Heritability of Changes in Brain Volume Over Time in Twin Pairs Discordant for Schizophrenia

Brans, Rachel G. H.; van Haren, Neeltje E. M.; van Baal, G. Caroline M.; Schnack, Hugo G.; Kahn, René S.; Pol, Hilleke E. Hulshoff

doi:10.1001/archpsyc.65.11.1259

Cited by 129Schizophrenia research and treatmentGenetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

Heritability of Changes in Brain Volume Over Time in Twin Pairs Discordant for Schizophrenia

Brans, Rachel G. H., van Haren, Neeltje E. M., van Baal, G. Caroline M., Schnack, Hugo G., Kahn, René S., Pol, Hilleke E. Hulshoff·2008·Archives of General Psychiatry

DOI 10.1001/archpsyc.65.11.1259

Open this paper in CoChat — free account

Abstract

CONTEXT: Structural brain abnormalities have consistently been found in schizophrenia, with increased familial risk for the disease associated with these abnormalities. Some brain volume changes are progressive over the course of the illness. Whether these progressive brain volume changes are mediated by genetic or disease-related factors is unknown. OBJECTIVE: To investigate whether genetic and/or environmental factors are associated with progressive brain volume changes in schizophrenia. DESIGN: Longitudinal 5-year follow-up in monozygotic (MZ) and dizygotic (DZ) twin pairs discordant for schizophrenia and healthy comparison twin pairs using brain magnetic resonance imaging. SETTING: Participants were recruited from the twin pair cohort at the University Medical Center Utrecht. PARTICIPANTS: A total of 92 participants completed the study: 9 MZ and 10 DZ twin pairs discordant for schizophrenia and 14 MZ and 13 DZ healthy twin pairs. MAIN OUTCOME MEASURES: Percentage volume changes of the whole brain; cerebral gray and white matter of the frontal, temporal, parietal, and occipital lobes; cerebellum; and lateral and third ventricles over time between and within twin pairs were compared using repeated measures analysis of covariance. Structural equation modeling was applied to estimate contributions of additive genetic and common and unique environmental factors. RESULTS: Significant decreases over time in whole brain and frontal and temporal lobe volumes were found in patients with schizophrenia and their unaffected co-twins compared with control twins. Bivariate structural equation modeling using cross-trait/cross-twin correlations revealed significant additive genetic influences on the correlations between schizophrenia liability and progressive whole brain (66%; 95% confidence interval [CI], 51%-100%), frontal lobe (76%; 95% CI, 54%-100%), and temporal lobe (79%; CI, 56%-100%) volume change. CONCLUSION: The progressive brain volume loss found in patients with schizophrenia and their unaffected co-twins is at least partly attributable to genetic factors related to the illness.

Integrity signals

Registry

Crossref · 10.1001/archpsyc.65.11.1259

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Progressive brain tissue loss in schizophrenia has been associated with genetic factors, disease-related factors, and antipsychotic medication intake.
“The (progressive) brain tissue loss has been associated with genetic factors and with disease-related factors 11,12 as well as effects of antipsychotic medication intake. 13”
From Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. (2015) · cites this paper as [11]
Progressive brain changes are present in discordant cotwins of patients with schizophrenia.
“Interestingly, progressive brain changes are also present in discordant cotwins of patients with schizophrenia, suggesting that these changes are familial, and possibly genetic, and can therefore not solely be explained by antipsychotic medication intake.9”
From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [9]
The progressive brain changes in schizophrenia are familial, and possibly genetic, and cannot be solely explained by antipsychotic medication intake.
“Interestingly, progressive brain changes are also present in discordant cotwins of patients with schizophrenia, suggesting that these changes are familial, and possibly genetic, and can therefore not solely be explained by antipsychotic medication intake.9”
From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [9]

The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378 · see citing works
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
A Diagnostic Interview
Endicott, J. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770310043002 · Cited by 5,686 · see citing works
A nonparametric method for automatic correction of intensity nonuniformity in MRI data
Sled, J. G., Zijdenbos, A. P., & Evans, A. C. (1998) · IEEE Transactions on Medical Imaging · doi:10.1109/42.668698 · Cited by 4,731 · see citing works
Synaptic Activity and the Construction of Cortical Circuits
Katz, L. C., & Shatz, C. J. (1996) · Science · doi:10.1126/science.274.5290.1133 · Cited by 3,048 · see citing works
Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies
Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1187 · Cited by 2,356 · see citing works
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346 · see citing works
The neurobiology of stress: from serendipity to clinical relevance11Published on the World Wide Web on 22 November 2000.
McEwen, B. S. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02950-4 · Cited by 1,827 · see citing works
Meta-analysis of regional brain volumes in schizophrenia
Wright, I. C., Rabe-Hesketh, S., Woodruff, P. W. R., David, A. S., Murray, R. M., & Bullmore, E. T. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.16 · Cited by 1,662 · see citing works
Epigenetic regulation in psychiatric disorders
Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400 · see citing works
The Comprehensive Assessment of Symptoms and History (CASH)
Andreasen, N. C. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080023004 · Cited by 1,314 · see citing works
Classical twin studies and beyond
Boomsma, D., Busjahn, A., & Peltonen, L. (2002) · Nature Reviews Genetics · doi:10.1038/nrg932 · Cited by 1,105 · cited 1× · see citing works
“The presence of shared environmental factors is suggested when correlations in DZ twins are larger than half of the MZ correlation.(18) The importance of unique environmental factors can first be obtained from the extent to which MZ twins do not resemble each other.”
Background
Global Assessment of Functioning
Hall, R. C. W. (1995) · Psychosomatics · doi:10.1016/s0033-3182(95)71666-8 · Cited by 1,099 · see citing works
The neurodevelopmental model of schizophrenia: update 2005
Rapoport, J. L., Addington, A. M., Frangou, S., & Psych, M. R. C. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001642 · Cited by 993 · see citing works
Automatic 3‐D model‐based neuroanatomical segmentation
Collins, D. L., Holmes, C. J., Peters, T. M., & Evans, A. C. (1995) · Human Brain Mapping · doi:10.1002/hbm.460030304 · Cited by 975 · see citing works
Schizophrenia genesis: the origins of madness
(1991) · Choice Reviews Online · doi:10.5860/choice.28-6500 · Cited by 832 · see citing works
The Camberwell Assessment of Need: The Validity and Reliability of an Instrument to Assess the Needs of People with Severe Mental Illness
Phelan, M., Slade, M., Thornicroft, G., Dunn, G., Holloway, F. A., Wykes, T., Strathdee, G., Loftus, L., McCrone, P., & Hayward, P. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.167.5.589 · Cited by 814 · see citing works
Antipsychotic Drug Effects on Brain Morphology in First-Episode Psychosis
Lieberman, J. A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.361 · Cited by 804 · see citing works
Analytic approaches to twin data using structural equation models
Rijsdijk, F. V. (2002) · Briefings in Bioinformatics · doi:10.1093/bib/3.2.119 · Cited by 761 · see citing works
Cortical rewiring and information storage
Chklovskii, D. B., Mel, B. W., & Svoboda, K. (2004) · Nature · doi:10.1038/nature03012 · Cited by 717 · see citing works
Astrocytes promote myelination in response to electrical impulses
Ishibashi, T., Dakin, K. A., Stevens, B., Lee, P. R., Kozlov, S. V., Stewart, C. L., & Fields, R. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.006 · Cited by 689 · see citing works
How widespread is adult neurogenesis in mammals?
Gould, E. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2147 · Cited by 658 · see citing works
Neural stem cell proliferation is decreased in schizophrenia, but not in depression
Reif, A., Fritzen, S., Finger, M., Strobel, A., Lauer, M., Schmitt, A., & Lesch, K.-P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001791 · Cited by 630 · see citing works
Structured interview for DSM-IV personality: SIDP-IV
Mowry, B. J. (1998) · Australian & New Zealand Journal of Psychiatry · Cited by 592 · see citing works
Structural Brain Imaging Evidence for Multiple Pathological Processes at Different Stages of Brain Development in Schizophrenia
Pantelis, C. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi034 · Cited by 573 · see citing works
Progressive Structural Brain Abnormalities and Their Relationship to Clinical Outcome
Ho, B., Andreasen, N. C., Nopoulos, P., Arndt, S. V., Magnotta, V. A., & Flaum, M. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.585 · Cited by 536 · see citing works
Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex
Zuo, Y., Yang, G., Kwon, E., & Gan, W.-B. (2005) · Nature · doi:10.1038/nature03715 · Cited by 436 · see citing works
Genetic influences on human brain structure: A review of brain imaging studies in twins
Peper, J. S., Brouwer, R. M., Boomsma, D. I., Kahn, R. S., & Pol, H. E. H. (2007) · Human Brain Mapping · doi:10.1002/hbm.20398 · Cited by 429 · see citing works
Self-citation
Brain Volume Changes in First-Episode Schizophrenia
Cahn, W., Pol, H. E. H., Lems, E. B. T. E., van Haren, N. E. M., Schnack, H. G., van der Linden, J. A., Schothorst, P. F., van Engeland, H., & Kahn, R. S. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.11.1002 · Cited by 398 · see citing works
Self-citation
Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia
Rapoport, J. L., Giedd, J. N., Blumenthal, J. D., Hamburger, S., Jeffries, N. O., Fernandez, T., Nicolson, R., Bedwell, J. S., Lenane, M., Zijdenbos, A. P., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.7.649 · Cited by 388 · see citing works
Neuropsychological Assessment of Monozygotic Twins Discordant for Schizophrenia
Goldberg, T. E. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810230082013 · Cited by 385 · see citing works
The Inheritance of Neuropsychological Dysfunction in Twins Discordant for Schizophrenia
Cannon, T. D., HUTTUNEN, M. O., Lönnqvist, J. K., Tuulio‐Henriksson, A., Pirkola, T., Glahn, D. C., Finkelstein, J. R. J., Hietanen, M., Kaprio, J. A., & Koskenvuo, M. J. (2000) · The American Journal of Human Genetics · doi:10.1086/303006 · Cited by 369 · see citing works
What Happens After the First Episode? A Review of Progressive Brain Changes in Chronically Ill Patients With Schizophrenia
Hulshoff Pol, H. E., & Kahn, R. S. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm168 · Cited by 364 · see citing works
Self-citation
Brain Volumes in Relatives of Patients With Schizophrenia
Boos, H. B. M., Aleman, A., Cahn, W., Pol, H. E. H., & Kahn, R. S. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.297 · Cited by 344 · see citing works
Self-citation
Association of DISC1/TRAX Haplotypes With Schizophrenia, Reduced Prefrontal Gray Matter, and Impaired Short- and Long-term Memory
Cannon, T. D., Hennah, W., van Erp, T. G. M., Thompson, P. M., Lonnqvist, J., Huttunen, M., Gasperoni, T., Tuulio-Henriksson, A., Pirkola, T., Toga, A. W., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1205 · Cited by 337 · see citing works
Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia
Cannon, T. D., Thompson, P. M., van Erp, T. G. M., Toga, A. W., Poutanen, V.-P., HUTTUNEN, M. O., Lönnqvist, J. K., Standerskjold-Nordenstam, C.-G., Narr, K. L., Khaledy, M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052023499 · Cited by 315 · see citing works
Evidence of newly generated neurons in the human olfactory bulb
Bédard, A., & Parent, A. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.03.021 · Cited by 308 · see citing works
Obstetric complications and age at onset in schizophrenia: an international collaborative meta-analysis of individual patient data
Verdoux, H., Geddes, J. R., Takei, N., Lawrie, S. M., Bovet, P., Eagles, J., Heun, R., McCreadie, R. G., McNeil, T. F., O’Callaghan, E., et al. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.9.1220 · Cited by 296 · see citing works
Progressive Brain Volume Loss in Schizophrenia Over the Course of the Illness: Evidence of Maturational Abnormalities in Early Adulthood
van Haren, N. E. M., Pol, H. E. H., Schnack, H. G., Cahn, W., Brans, R. G. H., Carati, I., Rais, M., & Kahn, R. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.01.004 · Cited by 278 · see citing works
Self-citation
Early and Late Neurodevelopmental Influences in the Prodrome to Schizophrenia: Contributions of Genes, Environment, and Their Interactions
Cannon, T. D., van Erp, T. G. M., Bearden, C. E., Loewy, R. L., Thompson, P. M., Toga, A. W., Huttunnen, M. O., Keshavan, M. S., Seidman, L. J., & Tsuang, M. T. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007037 · Cited by 267 · see citing works
Fetal Hypoxia and Structural Brain Abnormalities in Schizophrenic Patients, Their Siblings, and Controls
Cannon, T. D., van Erp, T. G. M., Rosso, I. M., HUTTUNEN, M. O., Lönnqvist, J. K., Pirkola, T., Salonen, O. L. M., Valanne, L. K., Poutanen, V.-P., & Standertskjöld-Nordenstam, C.-G. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.1.35 · Cited by 266 · see citing works
Neurotoxicity, Neuroplasticity, and Magnetic Resonance Imaging Morphometry
Weinberger, D. R., & McClure, R. K. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.6.553 · Cited by 261 · see citing works
Volume Changes in Gray Matter in Patients With Schizophrenia
Pol, H. E. H., Schnack, H. G., Bertens, M. G. B. C., van Haren, N. E. M., van der Tweel, I., Staal, W., Baaré, W. F. C., & Kahn, R. S. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.2.244 · Cited by 218 · see citing works
Self-citation
Substantial genetic overlap between neurocognition and schizophrenia: genetic modeling in twin samples
Toulopoulou, T., Picchioni, M., Rijsdijk, F. V., Hua-Hall, M., Ettinger, U., Sham, P. C., & Murray, R. M. (2008) · Annals of General Psychiatry · doi:10.1186/1744-859x-7-s1-s8 · Cited by 212 · see citing works
Volumes of Brain Structures in Twins Discordant for Schizophrenia
Baaré, W. F. C., van Oel, C. J., Pol, H. E. H., Schnack, H. G., Durston, S., Sitskoorn, M. M., & Kahn, R. S. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.1.33 · Cited by 207 · see citing works
Self-citation
Ventricular Enlargement in Poor-Outcome Schizophrenia
Davis, K. L., Buchsbaum, M. S., Shihabuddin, L., Spiegel-Cohen, J., Metzger, M. W., Frecska, E., Keefe, R. S. E., & Powchik, P. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00553-2 · Cited by 200 · see citing works
Early and late environmental risk factors for schizophrenia.
Mcdonald, C., & Murray, R. (2000) · Brain research. Brain research reviews · doi:10.1016/s0165-0173(99)00030-2 · Cited by 167 · see citing works
Cortical Brain Development in Nonpsychotic Siblings of Patients With Childhood-Onset Schizophrenia
Gogtay, N., GREENSTEIN, D. K., Lenane, M., CLASEN, L. S., Sharp, W. S., Gochman, P., Butler, P., Evans, A. C., & Rapoport, J. L. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.7.772 · Cited by 165 · see citing works
Elevated Prenatal Homocysteine Levels as a Risk Factor for Schizophrenia
Brown, A. S., Bottiglieri, T., Schaefer, C. A., Quesenberry, C. P., Liu, L., Bresnahan, M. A., & Susser, E. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.1.31 · Cited by 153 · see citing works
Hippocampal Volumes in Schizophrenic Twins
van Erp, T. G. M., Saleh, P. A., HUTTUNEN, M. O., Lönnqvist, J. K., Kaprio, J. A., Salonen, O. L. M., Valanne, L. K., Poutanen, V.-P., Standertskjöld-Nordenstam, C.-G., & Cannon, T. D. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.4.346 · Cited by 147 · see citing works
Clinical Features of Illness in Siblings With Schizophrenia or Schizoaffective Disorder
DeLisi, L. E. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800220057009 · Cited by 144 · see citing works
Automatic Segmentation of the Ventricular System from MR Images of the Human Brain
Schnack, H. G., Pol, H. E. H., Baaré, W. F. C., Viergever, M. A., & Kahn, R. S. (2001) · NeuroImage · doi:10.1006/nimg.2001.0800 · Cited by 118 · see citing works
Self-citation
Neuregulin 1 (8p12) and childhood-onset schizophrenia: susceptibility haplotypes for diagnosis and brain developmental trajectories
Addington, A. M., Gornick, M. C., Shaw, P., Seal, J., Gogtay, N., GREENSTEIN, D. K., CLASEN, L. S., Coffey, M., Gochman, P., Long, R. T. L., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001906 · Cited by 109 · see citing works
Automated Separation of Gray and White Matter from MR Images of the Human Brain
Schnack, H. G., Pol, H. E. H., Baaré, W. F. C., Staal, W., Viergever, M. A., & Kahn, R. S. (2001) · NeuroImage · doi:10.1006/nimg.2000.0669 · Cited by 100 · see citing works
Self-citation
Brain MRI abnormalities in schizophrenia: same genes or same environment?
Rijsdijk, F. V., van Haren, N. E. M., Picchioni, M., McDonald, C., Toulopoulou, T., Pol, H. E. H., Kahn, R. S., Murray, R. M., & Sham, P. C. (2005) · Psychological Medicine · doi:10.1017/s0033291705005167 · Cited by 94 · see citing works
Self-citation
Defining the course of brain structural change and plasticity in schizophrenia
DeLisi, L. E. (1999) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(99)00033-5 · Cited by 89 · see citing works
Stalking the Schizovirus
Torrey, Ε. F. (1988) · Schizophrenia Bulletin · doi:10.1093/schbul/14.2.223 · Cited by 62 · see citing works
Neurotoxicity, Neuroplasticity, and Magnetic Resonance Imaging Morphometry
Mathalon, D. H., Rapoport, J. L., Davis, K. L., & Krystal, J. H. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.846 · Cited by 51 · see citing works
Twin–singleton differences in brain structure using structural equation modelling
Pol, H. E. H., Posthuma, D., Baaré, W. F. C., de Geus, E. J. C., Schnack, H. G., van Haren, N. E. M., van Oel, C. J., Kahn, R. S., & Boomsma, D. I. (2002) · Brain · doi:10.1093/brain/awf035 · Cited by 50 · see citing works
Self-citation
Sulcal thickness as a vulnerability indicator for schizophrenia
Goghari, V. M., Rehm, K., Carter, C. S., & MacDonald, A. W. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.034595 · Cited by 43 · see citing works
Larger Brains in Medication Naive High-Functioning Subjects with Pervasive Developmental Disorder
Palmen, S. J. M. C., Pol, H. E. H., Kemner, C., Schnack, H. G., Janssen, J., KAHN, R. S., & van Engeland, H. (2004) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-004-5282-2 · Cited by 37 · see citing works
Self-citation
Twins With Schizophrenia: Genes or Germs?
Davis, J. O., & Phelps, J. A. (1995) · Schizophrenia Bulletin · doi:10.1093/schbul/21.1.13 · Cited by 35 · see citing works
A critical review of genetic studies of schizophrenia. I. Epidemiological and brain studies
Portin, P., & Alanen, Y. O. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb00365.x · Cited by 35 · see citing works
A Discordant Twin Study of Premorbid Cognitive Ability in Schizophrenia
Kremen, W. S., Lyons, M. J., Boake, C., Xian, H., Jacobson, K. C., Waterman, B. M., Eisen, S. A., Goldberg, J. H., Faraone, S. V., & Tsuang, M. T. (2006) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390500360414 · Cited by 28 · see citing works
Belastungen von Geschwistern schizophrener Patienten
Schmid, R., Schielein, T., Spießl, H., & Cording, C. (2006) · Psychiatrische Praxis · doi:10.1055/s-2005-866860 · Cited by 6 · see citing works
Progressive Brain Volume Changes and the Clinical Course of Schizophrenia in Men: A Longitudinal Magnetic Resonance Imaging Study
Mathalon, D. H., Sullivan, E. V., Lim, K. O., & Pfefferbaum, A. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.2.148

Flagged first, then by citations

Sorted by citations

The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway
Howes, O. D., & Kapur, S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp006 · Cited by 2,693 · see citing works
Schizophrenia
Kahn, R. S., Sommer, I. E., Murray, R. M., Meyer‐Lindenberg, A., Weinberger, D. R., Cannon, T. D., O’Donovan, M. C., Correll, C. U., Kane, J. M., van Os, J., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.67 · Cited by 1,132 · see citing works
Self-citation
The Diagnosis of Mental Disorders: The Problem of Reification
Hyman, S. E. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.3.022806.091532 · Cited by 1,052 · see citing works
Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies
Koolschijn, P. C. M. P., van Haren, N. E. M., Lensvelt‐Mulders, G. J. L. M., Hulshoff Pol, H. E., & Kahn, R. S. (2009) · Human Brain Mapping · doi:10.1002/hbm.20801 · Cited by 902 · see citing works
Self-citation
How Does Your Cortex Grow?
Raznahan, A., Shaw, P., Lalonde, F., Stockman, M., Wallace, G. L., Greenstein, D., Clasen, L., Gogtay, N., & Giedd, J. N. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0054-11.2011 · Cited by 712 · see citing works
Branching out: mechanisms of dendritic arborization
Jan, Y.-N., & Jan, L. Y. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2836 · Cited by 693 · see citing works
Are There Progressive Brain Changes in Schizophrenia? A Meta-Analysis of Structural Magnetic Resonance Imaging Studies
Olabi, B., Ellison-Wright, I., McIntosh, A. M., Wood, S. J., Bullmore, E. T., & Lawrie, S. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.032 · Cited by 485 · see citing works
Human brain changes across the life span: A review of 56 longitudinal magnetic resonance imaging studies
Hedman, A. M., van Haren, N. E. M., Schnack, H. G., Kahn, R. S., & Pol, H. E. H. (2011) · Human Brain Mapping · doi:10.1002/hbm.21334 · Cited by 485 · see citing works
Self-citation
Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies
Marsman, A., van den Heuvel, M. P., Klomp, D. W. J., Kahn, R. S., Luijten, P. R., & Hulshoff Pol, H. E. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr069 · Cited by 457 · see citing works
Self-citation
Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study
Schnack, H. G., van Haren, N. E. M., Nieuwenhuis, M., Pol, H. E. H., Cahn, W., & Kahn, R. S. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15070922 · Cited by 376 · see citing works
Self-citation
The Effect of Antipsychotic Treatment on Cortical Gray Matter Changes in Schizophrenia: Does the Class Matter? A Meta-analysis and Meta-regression of Longitudinal Magnetic Resonance Imaging Studies
Vita, A., Peri, L. M. D., Deste, G., Barlati, S., & Sacchetti, E. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.008 · Cited by 274 · see citing works
Integrating the Neurodevelopmental and Dopamine Hypotheses of Schizophrenia and the Role of Cortical Excitation-Inhibition Balance.
Howes, O., & Shatalina, E. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.06.017 · Cited by 233 · see citing works
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Brouwer, R. M., Klein, M., Grasby, K. L., Schnack, H. G., Jahanshad, N., Teeuw, J., Thomopoulos, S. I., Sprooten, E., Franz, C. E., Gogtay, N., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01042-4 · Cited by 227 · see citing works
Self-citation
Progressive lateral ventricular enlargement in schizophrenia: A meta-analysis of longitudinal MRI studies
Kempton, M. J., Stahl, D. R., Williams, S., & DeLisi, L. E. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.03.036 · Cited by 230 · see citing works
Genetic and Environmental Influences on Neuroimaging Phenotypes: A Meta-Analytical Perspective on Twin Imaging Studies
Blokland, G. A. M., de Zubicaray, G. I., McMahon, K. L., & Wright, M. J. (2012) · Twin Research and Human Genetics · doi:10.1017/thg.2012.11 · Cited by 221 · see citing works
Mean diffusivity and fractional anisotropy as indicators of disease and genetic liability to schizophrenia
Clark, K. A., Nuechterlein, K. H., Asarnow, R. F., Hamilton, L. S., Phillips, O. R., Hageman, N. S., Woods, R. P., Alger, J. R., Toga, A. W., & Narr, K. L. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.006 · Cited by 149 · see citing works
Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders
Ayhan, Y., Abazyan, B., Nomura, J., Kim, R., Ladenheim, B., Krasnova, I. N., Sawa, A., Margolis, R. L., Cadet, J. L., Mori, S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2009.144 · Cited by 148 · see citing works
Exercise therapy, cardiorespiratory fitness and their effect on brain volumes: a randomised controlled trial in patients with schizophrenia and healthy controls.
Scheewe, T. W., van Haren, N. E. M., Sarkisyan, G., Schnack, H. G., Brouwer, R. M., de Glint, M., Hulshoff Pol, H. E., Backx, F. J. G., Kahn, R. S., & Cahn, W. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.08.008 · Cited by 148 · see citing works
Self-citation
Genetic control of functional brain network efficiency in children
van den Heuvel, M. P., van Soelen, I. L. C., Stam, C. J., Kahn, R. S., Boomsma, D. I., & Hulshoff Pol, H. E. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.06.007 · Cited by 127 · see citing works
Self-citation
Overlapping and Segregating Structural Brain Abnormalities in Twins With Schizophrenia or Bipolar Disorder
van Baal, G. C. M. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1615 · Cited by 121 · see citing works
Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls.
Svatkova, A., Mandl, R. C. W., Scheewe, T. W., Cahn, W., Kahn, R. S., & Hulshoff Pol, H. E. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv033 · Cited by 120 · see citing works
Self-citation
The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia
Lett, T. A. P., Chakavarty, M. M., Felsky, D., Brandl, E. J., Tiwari, A. K., Gonçalves, V. F., Rajji, T. K., Daskalakis, Z. J., Meltzer, H. Y., Lieberman, J. A., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.17 · Cited by 119 · see citing works
Brain Plasticity and Intellectual Ability Are Influenced by Shared Genes
Brans, R. G. H., Kahn, R. S., Schnack, H. G., van Baal, G. C. M., Posthuma, D., van Haren, N. E. M., Lepage, C., Lerch, J. P., Collins, D. L., Evans, A. C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5841-09.2010 · Cited by 109 · see citing works
Self-citation
Motor dysfunction within the schizophrenia-spectrum: A dimensional step towards an underappreciated domain
Hirjak, D., Thomann, P. A., Kubera, K. M., Wolf, N. D., Sambataro, F., & Wolf, R. C. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.10.022 · Cited by 102 · see citing works
Reduced Frontal Glutamate + Glutamine and N-Acetylaspartate Levels in Patients With Chronic Schizophrenia but not in Those at Clinical High Risk for Psychosis or With First-Episode Schizophrenia
Natsubori, T., Inoue, H., Abe, O., Takano, Y., Iwashiro, N., Aoki, Y. Y., Koike, S., Yahata, N., Katsura, M., Gonoi, W., et al. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt124 · Cited by 100 · see citing works
Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease
Flint, J., Timpson, N. J., & Munafo, M. R. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.007 · Cited by 93 · see citing works
Brain Imaging During the Transition from Psychosis Prodrome to Schizophrenia
Chung, Y., & Cannon, T. D. (2015) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000286 · Cited by 92 · see citing works
Decreased left middle temporal gyrus volume in antipsychotic drug-naive, first-episode schizophrenia patients and their healthy unaffected siblings
Hu, M., Li, J., Eyler, L. T., Guo, X., Wei, Q., Tang, J., Liu, F., He, Z., Li, L., Jin, H., et al. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.12.018 · Cited by 87 · see citing works
Regional Gray Matter Volume in Monozygotic Twins Concordant and Discordant for Schizophrenia
Borgwardt, S., Picchioni, M., Ettinger, U., Toulopoulou, T., Murray, R. M., & McGuire, P. K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.026 · Cited by 84 · see citing works
7T Proton Magnetic Resonance Spectroscopy of Gamma-Aminobutyric Acid, Glutamate, and Glutamine Reveals Altered Concentrations in Patients With Schizophrenia and Healthy Siblings
Thakkar, K. N., Rösler, L., Wijnen, J. P., Boer, V. O., Klomp, D. W. J., Cahn, W., Kahn, R. S., & Neggers, S. F. W. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.04.007 · Cited by 82 · see citing works
Self-citation
Spontaneous neural activity in the right superior temporal gyrus and left middle temporal gyrus is associated with insight level in obsessive-compulsive disorder
Fan, J., Zhong, M., Gan, J., Liu, W., Niu, C., Liao, H., Zhang, H., Tan, C., Yi, J., & Zhu, X. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.08.027 · Cited by 82 · see citing works
Schizophrenia: From the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers
Stöber, G., Ben-Shachar, D., Cardon, M., Falkai, P., Fonteh, A., Gawlik, M., Glenthøj, B., Grünblatt, E., Jablensky, A., Kim, Y.-K., et al. (2009) · World Journal of Biological Psychiatry · doi:10.1080/15622970902898980 · Cited by 83 · see citing works
Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group
Brouwer, R. M., Panizzon, M. S., Glahn, D. C., Hibar, D. P., Hua, X., Jahanshad, N., Abramovic, L., de Zubicaray, G. I., Franz, C. E., Hansell, N. K., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23672 · Cited by 69 · see citing works
Self-citation
Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia
Lee, P. H., Baker, J. T., Holmes, A. J., Jahanshad, N., Ge, T., Jung, J. Y., Cruz, Y., Manoach, D. S., Hibar, D. P., Faskowitz, J., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.164 · Cited by 71 · see citing works
Tract-based diffusion tensor imaging in patients with schizophrenia and their non-psychotic siblings
Boos, H. B. M., Mandl, R. C. W., van Haren, N. E. M., Cahn, W., van Baal, G. C. M., Kahn, R. S., & Pol, H. E. H. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.015 · Cited by 72 · see citing works
Self-citation
Cortical thickness as a contributor to abnormal oscillations in schizophrenia?
Edgar, J. C., Chen, Y.-H., Lanza, M. R., Howell, B. C., Chow, V. Y., Heiken, K. F., Liu, S., Wootton, C., Hunter, M. A., Huang, M., et al. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.11.004 · Cited by 69 · see citing works
A family affair: brain abnormalities in siblings of patients with schizophrenia
Moran, M., Pol, H. E. H., & Gogtay, N. (2013) · Brain · doi:10.1093/brain/awt116 · Cited by 68 · see citing works
Self-citation
Basing psychiatric classification on scientific foundation: Problems and prospects
Uher, R., & Rutter, M. L. (2012) · International Review of Psychiatry · doi:10.3109/09540261.2012.721346 · Cited by 67 · see citing works
The neuroanatomy of psychotic diathesis: A meta-analytic review
Palaniyappan, L. K., Balain, V., & Liddle, P. F. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.06.007 · Cited by 64 · see citing works
Structural Brain Connectivity as a Genetic Marker for Schizophrenia
Bohlken, M. M., Brouwer, R. M., Mandl, R. C. W., van den Heuvel, M. P., Hedman, A. M., Binder, M. D., Cahn, W., Kahn, R. S., & Pol, H. E. H. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.1925 · Cited by 63 · see citing works
Self-citation
Impact of Polygenic Risk for Schizophrenia on Cortical Structure in UK Biobank
Neilson, E., Shen, X., Cox, S. R., Clarke, T., Wigmore, E. M., Gibson, J., Howard, D. M., Adams, M. J., Harris, M. A., Davies, G., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.013 · Cited by 62 · see citing works
Focal And Global Brain Measurements in Siblings of Patients With Schizophrenia
Boos, H. B. M., Cahn, W., van Haren, N. E. M., Derks, E. M., Brouwer, R. M., Schnack, H. G., Pol, H. E. H., & Kahn, R. S. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq147 · Cited by 59 · see citing works
Self-citation
Glutamatergic and Neuronal Dysfunction in Gray and White Matter: A Spectroscopic Imaging Study in a Large Schizophrenia Sample
Bustillo, J., Jones, T., Chen, H., Lemke, N. T., Abbott, C., Qualls, C., Stromberg, S. F., Cañive, J. M., & Gasparovic, C. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw122 · Cited by 58 · see citing works
Genetic and Environmental Influences on Pro-Inflammatory Monocytes in Bipolar Disorder
Padmos, R. C., van Baal, G. C. M., Vonk, R., Wijkhuijs, A. J. M., Kahn, R. S., Nolen, W. A., & Drexhage, H. A. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.116 · Cited by 55 · see citing works
Self-citation
Age-related brain trajectories in schizophrenia: A systematic review of structural MRI studies
Chiapponi, C., Piras, F., Fagioli, S., Piras, F., Caltagirone, C., & Spalletta, G. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.05.003 · Cited by 52 · see citing works
Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls
Raznahan, A., GREENSTEIN, D. K., Lee, Y., Long, R., CLASEN, L. S., Gochman, P., Addington, A. M., Giedd, J. N., Rapoport, J. L., & Gogtay, N. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.05.032 · Cited by 50 · see citing works
Guided exploration of genomic risk for gray matter abnormalities in schizophrenia using parallel independent component analysis with reference
Chen, J., Calhoun, V. D., Pearlson, G. D., Perrone‐Bizzozero, N. I., Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., Turner, J. A., Bustillo, J., Ehrlich, S., Sponheim, S. R., Cañive, J. M., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.073 · Cited by 51 · see citing works
Forty years of structural imaging in psychosis: promises and truth
Fusar‐Poli, P., & Meyer‐Lindenberg, A. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12619 · Cited by 50 · see citing works
Heritability of brain volume change and its relation to intelligence
Brouwer, R. M., Hedman, A. M., van Haren, N. E. M., Schnack, H. G., Brans, R. G. H., Smit, D. J. A., Kahn, R. S., Boomsma, D. I., & Pol, H. E. H. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.04.072 · Cited by 46 · see citing works
Self-citation
Disrupted asymmetry of inter- and intra-hemispheric functional connectivity in patients with drug-naive, first-episode schizophrenia and their unaffected siblings
Zhu, F., Liu, F., Guo, W., Chen, J., Su, Q., Zhang, Z., Li, H., Fan, X., & Zhao, J. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.012 · Cited by 48 · see citing works
Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism and Risk of Schizophrenia: A Meta-analysis of Case–Control Studies
Kheirollahi, M., Kazemi, E., & Ashouri, S. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0229-z · Cited by 48 · see citing works
Heritability of Subcortical and Limbic Brain Volume and Shape in Multiplex-Multigenerational Families with Schizophrenia
Roalf, D. R., Vandekar, S., Almasy, L. A., Ruparel, K., Satterthwaite, T. D., Elliott, M. A., Podell, J. E., Gallagher, S., Jackson, C. T., Prasad, K. M. R., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.009 · Cited by 45 · see citing works
Effects of brain‐derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia
Koolschijn, P. C. M. P., van Haren, N. E. M., Bakker, S. C., Hoogendoorn, M. L. C., Pol, H. E. H., & Kahn, R. S. (2009) · Hippocampus · doi:10.1002/hipo.20699 · Cited by 46 · see citing works
Self-citation
A longitudinal study of cortical changes and their cognitive correlates in patients followed up after first-episode psychosis
Gutiérrez-Galve, L., Chu, E. M.-Y., Leeson, V. C., Price, G. W., Barnes, T. R. E., Joyce, E. M., & Ron, M. A. (2014) · Psychological Medicine · doi:10.1017/s0033291714001433 · Cited by 46 · see citing works
Familial abnormalities of endocannabinoid signaling in schizophrenia
Koethe, D., Pahlisch, F., Hellmich, M., Rohleder, C., Mueller, J. K., Meyer‐Lindenberg, A., Torrey, E. F., Piomelli, D., & Leweke, F. M. (2018) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2018.1449966 · Cited by 46 · see citing works
Gene X Environment Interactions in Schizophrenia and Bipolar Disorder: Evidence from Neuroimaging
Geoffroy, P. A., Étain, B., & Houenou, J. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00136 · Cited by 46 · see citing works
Heritability of volumetric brain changes and height in children entering puberty
van Soelen, I. L. C., Brouwer, R. M., van Baal, G. C. M., Schnack, H. G., Peper, J. S., Chen, L., Kahn, R. S., Boomsma, D. I., & Pol, H. E. H. (2011) · Human Brain Mapping · doi:10.1002/hbm.21468 · Cited by 43 · see citing works
Self-citation
Neurodegeneration in schizophrenia
Archer, T. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.152 · Cited by 41 · see citing works
Progressive structural brain changes in schizophrenia
Puri, B. K. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.142 · Cited by 40 · see citing works
Genetic underpinnings of white matter ‘connectivity’: Heritability, risk, and heterogeneity in schizophrenia
Voineskos, A. N. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.034 · Cited by 39 · see citing works
Brain Biomarkers of Vulnerability and Progression to Psychosis.
Cannon, T. D. (2016) · Schizophrenia bulletin · doi:10.1093/schbul/sbv173 · Cited by 36 · see citing works
A Prospective Longitudinal Investigation of Cortical Thickness and Gyrification in Schizophrenia
Nelson, E. A., Kraguljac, N. V., White, D. M., Jindal, R. D., Shin, A. L., & Lahti, A. C. (2020) · The Canadian Journal of Psychiatry · doi:10.1177/0706743720904598 · Cited by 38 · see citing works
The course of brain abnormalities in schizophrenia: can we slow the progression?
van Haren, N. E. M., Cahn, W., Pol, H. E. H., & Kahn, R. S. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111408964 · Cited by 36 · see citing works
Self-citation
Heritability of Structural Brain Traits
Kaymaz, N., & van Os, J. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)89005-3 · Cited by 35 · see citing works
Disturbed grey matter coupling in schizophrenia
Collin, G., de Reus, M. A., Cahn, W., Pol, H. E. H., Kahn, R. S., & van den Heuvel, M. P. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.09.001 · Cited by 35 · see citing works
Self-citation
Delayed White Matter Growth Trajectory in Young Nonpsychotic Siblings of Patients With Childhood-Onset Schizophrenia
Gogtay, N., Hua, X., Stidd, R., Boyle, C. P., Lee, S., Weisinger, B., Chavez, A. M., Giedd, J. N., CLASEN, L. S., Toga, A. W., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2084 · Cited by 33 · see citing works
Heritability of cortical thickness changes over time in twin pairs discordant for schizophrenia
Hedman, A. M., van Haren, N. E. M., van Baal, G. C. M., Brouwer, R. M., Brans, R. G. H., Schnack, H. G., Kahn, R. S., & Pol, H. E. H. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.06.021 · Cited by 33 · see citing works
Self-citation
Workshop on defining the significance of progressive brain change in schizophrenia: December 12, 2008 American College of Neuropsychopharmacology (ACNP) all-day satellite, Scottsdale, Arizona
Borgwardt, S., Dickey, C. C., Pol, H. E. H., Whitford, T. J., & DeLisi, L. E. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.04.025 · Cited by 32 · see citing works
Self-citation
Prefrontal deviations in function but not volume are putative endophenotypes for schizophrenia
Owens, S. F., Picchioni, M., Ettinger, U., McDonald, C., Walshe, M., Schmechtig, A., Murray, R. M., Rijsdijk, F. V., & Toulopoulou, T. (2012) · Brain · doi:10.1093/brain/aws138 · Cited by 31 · see citing works
A Geographic Cline of Skull and Brain Morphology among Individuals of European Ancestry
Bakken, T. E., Dale, A. M., Schork, N. J., & Initiative, A. D. N. (2011) · Human Heredity · doi:10.1159/000330168 · Cited by 29 · see citing works
Trajectories of subcortical volume change in schizophrenia: A 5-year follow-up
van Haren, N. E. M., Schnack, H. G., Koevoets, M., Cahn, W., Pol, H. E. H., & Kahn, R. S. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.09.027 · Cited by 28 · see citing works
Self-citation
The genetic architecture of psychophysiological phenotypes
Munafo, M. R., & Jonathan Flint, C. (2014) · Psychophysiology · doi:10.1111/psyp.12355 · Cited by 26 · see citing works
Child and Adolescent Schizophrenia
Hollis, C. P., & Rapoport, J. L. (2010) · doi:10.1002/9781444327298.ch3 · Cited by 26 · see citing works
The heritability of brain metabolites on proton magnetic resonance spectroscopy in older individuals
Batouli, S. A. H., Sachdev, P. S., Wen, W. X., Wright, M. J., Suo, C., Ames, D. J., & Trollor, J. N. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.043 · Cited by 25 · see citing works
Are structural brain changes in schizophrenia related to antipsychotic medication? A narrative review of the evidence from a clinical perspective
Lawrie, S. M. (2018) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125318782306 · Cited by 24 · see citing works
G72 influences longitudinal change in frontal lobe volume in schizophrenia
Hartz, S. M., Ho, B., Andreasen, N. C., Librant, A. L., Rudd, D. S., Epping, E. A., & Wassink, T. H. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31033 · Cited by 23 · see citing works
Twin studies of brain structure and cognition in schizophrenia
Besteher, B., Brambilla, P., & Nenadić, I. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.021 · Cited by 23 · see citing works
Gyrification Connectomes in Unmedicated Patients With Schizophrenia and Following a Short Course of Antipsychotic Drug Treatment
Nelson, E. A., White, D. M., Kraguljac, N. V., & Lahti, A. C. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00699 · Cited by 21 · see citing works
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia
Palha, J. A., Santos, N. C., Marques, F., Sousa, J. C., Bessa, J. M., Miguelote, R. F. O., Sousa, N., & Belmonte-de-Abreu, P. S. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00031 · Cited by 21 · see citing works
Translational Neuroscience of Schizophrenia: Seeking a Meeting of Minds Between Mouse and Man
Kas, M. J., Kahn, R. S., Collier, D. A., Waddington, J. L., Ekelund, J., Porteous, D. J., Schughart, K., & Hovatta, I. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002917 · Cited by 20 · see citing works
Self-citation
Familial and environmental influences on brain volumes in twins with schizophrenia
Picchioni, M., Rijsdijk, F. V., Toulopoulou, T., Chaddock, C., Cole, J. H., Ettinger, U., Oses, A., Metcalfe, H., Murray, R. M., & McGuire, P. K. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140277 · Cited by 17 · see citing works
Polygenic risk scores and brain structures both contribute to externalizing behavior in childhood - A study in the Adolescent Brain and Cognitive Development (ABCD) cohort
Teeuw, J., Mota, N. R., Klein, M., Blankenstein, N. E., Tielbeek, J. J., Jansen, L. M. C., Franke, B., & Pol, H. E. H. (2023) · Neuroscience Applied · doi:10.1016/j.nsa.2023.101128 · Cited by 15 · see citing works
Self-citation
Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review
Jameei, H., Rakesh, D., Zalesky, A., Cairns, M. J., Reay, W. R., Wray, N. R., & Biase, M. A. D. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad087 · Cited by 15 · see citing works
Disease and genetic contributions toward local tissue volume disturbances in schizophrenia: A tensor‐based morphometry study
Yang, Y., Nuechterlein, K. H., Phillips, O. R., Gutman, B. A., Kurth, F., Dinov, I. D., Thompson, P. M., Asarnow, R. F., Toga, A. W., & Narr, K. L. (2011) · Human Brain Mapping · doi:10.1002/hbm.21349 · Cited by 15 · see citing works
Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder
Bootsman, F., Brouwer, R. M., Kemner, S. M., Schnack, H. G., van der Schot, A. C., Vonk, R., Hillegers, M. H. J., Boomsma, D. I., Pol, H. E. H., Nolen, W. A., et al. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.023 · Cited by 13 · see citing works
Self-citation
Genetic and environmental influences on structural brain development from childhood to adolescence: A longitudinal twin study on cortical thickness, surface area, and subcortical volume
van Drunen, L., Dobbelaar, S., Crone, E. A., & Wierenga, L. M. (2024) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2024.101407 · Cited by 14 · see citing works
Neurodevelopmental Trajectories, Disconnection, and Schizophrenia Risk
Keshavan, M. S., & Paus, T. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.1119 · Cited by 12 · see citing works
Dynamics of Brain Structure and its Genetic Architecture over the Lifespan
Brouwer, R. M., Klein, M., Grasby, K. L., Schnack, H. G., Jahanshad, N., Teeuw, J., Thomopoulos, S. I., Sprooten, E., Franz, C. E., Gogtay, N., et al. (2020) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.5658141 · Cited by 9 · see citing works
Self-citation
An integrative gene network-based approach to uncover the cellular and molecular infrastructures of schizophrenia
Bozorgmehr, A., Sadeghi, B., Zavari, E. S. T., Bahrami, E., Zamani, F., & Shahbazi, A. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118345 · Cited by 10 · see citing works
Is there change in intelligence quotient in chronically ill schizophrenia patients? A longitudinal study in twins discordant for schizophrenia
Hedman, A. M., van Haren, N. E. M., van Baal, G. C. M., Brans, R. G. H., Hijman, R., Kahn, R. S., & Pol, H. E. H. (2012) · Psychological Medicine · doi:10.1017/s0033291712000694 · Cited by 11 · see citing works
Self-citation
Neuropsychological and Structural Neuroimaging Endophenotypes in Schizophrenia
Stone, W. S., & Seidman, L. J. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy224 · Cited by 12 · see citing works
Dynamics of Brain Structure and its Genetic Architecture over the LifespanPreprint
Brouwer, R., Klein, M., Grasby, K., Schnack, H., Jahanshad, N., Teeuw, J., Thomopoulos, S., Sprooten, E., Franz, C., Gogtay, N., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.24.031138 · Cited by 17 · see citing works
Self-citation
Multivariate Genetic Structure of Externalizing Behavior and Structural Brain Development in a Longitudinal Adolescent Twin Sample
Teeuw, J., Klein, M., Mota, N. R., Brouwer, R. M., Ent, D. V. ‘., Al-Hassaan, Z., Franke, B., Boomsma, D. I., & Pol, H. E. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063176 · Cited by 8 · see citing works
Self-citation
Convergent and divergent gray matter volume abnormalities in unaffected first-degree relatives and ultra-high risk individuals of schizophrenia
Lin, B., Li, X., Ruan, S., Wu, Y.-X., Zhang, C., Wang, C., & Wang, L.-B. (2022) · Schizophrenia · doi:10.1038/s41537-022-00261-9 · Cited by 9 · see citing works
The 3rd Schizophrenia International Research Society Conference, 14–18 April 2012, Florence, Italy: Summaries of oral sessions
Abbs, B., Achalia, R. M., Adelufosi, A. O., Aktener, A. Y., Beveridge, N. J., Bhakta, S. G., Blackman, R. K., Bora, E., Byun, M. S., Cabanis, M., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.07.024 · Cited by 8 · see citing works
Functional, structural, and molecular imaging of the risk for anxiety and depression
Wolfensberger, S. P. A. (2011) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) · Cited by 9 · see citing works
Family-wise automatic classification in schizophrenia
Mandl, R. C. W., Brouwer, R. M., Cahn, W., Kahn, R. S., & Pol, H. E. H. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.002 · Cited by 8 · see citing works
Self-citation
Morphological changes in gray matter volume correlate with catechol-O-methyl transferase gene Val158Met polymorphism in first-episode treatment-naïve patients with schizophrenia
Li, M., Xiang, B., Li, Y.-F., Hu, X., Wang, Q., Guo, W., Lei, W., Huang, C., Zhao, L., Li, N., et al. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-014-1491-7 · Cited by 7 · see citing works
The association between hippocampal volume and life events in healthy twins
Bootsman, F., Kemner, S. M., Hillegers, M. H. J., Brouwer, R. M., Vonk, R., van der Schot, A. C., Pol, H. E. H., Nolen, W. A., Kahn, R. S., & van Haren, N. E. M. (2016) · Hippocampus · doi:10.1002/hipo.22589 · Cited by 8 · see citing works
Self-citation
Effects of a neurodevelopmental genes based polygenic risk score for schizophrenia and single gene variants on brain structure in non-clinical subjects: A preliminary report
Spalthoff, R., Degenhardt, F., Awasthi, S., Heilmann‐Heimbach, S., Besteher, B., Christian Gaser, B., Ripke, S., Nöthen, M. M., & Nenadić, I. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.07.061 · Cited by 7 · see citing works

S34-02 - Heritability of Cortical Thickness Change Over Time in Schizophrenia Patients and Their Discordant Co-Twins
van Haren, N. E. M., Brans, R. G. H., van Baal, C. G. C. M., Schnack, H. G., Kahn, R. S., & Pol, H. E. H. (2010) · European Psychiatry · doi:10.1016/s0924-9338(10)70096-1
Self-citation
Schizophrenia as a progressive brain disease
van Haren, N. E. M., Cahn, W., Pol, H. E. H., & Kahn, R. S. (2008) · European Psychiatry · doi:10.1016/j.eurpsy.2007.10.013 · Cited by 88 · see citing works
Self-citation
The Genetic and Environmental Determinants of the Association Between Brain Abnormalities and Schizophrenia: The Schizophrenia Twins and Relatives Consortium
van Haren, N. E. M., Rijsdijk, F. V., Schnack, H. G., Picchioni, M., Toulopoulou, T., Weisbrod, M., Sauer, H., van Erp, T. G., Cannon, T. D., HUTTUNEN, M. O., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.010 · Cited by 59 · see citing works
Self-citation
Brain MRI abnormalities in schizophrenia: same genes or same environment?
Rijsdijk, F. V., van Haren, N. E. M., Picchioni, M., McDonald, C., Toulopoulou, T., Pol, H. E. H., Kahn, R. S., Murray, R. M., & Sham, P. C. (2005) · Psychological Medicine · doi:10.1017/s0033291705005167 · Cited by 94 · see citing works
Self-citation
A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia
van Haren, N. E. M., Picchioni, M., McDonald, C., Marshall, N., Davis, N., Ribchester, T., Pol, H. E. H., Sharma, T., Sham, P. C., Kahn, R. S., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.033 · Cited by 87 · see citing works
Self-citation

Authors: Brans, R. G. H., van Haren, N. E. M., van Baal, G. C. M., Schnack, H. G., Kahn, R. S., & Pol, H. E. H.
Affiliations: University Medical Center Utrecht (NL)
ORCID: Schnack, Hugo G.
Kahn, René S.
Pol, Hilleke E. Hulshoff
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2008-11-03
Volume: 65
Issue: 11
Pages: 1259
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.65.11.1259
OpenAlex: W2124863104
Cited by: 129
References: 66
Citations by year: 2025: 1 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 11 · 2015: 14 · 2014: 7 · 2013: 11 · 2012: 18
FWCI: 8.41
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, brain volume changes, heritability, monozygotic twins, dizygotic twins, discordant twins, gray matter, white matter, frontal lobe, temporal lobe, cerebellum, ventricles, genetic susceptibility, environmental factors, structural brain abnormalities
MeSH terms: Adjustment Disorders, Adult, Brain, Marijuana Abuse, Cerebellum, Cerebral Cortex, Major Depressive Disorder, Diseases in Twins, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Phenotype, Psychotic Disorders, Reference Values, Schizophrenia, Schizotypal Personality Disorder, Twins, Dizygotic, Twins, Monozygotic, Cohort Studies, Comorbidity, Conduct Disorder, Genetic Predisposition to Disease, Third Ventricle, Lateral Ventricles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Heritability of Changes in Brain Volume Over Time in Twin Pairs Discordant for Schizophrenia

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks