATORS OF ADULT NEUROGENESIS IN THE HEALTHY AND DISEASED BRAIN
Grote, H., & Hannan, A. J. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04610.x · Cited by 105
Self-citation
Translational research on reserve against neurodegenerative disease: consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer’s Association Reserve, Resilience and Protective Factors Professional Interest Area working groups
Perneczky, R., Kempermann, G., Korczyn, A. D., Matthews, F. E., Ikram, M. A., Scarmeas, N., Chételat, G., Stern, Y., & Ewers, M. (2019) · BMC Medicine · doi:10.1186/s12916-019-1283-z · Cited by 114
Innovative Approaches and Therapies to Enhance Neuroplasticity and Promote Recovery in Patients with Neurological Disorders: A Narrative Review
Kumar, J., Patel, T., Sugandh, F., Dev, J., Kumar, U., Adeeb, M., Kachhadia, M. P., Puri, P., Prachi, F., Zaman, M., et al. (2023) · Cureus · doi:10.7759/cureus.41914 · Cited by 103
Care for Child Development: Basic Science Rationale and Effects of Interventions
Holt, R. L., & Mikati, M. A. (2011) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2010.11.009 · Cited by 109
Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons
Sanchez, P. E., Farès, R., Risso, J., Bonnet, C., Bouvard, S., Cavorsin, M. L., Georges, B., Moulin, C., Belmeguenaï, A., Bodennec, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901840106 · Cited by 101
Perinatal brain damage in children
Cioni, G., D’Acunto, G., & Guzzetta, A. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53884-0.00022-1 · Cited by 100
Transcription, Epigenetics and Ameliorative Strategies in Huntington’s Disease: a Genome-Wide Perspective
Valor, L. M. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8715-8 · Cited by 106
Short-Term Environmental Enrichment Rescues Adult Neurogenesis and Memory Deficits in APPSw,Ind Transgenic Mice
Valero, J., España, J., Parra‐Damas, A., Martín, E., Rodrı́guez-Álvarez, J., & Saura, C. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016832 · Cited by 108
Are behavioral effects of early experience mediated by oxytocin?
Bales, K. L., Boone, E., Epperson, P., Hoffman, G., & Carter, C. S. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00024 · Cited by 99
Behavior of neural stem cells in the Alzheimer brain
Waldau, B., & Shetty, A. K. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8053-y · Cited by 101
MeCP2 and Rett syndrome: reversibility and potential avenues for therapy
Gadalla, K. K. E., Bailey, M. E. S., & Cobb, S. (2011) · Biochemical Journal · doi:10.1042/bj20110648 · Cited by 101
Evaluation of Social and Physical Enrichment in Modulation of Behavioural Phenotype in C57BL/6J Female Mice
Kulesskaya, N., Rauvala, H., & Võikar, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024755 · Cited by 105
Environmental enrichment of laboratory rodents: the answer depends on the question.
Toth, L. A., Kregel, K. C., Leon, L., & Musch, T. I. (2011) · PubMed Central · Cited by 101
Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive-like behavior
Chabry, J., Nicolas, S., Cazareth, J., Murris, E., Guyon, A., Glaichenhaus, N., Heurteaux, C., & Petit-Paitel, A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.018 · Cited by 101
Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke
Hakon, J., Quattromani, M. J., Sjölund, C., Tomasevic, G., Carey, L. M., Lee, J., Ruscher, K., Wieloch, T. W., & Bauer, A. Q. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.11.022 · Cited by 94
Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE ε4 Genotype
Krell‐Roesch, J., Vemuri, P., Pink, A., Roberts, R. O., Stokin, G. B., Mielke, M. M., Christianson, T. J. H., Knopman, D. S., Petersen, R. C., Kremers, W. K., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3822 · Cited by 96
Parental enrichment and offspring development: Modifications to brain, behavior and the epigenome
Mychasiuk, R., Zahir, S. M., Schmold, N., Ilnytskyy, S., Kovalchuk, O., & Gibb, R. L. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.11.036 · Cited by 96
Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model
Griñán-Ferré, C., Izquierdo, V., Otero, E., Puigoriol-Illamola, D., Corpas, R., Sanfeliu, C., Ortuño-Sahagún, D., & Pallàs, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00224 · Cited by 94
GAME (Goals - Activity - Motor Enrichment): protocol of a single blind randomised controlled trial of motor training, parent education and environmental enrichment for infants at high risk of cerebral palsy
Morgan, C., Novak, I., Dale, R. C., Guzzetta, A., & Badawi, N. A. (2014) · BMC Neurology · doi:10.1186/s12883-014-0203-2 · Cited by 105
Behavioural differences between C57BL/6 and 129S6/SvEv strains are reinforced by environmental enrichment
Abramov, U., Puussaar, T., Raud, S., Kurrikoff, K., & Vasar, E. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.07.075 · Cited by 95
Is Cognitive Training an Effective Treatment for Preclinical and Early Alzheimer's Disease?
Gates, N. J., & Sachdev, P. S. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141302 · Cited by 98
Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection
Jurgens, H. A., & Johnson, R. W. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.05.015 · Cited by 95
Transformation of cortical and hippocampal neural circuit by environmental enrichment
Hirase, H., & Shinohara, Y. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.031 · Cited by 96
Effects of environmental enrichment on the incubation of cocaine craving
Chauvet, C., Goldberg, S. R., Jaber, M., & Solinas, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.014 · Cited by 100
Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi
Hattori, S., Hashimoto, R., Miyakawa, T., Yamanaka, H., Maeno, H., Wada, K., & Kunugi, H. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.036 · Cited by 101
Physical exercise prevents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy-treated rats
Winocur, G., Wojtowicz, J. M., Huang, J. W., & Tannock, I. F. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3394-0 · Cited by 95
Chronic sleep restriction causes a decrease in hippocampal volume in adolescent rats, which is not explained by changes in glucocorticoid levels or neurogenesis
Novati, A., Hulshof, H. J., Koolhaas, J. M., Lucassen, P. J., & Meerlo, P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.027 · Cited by 99
Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice
Côtel, M.-C., Jawhar, S., Christensen, D. Z., Bayer, T. A., & Wirths, O. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.012 · Cited by 97
Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington’s disease
Nithianantharajah, J., & Hannan, A. J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.043 · Cited by 91
Self-citation
Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage
Zhao, N., Zhong, C., Wang, Y., Zhao, Y., Gong, N., Zhou, G., Xu, T., & Hong, Z. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.08.014 · Cited by 96
Genes, plasticity and mental retardation
Vaillend, C., Poirier, R., & Laroche, S. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.01.009 · Cited by 104
Molecular evidence of synaptic pathology in the CA1 region in schizophrenia
Matosin, N., Fernandez, F., Lum, J. S., Engel, M., Andrews, J. L., Gassen, N. C., Wagner, K. V., Schmidt, M. V., & Newell, K. A. (2016) · Schizophrenia · doi:10.1038/npjschz.2016.22 · Cited by 94
Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment
Cattaud, V., Bezzina, C., Rey, C. C., Lejards, C., Dahan, L., & Verret, L. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.08.024 · Cited by 88
Differential effects of environmental enrichment, social-housing, and isolation-rearing on a rat gambling task: Dissociations between impulsive action and risky decision-making
Zeeb, F. D., Wong, A. C., & Winstanley, C. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2822-x · Cited by 95
TFOS Lifestyle: Impact of lifestyle challenges on the ocular surface
Galor, A., Britten‐Jones, A. C., Feng, Y., Ferrari, G., Goldblum, D., Gupta, P. K., Merayo-Llovés, J., Na, K., Naroo, S. A., Nichols, K. K., et al. (2023) · The Ocular Surface · doi:10.1016/j.jtos.2023.04.008 · Cited by 96
Environmental enrichment is associated with rapid volumetric brain changes in adult mice
Scholz, J., Allemang-Grand, R., Dazai, J., & Lerch, J. P. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.01.027 · Cited by 90
Hypoxia-Induced Developmental Delays of Inhibitory Interneurons Are Reversed by Environmental Enrichment in the Postnatal Mouse Forebrain
Komitova, M., Xenos, D., Salmaso, N., May Tran, K., Brand, T., Schwartz, M. L., Ment, L., & Vaccarino, F. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5286-12.2013 · Cited by 88
Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs
Sihvonen, A. J., Leo, V., Ripollés, P., Lehtovaara, T., Ylönen, A., Rajanaro, P., Laitinen, S., Forsblom, A., Saunavaara, J. P., Autti, T. H., et al. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51217 · Cited by 100
From Homeostasis to Neuroinflammation: Insights into Cellular and Molecular Interactions and Network Dynamics
Müller, L., Benedetto, S. D., & Müller, V. (2025) · Cells · doi:10.3390/cells14010054 · Cited by 102
A Comprehensive Analysis of Gait Impairment after Experimental Stroke and the Therapeutic Effect of Environmental Enrichment in Rats
Wang, Y., Bontempi, B., Hong, S. M., Mehta, K. M., Weinstein, P. R., Abrams, G., & Liu, J. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.82 · Cited by 90
Neurotoxicity of General Anesthetics
Perouansky, M. A., Hemmings, H. C., & Riou, B. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181bf1d61 · Cited by 89
Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice
Verret, L., Krezymon, A., Halley, H., Trouche, S. G., Zerwas, M., Lazouret, M., Lassalle, J., & Rampon, C. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.05.013 · Cited by 87
Increased Concentrations of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in the Rat Cerebellum After Exposure to Environmental Enrichment
Angelucci, F., Bartolo, P. D., Gelfo, F., Foti, F., Cutuli, D., Bossù, P., Caltagirone, C., & Petrosini, L. (2009) · The Cerebellum · doi:10.1007/s12311-009-0129-1 · Cited by 88
Rapid bilateral improvement in auditory cortex activity in postlingually deafened adults following cochlear implantation
Sandmann, P., Plotz, K., Hauthal, N., Vos, M. D., Schönfeld, R., & Debener, S. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.06.029 · Cited by 88
Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice
Yamaguchi, H., Hara, Y., Ago, Y., Takano, E., Hasebe, S., Nakazawa, T., Hashimoto, H., Matsuda, T., & Takuma, K. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.035 · Cited by 91
Cage-induced stereotypies, perseveration and the effects of environmental enrichment in laboratory mice
Gross, A. N.-M., Richter, S. H., Engel, A. K. J., & Würbel, H. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.06.007 · Cited by 87
Interventional programmes to improve cognition during healthy and pathological ageing: Cortical modulations and evidence for brain plasticity
Cespón, J., Miniussi, C., & Pellicciari, M. C. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.03.001 · Cited by 93
Mesenchymal Stem Cells Stimulate Endogenous Neurogenesis in the Subventricular Zone of Adult Mice
Kan, I., Barhum, Y., Melamed, E., & Offen, D. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9190-x · Cited by 86
Environmental enrichment attenuates cue-induced reinstatement of sucrose seeking in rats
Grimm, J. W., Osincup, D., Wells, B., Manaois, M., Fyall, A., Buse, C., & Harkness, J. H. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32831c3b18 · Cited by 85
Epigenetic Upregulation of Corticotrophin-Releasing Hormone Mediates Postnatal Maternal Separation-Induced Memory Deficiency
Wang, A., Nie, W., Li, H., Hou, Y.-H., Yu, Z., Fan, Q., & Sun, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094394 · Cited by 85
Inosine Augments the Effects of a Nogo Receptor Blocker and of Environmental Enrichment to Restore Skilled Forelimb Use after Stroke
Zai, L. J., Ferrari, C., Dice, C., Subbaiah, S., Havton, L. A., Coppola, G., Geschwind, D. H., Irwin, N., Huebner, E. A., Strittmatter, S. M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4498-10.2011 · Cited by 82
Layer and regional effects of environmental enrichment on the pyramidal neuron morphology of the rat
Gelfo, F., Bartolo, P. D., Giovine, A., Petrosini, L., & Leggio, M. G. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.01.010 · Cited by 85
Chronic atomoxetine treatment during adolescence decreases impulsive choice, but not impulsive action, in adult rats and alters markers of synaptic plasticity in the orbitofrontal cortex
Sun, H., Cocker, P. J., Zeeb, F. D., & Winstanley, C. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2419-9 · Cited by 87
The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity
de Winter, F., Kwok, J. C. F., Fawcett, J. W., Vo, T. T., Carulli, D., & Verhaagen, J. (2016) · Neural Plasticity · doi:10.1155/2016/3679545 · Cited by 84
Socioeconomic status and brain injury in children born preterm: modifying neurodevelopmental outcome
Benavente‐Fernández, I., Siddiqi, A., & Miller, S. P. (2019) · Pediatric Research · doi:10.1038/s41390-019-0646-7 · Cited by 81
The role of enriched environment in neural development and repair
Han, Y., Yuan, M., Guo, Y., Shen, X.-Y., Gao, Z.-K., & Bi, X. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.890666 · Cited by 96
The gut-brain connection: Exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders
Damiani, F., Cornuti, S., & Tognini, P. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109491 · Cited by 95
Long-lasting and transgenerational effects of an environmental enrichment on memory formation
Arai, J. A., & Feig, L. A. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.11.003 · Cited by 87
Epigenetic dynamics in psychiatric disorders: Environmental programming of neurodevelopmental processes
Kofink, D., Boks, M. P. M., Timmers, H. T. M., & Kas, M. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.020 · Cited by 83
Environmental enrichment as a method to improve cognitive function. What can we learn from animal models?
Fischer, A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.039 · Cited by 82
Improvements to Healthspan Through Environmental Enrichment and Lifestyle Interventions: Where Are We Now?
Queen, N. J., Hassan, Q. N., & Cao, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00605 · Cited by 86
Environmental Enrichment Influences BDNF and NR1 Levels in the Hippocampus and Restores Cognitive Impairment in Chronic Cerebral Hypoperfused Rats
Sun, H., Zhang, J., Zhang, L., Liu, H., Zhu, H., & Yang, Y. (2010) · Current Neurovascular Research · doi:10.2174/156720210793180819 · Cited by 83
Nerve agent intoxication: recent neuropathophysiological findings and subsequent impact on medical management prospects.
Collombet, J. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.07.003 · Cited by 83
Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models
Homberg, J. R., Kyzar, E. J., Nguyen, M., Norton, W., Pittman, J. T., Poudel, M. K., Gaikwad, S., Nakamura, S., Koshiba, M., Yamanouchi, H., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.013 · Cited by 86
Enriched housing enhances recovery of limb placement ability and reduces aggrecan-containing perineuronal nets in the rat somatosensory cortex after experimental stroke.
Madinier, A., Quattromani, M. J., Sjölund, C., Ruscher, K., & Wieloch, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093121 · Cited by 82
Environmental Enrichment Restores Memory Functioning in Mice with Impaired IL-1 Signaling via Reinstatement of Long-Term Potentiation and Spine Size Enlargement
Goshen, I., Avital, A., Kreisel, T., Licht, T., Segal, M., & Yirmiya, R. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5352-08.2009 · Cited by 82
“, 2001) and its ability to restore the memory impairments that accompany disorders and injuries of the nervous system (van Praag et al., 2000; Nithianantharajah and Hannan, 2006; Fischer et al., 2007).”
Background
Language development after cochlear implantation: an epigenetic model
The CDaCI Investigative Team, Markman, T. M., Quittner, A. L., Eisenberg, L. S., Tobey, E. A., Thal, D. J., Niparko, J. K., & Wang, N. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-011-9098-z · Cited by 89
Noninvasive Strategies to Promote Functional Recovery after Stroke
Faralli, A., Bigoni, M., Mauro, A., Rossi, F., & Carulli, D. (2013) · Neural Plasticity · doi:10.1155/2013/854597 · Cited by 91
Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome
Begenisic, T., Spolidoro, M., Braschi, C., Baroncelli, L., Milanese, M., Pietra, G., Fabbri, M. E., Bonanno, G., Cioni, G., Maffei, L., et al. (2011) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2011.00029 · Cited by 81
Neuroinflammation in autism spectrum disorders: Exercise as a “pharmacological” tool
Toscano, C. V. A., Barros, L., Lima, A. B., Nunes, T., Carvalho, H. M., & Gaspar, J. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.023 · Cited by 91
Reduction of Cerebral Oxidative Stress Following Environmental Enrichment in Mice with Alzheimer‐Like Pathology
Herring, A., Blome, M., Ambrée, O., Sachser, N., Paulus, W., & Keyvani, K. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00257.x · Cited by 87
Animal models of gene–environment interaction in schizophrenia: A dimensional perspective
Ayhan, Y., McFarland, R., & Pletnikov, M. V. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.002 · Cited by 82
Rearing in enriched environment increases parvalbumin-positive small neurons in the amygdala and decreases anxiety-like behavior of male rats
Urakawa, S., Takamoto, K., Hori, E., Sakai, N., Ono, T., & Nishijo, H. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-13 · Cited by 80
Adult hippocampal neurogenesis and memory interference
Winocur, G., Becker, S., Luu, P., Rosenzweig, S., & Wojtowicz, J. M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.032 · Cited by 89
Physical, cognitive and social activity levels of stroke patients undergoing rehabilitation within a mixed rehabilitation unit
Janssen, H., Ada, L., Bernhardt, J. A., McElduff, P., Pollack, M. R. P., Nilsson, M., & Spratt, N. J. (2012) · Clinical Rehabilitation · doi:10.1177/0269215512466252 · Cited by 82
Therapeutic Utility of Phosphodiesterase Type I Inhibitors in Neurological Conditions
Medina, A. E. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00021 · Cited by 81
Environmental enrichment exerts sex-specific effects on emotionality in C57BL/6J mice
Lin, E.-J. D., Choi, E., Liu, X., Martin, A. S., & During, M. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.019 · Cited by 86
Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus
Wolf, S. A., Steiner, B., Wengner, A. M., Lipp, M., Kammertoens, T., & Kempermann, G. (2009) · The FASEB Journal · doi:10.1096/fj.08-113944 · Cited by 80
Binding of TFIIIC to SINE Elements Controls the Relocation of Activity-Dependent Neuronal Genes to Transcription Factories
Crepaldi, L., Policarpi, C., Coatti, A., Sherlock, W. T., Jongbloets, B. C., Down, T. A., & Riccio, A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003699 · Cited by 79
Late-Life Environmental Enrichment Induces Acetylation Events and Nuclear Factor κB-Dependent Regulations in the Hippocampus of Aged Rats Showing Improved Plasticity and Learning
Neidl, R., Schneider‐Anthony, A., Bousiges, O., Majchrzak, M. J., Barbelivien, A., de Vasconcelos, A. P., Dorgans, K., Doussau, F., Loeffler, J., Cassel, J., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3239-15.2016 · Cited by 77
Epigenetics and meditation
Kaliman, P. (2018) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.11.010 · Cited by 91
Early-life environmental enrichment generates persistent individualized behavior in mice
Zocher, S., Schilling, S., Grzyb, A. N., Adusumilli, V. S., Lopes, J. B., Günther, S., Overall, R. W., Winter, Y., & Kempermann, G. (2020) · Science Advances · doi:10.1126/sciadv.abb1478 · Cited by 86
The Effects of Environmental Enrichment on Depressive and Anxiety-Relevant Behaviors in Socially Isolated Prairie Voles
Grippo, A. J., Ihm, E., Wardwell, J., McNeal, N., Scotti, M. L., Moenk, D. A., Chandler, D. L., LaRocca, M. A., & Preihs, K. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000052 · Cited by 78
Environmental enrichment improves cognitive deficits in Spontaneously Hypertensive Rats (SHR): Relevance for Attention Deficit/Hyperactivity Disorder (ADHD)
Pamplona, F. A., Pandolfo, P., Savoldi, R., Prediger, R. D., & Takahashi, R. N. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.06.012 · Cited by 82
Brain plasticity and early development: Implications for early intervention in neurodevelopmental disorders
Inguaggiato, E., Sgandurra, G., & Cioni, G. (2017) · Neuropsychiatrie de l Enfance et de l Adolescence · doi:10.1016/j.neurenf.2017.03.009 · Cited by 87
Differential impact of stress and environmental enrichment on corticolimbic circuits
Smail, M. A., Smith, B. L., Nawreen, N., & Herman, J. P. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172993 · Cited by 80
Comparative effects of furnished and battery cages on egg production and physiological parameters in White Leghorn hens
Pohle, K., & Cheng, H. W. (2009) · Poultry Science · doi:10.3382/ps.2009-00171 · Cited by 78

Authors: Nithianantharajah, J., & Hannan, A. J.
Affiliations: The University of Melbourne (AU)
Corresponding author: Hannan, Anthony J.
ORCID: Nithianantharajah, Jess
Hannan, Anthony J.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2006-09
Volume: 7
Issue: 9
Pages: 697-709
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1970
OpenAlex: W2054282296
Cited by: 1,771
References: 180
Citations by year: 2026: 61 · 2025: 74 · 2024: 78 · 2023: 89 · 2022: 109 · 2021: 113 · 2020: 113 · 2019: 106 · 2018: 125 · 2017: 82 · 2016: 95 · 2015: 101 · 2014: 95 · 2013: 88 · 2012: 95
FWCI: 3.79
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: environmental enrichment, experience-dependent plasticity, neuroplasticity, adult neurogenesis, synaptic plasticity, Huntington's disease, Alzheimer's disease, Parkinson's disease, fragile X syndrome, Down syndrome, brain injury, gene-environment interaction, central nervous system disorders, treatment options, rodent models
MeSH terms: Animals, Cell Survival, Disease Models, Animal, Environment Design, Humans, Nervous System Malformations, Neuronal Plasticity, Rodentia, Sensory Deprivation, Neurodegenerative Diseases, Recovery of Function

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Enriched environments, experience-dependent plasticity and disorders of the nervous system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks