The DOI matches its Crossref record; 117 of the 118 references it cites were found in a registry or an index, and 1 are not checked yet.
Why do many psychiatric disorders emerge during adolescence?
Open accessAbstract
The peak age of onset for many psychiatric disorders is adolescence, a time of remarkable physical and behavioural changes. The processes in the brain that underlie these behavioural changes have been the subject of recent investigations. What do we know about the maturation of the human brain during adolescence? Do structural changes in the cerebral cortex reflect synaptic pruning? Are increases in white-matter volume driven by myelination? Is the adolescent brain more or less sensitive to reward? Finding answers to these questions might enable us to further our understanding of mental health during adolescence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“this developmental period is also associated with increased risk taking, accidents, and susceptibility to psychopathology (Crone et al., 2016; Giedd et al., 2008; Kessler, Berglund, et al., 2005; Steinberg, 2007).”
From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Giedd et al., 2008
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Despite these limitations, it is thought that reductions in gray matter volume might reflect synaptic reorganization and/or increases in white matter integrity (Paus et al. 2008).”
From Is Adolescence a Sensitive Period for Sociocultural Processing? (2014) · cites this paper as Paus et al. 2008
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Further, adolescence is a time of increased vulnerability to develop anxiety or depressive symptoms (Paus et al., 2008)”
From Effects of traumatic experiences on obsessive-compulsive and internalizing symptoms: The role of avoidance and mindfulness. (2018) · cites this paper as Paus et al., 2008
The cited source says what the claim attributes to it.
In the citing paper
“Faced with this cocktail of stressful new experiences on a background of unstable hormones and altered brain function, it is perhaps unsurprising that adolescents are vulnerable to mental health problems (Kessler et al., 2005;Lee et al., 2014;Paus et al., 2008).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Paus et al., 2008
The cited source says what the claim attributes to it.
In the citing paper
“Magnetic Resonance Imaging (MRI) studies in humans have shown that white matter volume steadily increases from childhood into adolescence, accompanied by changes in Diffusion Weighted Imaging (DWI) parameters, suggesting that maturation of axons/myelin sheaths represents an ongoing (developmental) process (Paus et al., 2008).”
From Acceptance and Commitment Therapy and white matter plasticity in individuals with subclinical depression and psychotic experiences: A Randomised Controlled Trial (2023) · cites this paper as Paus et al., 2008
In the citing paper
“Early abnormalities of maturational changes appear from the ectodermal phase to the first year after birth (first-wave hits) 49 .”
From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [49]
In the citing paper
“Depression typically does not emerge until the adolescent period despite early environmental insults, and this relatively late onset of depression has been documented in both human and non-human animal models of ELS”
From Reduced nucleus accumbens reactivity and adolescent depression following early-life stress (2013) · cites this paper as Paus et al., 2008
In the citing paper
“It has been well established in the literature that children, and especially adolescents, are susceptible to experiencing mental health problems, while most mental disorders have their onset in this age period [51,52].”
From Exploring the Impact of COVID-19 on Mental Health Outcomes in Children and Adolescents: A Systematic Review (2020) · cites this paper as [52]
In the citing paper
“It has been well established in the literature that children, and especially adolescents, are susceptible to experiencing mental health problems, while most mental disorders have their onset in this age period [51,52].”
From Exploring the Impact of COVID-19 on Mental Health Outcomes in Children and Adolescents: A Systematic Review (2020) · cites this paper as [52]
In the citing paper
“It is important to resolve these inconsistencies to gain a better understanding of the neural correlates of risky behaviors and risk factors for psychopathology that emerge during adolescence (Galvan, 2010; Paus et al., 2008).”
From A systematic review of fMRI reward paradigms used in studies of adolescents vs. adults: The impact of task design and implications for understanding neurodevelopment (2013) · cites this paper as Paus et al., 2008
In the citing paper
“Instead, grey matter decline may reflect an artefact of increased myelination of intra-cortical axons (Bourgeois and Rakic, 1993, Paus, 2005, Paus et al., 2008).”
From Neurocognitive bases of emotion regulation development in adolescence (2015) · cites this paper as Paus et al., 2008
In the citing paper
“Adolescence is a period of increased emotional reactivity and psychopathology.”
From Neurocognitive bases of emotion regulation development in adolescence (2015) · cites this paper as Paus et al., 2008
In the citing paper
“Evidence suggests that structural brain development in brain regions subserving emotion regulation continues into adulthood (Paus et al., 2008).”
From Neurocognitive bases of emotion regulation development in adolescence (2015) · cites this paper as Paus et al., 2008
In the citing paper
“Psychopathology associated with internalising symptoms notably increases during the adolescent years (Lee et al., 2014, Paus et al., 2008).”
From Neurocognitive bases of emotion regulation development in adolescence (2015) · cites this paper as Paus et al., 2008
In the citing paper
“Given that the onset of many psychiatric conditions occurs during adolescence (72), and that genotype variations have been associated with the incidence of developmental psychiatric disorders, elucidating the role of genetics in determining brain function during childhood and adolescence is critical to our understanding of the development of these disorders.”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [72]
In the citing paper
“We then analyzed transcriptional dynamics in each of the neuron subtypes between adolescence8,9 (P21) and adulthood (P60) in mouse, a critical postnatal period believed to be associated with greatly increased neuroplasticity, and manifestation of most neuropsychiatric disorders7,10.”
From Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction (2019) · cites this paper as [10]
In the citing paper
“transcriptional plasticity during this period is believed to play a key role in disease pathogenesis10.”
From Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction (2019) · cites this paper as [10]
In the citing paper
“Since initial manifestation of these disorders frequently occur during adolescence”
From Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction (2019) · cites this paper as [10]
In the citing paper
“Many psychiatric disorders associated with genetic defects surface during adolescence10.”
From Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction (2019) · cites this paper as [10]
In the citing paper
“A potential imbalance between the time courses of cortical and subcortical neural circuitry development is one hypothesized mechanism of adolescent vulnerability to disorders such as SAD (Paus et al., 2008).”
From Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience (2014) · cites this paper as Paus et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Rizzolatti, G., & Craighero, L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144230 · Cited by 7,433
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,551
Dynamic mapping of human cortical development during childhood through early adulthood
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402680101 · Cited by 5,604 · cited 1×
“Plots of grey-matter density (top graph) are based on data by Gogtay et al.(8) and illustrate the local grey-matter density in th mid-dorsolateral”
MethodSelf-citationBrain development during childhood and adolescence: a longitudinal MRI study
Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., Paus, T., Evans, A. C., & Rapoport, J. L. (1999) · Nature Neuroscience · doi:10.1038/13158 · Cited by 5,552
Self-citationA social neuroscience perspective on adolescent risk-taking
Steinberg, L. (2008) · Developmental Review · doi:10.1016/j.dr.2007.08.002 · Cited by 3,644
A self‐report measure of pubertal status: Reliability, validity and initial norms
Petersen, A. C., Crockett, L., Richards, M., & Boxer, A. (1988) · Journal of Youth and Adolescence · doi:10.1007/bf01537962 · Cited by 3,129
Cognitive and affective development in adolescence
Steinberg, L. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.12.005 · Cited by 2,978
Synaptic density in human frontal cortex —Developmental changes and effects of aging
Peter R., H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90349-4 · Cited by 2,645
Animal Physiology: Adaptation and Environment
Schmidt‐Nielsen, K. (1962) · Cited by 2,489
Flagged first, then by citations
Research works printed but not linked: 2
- Kaes, T. Die Grosshirnrinde des Menschen in ihren Massen und ihrem Fasergehalt (Fisher, Jena, 1907).
- Conel, J. Postnatal development of the human cerebral cortex: the cortex of the seventy- two- month infant. Vol. 8. (Harvard Univ. Press, Cambridge, Massachusetts, 1967).
Cited by
Sorted by citations
Items 301–400 of 1,033
Emotional Awareness in Depressive and Anxiety Symptoms in Youth: A Meta-Analytic Review
Sendzik, L., Schäfer, J., Samson, A. C., Naumann, E., & Tuschen‐Caffier, B. (2017) · Journal of Youth and Adolescence · doi:10.1007/s10964-017-0629-0 · Cited by 132
Reynolds, L. M., Pokinko, M., Torres-Berrío, A., Cuesta, S., Lambert, L. C., Del Cid Pellitero, E., Wodzinski, M., Manitt, C., Krimpenfort, P., Kolb, B., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.009 · Cited by 129
Peer facilitation of emotion regulation in adolescence
Sahi, R. S., Eisenberger, N. I., & Silvers, J. A. (2023) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2023.101262 · Cited by 129
Viveros, M., Llorente, R., Suárez, J., Llorente‐Berzal, A., López‐Gallardo, M., & de Fonseca, F. R. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111408956 · Cited by 128
Emerging depression in adolescence coincides with accelerated frontal cortical thinning
Bos, M. G. N., Peters, S., van de Kamp, F. C., Crone, E. A., & Tamnes, C. K. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12895 · Cited by 128
Norbom, L. B., Ferschmann, L., Parker, N., Agartz, I., Andreassen, O. A., Paus, T., Westlye, L. T., & Tamnes, C. K. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102109 · Cited by 129
Self-citationCheng, C., Hsu, J.-W., Huang, K., Bai, Y., Su, T., Li, C., Yang, A. C., Chang, W.-H., Chen, T., Tsai, S., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.02.025 · Cited by 128
Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats
Friemel (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00039 · Cited by 127
Marco, E. M., Valero, M., de la Serna, O., Aisa, B., Borcel, É., Ramírez, M. J., & Viveros, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.014 · Cited by 127
Giovanoli, S., Engler, H., Engler, A., Richetto, J., Feldon, J., Riva, M. A., Schedlowski, M., & Meyer, U. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.38 · Cited by 127
Marek, S. A., Tervo‐Clemmens, B., Nielsen, A. N., Wheelock, M. D., Miller, R. L., Laumann, T. O., Earl, E., Foran, W., Cordova, M., Doyle, O. J., et al. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2019.100706 · Cited by 127
Jernigan, T. L., Baaré, W. F. C., Stiles, J., & Madsen, K. S. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53884-0.00019-1 · Cited by 126
Renard, J., Szkudlarek, H. J., Kramar, C. P., Jobson, C. E. L., Moura, K., Rushlow, W. J., & Laviolette, S. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-11645-8 · Cited by 125
MacCabe, J. H., Wicks, S., Löfving, S., David, A. S., Berndtsson, Å., Gustafsson, J., Allebeck, P., & Dalman, C. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.43 · Cited by 125
Global and regional white matter development in early childhood
Reynolds, J. E., Grohs, M. N., Dewey, D., & Lebel, C. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.04.004 · Cited by 124
Dir, A. L., Bell, R. L., Adams, Z. W., & Hulvershorn, L. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00289 · Cited by 124
Cacciatore, R., Korteniemi-Poikela, E., & Kaltiala‐Heino, R. (2019) · International Journal of Sexual Health · doi:10.1080/19317611.2019.1645783 · Cited by 124
Brand, S., Gerber, M., Kalak, N., Kirov, R., Lemola, S., Clough, P., Pühse, U., & Holsboer‐Trachsler, E. (2013) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2013.07.017 · Cited by 124
Exciting fear in adolescence: does pubertal development alter threat processing?
Spielberg, J. M., Olino, T. M., Forbes, E. E., & Dahl, R. E. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.01.004 · Cited by 123
Pascual, M., Pla, A., Miñarro, J., & Guerri, C. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt164 · Cited by 123
Wassenaar, T. M., Wheatley, C., Beale, N., Nichols, T. E., Salvan, P., Meaney, A., Atherton, K., Diaz‐Ordaz, K., Dawes, H., & Johansen‐Berg, H. (2021) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-021-01113-y · Cited by 124
Pedrini, L., Meloni, S., Lanfredi, M., & Rossi, R. (2022) · Journal of Adolescence · doi:10.1002/jad.12090 · Cited by 128
Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
Lin, L., & Sibille, E. L. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00110 · Cited by 122
Zuddas, A., Zanni, R., & Usala, T. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.04.001 · Cited by 121
LeWinn, K. Z., Connolly, C. G., Wu, J., Drahos, M., Hoeft, F., Ho, T. C., Simmons, A. N., & Yang, T. T. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.04.021 · Cited by 121
Exercising, sleep-EEG patterns, and psychological functioning are related among adolescents
Brand, S., Gerber, M., Beck, J., Hatzinger, M., Pühse, U., & Holsboer-Trachsler, E. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970903522501 · Cited by 120
Hammerslag, L. R., & Gulley, J. M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.008 · Cited by 122
Short-range connections in the developmental connectome during typical and atypical brain maturation
Ouyang, M., Kang, H., Detre, J. A., Roberts, T. P. L., & Huang, H. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.007 · Cited by 120
Intravenous Ketamine for Adolescents with Treatment-Resistant Depression: An Open-Label Study
Cullen, K. R., Amatya, P., Roback, M. G., Albott, C. S., Schreiner, M. W., Ren, Y., Eberly, L. E., Carstedt, P. A., Samikoglu, A., Gunlicks‐Stoessel, M., et al. (2018) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0030 · Cited by 120
Ziegler, G., Hauser, T. U., Moutoussis, M., Bullmore, E. T., Goodyer, I. M., Fonagy, P., Jones, P. B., Lindenberger, U., & Dolan, R. J. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0394-3 · Cited by 120
Reichelt, A. C., Killcross, S., Hambly, L. D., Morris, M. J., & Westbrook, R. F. (2015) · Learning & Memory · doi:10.1101/lm.038000.114 · Cited by 120
McGorry, P. D. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.03.016 · Cited by 119
McPhie, M. L., & Rawana, J. S. (2015) · Journal of Adolescence · doi:10.1016/j.adolescence.2015.01.008 · Cited by 119
Kadosh, K. C., Luo, Q., Burca, C. D., Sokunbi, M. O., Feng, J., Linden, D. E. J., & Lau, J. Y. F. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.070 · Cited by 118
New insights into early-life stress and behavioral outcomes
Bolton, J. L., Molet, J., Ivy, A. S., & Baram, T. Z. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.12.012 · Cited by 118
Peer victimization and its impact on adolescent brain development and psychopathology
Quinlan, E. B., Barker, E. D., Luo, Q., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Desrivières, S., Flor, H., Frouin, V., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0297-9 · Cited by 118
Self-citationAccelerated longitudinal cortical thinning in adolescence
Zhou, D., Lebel, C. A., Treit, S., Evans, A. C., & Beaulieu, C. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.10.005 · Cited by 118
Peach, H. D., & Gaultney, J. F. (2013) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2013.03.012 · Cited by 117
Bondi, C. O., Taha, A. Y., Tock, J., Totah, N. K. B., Cheon, Y., Torres, G. E., Rapoport, S. I., & Moghaddam, B. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.007 · Cited by 117
Vink, M., Zandbelt, B. B., Gladwin, T., Hillegers, M., Hoogendam, J. M., van den Wildenberg, W. P. M., Du Plessis, S., & Kahn, R. S. (2014) · Human Brain Mapping · doi:10.1002/hbm.22483 · Cited by 116
Social media use in adolescents with and without mental health conditions
Fassi, L., Ferguson, A. M., Przybylski, A. K., Ford, T. J., & Orben, A. C. (2025) · Nature Human Behaviour · doi:10.1038/s41562-025-02134-4 · Cited by 116
Neurobiology of adolescent substance use and addictive behaviors: treatment implications.
Hammond, C. J., Mayes, L. C., & Potenza, M. N. (2014) · PubMed · Cited by 116
van Duijvenvoorde, A. C. K., Westhoff, B., de Vos, F., Wierenga, L. M., & Crone, E. A. (2019) · Human Brain Mapping · doi:10.1002/hbm.24630 · Cited by 115
Gray Matter Alterations in Schizophrenia High-Risk Youth and Early-Onset Schizophrenia
Brent, B. K., Thermenos, H. W., Keshavan, M. S., & Seidman, L. J. (2013) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2013.06.003 · Cited by 115
Self-citationHerrero, R., Mira, A., Cormo, G., Etchemendy, E., Baños, R., García‐Palacios, A., Ebert, D. D., Franke, M., Berger, T., Schaub, M. P., et al. (2018) · Internet Interventions · doi:10.1016/j.invent.2018.03.005 · Cited by 115
Adaptive working memory training can reduce anxiety and depression vulnerability in adolescents
Beloe, P., & Derakshan, N. (2019) · Developmental Science · doi:10.1111/desc.12831 · Cited by 115
Adolescent brain development: Implications for the juvenile criminal justice system.
Luna, B., & Wright, C. M. (2015) · American Psychological Association eBooks · doi:10.1037/14643-005 · Cited by 115
Adolescent Brain Maturation and Cortical Folding: Evidence for Reductions in Gyrification
Klein, D. N., Rotarska-Jagiela, A., Genç, E., Sritharan, S., Mohr, H. M., Roux, F., Han, C. E., Kaiser, M., Singer, W., & Uhlhaas, P. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084914 · Cited by 114
Zhang, J., Yao, W., Dong, C., Yang, C., Ren, Q., Ma, M., Han, M., Wu, J., Ushida, Y., Suganuma, H., et al. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.10.004 · Cited by 114
The emergence of gonadal hormone influences on dopaminergic function during puberty
Kuhn, C., Johnson, M., Thomae, A., Luo, B., Simon, S. A., Zhou, G., & Walker, Q. D. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.10.015 · Cited by 113
Cannabis and alcohol use, and the developing brain
Meruelo, A. D., Castro, N., Cota, C. I., & Tapert, S. F. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.025 · Cited by 113
Abnormal Cortical Growth in Schizophrenia Targets Normative Modules of Synchronized Development
Alexander‐Bloch, A. F., Reiss, P. T., Rapoport, J. L., Mcadams, H., Giedd, J. N., Bullmore, E. T., & Gogtay, N. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.010 · Cited by 112
Self-citationNeurobiology of depression: A neurodevelopmental approach
Lima‐Ojeda, J. M., Rupprecht, R., & Baghai, T. C. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1289240 · Cited by 113
Bauer, C. C. C., Rozenkrantz, L., Caballero, C., Nieto-Castañón, A., Scherer, E., West, M. R., Mrazek, M. D., Phillips, D. T., Gabrieli, J. D. E., & Whitfield, S. (2020) · Human Brain Mapping · doi:10.1002/hbm.25197 · Cited by 112
A Meta-Analytic Review of Emotion Regulation Focused Psychosocial Interventions for Adolescents
Eadeh, H., Breaux, R., & Nikolas, M. A. (2021) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-021-00362-4 · Cited by 112
Taylor, S., Barker, L. A., Heavey, L., & McHale, S. (2012) · Developmental Psychology · doi:10.1037/a0029871 · Cited by 113
A focus on adolescence to reduce neurological, mental health and substance-use disability
Davidson, L. L., Grigorenko, E. L., Boivin, M. J., Rapa, E., & Stein, A. L. (2015) · Nature · doi:10.1038/nature16030 · Cited by 112
Social stress models in depression research: what do they tell us?
Chaouloff, F. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1606-x · Cited by 112
Myelin and Axon Abnormalities in Schizophrenia Measured with Magnetic Resonance Imaging Techniques
Du, F., Cooper, A. J., Thida, T., Shinn, A. K., Cohen, B. M., & Öngür, D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.003 · Cited by 110
Wood, S. J., Yung, A. R., McGorry, P. D., & Pantelis, C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.034 · Cited by 110
Bistoletti, M., Caputi, V., Baranzini, N., Marchesi, N., Filpa, V., Marsilio, I., Cerantola, S., Terova, G., Baj, A., Grimaldi, A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212856 · Cited by 109
The neurobiological effects of childhood maltreatment on brain structure, function, and attachment
Tomoda, A., Nishitani, S., Takiguchi, S., Fujisawa, T. X., Sugiyama, T., & Teicher, M. H. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01779-y · Cited by 115
O’Connor, M., Sanson, A. V., Toumbourou, J. W., Norrish, J. M., & Olsson, C. A. (2016) · Journal of Happiness Studies · doi:10.1007/s10902-016-9723-3 · Cited by 109
The developing human brain: age‐related changes in cortical, subcortical, and cerebellar anatomy
Sussman, D., Leung, R. C., Chakravarty, M. M., Lerch, J. P., & Taylor, M. J. (2016) · Brain and Behavior · doi:10.1002/brb3.457 · Cited by 109
The Development of Adolescent Social Cognition
Burnett, S., & Blakemore, S. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04509.x · Cited by 108
Caouette, J. D., & Guyer, A. E. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2013.10.003 · Cited by 108
Hubs in the human fetal brain network
van den Heuvel, M. I., Turk, E., Manning, J. H., Hect, J., Hernandez-Andrade, E., Hassan, S. S., Romero, R., van den Heuvel, M. P., & Thomason, M. E. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.02.001 · Cited by 108
“…notion, the origins of neurodevelopmental disorders are increasingly attributed to alterations occurring during the prenatal period (Di Martino et al., 2014; Paneth et al., 2005; Rosenbaum et al., 2007) despite onsets in symptomatology between the 3rd and 20th years of life (Paus et al., 2008).”
Childhood Maltreatment and Development of Substance Use Disorders
Edalati, H., & Krank, M. D. (2015) · Trauma Violence & Abuse · doi:10.1177/1524838015584370 · Cited by 108
Developmental rodent models of fear and anxiety: from neurobiology to pharmacology
Ganella, D. E., & Kim, J. H. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12643 · Cited by 107
Maturation of the human striatal dopamine system revealed by PET and quantitative MRI
Larsen, B., Olafsson, V., Calabro, F., Laymon, C., Tervo-Clemmens, B., Campbell, E., Minhas, D., Montez, D., Price, J., & Luna, B. (2020) · Nature Communications · doi:10.1038/s41467-020-14693-3 · Cited by 107
Cai, R. Y., Richdale, A. L., Dissanayake, C., & Uljarević, M. (2018) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3318-7 · Cited by 107
Connectome-wide network analysis of youth with Psychosis-Spectrum symptoms
Satterthwaite, T. D., Vandekar, S., Wolf, D. H., Bassett, D. S., Ruparel, K., Shehzad, Z. E., Craddock, R. C., Shinohara, R. T., Moore, T. M., Gennatas, E. D., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.66 · Cited by 107
Yolton, K. A., Khoury, J. C., Burkle, J. W., LeMasters, G. K., Cecil, K. M., & Ryan, P. (2019) · Environmental Research · doi:10.1016/j.envres.2019.03.005 · Cited by 107
Microglia-mediated synaptic pruning is impaired in sleep-deprived adolescent mice
Tuan, L., & Lee, L. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104517 · Cited by 107
Pubertal development of the understanding of social emotions: Implications for education
Heyes, S. B., Thompson, S., Bird, G., & Blakemore, S. (2010) · Learning and Individual Differences · doi:10.1016/j.lindif.2010.05.007 · Cited by 107
Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults
McCutcheon, J. E., Conrad, K. L., Carr, S. B., Ford, K. A., McGehee, D. S., & Marinelli, M. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00077.2012 · Cited by 106
Luby, J. L., Belden, A. C., Jackson, J. J., Lessov‐Schlaggar, C. N., Harms, M. P., Tillman, R., Botteron, K. N., Whalen, D. J., & Barch, D. M. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.2356 · Cited by 106
Gee, D. G., Fetcho, R. N., Jing, D., Li, A., Glatt, C. E., Drysdale, A. T., Cohen, A. O., Dellarco, D. V., Yang, R. R., Dale, A. M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600013113 · Cited by 106
Gyllenberg, D., Marttila, M., Sund, R., Jokiranta‐Olkoniemi, E., Sourander, A., Gissler, M., & Ristikari, T. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30038-5 · Cited by 106
Wang, Y., Ho, U., Ko, M., Liao, C., & Lee, L. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0355-4 · Cited by 106
Henderson, S. E., Johnson, A. R., Vallejo, A. I., Katz, L., Wong, E. W., & Gabbay, V. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00152 · Cited by 106
Iñiguez, S. D., Aubry, A., Riggs, L. M., Alipio, J. B., Zanca, R. M., Flores-Ramirez, F. J., Hernandez, M. A., Nieto, S. J., Musheyev, D., & Serrano, P. A. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.07.001 · Cited by 105
D'Amico, E. J., Tucker, J. S., Miles, J. N. V., Ewing, B. A., Shih, R. A., & Pedersen, E. R. (2016) · Addiction · doi:10.1111/add.13442 · Cited by 105
Rebuli, M. E., & Patisaul, H. B. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.08.021 · Cited by 105
Roles of age, gender and psychological difficulties in adolescent mentalizing
Poznyak, E., Morosan, L., Perroud, N. A., Speranza, M., Badoud, D., & Debbané, M. (2019) · Journal of Adolescence · doi:10.1016/j.adolescence.2019.06.007 · Cited by 105
High susceptibility to chronic social stress is associated with a depression-like phenotype
Schmidt, M. V., Scharf, S. H., Sterlemann, V., Ganea, K., Liebl, C., Holsboer, F., & Müller, M. B. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.10.002 · Cited by 105
The relationship between music-related mood regulation and psychopathology in young people
Thomson, C. J., Reece, J., & Benedetto, M. D. (2014) · Musicae Scientiae · doi:10.1177/1029864914521422 · Cited by 104
Behavioural, emotional and social development of children who stutter
McAllister, J. (2016) · Journal of Fluency Disorders · doi:10.1016/j.jfludis.2016.09.003 · Cited by 105
Alnæs, D., Kaufmann, T., Doan, N. T., Córdova‐Palomera, A., Wang, Y., Bettella, F., Moberget, T., Andreassen, O. A., & Westlye, L. T. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.4277 · Cited by 104
Tan, T., Wang, W., Liu, T., Zhong, P., Conrow‐Graham, M., Tian, X., & Yan, Z. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108874 · Cited by 104
Parkes, L., Moore, T. M., Calkins, M. E., Cook, P. A., Cieslak, M., Roalf, D. R., Wolf, D. H., Gur, R. C., Gur, R. E., Satterthwaite, T. D., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01342-6 · Cited by 104
Ho, T. C., Gifuni, A. J., & Gotlib, I. H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01171-5 · Cited by 108
Jacobus, J., Squeglia, L. M., Meruelo, A. D., Castro, N., Brumback, T., Giedd, J. N., & Tapert, S. F. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.04.006 · Cited by 104
Self-citationPubertal testosterone influences threat-related amygdala–orbitofrontal cortex coupling
Spielberg, J. M., Forbes, E. E., Ladouceur, C. D., Worthman, C. M., Olino, T. M., Ryan, N. D., & Dahl, R. E. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu062 · Cited by 104
Brand, S., Kalak, N., Gerber, M., Clough, P., Lemola, S., Bahmani, D. S., Pühse, U., & Holsboer‐Trachsler, E. (2016) · Journal of Sports Sciences · doi:10.1080/02640414.2016.1167936 · Cited by 104
Gabriele, M., Lopez Tobon, A., D'Agostino, G., & Testa, G. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.12.013 · Cited by 103
Functional Neuroimaging Abnormalities in Youth With Psychosis Spectrum Symptoms
Wolf, D. H., Satterthwaite, T. D., Calkins, M. E., Ruparel, K., Elliott, M. A., Hopson, R. D., Jackson, C. T., Prabhakaran, K., Bilker, W. B., Hakonarson, H. H., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.3169 · Cited by 103
O’Neill, S. M., McLafferty, M., Ennis, E., Lapsley, C. R., Bjourson, T., Armour, C., Murphy, S., Bunting, B., & Murray, E. K. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.06.006 · Cited by 103
Vendruscolo, L. F., Gueye, A. B., Darnaudéry, M., Ahmed, S. H., & Cador, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009296 · Cited by 103
Physiological markers of anxiety are increased in children of abused mothers
Jovanovic, T., Smith, A., Kamkwalala, A., Poole, J., Samples, T., Norrholm, S. D., Ressler, K. J., & Bradley, B. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02410.x · Cited by 102
Metadata
- Authors
- Paus, T., Keshavan, M., & Giedd, J. N.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Beth Israel Deaconess Medical Center (US)
- National Institute of Mental Health (US)
- Corresponding author
- Paus, Tomáš
- Giedd, Jay N.
- Venue
- Nature Reviews Neuroscience
- Published
- 2008-11-12
- Volume
- 9
- Issue
- 12
- Pages
- 947-957
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC2762785
- OpenAlex
- W2040073285
- Semantic Scholar
- 7c469b7f89043f4867b02938be67d786fc761827
- Cited by
- 3,123
- References
- 117
- Citations by year
- 2026: 198 · 2025: 230 · 2024: 213 · 2023: 242 · 2022: 230 · 2021: 262 · 2020: 251 · 2019: 162 · 2018: 202 · 2017: 147 · 2016: 179 · 2015: 186 · 2014: 148 · 2013: 149 · 2012: 100
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (Z01MH002794)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- adolescent brain development, mental illness, synaptic pruning, cortical maturation, white matter myelination, reward sensitivity
- MeSH terms
- Adolescent, Mental Disorders, Brain, Humans, Synaptic Transmission, Peer Group, Sex Characteristics, Age of Onset, Adolescent Development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
