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Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders
Abstract
Advances in our understanding of the mechanisms of tau-mediated neurodegeneration in Alzheimer's disease (AD) and related tauopathies, which are characterized by prominent CNS accumulations of fibrillar tau inclusions, are rapidly moving this previously underexplored disease pathway to centre stage for disease-modifying drug discovery efforts. However, controversies abound concerning whether or not the deleterious effects of tau pathologies result from toxic gains-of-function by pathological tau or from critical losses of normal tau function in the disease state. This Review summarizes the most recent advances in our knowledge of the mechanisms of tau-mediated neurodegeneration to forge an integrated concept of those tau-linked disease processes that drive the onset and progression of AD and related tauopathies.
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“WPC2 also contains numerous cytoskeletal proteins, as exemplified by tau that is hyperphosphorylated and aggregated to contribute to neurodegeneration (Ballatore et al., 2007).”
From Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression (2020) · cites this paper as Ballatore et al., 2007
In the citing paper
“The most widely used transgenic models express mutant forms of the amyloid precursor protein (APP) gene, with or without presenilin-1/2 (PSEN1/2), which are associated with autosomal-dominant, early-onset AD, or, alternatively, MAPT mutations, which cause familial frontotemporal dementia (FTD).”
From Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models (2020) · cites this paper as Ballatore et al., 2007
In the citing paper
“These models recapitulate features of AD neuropathology, including plaques or tangles, along with variable degree of neuronal dysfunction or loss and progressive behavioral impairment (Ballatore et al., 2007; Esquerda-Canals et al., 2017).”
From Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models (2020) · cites this paper as Ballatore et al., 2007
In the citing paper
“Together, these studies indicate that chronic neuroinflammation could provoke tau pathology thereby worsening neuronal injury and long-term outcome.”
From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [150]
In the citing paper
“A robust and persistent neuroinflammatory response may then be sufficient to promote phosphorylation, aggregation, and subsequent neurodegeneration; key features of AD (149–151).”
From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [150]
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Metadata
- Authors
- Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Trojanowski, John Q.
- Venue
- Nature Reviews Neuroscience
- Published
- 2007-09
- Volume
- 8
- Issue
- 9
- Pages
- 663-672
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2034286717
- Cited by
- 2,174
- References
- 105
- Citations by year
- 2026: 70 · 2025: 94 · 2024: 113 · 2023: 108 · 2022: 129 · 2021: 117 · 2020: 161 · 2019: 138 · 2018: 135 · 2017: 139 · 2016: 137 · 2015: 117 · 2014: 123 · 2013: 102 · 2012: 104
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health (5u01ag024904-10)
- National Institute on Aging (P01AG014382, P01AG011542, P01AG014449, U01AG24904, P30AG010124, P01AG009215, P01AG017586, P01AG019724)
- National Institute of Neurological Disorders and Stroke (P01NS044233)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tau protein, Alzheimer's disease, tauopathy, neurofibrillary tangles, tau hyperphosphorylation, pathological tau
- MeSH terms
- Alzheimer Disease, Animals, Humans, Models, Biological, Nerve Degeneration, tau Proteins, Tauopathies
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