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Salience processing and insular cortical function and dysfunction

Uddin, Lucina Q.·2015·Nature Reviews Neuroscience

DOI 10.1038/nrn3857

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Abstract

The brain is constantly bombarded by stimuli, and the relative salience of these inputs determines which are more likely to capture attention. A brain system known as the 'salience network', with key nodes in the insular cortices, has a central role in the detection of behaviourally relevant stimuli and the coordination of neural resources. Emerging evidence suggests that atypical engagement of specific subdivisions of the insula within the salience network is a feature of many neuropsychiatric disorders.

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Ryali, S., Chen, T., Supekar, K. & Menon, V. A parcellation scheme based on von Mises-Fisher distributions and Markov random fields for segmenting brain regions using resting-state fMRI. Neuroimage 65, 83–96 (2013). · DOI

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Authors: Uddin, L. Q.
Affiliations: University of Miami (US)
Corresponding author: Uddin, Lucina Q.
ORCID: Uddin, Lucina Q.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2014-11-19
Volume: 16
Issue: 1
Pages: 55-61
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3857
OpenAlex: W2072799373
Cited by: 2,083
References: 128
Citations by year: 2026: 174 · 2025: 202 · 2024: 214 · 2023: 192 · 2022: 226 · 2021: 228 · 2020: 192 · 2019: 181 · 2018: 169 · 2017: 134 · 2016: 110 · 2015: 58 · 2014: 1
FWCI: 9.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (K01MH092288)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords: insula, salience processing, salience network, attention, neuropsychiatric disorders, stimulus detection
MeSH terms: Mental Disorders, Brain Mapping, Cerebral Cortex, Humans, Nerve Net, Neural Pathways

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Salience processing and insular cortical function and dysfunction

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