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Salience processing and insular cortical function and dysfunction
Abstract
The brain is constantly bombarded by stimuli, and the relative salience of these inputs determines which are more likely to capture attention. A brain system known as the 'salience network', with key nodes in the insular cortices, has a central role in the detection of behaviourally relevant stimuli and the coordination of neural resources. Emerging evidence suggests that atypical engagement of specific subdivisions of the insula within the salience network is a feature of many neuropsychiatric disorders.
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“The CEN, anchored in the dorsolateral prefrontal cortex (dlPFC) and posterior parietal cortices (PPC), is associated with executive functioning [36–42].”
In the citing paper
“Cognitive flexibility is difficult to isolate, as it requires the confluence of several aspects of executive function20,28.”
From Cognitive and behavioural flexibility: Neural mechanisms and clinical considerations (2021) · cites this paper as [28]
In the citing paper
“the dorsal anterior insula (dAI), which detects behaviorally-relevant stimuli and coordinates dynamic switches between brain networks (29).”
From Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder (2021) · cites this paper as [29]
In the citing paper
“and the dorsal AI in salience processing (Menon, 2015; Uddin, 2015)”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Uddin, 2015
In the citing paper
“As a core hub of the salience network (Menon, 2015; Uddin, 2015)”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Uddin, 2015
In the citing paper
“Given the role of the ventral AI in emotional processing (Nieuwenhuys, 2012; Uddin, 2015; Wager and Barrett, 2017)”
From Oxytocin facilitates approach behavior to positive social stimuli via decreasing anterior insula activity (2018) · cites this paper as Uddin, 2015
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Metadata
- Authors
- Uddin, L. Q.
- Affiliations
- University of Miami (US)
- Corresponding author
- Uddin, Lucina Q.
- ORCID
- Uddin, Lucina Q.
- Venue
- Nature Reviews Neuroscience
- Published
- 2014-11-19
- Volume
- 16
- Issue
- 1
- Pages
- 55-61
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2072799373
- Cited by
- 2,083
- References
- 128
- Citations by year
- 2026: 174 · 2025: 202 · 2024: 214 · 2023: 192 · 2022: 226 · 2021: 228 · 2020: 192 · 2019: 181 · 2018: 169 · 2017: 134 · 2016: 110 · 2015: 58 · 2014: 1
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K01MH092288)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- insula, salience processing, salience network, attention, neuropsychiatric disorders, stimulus detection
- MeSH terms
- Mental Disorders, Brain Mapping, Cerebral Cortex, Humans, Nerve Net, Neural Pathways
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