The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Salience processing and insular cortical function and dysfunction
Abstract
The brain is constantly bombarded by stimuli, and the relative salience of these inputs determines which are more likely to capture attention. A brain system known as the 'salience network', with key nodes in the insular cortices, has a central role in the detection of behaviourally relevant stimuli and the coordination of neural resources. Emerging evidence suggests that atypical engagement of specific subdivisions of the insula within the salience network is a feature of many neuropsychiatric disorders.
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In the citing paper
“The CEN, anchored in the dorsolateral prefrontal cortex (dlPFC) and posterior parietal cortices (PPC), is associated with executive functioning [36–42].”
In the citing paper
“Cognitive flexibility is difficult to isolate, as it requires the confluence of several aspects of executive function20,28.”
From Cognitive and behavioural flexibility: Neural mechanisms and clinical considerations (2021) · cites this paper as [28]
In the citing paper
“the dorsal anterior insula (dAI), which detects behaviorally-relevant stimuli and coordinates dynamic switches between brain networks (29).”
From Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder (2021) · cites this paper as [29]
In the citing paper
“and the dorsal AI in salience processing (Menon, 2015; Uddin, 2015)”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Uddin, 2015
In the citing paper
“As a core hub of the salience network (Menon, 2015; Uddin, 2015)”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Uddin, 2015
In the citing paper
“Given the role of the ventral AI in emotional processing (Nieuwenhuys, 2012; Uddin, 2015; Wager and Barrett, 2017)”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Uddin, 2015
Citations
Cites
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Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Saliency, switching, attention and control: a network model of insula function
Menon, V., & Uddin, L. Q. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0262-0 · Cited by 5,592
Self-citationFunctional Network Organization of the Human Brain
Power, J. D., Cohen, A. L., Nelson, S. M., Wig, G. S., Barnes, K. A., Church, J. A., Vogel, A. C., Laumann, T. O., Miezin, F. M., Schlaggar, B. L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.006 · Cited by 4,124
The reorienting system of the human brain: from environment to theory of mind
Corbetta, M., Patel, G., & Shulman, G. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.017 · Cited by 3,889
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Yarkoni, T., Poldrack, R. A., Nichols, T. E., Van Essen, D. C., & Wager, T. D. (2011) · Nature Methods · doi:10.1038/nmeth.1635 · Cited by 3,686
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406
Sridharan, D., Levitin, D. J., & Menon, V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800005105 · Cited by 2,892
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Research works printed but not linked: 1
- Ryali, S., Chen, T., Supekar, K. & Menon, V. A parcellation scheme based on von Mises-Fisher distributions and Markov random fields for segmenting brain regions using resting-state fMRI. Neuroimage 65, 83–96 (2013). · DOI
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Neural correlates of cognitive control deficits in pediatric mild traumatic brain injury
van der Horn, H. J., Dodd, A. B., Wick, T. V., Robertson‐Benta, C. R., McQuaid, J. R., Hittson, A. K., Ling, J. M., Zotev, V. S., Ryman, S. G., Erhardt, E. B., et al. (2023) · Human Brain Mapping · doi:10.1002/hbm.26504 · Cited by 14
The Cognitive Neuroscience of Psychological Treatment Action in Depression and Anxiety
Young, K. S., & Craske, M. G. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0137-x · Cited by 13
Perez, T. M., Glue, P., Adhia, D. B., Navid, M. S., Zeng, J., Dillingham, P., Smith, M., Niazi, I. K., Young, C. K., & De Ridder, D. (2022) · Trials · doi:10.1186/s13063-022-06863-z · Cited by 8
Neuroimaging oxytocin modulation of social reward learning in schizophrenia
Mouchlianitis, E. D., Tracy, D. K., Wigton, R., Vanes, L. D., Fett, A.-K., & Shergill, S. S. (2022) · BJPsych Open · doi:10.1192/bjo.2022.577 · Cited by 8
Association of brain network dynamics with plasma biomarkers in subjective memory complainers
Chiesa, P. A., Houot, M., Vergallo, A., Cavedo, E., Lista, S., Potier, M. C., Zetterberg, H., Blennow, K., Vanmechelen, E., De Vos, A., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.12.017 · Cited by 7
Neural Representation of Valenced and Generic Probability and Uncertainty
Kim, J.-C., Hellrung, L., Grueschow, M., Nebe, S., Nagy, Z., & Tobler, P. N. (2024) · The Journal of Neuroscience · doi:10.1523/jneurosci.0195-24.2024 · Cited by 5
Vaisvaser, S. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1726099 · Cited by 4
Metadata
- Authors
- Uddin, L. Q.
- Affiliations
- University of Miami (US)
- Corresponding author
- Uddin, Lucina Q.
- ORCID
- Uddin, Lucina Q.
- Venue
- Nature Reviews Neuroscience
- Published
- 2014-11-19
- Volume
- 16
- Issue
- 1
- Pages
- 55-61
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2072799373
- Cited by
- 2,083
- References
- 128
- Citations by year
- 2026: 174 · 2025: 202 · 2024: 214 · 2023: 192 · 2022: 226 · 2021: 228 · 2020: 192 · 2019: 181 · 2018: 169 · 2017: 134 · 2016: 110 · 2015: 58 · 2014: 1
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K01MH092288)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- insula, salience processing, salience network, attention, neuropsychiatric disorders, stimulus detection
- MeSH terms
- Mental Disorders, Brain Mapping, Cerebral Cortex, Humans, Nerve Net, Neural Pathways
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