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NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

Lau, C. Geoffrey, Zukin, R. Suzanne·2007·Nature Reviews Neuroscience

DOI 10.1038/nrn2153

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Abstract

The number and subunit composition of synaptic N-methyl-D-aspartate receptors (NMDARs) are not static, but change in a cell- and synapse-specific manner during development and in response to neuronal activity and sensory experience. Neuronal activity drives not only NMDAR synaptic targeting and incorporation, but also receptor retrieval, differential sorting into the endosomal-lysosomal pathway and lateral diffusion between synaptic and extrasynaptic sites. An emerging concept is that activity-dependent, bidirectional regulation of NMDAR trafficking provides a dynamic and potentially powerful mechanism for the regulation of synaptic efficacy and remodelling, which, if dysregulated, can contribute to neuropsychiatric disorders such as cocaine addiction, Alzheimer's disease and schizophrenia.

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Glutamate receptor ion channels
Mayer, M. L. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.004 · Cited by 3,655
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS
Conn, P. J., & Pin, J. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.205 · Cited by 3,083
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323
Genetic enhancement of learning and memory in mice
Tang, Y., Shimizu, E., Dubé, G., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999) · Nature · doi:10.1038/43432 · Cited by 1,878
Metaplasticity: the plasticity of synaptic plasticity
Abraham, W. C., & Bear, M. F. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80018-x · Cited by 1,833
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686
Neuregulin 1 and Susceptibility to Schizophrenia
Stefánsson, H., Pétursson, H., Sigurðsson, E., Steinthórsdóttir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342734 · Cited by 1,671
PDZ domain proteins of synapses
Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,630
Regulation of NMDA receptor trafficking by amyloid-β
Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561 · cited 1×
“PP2B dephosphorylates and activates striatal-enriched tyrosine phosphatase (STEP), which dephosphorylates the NR2B subunit at Tyr1472 and promotes internalization of NR2B-containing NMDAR”
Background
Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
Sheng, M., Cummings, J., Roldan, L. A., Jan, Y. N., & Jan, L. Y. (1994) · Nature · doi:10.1038/368144a0 · Cited by 1,377
PSD-95 Involvement in Maturation of Excitatory Synapses
El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303
Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons
Saal, D., Dong, Y., Bonci, A., & Malenka, R. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00021-7 · Cited by 1,147
Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity
Liu, L., Wong, T. P., Pozza, M. F., Lingenhoehl, K., Wang, Y., Sheng, M., Auberson, Y. P., & Wang, Y. T. (2004) · Science · doi:10.1126/science.1096615 · Cited by 1,131
A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.
Lisman, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9574 · Cited by 1,127
Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
Mohn, A. R., Gainetdinov, R. R., Caron, M. G., & Koller, B. H. (1999) · Cell · doi:10.1016/s0092-8674(00)81972-8 · Cited by 1,075
Receptor trafficking and synaptic plasticity
Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046
AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss
Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977
Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal Neurons
Lu, W.-Y., Man, H., Ju, W. H., Trimble, W. S., MacDonald, J. F., & Wang, Y. T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00194-5 · Cited by 935
Molecular motors and mechanisms of directional transport in neurons
Hirokawa, N., & Takemura, R. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1624 · Cited by 856
Specific Coupling of NMDA Receptor Activation to Nitric Oxide Neurotoxicity by PSD-95 Protein
Sattler, R., Xiong, Z., Lu, W.-Y., Hafner, M., MacDonald, J. F., & Tymianski, M. (1999) · Science · doi:10.1126/science.284.5421.1845 · Cited by 840
Role of Distinct NMDA Receptor Subtypes at Central Synapses
Cull-Candy, S. G., & Leszkiewicz, D. N. (2004) · Science s STKE · doi:10.1126/stke.2552004re16 · Cited by 796
The Incorporation of NMDA Receptors with a Distinct Subunit Composition at Nascent Hippocampal Synapses In Vitro
Tovar, K. R., & Westbrook, G. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04180.1999 · Cited by 777
Kinesin Superfamily Motor Protein KIF17 and mLin-10 in NMDA Receptor-Containing Vesicle Transport
Setou, M., Nakagawa, T., Seog, D., & Hirokawa, N. (2000) · Science · doi:10.1126/science.288.5472.1796 · Cited by 727
Developmental changes in distribution of NMDA receptor channel subunit mRNAs
Watanabe, M., Inoue, Y., Sakimura, K., & Mishina, M. (1992) · Neuroreport · doi:10.1097/00001756-199212000-00027 · Cited by 721
Activity-Dependent Decrease in NMDA Receptor Responses During Development of the Visual Cortex
Carmignoto, G., & Vicini, S. (1992) · Science · doi:10.1126/science.1279803 · Cited by 721
Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine
Borgland, S. L., Taha, S. A., Sarti, F., Fields, H. L., & Bonci, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.016 · Cited by 718
Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression
Massey, P. V., Johnson, B. E., Moult, P. R., Auberson, Y. P., Brown, M. W., Molnár, E., Collingridge, G. L., & Bashir, Z. I. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1697-04.2004 · Cited by 712
NMDA Receptor Subunit Composition Controls Synaptic Plasticity by Regulating Binding to CaMKII
Barria, A., & Malinow, R. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.034 · Cited by 709
Regulatory mechanisms of AMPA receptors in synaptic plasticity
Derkach, V. A., Oh, M. C., Guire, E. S., & Soderling, T. R. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2055 · Cited by 708
Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
O’Brien, R. J., Kamboj, S., Ehlers, M. D., Rosen, K. R., Fischbach, G. D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80624-8 · Cited by 688
NR2A Subunit Expression Shortens NMDA Receptor Synaptic Currents in Developing Neocortex
Flint, A. C., Maisch, U. S., Weishaupt, J. H., Kriegstein, A. R., & Monyer, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02469.1997 · Cited by 623
Schizophrenia: Diverse Approaches to a Complex Disease
Sawa, A., & Snyder, S. H. (2002) · Science · doi:10.1126/science.1070532 · Cited by 599
Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo
Quinlan, E. M., Philpot, B. D., Huganir, R. L., & Bear, M. F. (1999) · Nature Neuroscience · doi:10.1038/7263 · Cited by 579
Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia
Hahn, C.-G., Wang, H.-Y., Cho, D.-S., Talbot, K., Gur, R. E., Berrettini, W. H., Bakshi, K. P., Kamins, J., Borgmann‐Winter, K. E., Siegel, S. J., et al. (2006) · Nature Medicine · doi:10.1038/nm1418 · Cited by 564
Molecular determinants of NMDA receptor internalization
Roche, K. W., Standley, S., McCallum, J., Dune Ly, C., Ehlers, M. D., & Wenthold, R. J. (2001) · Nature Neuroscience · doi:10.1038/90498 · Cited by 550
Internalization of ionotropic glutamate receptors in response to mGluR activation
Snyder, E. M., Philpot, B. D., Huber, K. M., Dong, X., Fallon, J. R., & Bear, M. F. (2001) · Nature Neuroscience · doi:10.1038/nn746 · Cited by 539
Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death
Liu, S. J., & Zukin, R. S. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.01.006 · Cited by 530
Self-citation
Subunit-Specific NMDA Receptor Trafficking to Synapses
Barria, A., & Malinow, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00776-6 · Cited by 515
Assembly of New Individual Excitatory Synapses
Friedman, H., Bresler, T., Garner, C. C., & Ziv, N. E. (2000) · Neuron · doi:10.1016/s0896-6273(00)00009-x · Cited by 499
Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons
Rao, A., & Craig, A. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80962-9 · Cited by 492
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
Miyakawa, T., Leiter, L. M., Gerber, D. J., Gainetdinov, R. R., Sotnikova, T. D., Zeng, H., Caron, M. G., & Tonegawa, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432926100 · Cited by 489
Alternatively spliced isoforms of the NMDARI receptor subunit
Zukin, R. S., & Bennett, M. V. L. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93920-s · Cited by 464
Self-citation
Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro
Williams, K. L., Russell, S. L., Shen, Y. M., & Molinoff, P. B. (1993) · Neuron · doi:10.1016/0896-6273(93)90317-k · Cited by 461
Mobile NMDA Receptors at Hippocampal Synapses
Tovar, K. R., & Westbrook, G. L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00658-x · Cited by 448
Role of ampa receptor endocytosis in synaptic plasticity
Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072500 · Cited by 448
Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex.
Philpot, B. D., Sekhar, A. K., Shouval, H., & Bear, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00187-8 · Cited by 440
Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience
Kirkwood, A., Lee, H., & Bear, M. F. (1995) · Nature · doi:10.1038/375328a0 · Cited by 430
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Groc, L., Heine, M., Cognet, L., Brickley, K., Stephenson, F. A., Lounis, B., & Choquet, D. (2004) · Nature Neuroscience · doi:10.1038/nn1270 · Cited by 429
The role of receptor diffusion in the organization of the postsynaptic membrane
Choquet, D., & Triller, A. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1077 · Cited by 427
Glycine binding primes NMDA receptor internalization
Nong, Y., Huang, Y., Ju, W. H., Kalia, L. V., Ahmadian, G., Wang, Y. T., & Salter, M. W. (2003) · Nature · doi:10.1038/nature01497 · Cited by 427
Neuroanatomy (Text and Atlas)
Hlavin, L. (1990) · Neurology · doi:10.1212/wnl.40.2.388-c · Cited by 425
Protein kinase C modulates NMDA receptor trafficking and gating
Lan, J.-Y., Skeberdis, V. A., Jover, T., Grooms, S. Y., Lin, Y., Araneda, R. C., Zheng, X., Bennett, M. V. L., & Zukin, R. S. (2001) · Nature Neuroscience · doi:10.1038/86028 · Cited by 421
Self-citation
An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing
Scott, D. B., Blanpied, T. A., Swanson, G. T., Zhang, C., & Ehlers, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03063.2001 · Cited by 418
Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.
Elias, G. M., Funke, L., Stein, V., Grant, S., Bredt, D., & Nicoll, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.012 · Cited by 413
The Synaptic Localization of NR2B-Containing NMDA Receptors Is Controlled by Interactions with PDZ Proteins and AP-2
Prybylowski, K., Chang, K., Sans, N., Kan, L., Vicini, S., & Wenthold, R. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.016 · Cited by 405
Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons
Liao, D., Zhang, X., O’Brien, R., Ehlers, M., & Huganir, R. L. (1999) · Nature Neuroscience · doi:10.1038/4540 · Cited by 396
Dynamics and Regulation of Clathrin Coats at Specialized Endocytic Zones of Dendrites and Spines
Blanpied, T. A., Scott, D. B., & Ehlers, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00979-0 · Cited by 392
G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors
Lu, W.-Y., Xiong, Z.-G., Lei, S., Orser, B. A., Dudek, E. M., Browning, M. D., & MacDonald, J. F. (1999) · Nature Neuroscience · doi:10.1038/7243 · Cited by 384
Bidirectional, experience-dependent regulation of N- methyl- d -aspartate receptor subunit composition in the rat visual cortex during postnatal development
Quinlan, E. M., Olstein, D. H., & Bear, M. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12876 · Cited by 382
Dopamine D1 Receptor-Dependent Trafficking of Striatal NMDA Glutamate Receptors to the Postsynaptic Membrane
Dunah, A. W., & Standaert, D. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05546.2001 · Cited by 374
NMDA receptor surface mobility depends on NR2A-2B subunits
Groc, L., Heine, M., Cousins, S. L., Stephenson, F. A., Lounis, B., Cognet, L., & Choquet, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605238103 · Cited by 371
Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus
Bashir, Z. I., Alford, S. T., Davies, S. N., Randall, A. D., & Collingridge, G. L. (1991) · Nature · doi:10.1038/349156a0 · Cited by 370
LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1
Grosshans, D. R., Clayton, D. A., Coultrap, S. J., & Browning, M. D. (2001) · Nature Neuroscience · doi:10.1038/nn779 · Cited by 362
PDZ Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants
Standley, S., Roche, K. W., McCallum, J. D., Sans, N., & Wenthold, R. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00161-6 · Cited by 352
Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses
Watt, A. J., van Rossum, M. C. W., MacLeod, K. M., Nelson, S. B., & Turrigiano, G. G. (2000) · Neuron · doi:10.1016/s0896-6273(00)81202-7 · Cited by 350
NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
Sans, N., Prybylowski, K., Petralia, R. S., Chang, K., Wang, Y.-X., Racca, C., Vicini, S., & Wenthold, R. J. (2003) · Nature Cell Biology · doi:10.1038/ncb990 · Cited by 327
Decoding NMDA Receptor Signaling: Identification of Genomic Programs Specifying Neuronal Survival and Death
Zhang, S.-J., Steijaert, M. N., Lau, D., Schütz, G., Delucinge-Vivier, C., Descombes, P., & Bading, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.025 · Cited by 313
Experience Strengthening Transmission by Driving AMPA Receptors into Synapses
Takahashi, T., Svoboda, K., & Malinow, R. (2003) · Science · doi:10.1126/science.1079886 · Cited by 306
Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons
Liu, Q.-S., Pu, L., & Poo, M. (2005) · Nature · doi:10.1038/nature04050 · Cited by 305
Lack of NMDA Receptor Subtype Selectivity for Hippocampal Long-Term Potentiation
Berberich, S., Punnakkal, P., Jensen, V., Pawlak, V., Seeburg, P. H., Hvalby, Ø., & Köhr, G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1905-05.2005 · Cited by 304
NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity
Carroll, R. C., & Zukin, R. S. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02272-5 · Cited by 303
Self-citation
Insulin promotes rapid delivery of N -methyl- d - aspartate receptors to the cell surface by exocytosis
Skeberdis, V. A., Lan, J.-Y., Zheng, X., Zukin, R. S., & Bennett, M. V. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051634698 · Cited by 303
Self-citation
Neuroanatomy: Text and Atlas
Martin, J. H. (1989) · Cited by 295
Synaptic and Extrasynaptic NMDA Receptor NR2 Subunits in Cultured Hippocampal Neurons
Thomas, C. G., Miller, A., & Westbrook, G. L. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00771.2005 · Cited by 286
Rapid recruitment of NMDA receptor transport packets to nascent synapses
Washbourne, P., Bennett, J. E., & McAllister, A. K. (2002) · Nature Neuroscience · doi:10.1038/nn883 · Cited by 284
Interactions of Calmodulin and α-Actinin with the NR1 Subunit Modulate Ca2+-Dependent Inactivation of NMDA Receptors
Krupp, J., Vissel, B., Thomas, C. G., Heinemann, S. F., & Westbrook, G. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01165.1999 · Cited by 283
Calmodulin Mediates Calcium-Dependent Inactivation of N-Methyl-D-Aspartate Receptors
Zhang, S., Ehlers, M., Bernhardt, J. P., Su, C.-T., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80553-x · Cited by 278
Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC , encoding the calcineurin gamma subunit
Gerber, D. J., Hall, D., Miyakawa, T., Demars, S., Gogos, J. A., Karayiorgou, M., & Tonegawa, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432927100 · Cited by 256
A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux
Vissel, B., Krupp, J., Heinemann, S. F., & Westbrook, G. L. (2001) · Nature Neuroscience · doi:10.1038/88404 · Cited by 252
Activity-Dependent mRNA Splicing Controls ER Export and Synaptic Delivery of NMDA Receptors
Mu, Y., Otsuka, T., Horton, A. C., Scott, D. B., & Ehlers, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00676-7 · Cited by 246
Dopamine D 1 Activation Potentiates Striatal NMDA Receptors by Tyrosine Phosphorylation-Dependent Subunit Trafficking
Hallett, P. J., Spoelgen, R., Hyman, B. T., Standaert, D. G., & Dunah, A. W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0792-06.2006 · Cited by 244
Subunit-Specific Regulation of NMDA Receptor Endocytosis
Lavezzari, G., McCallum, J. D., Dewey, C. M., & Roche, K. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1890-04.2004 · Cited by 244
Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5Preprint
Jia, Z., Lu, Y., Henderson, J., Taverna, F. A., Romano, C., Abramow-Newerly, W., Wojtowicz, J. M., & Roder, J. (1998) · Learning & Memory · doi:10.1101/lm.5.4.331 · Cited by 240
Lateral organization of endocytic machinery in dendritic spines
Rácz, B., Blanpied, T. A., Ehlers, M., & Weinberg, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1303 · Cited by 236
Ontogeny of postsynaptic density proteins at glutamatergic synapses
Petralia, R. S., Sans, N., Wang, Y.-X., & Wenthold, R. J. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.013 · Cited by 236
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression
Morishita, W., Lü, W., Smith, G. B., Nicoll, R. A., Bear, M. F., & Malenka, R. C. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.005 · Cited by 235
Learning Mechanisms in Addiction: Synaptic Plasticity in the Ventral Tegmental Area as a Result of Exposure to Drugs of Abuse
Kauer, J. A. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032102.112534 · Cited by 232
Presynaptic ionotropic receptors and control of transmitter release
Engelman, H. S., & MacDermott, A. B. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1297 · Cited by 230
Generation of Silent Synapses by Acute In Vivo Expression of CaMKIV and CREB
Marie, H., Morishita, W., Yu, X., Calakos, N., & Malenka, R. C. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.039 · Cited by 226
Regulation of NMDA Receptors by Neuregulin Signaling in Prefrontal Cortex
Gu, Z., Jiang, Q., Fu, A. K. Y., Ip, N. Y., & Yan, Z. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1086-05.2005 · Cited by 220
KIF17 Dynamics and Regulation of NR2B Trafficking in Hippocampal Neurons
Guillaud, L., Setou, M., & Hirokawa, N. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00131.2003 · Cited by 218
Experience-Dependent Plasticity in Adult Visual Cortex
Karmarkar, U. R., & Dan, Y. (2006) · Neuron · doi:10.1016/j.neuron.2006.11.001 · Cited by 218
Obligatory Role of NR2A for Metaplasticity in Visual Cortex
Philpot, B. D., Cho, K. K. A., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.027 · Cited by 207
C-Terminal Truncation of NR2A Subunits Impairs Synaptic But Not Extrasynaptic Localization of NMDA Receptors
Steigerwald, F., Schulz, T. W., Schenker, L. T., Kennedy, M., Seeburg, P., & Köhr, G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04573.2000 · Cited by 204
NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1
Yaka, R., Thornton, C., Vagts, A. J., Phamluong, K., Bonci, A., & Dorit Ron, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062046299 · Cited by 199
Estrogen-Induced Increase in the Magnitude of Long-Term Potentiation Occurs Only When the Ratio of NMDA Transmission to AMPA Transmission Is Increased
Smith, C. C., & McMahon, L. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0762-05.2005 · Cited by 196
Postsynaptic Density Protein-95 Regulates NMDA Channel Gating and Surface Expression
Lin, Y., Skeberdis, V. A., Francesconi, A., Bennett, M. V. L., & Zukin, R. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3159-04.2004 · Cited by 192
Self-citation
Estradiol-Induced Increase in the Magnitude of Long-Term Potentiation Is Prevented by Blocking NR2B-Containing Receptors
Smith, C. C., & McMahon, L. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5279-05.2006 · Cited by 191
Evidence for Altered NMDA Receptor Function as a Basis for Metaplasticity in Visual Cortex
Philpot, B. D., Espinosa, J. S., & Bear, M. F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05583.2003 · Cited by 187
Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses
Morishita, W., Marie, H., & Malenka, R. C. (2005) · Nature Neuroscience · doi:10.1038/nn1506 · Cited by 186
Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice
Wong, R. W.-C., Setou, M., Teng, J., Takei, Y., & Hirokawa, N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222371099 · Cited by 186
Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors
Scott, D. B., Blanpied, T. A., & Ehlers, M. D. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00250-8 · Cited by 186
NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses
Barth, A. L., & Malenka, R. C. (2001) · Nature Neuroscience · doi:10.1038/85070 · Cited by 183
Barrel Cortex Critical Period Plasticity Is Independent of Changes in NMDA Receptor Subunit Composition
Lu, H., Gonzalez, E., & Crair, M. C. (2001) · Neuron · doi:10.1016/s0896-6273(01)00501-3 · Cited by 180
A proportional but slower NMDA potentiation follows AMPA potentiation in LTP
Watt, A. J., Sjöström, P. J., Häusser, M., Nelson, S. B., & Turrigiano, G. G. (2004) · Nature Neuroscience · doi:10.1038/nn1220 · Cited by 178
Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation
O'Connor, J. J., Rowan, M. J., & Anwyl, R. (1994) · Nature · doi:10.1038/367557a0 · Cited by 178
Separable features of visual cortical plasticity revealed by N -methyl- d -aspartate receptor 2A signaling
Fagiolini, M., Katagiri, H., Miyamoto, H., Mori, H., Grant, S. G. N., Mishina, M., & Hensch, T. K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536089100 · Cited by 178
Postsynaptic Density Assembly Is Fundamentally Different from Presynaptic Active Zone Assembly
Bresler, T., Shapira, M., Boeckers, T. M., Dresbach, T., Futter, M., Garner, C. C., Rosenblum, K., Gundelfinger, E. D., & Ziv, N. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3819-03.2004 · Cited by 174
Activation of NR2A-Containing NMDA Receptors Is Not Obligatory for NMDA Receptor-Dependent Long-Term Potentiation
Weitlauf, C., Honse, Y., Auberson, Y. P., Mishina, M., Lovinger, D. M., & Winder, D. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2388-05.2005 · Cited by 170
Cycling of NMDA Receptors during Trafficking in Neurons before Synapse Formation
Washbourne, P., Liu, X.-B., Jones, E. G., & McAllister, A. K. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2555-04.2004 · Cited by 167
Chronic Ethanol Induces Synaptic But Not Extrasynaptic Targeting of NMDA Receptors
Carpenter‐Hyland, E. P., Woodward, J. J., & Chandler, L. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-04.2004 · Cited by 166
Differential regulation of synaptic and extra-synaptic NMDA receptors
Li, B., Chen, N., Luo, T., Otsu, Y., Murphy, T. H., & Raymond, L. A. (2002) · Nature Neuroscience · doi:10.1038/nn912 · Cited by 162
A Molecular Mechanism for Stabilization of Learning-Induced Synaptic Modifications
Quinlan, E. M., Lebel, D., Brosh, I., & Barkai, E. (2004) · Neuron · doi:10.1016/s0896-6273(03)00874-2 · Cited by 161
Assembly intracellular targeting and cell surface expression of the human N-methyl-d-aspartate receptor subunits NR1a and NR2A in transfected cells
McIlhinney, R. A. J., Bourdellès, B. L., Molnár, E., Tricaud, N., Streit, P., & Whiting, P. J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00121-x · Cited by 160
State-Dependent Heterogeneity in Synaptic Depression between Pyramidal Cell Pairs
Montgomery, J. M., & Madison, D. V. (2002) · Neuron · doi:10.1016/s0896-6273(02)00606-2 · Cited by 152
Impaired NMDA Receptor-Mediated Postsynaptic Function and Blunted NMDA Receptor-Dependent Persistent Pain in Mice Lacking Postsynaptic Density-93 Protein
Tao, Y., Rumbaugh, G., Wang, G., Petralia, R. S., Zhao, C., Kauer, F., Tao, F., Zhuo, M., Wenthold, R. J., Raja, S. N., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06703.2003 · Cited by 151
Rapid Synaptic Remodeling by Protein Kinase C: Reciprocal Translocation of NMDA Receptors and Calcium/Calmodulin-Dependent Kinase II
Fong, D. K., Rao, A., Crump, F. T., & Craig, A. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02153.2002 · Cited by 150
NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity
Nakazawa, T., Komai, S., Watabe, A. M., Kiyama, Y., Fukaya, M., Arima‐Yoshida, F., Horai, R., Sudo, K., Ebine, K., Delawary, M., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601156 · Cited by 149
Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5Receptor-Dependent Redistribution of NMDA Receptors
Schilström, B., Yaka, R., Argilli, E., Suvarna, N. U., Schumann, J., Chen, B. T., Carman, M., Singh, V., Mailliard, W. S., Dorit Ron, A., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5179-05.2006 · Cited by 147
Synapse-Specific Downregulation of NMDA Receptors by Early Experience: A Critical Period for Plasticity of Sensory Input to Olfactory Cortex
Franks, K. M., & Isaacson, J. S. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.024 · Cited by 144
Differential Surface Expression and Phosphorylation of the N-Methyl-D-aspartate Receptor Subunits NR1 and NR2 in Cultured Hippocampal Neurons
Hall, R. A., & Soderling, T. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4135 · Cited by 143
cAMP-Dependent Protein Kinase Mediates Activity-Regulated Synaptic Targeting of NMDA Receptors
Crump, F. T., Dillman, K. S., & Craig, A. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05079.2001 · Cited by 140
Independent mechanisms for long-term depression of AMPA and NMDA responses.
Selig, D. K., Hjelmstad, G., Herron, C., Nicoll, R., & Malenka, R. (1995) · Neuron · doi:10.1016/0896-6273(95)90045-4 · Cited by 137
Role of the Carboxy-Terminal Region of the GluRε2 Subunit in Synaptic Localization of the NMDA Receptor Channel
Mori, H., Manabe, T., Watanabe, M., Satoh, Y., Suzuki, N., Toki, S., Nakamura, K., Yagi, T., Kushiya, E., Takahashi, T., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80567-x · Cited by 136
Endocytosis and Degradative Sorting of NMDA Receptors by Conserved Membrane-Proximal Signals
Scott, D. B., Michailidis, I. E., Mu, Y., Logothetis, D. E., & Ehlers, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0780-04.2004 · Cited by 130
mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression
Sans, N., Wang, P. Y., Du, Q., Petralia, R. S., Wang, Y., Nakka, S., Blumer, J., Macara, I. G., & Wenthold, R. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1325 · Cited by 126
Long-Term Depression of NMDA Receptor-Mediated Synaptic Transmission Is Dependent on Activation of Metabotropic Glutamate Receptors and Is Altered to Long-Term Potentiation by Low Intracellular Calcium Buffering
Harney, S. C., Rowan, M. J., & Anwyl, R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2753-05.2006 · Cited by 119
Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking
Lan, J.-Y., Skeberdis, V. A., Jover, T., Zheng, X., Bennett, M. V. L., & Zukin, R. S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06058.2001 · Cited by 118
Self-citation
PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating
Lin, Y., Jover‐Mengual, T., Wong, J., Bennett, M. V. L., & Zukin, R. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609924104 · Cited by 118
Self-citation
Co-stimulation of mGluR5 and N-Methyl-D-aspartate Receptors Is Required for Potentiation of Excitatory Synaptic Transmission in Hippocampal Neurons
Kotecha, S. A., Jackson, M. F., Al‐Mahrouki, A., Roder, J., Orser, B. A., & MacDonald, J. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301946200 · Cited by 114
Protein kinase C potentiation of N -methyl- d -aspartate receptor activity is not mediated by phosphorylation of N -methyl- d -aspartate receptor subunits
Zheng, X., Zhang, L., Wang, A. P., Bennett, M. V. L., & Zukin, R. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15262 · Cited by 111
Self-citation
Regulation of NMDA receptor trafficking and function by striatal‐enriched tyrosine phosphatase (STEP)
Braithwaite, S. P., Adkisson, M., Leung, J., Nava, A., Masterson, B., Urfer, R., Oksenberg, D., & Nikolich, K. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04837.x · Cited by 108
The Relative Contribution of NMDA Receptor Channels in the Expression of Long‐term Potentiation in the Hippocampal CA1 Region
Asztely, F., Wigström, H., & Gustafsson, B. (1992) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1992.tb00177.x · Cited by 107
Rapid acquisition of dendritic spines by visual thalamic neurons after blockade of N-methyl-D-aspartate receptors.
Rocha, M., & Sur, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.8026 · Cited by 98
N-Methyl-D-aspartate receptors are clustered and immobilized on dendrites of living cortical neurons.
Benke, T. A., Jones, O., Collingridge, G. L., & Angelides, K. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7819 · Cited by 97
Neuroanatomy
Wolf, M. K. (1997) · Neurology · doi:10.1212/wnl.48.1.300-a · Cited by 86
Export from the Endoplasmic Reticulum of Assembled N-Methyl-D-aspartic Acid Receptors Is Controlled by a Motif in the C Terminus of the NR2 Subunit
Hawkins, L. M., Prybylowski, K., Chang, K., Moussan, C., Stephenson, F. A., & Wenthold, R. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402599200 · Cited by 86
PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat
Losi, G., Prybylowski, K., Fu, Z., Luo, J., Wenthold, R. J., & Vicini, S. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00021.x · Cited by 85
Ethanol Alters Trafficking and Functional N-Methyl-D-aspartate Receptor NR2 Subunit Ratio via H-Ras
Suvarna, N. U., Borgland, S. L., Wang, J., Phamluong, K., Auberson, Y. P., Bonci, A., & Dorit Ron, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504120200 · Cited by 83
Developmental Decrease in NMDA Receptor Desensitization Associated with Shift to Synapse and Interaction with Postsynaptic Density-95
Li, B., Otsu, Y., Murphy, T. H., & Raymond, L. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11244.2003 · Cited by 78
PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat
Losi, G., Prybylowski, K., Fu, Z., et al. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034918 · Cited by 69
Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state
Montgomery, J. M., Selcher, J. C., Hanson, J. E., & Madison, D. V. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-48 · Cited by 67
Dissociation of experience-dependent and -independent changes in excitatory synaptic transmission during development of barrel cortex
Mierau, S. B., Meredith, R. M., Upton, A. L., & Paulsen, O. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402916101 · Cited by 67
Long‐term Potentiation of NMDA Receptor‐mediated EPSP in Guinea‐pig Hippocampal Slices
Berretta, N., Berton, F., Bianchi, R., Brunelli, M., Capogna, M., & Francesconi, W. G. (1991) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1991.tb00096.x · Cited by 63
Expression of LTP by AMPA and/or NMDA receptors is determined by the extent of NMDA receptors activation during the tetanus
Aniksztejn, L., & Ben‐Ari, Y. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.6.2349 · Cited by 48
A Three Amino Acid Tail Following the TM4 Region of the N-Methyl-D-aspartate Receptor (NR) 2 Subunits Is Sufficient to Overcome Endoplasmic Reticulum Retention of NR1-1a Subunit
Yang, W., Zheng, C.-Y., Qilin, S., Yang, X., Qiu, S., Liu, C., Chen, Z., Duan, S., & Luo, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700050200 · Cited by 45
Afferent high strength tetanizations favour potentiation of the NMDA vs. AMPA receptor-mediated component of field EPSP in CA1 hippocampal slices of rats
Bayazitov, I. T., & Kleschevnikov, A. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02279-4 · Cited by 16

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Authors: Lau, C. G., & Zukin, R. S.
Affiliations: Albert Einstein College of Medicine (US)
Corresponding author: Zukin, R. Suzanne
ORCID: Lau, C. Geoffrey
Zukin, R. Suzanne
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2007-06
Volume: 8
Issue: 6
Pages: 413-426
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2153
OpenAlex: W1985241009
Cited by: 1,159
References: 154
Citations by year: 2026: 27 · 2025: 27 · 2024: 35 · 2023: 50 · 2022: 39 · 2021: 60 · 2020: 54 · 2019: 70 · 2018: 75 · 2017: 66 · 2016: 51 · 2015: 78 · 2014: 70 · 2013: 69 · 2012: 89
FWCI: 6.05
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (NS-20752, R01NS020752)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: NMDA receptor, receptor trafficking, synaptic plasticity, postsynaptic density, receptor subunit composition, synaptic targeting, endolysosomal pathway, extrasynaptic receptors, activity-dependent regulation, cocaine dependence, Alzheimer's disease, schizophrenia, neuropsychiatric disorders
MeSH terms: Animals, Mental Disorders, Brain, Endocytosis, Humans, Synaptic Transmission, Neuronal Plasticity, Synapses, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Protein Transport

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NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

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