Cited by 1,771Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.

Enriched environments, experience-dependent plasticity and disorders of the nervous system

Nithianantharajah, Jess, Hannan, Anthony J.·2006·Nature Reviews Neuroscience

DOI 10.1038/nrn1970

Open this paper in CoChat — free account

Abstract

Behavioural, cellular and molecular studies have revealed significant effects of enriched environments on rodents and other species, and provided new insights into mechanisms of experience-dependent plasticity, including adult neurogenesis and synaptic plasticity. The demonstration that the onset and progression of Huntington's disease in transgenic mice is delayed by environmental enrichment has emphasized the importance of understanding both genetic and environmental factors in nervous system disorders, including those with Mendelian inheritance patterns. A range of rodent models of other brain disorders, including Alzheimer's disease and Parkinson's disease, fragile X and Down syndrome, as well as various forms of brain injury, have now been compared under enriched and standard housing conditions. Here, we review these findings on the environmental modulators of pathogenesis and gene-environment interactions in CNS disorders, and discuss their therapeutic implications.

Integrity signals

Registry

Crossref · 10.1038/nrn1970

Cites

180 of 180 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Epidemiology of Parkinson's disease
de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110
What is cognitive reserve? Theory and research application of the reserve concept
STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786

Flagged first, then by citations

Show all 180 references

Research works printed but not linked: 1

Valenzuela, M. J. & Sachdev, P. Brain reserve and dementia: a systematic review. Psychol. Med. 36, 441–454 (2006). · DOI · Paper page

Sorted by citations

Items 601–700 of 999

The effects of gestational and postpartum environmental enrichment on the mother rat: A preliminary investigation
Sparling, J. E., Mahoney, M. M., Baker, S., & Bielajew, C. H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.041 · Cited by 35
Prenatal Enriched Environment improves emotional and attentional reactivity to adulthood stress
Cymerblit‐Sabba, A., Lasri, T., Gruper, M., Aga‐Mizrachi, S., Zubedat, S., & Avital, A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.12.019 · Cited by 36
Cognitive endophenotypes, gene–environment interactions and experience-dependent plasticity in animal models of schizophrenia
Burrows, E. L., & Hannan, A. J. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.11.015 · Cited by 35
Self-citation
Environmental Enrichment Increased Bdnf Transcripts in the Prefrontal Cortex: Implications for an Epigenetically Controlled Mechanism
Costa, G. D. A., Silva, N. K. D. G. T., Marianno, P., Chivers, P., Bailey, A., & Camarini, R. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2023.07.001 · Cited by 37
Correlates of birth origin effects on the development of stereotypic behaviour in striped mice, Rhabdomys
Jones, M. A., Mason, G. J., & Pillay, N. (2011) · Animal Behaviour · doi:10.1016/j.anbehav.2011.04.010 · Cited by 38
Brain-Derived Neurotrophic Factor Induces Cell Survival and the Migration of Murine Adult Hippocampal Precursor Cells During Differentiation In Vitro
Ortíz‐López, L., Vega‐Rivera, N. M., Babu, H., & Ramírez-Rodríguez, G. B. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9673-x · Cited by 34
Environmental enrichment enhances systems-level consolidation of a spatial memory after lesions of the ventral midline thalamus
Ali, M., Cholvin, T., Muller, M., Cosquer, B., Kelche, C. R., Cassel, J., & de Vasconcelos, A. P. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.03.021 · Cited by 36
Role of early environmental enrichment on the social dominance tube test at adulthood in the rat
Cao, W.-Y., Hu, Z., Xu, Y., Zhang, W.-J., Huang, F., Qiao, X., Cui, Y., Wan, W., Wang, X., Liu, D., et al. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4717-3 · Cited by 35
Environmental enrichment accelerates ocular dominance plasticity in mouse visual cortex whereas transfer to standard cages resulted in a rapid loss of increased plasticity
Kalogeraki, E., Pielecka-Fortuna, J., & Löwel, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186999 · Cited by 39
Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells
Moon, H. Y., Javadi, S., Stremlau, M. H., Yoon, K. J., Becker, B., Kang, S.-U., Zhao, X., & van Praag, H. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.041 · Cited by 36
An enriched environment increases the expression of fibronectin type III domain-containing protein 5 and brain-derived neurotrophic factor in the cerebral cortex of the ischemic mouse brain
Wu, Y., Wang, C.-J., Wu, Y., Wang, Y., Wang, N., Kuang, S., Liu, G., Xie, H., Jiang, C., & Wu, J. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.276339 · Cited by 34
Effect of different types of exercises on psychological and cognitive features in people with Parkinson's disease: A randomized controlled trial
Gobbi, L. T. B., Pelicioni, P. H. S., Lahr, J., Lirani‐Silva, E., Teixeira-Arroyo, C., & dos Santos, P. C. R. (2020) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2020.05.011 · Cited by 35
Environmental enrichment-inspired pharmacological tools for the treatment of addiction
Solinas, M., Chauvet, C., Lafay‐Chebassier, C., Jaafari, N., & Thiriet, N. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.09.001 · Cited by 37
Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review
Hua, M., & Jia, M. (2020) · Neurodegenerative Diseases · doi:10.1159/000513196 · Cited by 36
Histone Deacetylases 1 and 2 in Memory Function
Pao, P.-C., & Tsai, L.-H. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00775 · Cited by 34
Environmental enrichment increases doublecortin-associated new neurons and decreases neuronal death without modifying anxiety-like behavior in mice chronically exposed to toluene
Páez-Martı́nez, N., Flores-Serrano, Z., Ortíz‐López, L., & Ramírez-Rodríguez, G. B. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.007 · Cited by 34
Influence of environmental enrichment on an object recognition task in CF1 mice
Viola, G. G., Botton, P. H. S., Moreira, J. D., Ardais, A. P., Oses, J. P., & Souza, D. O. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.10.003 · Cited by 34
Benefits of a Ball and Chain: Simple Environmental Enrichments Improve Welfare and Reproductive Success in Farmed American Mink (Neovison vison)
Meagher, R. K., Dallaire, J. A., Campbell, D. L. M., Ross, M., Møller, S. H., Hansen, S. W., Díez‐León, M., Palme, R., & Mason, G. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110589 · Cited by 34
Physiological effects of enriched environment exposure and LTP induction in the hippocampus in vivo do not transfer faithfully to in vitro slicesPreprint
Eckert, M. J., & Abraham, W. C. (2010) · Learning & Memory · doi:10.1101/lm.1822610 · Cited by 34
Prevalence, Risk Factors, Pathophysiology, Potential Biomarkers and Management of Feline Idiopathic Cystitis: An Update Review
He, C., Fan, K. C., Hao, Z., Tang, N., Li, G., & Wang, S. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.900847 · Cited by 49
Enriched environment preconditioning induced brain ischemic tolerance without reducing infarct volume and edema: The possible role of enrichment-related physical activity increase
Xie, H., Wu, Y., Jia, J., Liu, G., Zhang, F., Zhang, Q., Yu, K., Hu, Y., Bai, Y., & Hu, R. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.052 · Cited by 33
Neurocritical Care for Neonates
Glass, H. C., Bonifacio, S. L., Shimotake, T. K., & Ferriero, D. M. (2011) · Current Treatment Options in Neurology · doi:10.1007/s11940-011-0144-7 · Cited by 33
Vascular Endothelial Growth Factor-dependent Spinogenesis Underlies Antidepressant-like Effects of Enriched Environment
Huang, Y.-F., Yang, C., Huang, C., & Hsu, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.392076 · Cited by 34
The influence of aripiprazole, olanzapine and enriched environment on depressant-like behavior, spatial memory dysfunction and hippocampal level of BDNF in prenatally stressed rats
Nowakowska, E., Kus, K., Ratajczak, P., Cichocki, M., & Woźniak, A. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2013.12.008 · Cited by 33
Effects of Mild Blast Traumatic Brain Injury on Cognitive- and Addiction-Related Behaviors
Muelbl, M. J., Slaker, M. L., Shah, A. S., Nawarawong, N. N., Gerndt, C. H., Budde, M. D., Stemper, B. D., & Olsen, C. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-28062-0 · Cited by 35
Rethinking the Reserve with a Translational Approach: Novel Ideas on the Construct and the Interventions
Serra, L., Gelfo, F., Petrosini, L., Domenico, C. D., Bozzali, M., & Caltagirone, C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180609 · Cited by 32
Enriched Environmental Conditions Modify the Gut Microbiome Composition and Fecal Markers of Inflammation in Parkinson’s Disease
Singh, Y., El-Hadidi, M. S., Admard, J., Wassouf, Z., Schulze-Hentrich, J. M., Kohlhofer, U., Quintanilla‐Martínez, L., Huson, D. H., Rieß, O., & Casadei, N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01032 · Cited by 33
Interaction effect of Alzheimer's disease pathology and education, occupation, and socioeconomic status as a proxy for cognitive reserve on cognitive performance: in vivo positron emission tomography study
Yasuno, F., Minami, H., Hattori, H., & Initiative, A. D. N. (2020) · Psychogeriatrics · doi:10.1111/psyg.12552 · Cited by 32
Altering the rehabilitation environment to improve stroke survivor activity: A Phase II trial
Janssen, H., Ada, L., Middleton, S., Pollack, M. R. P., Nilsson, M., Churilov, L. P., Blennerhassett, J. M., Faux, S. G., New, P. W., McCluskey, A., et al. (2021) · International Journal of Stroke · doi:10.1177/17474930211006999 · Cited by 33
Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling
Krüttner, S., Falasconi, A., Valbuena, S., Galimberti, I., Bouwmeester, T., Arber, S., & Caroni, P. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.001 · Cited by 31
The individuality paradigm: Automated longitudinal activity tracking of large cohorts of genetically identical mice in an enriched environment
Kempermann, G., Lopes, J. B., Zocher, S., Schilling, S., Ehret, F., Garthe, A., Karasinsky, A., Brandmaier, A. M., Lindenberger, U., Winter, Y., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105916 · Cited by 39
Developmental forebrain cholinergic lesion and environmental enrichment: Behaviour, CA1 cytoarchitecture and neurogenesis
Fréchette, M., Rennie, K., & Pappas, B. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.11.082 · Cited by 33
Presynaptic active zone density during development and synaptic plasticity
Clarke, G. L. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00012 · Cited by 33
TNF-α and Microglial Hormetic Involvement in Neurological Health & Migraine
Kraig, R. P., Mitchell, H. M., Christie-Pope, B. C., Kunkler, P. E., White, D. M., Tang, Y., & Langan, G. P. (2010) · Dose-Response · doi:10.2203/dose-response.09-056.kraig · Cited by 34
Translational models of stress and resilience: An applied neuroscience methodology review
Albayrak, Z. S., Vaz, A., Bordes, J., Ünlü, S., Sep, M. S. C., Vinkers, C. H., Pinto, L., & Eser, H. Y. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104064 · Cited by 43
Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathy
Grünewald, B., Wickel, J., Hahn, N., Rahmati, V., Rupp, H., Chung, H., Haselmann, H., Strauß, A., Schmidl, L., Hempel, N., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.05.001 · Cited by 32
The effects of isolated and enriched housing conditions on baseline and drug-induced behavioural responses in the male rat
Simpson, J., & Kelly, J. P. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.06.015 · Cited by 32
La música como una herramienta terapéutica en medicina
Miranda, M., Hazard, S., & Miranda, P. V. (2017) · Revista chilena de neuro-psiquiatría · doi:10.4067/s0717-92272017000400266 · Cited by 54
Postweaning Enriched Environment Enhances Cognitive Function and Brain-Derived Neurotrophic Factor Signaling in the Hippocampus in Maternally Separated Rats
Cordier, J. M., Aguggia, J. P., Danelon, V., Mir, F. R., Rivarola, M. A., & Mascó, D. H. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.09.058 · Cited by 32
Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy
Wegner, W., Steffens, H., Gregor, C., Wolf, F., & Willig, K. I. (2022) · eLife · doi:10.7554/elife.73603 · Cited by 30
ATP-mediated signalling in the central synapses
Lalo, U., & Pankratov, Y. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109477 · Cited by 35
Methylphenidate and environmental enrichment ameliorate the deleterious effects of prenatal stress on attention functioning
Zubedat, S., Aga‐Mizrachi, S., Cymerblit‐Sabba, A., Ritter, A., Nachmani, M., & Avital, A. (2015) · Stress · doi:10.3109/10253890.2015.1023790 · Cited by 32
Neocortical plasticity deficits in fetal alcohol spectrum disorders: Lessons from barrel and visual cortex
Medina, A. E., & Krahe, T. E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21447 · Cited by 32
Role of Hypothalamic VGF in Energy Balance and Metabolic Adaption to Environmental Enrichment in Mice
Foglesong, G. D., Huang, W., Liu, X., Slater, A. M., Siu, J. J., Yildiz, V. O., Salton, S. R., & Cao, L. (2015) · Endocrinology · doi:10.1210/en.2015-1627 · Cited by 33
Editorial: Environmental Enrichment: Enhancing Neural Plasticity, Resilience, and Repair
Kentner, A. C., Lambert, K. G., Hannan, A. J., & Donaldson, S. T. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00075 · Cited by 32
Self-citation
Communication partner training with familiar partners of people with aphasia: A systematic review and synthesis of barriers and facilitators to implementation
Shrubsole, K., Power, E., & Hallé, M. (2022) · International Journal of Language & Communication Disorders · doi:10.1111/1460-6984.12805 · Cited by 35
VEGF reverts the cognitive impairment induced by a focal traumatic brain injury during the development of rats raised under environmental enrichment
Ortuzar, N., Rico‐Barrio, I., Bengoetxea, H., Argandoña, E., & Lafuente, J. V. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.036 · Cited by 31
Enriched environment induces beneficial effects on memory deficits and microglial activation in the hippocampus of type 1 diabetic rats
Piazza, F. V., Segabinazi, E., Centenaro, L. A., do Nascimento, P. S., Achaval, M., & Marcuzzo, S. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9467-2 · Cited by 31
Environmental Enrichment Modulates Cortico-Cortical Interactions in the Mouse
Garbo, A. D., Mainardi, M., Chillemi, S., Maffei, L., & Caleo, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025285 · Cited by 33
Enriched environment combined with fluoxetine ameliorates depression-like behaviors and hippocampal SYP expression in a rat CUS model
Liu, C., Gu, J.-Y., Han, J.-H., Yan, F.-L., Li, Y., Lv, T.-T., Zhao, L.-Q., Shao, Q.-J., Feng, Y.-Y., Zhang, X., et al. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.09.009 · Cited by 33
Enriched Environment and Effects on Neuropathic Pain: Experimental Findings and Mechanisms
Tai, W. L., Yeung, S. C., & Cheung, C. W. (2018) · Pain Practice · doi:10.1111/papr.12706 · Cited by 35
Environmental enrichment restores oxidative balance in animals chronically exposed to toluene: Comparison with melatonin
Montes, S., Yee-Rios, Y., & Páez-Martı́nez, N. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.11.007 · Cited by 31
Cerebral plasticity as the basis for upper limb recovery following brain damage
Lotze, M., Ladda, A. M., & Stephan, K. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.01.027 · Cited by 31
Sigma-1 (σ1) receptor activity is necessary for physiological brain plasticity in mice
Crouzier, L., Couly, S., Roques, C., Peter, C., Belkhiter, R., Jacquemin, M. A., Bonetto, A., Delprat, B., & Maurice, T. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.08.010 · Cited by 31
Defective memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome
Li, J., Jiang, R. Y., Arendt, K. L., Hsu, Y., Zhai, S. R., & Chen, L. (2020) · eLife · doi:10.7554/elife.61882 · Cited by 34
Enriched environment prevents memory deficits in type 1 diabetic rats
Piazza, F. V., Pinto, G. V., Trott, G., Marcuzzo, S., Gomez, R., & Fernandes, M. D. C. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.09.017 · Cited by 31
Environmental enrichment causes a global potentiation of neuronal responses across stimulus complexity and lamina of sensory cortex
Alwis, D. S., & Rajan, R. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00124 · Cited by 33
Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice
Morelli, E., Ghiglieri, V., Pendolino, V., Bagetta, V., Pignataro, A., Fejtová, A., Costa, C., Ammassari‐Teule, M., Gundelfinger, E. D., Picconi, B., et al. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.05.010 · Cited by 31
Antidepressive behaviors induced by enriched environment might be modulated by glucocorticoid levels
Xu, Z., Hou, B., Zhang, Y., Gao, Y., Wu, Y., Zhao, S.-F., & Zhang, C. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.07.004 · Cited by 31
The development of repetitive motor behaviors in deer mice: Effects of environmental enrichment, repeated testing, and differential mediation by indirect basal ganglia pathway activation
Bechard, A. R., Bliznyuk, N., & Lewis, M. H. (2017) · Developmental Psychobiology · doi:10.1002/dev.21503 · Cited by 32
Ketamine-induced apoptosis in the mouse cerebral cortex follows similar characteristic of physiological apoptosis and can be regulated by neuronal activity
Wang, Q., Shen, F.-Y., Zou, R., Zheng, J.-J., Yu, X., & Wang, Y. (2017) · Molecular Brain · doi:10.1186/s13041-017-0302-2 · Cited by 33
Effects of pre-reproductive maternal enrichment on maternal care, offspring’s play behavior and oxytocinergic neurons
Cutuli, D., Berretta, E., Caporali, P., Sampedro-Piquero, P., De Bartolo, P., Laricchiuta, D., Gelfo, F., Pesoli, M., Foti, F., Farioli Vecchioli, S., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.015 · Cited by 30
Enriched environment attenuates ferroptosis after cerebral ischemia/reperfusion injury by regulating iron metabolism
Luo, Q., Zheng, J., Fan, B., Liu, J., Liao, W., & Zhang, X. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110778 · Cited by 30
Long-term running alleviates some behavioral and molecular abnormalities in Down syndrome mouse model Ts65Dn
Kida, E., Rabe, A., Walus, M., Albertini, G., & Golabek, A. A. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.11.022 · Cited by 31
Cognitive enhancement by pharmacological and behavioral interventions: the murine Down syndrome model
Möhler, H. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.06.028 · Cited by 30
Experience-dependent reduction of soluble β-amyloid oligomers and rescue of cognitive abilities in middle-age Ts65Dn mice, a model of Down syndrome
Sansevero, G., Begenisic, T., Mainardi, M., & Sale, A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.06.006 · Cited by 31
Environmental effects on Drosophila brain development and learning
Wang, X., Amei, A., de Belle, J. S., & Roberts, S. P. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.169375 · Cited by 39
Proteomics of Multiple Sclerosis: Inherent Issues in Defining the Pathoetiology and Identifying (Early) Biomarkers
Sen, M. K., Almuslehi, M. S. M., Shortland, P. J., Mahns, D. A., & Coorssen, J. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147377 · Cited by 31
Neuroarchitecture Assessment: An Overview and Bibliometric Analysis
Ghamari, H., Golshany, N., Rad, P. N., & Behzadi, F. (2021) · European Journal of Investigation in Health Psychology and Education · doi:10.3390/ejihpe11040099 · Cited by 33
Brain is modulated by neuronal plasticity during postnatal development
Kourosh‐Arami, M., Hosseini, N., & Komaki‬, A. (2021) · The Journal of Physiological Sciences · doi:10.1186/s12576-021-00819-9 · Cited by 36
Activity-dependent structural plasticity of Purkinje cell spines in cerebellar vermis and hemisphere
Bartolo, P. D., Florenzano, F., Burello, L., Gelfo, F., & Petrosini, L. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0833-6 · Cited by 30
Influence of Aging and Enriched Environment on Motor Activity and Emotional Responses in Mice
Tévar, C. Z., Marco, E. M., Arranz, L., Castro, N. M. D., Viveros, M., & la Fuente, M. D. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.060 · Cited by 30
Hippocampal neurogenesis in food‐storing red squirrels: the impact of age and spatial behavior
Johnson, K. M., Boonstra, R., & Wojtowicz, J. M. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00589.x · Cited by 30
Effects of environmental manipulations in genetically targeted animal models of affective disorders
Renoir, T., Pang, T. Y., & Hannan, A. J. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.04.003 · Cited by 32
Self-citation
Intensification of maternal care by double‐mothering boosts cognitive function and hippocampal morphology in the adult offspring
D'Amato, F. R., Zanettini, C., Sgobio, C., Sarli, C., Carone, V., Moles, A., & Ammassari‐Teule, M. (2010) · Hippocampus · doi:10.1002/hipo.20750 · Cited by 31
Automated quantitative analysis to assess motor function in different rat models of impaired coordination and ataxia
Kyriakou, E. I., van de Kieft, J. G., de Heer, R. C., Spink, A., Nguyen, H. P., Homberg, J. R., & van der Harst, J. E. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.12.001 · Cited by 30
Preventive and therapeutic effects of environmental enrichment in Wistar rats submitted to neonatal hypoxia-ischemia
Durán‐Carabali, L. E., Arcego, D. M., Sanches, E. F., Odorcyk, F. K., Marques, M. R., Tosta, A., Reichert, L., Carvalho, A. V. S., Dalmaz, C., & Netto, C. A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.036 · Cited by 32
Transgenic Alzheimer mice in a semi-naturalistic environment: More plaques, yet not compromised in daily life
Lewejohann, L., Reefmann, N., Widmann, P., Ambrée, O., Herring, A., Keyvani, K., Paulus, W., & Sachser, N. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.01.037 · Cited by 32
Environmental Enrichment
Young, R. J., de Azevedo, C. S., & Cipreste, C. F. (2019) · Wiley eBooks · doi:10.1002/9781118968543.ch6 · Cited by 32
Neuropsychiatric Disorders: Bridging the Gap Between Neurology and Psychiatry
Taslim, S., Shadmani, S., Saleem, A. R., Kumar, A., Brahma, F., Blank, N., Bashir, M. A., Ansari, D., Kumari, K., Tanveer, M. U., et al. (2024) · Cureus · doi:10.7759/cureus.51655 · Cited by 29
Retracted
Prenatal immune activation in mice blocks the effects of environmental enrichment on exploratory behavior and microglia density
Buschert, J., Sakalem, M. E., Saffari, R., Hohoff, C., Rothermundt, M., Arolt, V., Zhang, W., & Ambrée, O. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.01.005 · Cited by 29
Environmental enrichment induces behavioural disturbances in neuropeptide Y knockout mice
Reichmann, F., Wegerer, V., Jain, P., Mayerhofer, R., Hassan, A. M., Fröhlich, E. E., Bock, E., Pritz, E., Herzog, H., Holzer, P. D., et al. (2016) · Scientific Reports · doi:10.1038/srep28182 · Cited by 29
Environmental Enrichment During Adolescence Acts as a Protective and Therapeutic Tool for Ethanol Binge-Drinking, Anxiety-Like, Novelty Seeking and Compulsive-Like Behaviors in C57BL/6J Mice During Adulthood
Rodríguez‐Ortega, E., de la Fuente, L., de Amo, E., & Cubero, I. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00177 · Cited by 30
Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes
Kokras, N., Sotiropoulos, I., Besinis, D., Tzouveka, E. L., Almeida, O. F. X., Sousa, N., & Dalla, C. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.11.1107 · Cited by 31
Enriched environment alleviates stress-induced dry-eye through the BDNF axis
Sano, K., Kawashima, M., Imada, T., Suzuki, T., Nakamura, S., Mimura, M., Tanaka, K. F., & Tsubota, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-39467-w · Cited by 29
Modulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene Tcf4
Badowska, D. M., Brzózka, M. M., Kannaiyan, N. R., Thomas, C., Dibaj, P., Chowdhury, A., Steffens, H., Turck, C. W., Falkai, P., Schmitt, A., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01026-7 · Cited by 31
Alternative splicing of neurexins 1–3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis
Marchese, E., Valentini, M., Sante, G. D., Cesari, E., Adinolfi, A., Corvino, V., Ria, F., Sette, C., & Geloso, M. C. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113497 · Cited by 33
Dual Profile of Environmental Enrichment and Autistic-Like Behaviors in the Maternal Separated Model in Rats
Mansouri, M., Pouretemad, H., Wegener, G., Roghani, M., Afshari, M., Mallard, C. E., & Ardalan, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031173 · Cited by 29
Natural antioxidants enhance the power of physical and mental activities versus risk factors inducing progression of Alzheimer's disease in rats
Ali, A. A., El-Fattah, A. I. A., Abu‐Elfotuh, K., & Elariny, H. A. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107729 · Cited by 30
Functional brain connectivity during exposure to the scale and color of interior built environments
Bower, I. S., Hill, A. T., & Enticott, P. G. (2022) · Human Brain Mapping · doi:10.1002/hbm.26061 · Cited by 31
Remodelling of myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment in the young adult brain
Nicholson, M., Wood, R. J., Gonsalvez, D. G., Hannan, A. J., Fletcher, J. L., Xiao, J., & Murray, S. S. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15840 · Cited by 27
Self-citation
Alteration in Social Interaction and Tactile Discrimination of Juvenile Autistic-Like Rats Following Tactile Stimulation and Whisker Deprivation
Ahmadi, B. B. M., Afarinesh, M. R., Jafaripour, L., & Sheibani, V. (2022) · Brain and Behavior · doi:10.1002/brb3.2993 · Cited by 27
Developing Medications Targeting Glutamatergic Dysfunction in Autism: Progress to Date
Fung, L. K., & Hardan, A. Y. (2015) · CNS Drugs · doi:10.1007/s40263-015-0252-0 · Cited by 28
Early cognitive stimulation compensates for memory and pathological changes in Tg2576 mice
Gereñu, G., Dobarro, M., Ramírez, M. J., & Gil-Bea, F. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.02.018 · Cited by 29
HDAC2 (Histone deacetylase 2): A critical factor in environmental enrichment‐mediated stroke recovery
Lin, Y., Yao, M., Wu, H., Dong, J. P., Ni, H., Kou, X., Chang, L., Luo, C., & Zhu, D. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15043 · Cited by 29
Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease
Spires‐Jones, T. L., & Hannan, A. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04275.x · Cited by 31
Self-citation
Neurodegenerative disorders, metabolic icebergs, and mitohormesis
Phillips, M. C. L., & Picard, M. A. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00435-8 · Cited by 31
Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis
Ago, Y., Yoneyama, M., Ishihama, T., Kataoka, S., Kawada, K., Tanaka, T. S., Ogita, K., Shintani, N., Hashimoto, H., Baba, A., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.044 · Cited by 28
Sex differences in the benefits of rehabilitative training during adolescence following neonatal hypoxia–ischemia in rats
Tsuji, M., Aoo, N., Harada, K., Sakamoto, Y., Akitake, Y., Irie, K., Mishima, K., Ikeda, T., & Fujiwara, M. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.09.002 · Cited by 28
Environmental Enrichment Decreases Asphyxia-Induced Neurobehavioral Developmental Delay in Neonatal Rats
Kiss, P., Vadasz, G., Kiss-Illes, B., Horváth, G., Tamás, A., Reglődi, D., & Koppán, M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141122258 · Cited by 28

Authors: Nithianantharajah, J., & Hannan, A. J.
Affiliations: The University of Melbourne (AU)
Corresponding author: Hannan, Anthony J.
ORCID: Nithianantharajah, Jess
Hannan, Anthony J.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2006-09
Volume: 7
Issue: 9
Pages: 697-709
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1970
OpenAlex: W2054282296
Cited by: 1,771
References: 180
Citations by year: 2026: 61 · 2025: 74 · 2024: 78 · 2023: 89 · 2022: 109 · 2021: 113 · 2020: 113 · 2019: 106 · 2018: 125 · 2017: 82 · 2016: 95 · 2015: 101 · 2014: 95 · 2013: 88 · 2012: 95
FWCI: 3.79
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: environmental enrichment, experience-dependent plasticity, neuroplasticity, adult neurogenesis, synaptic plasticity, Huntington's disease, Alzheimer's disease, Parkinson's disease, fragile X syndrome, Down syndrome, brain injury, gene-environment interaction, central nervous system disorders, treatment options, rodent models
MeSH terms: Animals, Cell Survival, Disease Models, Animal, Environment Design, Humans, Nervous System Malformations, Neuronal Plasticity, Rodentia, Sensory Deprivation, Neurodegenerative Diseases, Recovery of Function

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Enriched environments, experience-dependent plasticity and disorders of the nervous system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks