The epidemiology of ALS: a conspiracy of genes, environment and time

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Neumann, M., Sampathu, D. M., Kwong, L. K., Truax, A. C., Micsenyi, M. C., Chou, T. T., Bruce, J., Schuck, T., Grossman, M., Clark, C. M., et al. (2006) · Science · doi:10.1126/science.1134108 · Cited by 6,576

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

Andersen, P. M., & Al-Chalabi, A. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.150 · Cited by 687

Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players

Chio, A. (2005) · Brain · doi:10.1093/brain/awh373 · Cited by 484

p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS

Al-Sarraj, S., King, A., Troakes, C., Smith, B., Maekawa, S., Bodi, I., Rogelj, B., Al-Chalabi, A., Hortobágyi, T., & Shaw, C. E. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0911-2 · Cited by 475

Premorbid weight, body mass, and varsity athletics in ALS

Scarmeas, N., Shih, T., Stern, Y., Ottman, R., & Rowland, L. P. (2002) · Neurology · doi:10.1212/wnl.59.5.773 · Cited by 246

Population-Based Case-Control Study of Amyotrophic Lateral Sclerosis in Western Washington State. I. Cigarette Smoking and Alcohol Consumption

Nelson, L. M., McGuire, V., Longstreth, W. T., & Matkin, C. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010183 · Cited by 174

Sports and trauma in amyotrophic lateral sclerosis revisited

Armon, C. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.06.021 · Cited by 89

Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria

Strong, M. J., Abrahams, S., Goldstein, L. H., Woolley, S., Mclaughlin, P., Snowden, J., Mioshi, E., Roberts-South, A., Benatar, M., HortobáGyi, T., et al. (2017) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2016.1267768 · Cited by 909

Potential roles of gut microbiome and metabolites in modulating ALS in mice

Blacher, E., Bashiardes, S., Shapiro, H., Rothschild, D., Mor, U., Dori-Bachash, M., Kleimeyer, C., Moresi, C., Harnik, Y., Zur, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1443-5 · Cited by 700

Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study

Al-Chalabi, A., Calvo, A., Chio, A., Colville, S., Ellis, C. M., Hardiman, O., Heverin, M., Howard, R. S., Huisman, M. H. B., Keren, N., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70219-4 · Cited by 411

Gene discovery in amyotrophic lateral sclerosis: implications for clinical management

Al-Chalabi, A., van den Berg, L. H., & Veldink, J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.182 · Cited by 287

Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis

Ryan, M., Heverin, M., McLaughlin, R. L., & Hardiman, O. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.2044 · Cited by 244

The multistep hypothesis of ALS revisited: The role of genetic mutations

Chiò, A., Mazzini, L., D'Alfonso, S., Corrado, L., Canosa, A., Moglia, C., Manera, U., Bersano, E., Brunetti, M., Barberis, M., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005996 · Cited by 212

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

Burk, K., & Pasterkamp, R. J. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01964-7 · Cited by 162

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

Peng, B., Yang, Q., B Joshi, R., Liu, Y., Akbar, M., Song, B.-J., Zhou, S., & Wang, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072316 · Cited by 156

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1

Tripathi, P., Rodriguez-Muela, N., Klim, J. R., de Boer, A. S., Agrawal, S., Sandoe, J., Lopes, C. S., Ogliari, K. S., Williams, L. A., Shear, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.008 · Cited by 123

The human gut microbiota in people with amyotrophic lateral sclerosis

Nicholson, K., Bjornevik, K., Abu-Ali, G., Chan, J., Cortese, M., Dedi, B., Jeon, M., Xavier, R., Huttenhower, C., Ascherio, A., et al. (2021) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2020.1828475 · Cited by 123

Neuromuscular Junction Dismantling in Amyotrophic Lateral Sclerosis

Cappello, V., & Francolini, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102092 · Cited by 119

What causes amyotrophic lateral sclerosis?

Martin, S., Al Khleifat, A., & Al-Chalabi, A. (2017) · F1000Research · doi:10.12688/f1000research.10476.1 · Cited by 107

Prior medical conditions and the risk of amyotrophic lateral sclerosis

Seelen, M., van Doormaal, P. T. C., Visser, A. E., Huisman, M. H. B., Roozekrans, M. H. J., de Jong, S. W., van der Kooi, A. J., de Visser, M., Voermans, N. C., Veldink, J. H., et al. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7445-1 · Cited by 104

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis

Nassif, M., Valenzuela, V., Rojas-Rivera, D., Vidal, R., Matus, S., Castillo, K., Fuentealba, Y., Kroemer, G., Levine, B., & Hetz, C. (2014) · Autophagy · doi:10.4161/auto.28784 · Cited by 100

Environmental Risk Factors and Amyotrophic Lateral Sclerosis: An Umbrella Review and Critical Assessment of Current Evidence from Systematic Reviews and Meta-Analyses of Observational Studies

Belbasis, L., Bellou, V., & Evangelou, E. (2016) · Neuroepidemiology · doi:10.1159/000443146 · Cited by 82

High BMI is associated with low ALS risk: A population-based study

Nakken, O., Meyer, H. E., Stigum, H., & Holmøy, T. (2019) · Neurology · doi:10.1212/wnl.0000000000007861 · Cited by 72

Body Mass Index and Amyotrophic Lateral Sclerosis: A Study of US Military Veterans

Mariosa, D., Beard, J. D., Umbach, D. M., Bellocco, R., Keller, J., Peters, T. L., Allen, K. D., Ye, W., Sandler, D. P., Schmidt, S., et al. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kww140 · Cited by 67

Incidence and Geographical Variation of Amyotrophic Lateral Sclerosis (ALS) in Southern Germany – Completeness of the ALS Registry Swabia

Uenal, H., Rosenbohm, A., Kufeldt, J., Weydt, P., Goder, K., Ludolph, A., Rothenbacher, D., Nagel, G., & and the ALS registry Study Group (2014) · PLoS ONE · doi:10.1371/journal.pone.0093932 · Cited by 64

Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment

Calió, M. L., Henriques, E., Siena, A., Bertoncini, C. R. A., Gil-Mohapel, J., & Rosenstock, T. R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00679 · Cited by 64

The role of pre‐morbid diabetes on developing amyotrophic lateral sclerosis

D'Ovidio, F., d'Errico, A., Carnà, P., Calvo, A., Costa, G., & Chiò, A. (2018) · European Journal of Neurology · doi:10.1111/ene.13465 · Cited by 59

Epidemiological evidence that physical activity is not a risk factor for ALS

Hamidou, B., Couratier, P., Besançon, C., Nicol, M., Preux, P. M., & Marin, B. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9923-2 · Cited by 55

The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis

Cox, L. M., Calcagno, N., Gauthier, C., Madore, C., Butovsky, O., & Weiner, H. L. (2022) · Microbiome · doi:10.1186/s40168-022-01232-z · Cited by 53

Military service and related risk factors for amyotrophic lateral sclerosis

McKay, K. A., Smith, K. A., Smertinaite, L., Fang, F., Ingre, C., & Taube, F. (2021) · Acta Neurologica Scandinavica · doi:10.1111/ane.13345 · Cited by 50

Psychotherapy and pharmacotherapy interventions to reduce distress or improve well-being in people with amyotrophic lateral sclerosis: a systematic review

Gould, R. L., Coulson, M. C., Brown, R. G., Goldstein, L. H., Al-Chalabi, A., & Howard, R. J. (2015) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2015.1062515 · Cited by 47

Infectious agents and amyotrophic lateral sclerosis: another piece of the puzzle of motor neuron degeneration

Castanedo-Vazquez, D., Bosque-Varela, P., Sainz-Pelayo, A., & Riancho, J. (2019) · Journal of Neurology · doi:10.1007/s00415-018-8919-3 · Cited by 41

Gut microbiome and amyotrophic lateral sclerosis: a systematic review of current evidence

Sun, J., Huang, T., Debelius, J. W., & Fang, F. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13336 · Cited by 43

Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis

Huang, Z., Liu, Q., Peng, Y., Dai, J., Xie, Y., Chen, W., Long, S., Pei, Z., Su, H., & Yao, X. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00218 · Cited by 38

Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium

Pupillo, E., Poloni, M., Bianchi, E., Giussani, G., Logroscino, G., Zoccolella, S., Chiò, A., Calvo, A., Corbo, M., Lunetta, C., et al. (2018) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2017.1386687 · Cited by 38

Liquid-liquid phase separation in Alzheimer’s disease

Fu, Q., Zhang, B., Chen, X., & Chu, L. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02407-3 · Cited by 33

Effect modification of the association between total cigarette smoking and ALS risk by intensity, duration and time-since-quitting: Euro-MOTOR

Peters, S., Visser, A. E., D'Ovidio, F., Vlaanderen, J., Portengen, L., Beghi, E., Chio, A., Logroscino, G., Hardiman, O., Pupillo, E., et al. (2020) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-320986 · Cited by 33

Chitinase Signature in the Plasticity of Neurodegenerative Diseases

Russo, C., Valle, M. S., Casabona, A., & Malaguarnera, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076301 · Cited by 29

Relationship of statins and other cholesterol-lowering medications and risk of amyotrophic lateral sclerosis in the US elderly

Freedman, D. M., Kuncl, R. W., Cahoon, E. K., Rivera, D. R., & Pfeiffer, R. M. (2018) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2018.1511731 · Cited by 28

A randomised controlled trial of acceptance and commitment therapy plus usual care compared to usual care alone for improving psychological health in people with motor neuron disease (COMMEND): study protocol.

Gould, R. L., Thompson, B. J., Rawlinson, C., Kumar, P., White, D., Serfaty, M. A., Graham, C. D., McCracken, L. M., Bursnall, M., Bradburn, M., et al. (2022) · BMC Neurology · doi:10.1186/s12883-022-02950-5 · Cited by 16

Association of fractures with the incidence of amyotrophic lateral sclerosis

Peters, T. L., Weibull, C. E., Fang, F., Sandler, D. P., Lambert, P. C., Ye, W., & Kamel, F. (2017) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2017.1300287 · Cited by 19

Poor Bone Quality in Patients With Amyotrophic Lateral Sclerosis

Caplliure-Llopis, J., Escrivá, D., Benlloch, M., de la Rubia Ortí, J. E., Estrela, J. M., & Barrios, C. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.599216 · Cited by 19

Environmental risk factors for amyotrophic lateral sclerosis: a case–control study in Canada and France

Beaudin, M., Salachas, F., Pradat, P.-F., & Dupré, N. (2022) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2022.2028167 · Cited by 12

Acceptance and Commitment Therapy for people living with motor neuron disease: an uncontrolled feasibility study

Gould, R. L., Rawlinson, C., Thompson, B., Weeks, K., Gossage-Worrall, R., Cantrill, H., Serfaty, M. A., Graham, C. D., McCracken, L. M., White, D., et al. (2023) · Pilot and Feasibility Studies · doi:10.1186/s40814-023-01354-7 · Cited by 10

Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study

Chourpiliadis, C., Seitz, C., Lovik, A., Joyce, E. E., Pan, L., Hu, Y., Kläppe, U., Samuelsson, K., Press, R., Ingre, C., et al. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12496-w · Cited by 10

Pre-Morbid Risk Factors for Amyotrophic Lateral Sclerosis: Prospective Cohort Study

Batty, G. D., & Gale, C. R. (2021) · Clinical Epidemiology · doi:10.2147/clep.s329521 · Cited by 5

Hospital-Diagnosed Traumatic Head Injury and Associated Risk of Developing ALS: A Nationwide Population-Based Case-Control Study

Levison, L., Jepsen, P., Blicher, J. U., & Andersen, H. (2025) · Neurology · doi:10.1212/wnl.0000000000213809 · Cited by 3

Head trauma and environment progression of amyotrophic lateral sclerosis: long-term data from the National ALS Registry

Martinez-Nunez, A. E., Guo, J., Dorsey, E. R., Ruffing, K. W., Wymer, J., & Okun, M. S. (2026) · BMJ Neurology Open · doi:10.1136/bmjno-2026-001574 · Cited by 1