Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders

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Protein aggregation and neurodegenerative disease

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The blood-brain barrier: Bottleneck in brain drug development

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Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

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Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

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Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

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The distribution of tau in the mammalian central nervous system.

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Inhibitory Effects of Auraptene and Naringin on Astroglial Activation, Tau Hyperphosphorylation, and Suppression of Neurogenesis in the Hippocampus of Streptozotocin-Induced Hyperglycemic Mice

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Alzheimer's disease brain‐derived extracellular vesicles reveal altered synapse‐related proteome and induce cognitive impairment in mice

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Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer's disease

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Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease

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Small heat shock protein 22 kDa can modulate the aggregation and liquid–liquid phase separation behavior of tau

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Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance

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How Does Hyperphopsphorylation Promote Tau Aggregation and Modulate Filament Structure and Stability?

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Multistage Screening Reveals Chameleon Ligands of the Human Farnesyl Pyrophosphate Synthase: Implications to Drug Discovery for Neurodegenerative Diseases

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Integrated Approaches for Analyzing U1-70K Cleavage in Alzheimer’s Disease

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Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins

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Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluation

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Phosphorylation of soluble tau differs in Pick’s disease and Alzheimer’s disease brains

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Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer’s Disease

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Microcystin‐LR‐Caused ROS generation involved in p38 activation and tau hyperphosphorylation in neuroendocrine (PC12) cells

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Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease

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Physiological and pathological functions of LRRK2: implications from substrate proteins

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Peripheral cytokine and fatty acid associations with neuroinflammation in AD and aMCI patients: An exploratory study

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Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo

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Planar cell polarity signaling components are a direct target of β-amyloid–associated degeneration of glutamatergic synapses

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Alzheimer’s Disease and other Tauopathies: Exploring Efficacy of Medicinal Plant-derived Compounds in Alleviating Tau-mediated Neurodegeneration

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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy

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In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid β-protein-induced neurotoxicity and memory impairment

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The molecular pathology of Alzheimer’s disease

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The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer s disease

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Dendritic Spine Density, Morphology, and Fibrillar Actin Content Surrounding Amyloid-β Plaques in a Mouse Model of Amyloid-β Deposition

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Drosophila microRNA-34 Impairs Axon Pruning of Mushroom Body γ Neurons by Downregulating the Expression of Ecdysone Receptor

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Autophagy and Human Neurodegenerative Diseases—A Fly’s Perspective

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Legionella effector LnaB is a phosphoryl-AMPylase that impairs phosphosignalling

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Yeast buddies helping to unravel the complexity of neurodegenerative disorders

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Neurofibrillary Tangles of Aβx-40 in Alzheimer’s Disease Brains

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Neurodegenerative Disease-Related Proteins within the Epidermal Layer of the Human Skin

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Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors

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Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer’s Disease Brain

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A Machine Learning–Based Approach to Discrimination of Tauopathies Using [ 18F ] PM‐PBB3 PET Images

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The Imbalance of Vascular Molecules in Alzheimer's Disease

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MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications

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Structural Basis of Small Molecule Targetability of Monomeric Tau Protein

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Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer’s disease

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Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration

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Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model

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Biomarkers for Cognitive Impairment in Parkinson Disease

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Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration

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Tau Imaging in Alzheimer's Disease Diagnosis and Clinical Trials

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Loss of Ca2+/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease

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Naturally Occurring Autoantibodies Against β-Amyloid

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Liquid-liquid phase separation in Alzheimer’s disease

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The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation

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Heterogeneous Tau-Tubulin Complexes Accelerate Microtubule Polymerization

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Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ

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Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models

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Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β

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The Role of Axonopathy in Parkinson's Disease

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Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer’s Disease Models

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Targeting Protein Aggregates with Natural Products: An Optional Strategy for Neurodegenerative Diseases

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Complicated Role of Post-translational Modification and Protease-Cleaved Fragments of Tau in Alzheimer’s Disease and Other Tauopathies

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A Novel Perspective on Tau in Alzheimers Disease

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Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer

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Relationship between long non-coding RNAs and Alzheimer’s disease: a systematic review

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SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer’s Disease Mouse Model

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