HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

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Immunosuppressive effects of apoptotic cells

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Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

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HMGB1 is a therapeutic target for sterile inflammation and infection

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High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

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Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

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Macrophage Polarization in Inflammatory Diseases

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Mitochondrial and metabolic dysfunction in ageing and age-related diseases

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HMGB1 in health and disease

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The role of oxidative stress during inflammatory processes

Lugrin, J., Rosenblatt‐Velin, N., Parapanov, R., & Liaudet, L. (2013) · Biological Chemistry · doi:10.1515/hsz-2013-0241 · Cited by 766

Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview

Delgado‐Rizo, V., Martinez-Guzman, M. A., Íñiguez-Gutiérrez, L., García-Orozco, A., Alvarado‐Navarro, A., & Fafutis‐Morris, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00081 · Cited by 703

DAMPs from Cell Death to New Life

Vénéreau, E., Ceriotti, C., & Bianchi, M. E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00422 · Cited by 703

Interleukin-33 in tissue homeostasis, injury, and inflammation

Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

Yang, H., Antoine, D. J., Andersson, U., & Tracey, K. J. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1212662 · Cited by 542

Prevalence and Clinical Significance of Sterile Intra-amniotic Inflammation in Patients with Preterm Labor and Intact Membranes

Romero, R. J., Miranda, J., Chaiworapongsa, T., Korzeniewski, S. J., Chaemsaithong, P., Gotsch, F., Dong, Z., Ahmed, A. I., Yoon, B. H., Hassan, S. S., et al. (2014) · American Journal of Reproductive Immunology · doi:10.1111/aji.12296 · Cited by 495

Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease

Lau, S.-F., Cao, H., Fu, A. K. Y., & Ip, N. Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008762117 · Cited by 476

Dying cells actively regulate adaptive immune responses

Yatim, N., Cullen, S., & Albert, M. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.9 · Cited by 442

The Role of HMGB1 in the Pathogenesis of Inflammatory and Autoimmune Diseases

Magna, M., & Pisetsky, D. S. (2014) · Molecular Medicine · doi:10.2119/molmed.2013.00164 · Cited by 358

HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4

Tadié, J., Bae, H., Jiang, S., Park, D. W., Bell, C. P., Yang, H., Pittet, J., Tracey, K. J., Thannickal, V. J., Abraham, E. H., et al. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00151.2012 · Cited by 368

DAMPs, MAMPs, and NAMPs in plant innate immunity

Choi, H. W., & Klessig, D. F. (2016) · BMC Plant Biology · doi:10.1186/s12870-016-0921-2 · Cited by 378

Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

Nieuwenhuijs‐Moeke, G. J., Pischke, S. E., Berger, S. P., Sanders, J., Pol, R. A., Struys, M. M. R. F., Ploeg, R. J., & Leuvenink, H. G. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010253 · Cited by 336

HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction

Paudel, Y. N., Shaikh, M. F., Chakraborti, A., Kumari, Y., Aledo-Serrano, Á., Aleksovska, K., Alvim, M. K. M., & Othman, I. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00628 · Cited by 311

Idiosyncratic Adverse Drug Reactions: Current Concepts

Uetrecht, J., & Naisbitt, D. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.007450 · Cited by 320

HMGB1 as a therapeutic target in disease

Xue, J., Suarez, J. S., Minaai, M., Li, S., Gaudino, G., Pass, H. I., Carbone, M., & Yang, H. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30125 · Cited by 299

Sterile inflammation and pregnancy complications: a review

Nadeau‐Vallée, M., Obari, D., Palacios, J. L., Brien, M., Duval, C., Chemtob, S., & Girard, S. (2016) · Reproduction · doi:10.1530/rep-16-0453 · Cited by 277

Inflammation in epileptogenesis after traumatic brain injury

Webster, K. M., Sun, M., Crack, P. J., O'Brien, T. J., Shultz, S. R., & Semple, B. D. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0786-1 · Cited by 281

Oxidative stress-mediated HMGB1 biology

Yan, Y. Q., Tang, D., & Kang, R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00093 · Cited by 268

Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

Paudel, Y. N., Angelopoulou, E., Piperi, C., Othman, I., Aamir, K., & Shaikh, M. F. (2020) · Cells · doi:10.3390/cells9020383 · Cited by 257

HMGB1 as biomarker and drug target

Vénéreau, E., Leo, F. D., Mezzapelle, R., Careccia, G., Musco, G., & Bianchi, M. E. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.06.031 · Cited by 245

Aged neutrophils contribute to the first line of defense in the acute inflammatory response

Uhl, B., Vadlau, Y., Zuchtriegel, G., Nekolla, K., Sharaf, K., Gaertner, F. C., Maßberg, S., Krombach, F., & Reichel, C. A. (2016) · Blood · doi:10.1182/blood-2016-05-718999 · Cited by 253

Perivascular Inflammation in Pulmonary Arterial Hypertension

Hu, Y., Chi, L., Kuebler, W. M., & Goldenberg, N. M. (2020) · Cells · doi:10.3390/cells9112338 · Cited by 245

Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation

Vogl, T., Stratis, A., Wixler, V., Völler, T., Thurainayagam, S., Jorch, S. K., Zenker, S., Dreiling, A., Chakraborty, D., Fröhling, M., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci89867 · Cited by 233

Indirect regulation of HMGB1 release by gasdermin D

Volchuk, A., Ye, A. A., Chi, L., Steinberg, B. E., & Goldenberg, N. M. (2020) · Nature Communications · doi:10.1038/s41467-020-18443-3 · Cited by 232

A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses

Wang, X., Liu, Y., Xue, C., Hu, Y., Zhao, Y., Cai, K., Li, M., & Luo, Z. Y. (2022) · Nature Communications · doi:10.1038/s41467-022-33301-0 · Cited by 240

The origin and properties of extracellular DNA: From PAMP to DAMP

Pisetsky, D. S. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.04.006 · Cited by 231

Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation

Pierdomenico, M., Negroni, A., Stronati, L., Vitali, R., Prete, E., Bertin, J., Gough, P. J., Aloi, M., & Cucchiara, S. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.403 · Cited by 223

Danger Signals Activating the Immune Response after Trauma

Hirsiger, S., Simmen, H., Werner, C. M. L., Wanner, G. A., & Rittirsch, D. (2012) · Mediators of Inflammation · doi:10.1155/2012/315941 · Cited by 216

Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility

Zhang, P., Yang, M., Chen, C., Liu, L., Wei, X., & Zeng, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01455 · Cited by 219

Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis

Maugeri, N., Capobianco, A., Rovere, P. Q., Ramirez, G. A., Tombetti, E., Valle, P. D., Monno, A., D’Alberti, V., Gasparri, A. M., Franchini, S., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao3089 · Cited by 215

Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice

Kang, R., Zhang, Q., Hou, W., Yan, Z., Chen, R., Bonaroti, J. W., Bansal, P., Billiar, T. R., Tsung, A., Wang, Q., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.12.015 · Cited by 213

Sepsis-Induced Cardiomyopathy: Mechanisms and Treatments

Liu, Y., Yu, M., Shou, S., & Chai, Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01021 · Cited by 208

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation

Zhu, X., Messer, J. S., Wang, Y., Lin, F., Cham, C. M., Chang, J. J., Billiar, T. R., Lotze, M. T., Boone, D. L., & Chang, E. B. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76344 · Cited by 208

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

Chi, W., Chen, H., Li, F., Zhu, Y., Yin, W. H., & Zhuo, Y. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0360-2 · Cited by 205

Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease

Al-Ghraiybah, N. F., Wang, J., Alkhalifa, A. E., Roberts, A. B., Raj, R., Yang, E., & Kaddoumi, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810572 · Cited by 212

Risk factors and disease mechanisms in myositis

Miller, F. W., Lamb, J. A., Schmidt, J., & Nagaraju, K. (2018) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2018.48 · Cited by 193

Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity

Vogl, T., Eisenblätter, M., Völler, T., Zenker, S., Hermann, S., van Lent, P., Faust, A., Geyer, C., Petersen, B., Roebrock, K., et al. (2014) · Nature Communications · doi:10.1038/ncomms5593 · Cited by 197

The Dendritic Cell Response to Classic, Emerging, and Homeostatic Danger Signals. Implications for Autoimmunity

Gallo, P. M., & Gallucci, S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00138 · Cited by 203

High‐mobility group box‐1 in sterile inflammation

Tsung, A., Tohme, S., & Billiar, T. R. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12276 · Cited by 187

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection

Yanai, H., Matsuda, A., An, J., Koshiba, R., Nishio, J., Negishi, H., Ikushima, H., Onoe, T., Ohdan, H., Yoshida, N., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320808110 · Cited by 184

Necrotic Myocardial Cells Release Damage‐Associated Molecular Patterns That Provoke Fibroblast Activation In Vitro and Trigger Myocardial Inflammation and Fibrosis In Vivo

Zhang, W., Lavine, K. J., Epelman, S., Evans, S. A., Weinheimer, C. J., Barger, P. M., & Mann, D. L. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.001993 · Cited by 181

Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis

Agalave, N. M., Larsson, M., Abdelmoaty, S., Su, J., Baharpoor, A., Lundbäck, P., Palmblad, K., Andersson, U., Harris, H. E., & Svensson, C. I. (2014) · Pain · doi:10.1016/j.pain.2014.06.007 · Cited by 179

C1q and HMGB1 reciprocally regulate human macrophage polarization

Son, M., Porat, A., He, M., Suurmond, J., Santiago‐Schwarz, F., Andersson, U., Coleman, T. R., Volpe, B. T., Tracey, K. J., Al‐Abed, Y., et al. (2016) · Blood · doi:10.1182/blood-2016-05-719757 · Cited by 182

Enlightening the role of high mobility group box 1 (HMGB1) in inflammation: Updates on receptor signalling

Paudel, Y. N., Angelopoulou, E., Piperi, C., Balasubramaniam, V. R. M. T., Othman, I., & Shaikh, M. F. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172487 · Cited by 181

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.11.004 · Cited by 173

ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury

Kamo, N., Ke, B., Ghaffari, A. A., Shen, X., Busuttil, R. W., Cheng, G., & Kupiec‐Weglinski, J. W. (2013) · Hepatology · doi:10.1002/hep.26320 · Cited by 170

Critical role of RAGE and HMGB1 in inflammatory heart disease

Bangert, A., Andrassy, M., Müller, A., Bockstahler, M., Fischer, A., Volz, C. H., Leib, C., Göser, S., Korkmaz‐Icöz, S., Zittrich, S., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522288113 · Cited by 173

Silica induces NLRP3 inflammasome activation in human lung epithelial cells

Peeters, P. M., Perkins, T. N., Wouters, E. F. �., Mossman, B. T., & Reynaert, N. L. (2013) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-10-3 · Cited by 170

Regulation of Toll‐like receptor signaling pathways in innate immune responses

Qian, C., & Cao, X. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06786.x · Cited by 167

Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation

Wang, Z., Zhou, H., Zheng, H., Zhou, X., Shen, G., Teng, X., Liu, X., Zhang, J., Wei, X., Hu, Z., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1725381 · Cited by 168

Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells

Liu, X., Lu, B., Fu, J., Zhu, X., Song, E., & Song, Y. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124050 · Cited by 167

Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19

Thimmulappa, R. K., Mudnakudu-Nagaraju, K. K., Shivamallu, C., Subramaniam, K., Radhakrishnan, A., Bhojraj, S., & Kuppusamy, G. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06350 · Cited by 168

NF-κB in acute pancreatitis: Mechanisms and therapeutic potential

Jakkampudi, A., Jangala, R., Reddy, B. R., Sasikala, M., Reddy, D. N., & Talukdar, R. (2016) · Pancreatology · doi:10.1016/j.pan.2016.05.001 · Cited by 160

Sepsis Biomarkers: Advancements and Clinical Applications—A Narrative Review

He, R., Yue, G.-L., Dong, M.-L., Wang, J., & Cheng, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169010 · Cited by 185

Inflammasomes, the eye and anti-inflammasome therapy

Yerramothu, P., Vijay, A. K., & Willcox, M. D. P. (2017) · Eye · doi:10.1038/eye.2017.241 · Cited by 155

Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review

Lü, B., Wang, C., Wang, M., Li, W., Chen, F., Tracey, K. J., & Wang, H. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.909730 · Cited by 153

Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications

Boyapati, R. K., Rossi, A. G., Satsangi, J., & Ho, G. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.14 · Cited by 150

HMGB1 upregulates NF-kB by inhibiting IKB-α and associates with diabetic retinopathy

Liang, W., Yang, H., Liu, H., Qian, W., & Chen, X. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117146 · Cited by 141

Role of inflammation in epilepsy and neurobehavioral comorbidities: Implication for therapy

Paudel, Y. N., Shaikh, M. F., Shah, S. Z., Kumari, Y., & Othman, I. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.08.020 · Cited by 140

MIR34Aregulates autophagy and apoptosis by targetingHMGB1in the retinoblastoma cell

Liu, K., Huang, J. X., Xie, M., Yu, Y. H., Zhu, S., Kang, R., Cao, L., Tang, D., & Duan, X. (2014) · Autophagy · doi:10.4161/auto.27418 · Cited by 137

ERK/Drp1‐dependent mitochondrial fission contributes to HMGB1‐induced autophagy in pulmonary arterial hypertension

Feng, W., Wang, J., Yan, X., Zhang, Q., Chai, L., Wang, Q., Shi, W., Chen, Y., Liu, J., Qu, Z., et al. (2021) · Cell Proliferation · doi:10.1111/cpr.13048 · Cited by 135

Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus

Hartl, J., Serpas, L., Wang, Y., Rashidfarrokhi, A., Perez, O. A., Sally, B., Sisirak, V., Soni, C., Khodadadi‐Jamayran, A., Tsirigos, A., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201138 · Cited by 130

Blood biomarkers in ischemic stroke: potential role and challenges in clinical practice and research

Makris, K., Haliassos, A., Chondrogianni, M. E., & Tsivgoulis, G. K. (2018) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2018.1461190 · Cited by 130

Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases

Chen, R., Hou, W., Zhang, Q., Kang, R., Fan, X., & Tang, D. (2013) · Molecular Medicine · doi:10.2119/molmed.2013.00099 · Cited by 130

Emerging and critical issues in the pathogenesis of lupus

Gatto, M., Zen, M., Ghirardello, A., Bettio, S., Bassi, N., Iaccarino, L., Punzi, L., & Doria, A. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.09.003 · Cited by 132

Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

Roy, A., Ganesh, G., Sippola, H., Bolin, S., Sawesi, O., Dagälv, A., Schlenner, S., Feyerabend, T. B., Rodewald, H.-R., Kjellén, L., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.435156 · Cited by 132

HMGB1 Promotes a p38MAPK Associated Non-Infectious Inflammatory Response Pathway in Human Fetal Membranes

Bredeson, S., Papaconstantinou, J., DeFord, J. H., Kechichian, T. B., Syed, T. A., Saade, G. R., & Menon, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113799 · Cited by 124

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

de Almeida, L., Khare, S., Misharin, A. V., Patel, R., Ratsimandresy, R. A., Wallin, M., Perlman, H., Greaves, D. R., Hoffman, H. M., Dorfleutner, A., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.018 · Cited by 132

Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia

Hwang, J. S., Choi, H. S., Ham, S. A., Yoo, T., Lee, W. J., Paek, K. S., & Seo, H. G. (2015) · Scientific Reports · doi:10.1038/srep15971 · Cited by 119

Role of Toll-like receptor-4 in renal graft ischemia-reperfusion injury

Zhao, H., Perez, J. S., Lu, K., George, A. J. T., & Ma, D. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00469.2013 · Cited by 120

HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients

Napolitano, A., Antoine, D. J., Pellegrini, L., Baumann, F., Pagano, I., Pastorino, S., Goparaju, C. M. V., Prokrym, K., Canino, C., Pass, H. I., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1130 · Cited by 117

HMGB1 protein as a novel target for cancer

Tripathi, A. S., Shrinet, K., & Kumar, A. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.03.002 · Cited by 116

A Janus Tale of Two Active High Mobility Group Box 1 (HMGB1) Redox States

Tang, D., Billiar, T. R., & Lotze, M. T. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00314 · Cited by 112

Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism

An, R. F., Zhao, L., Xi, C., Li, H., Shen, G., Liu, H., Zhang, S., & Sun, L. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0526-1 · Cited by 113

Innate immune memory: Implications for host responses to damage‐associated molecular patterns

Crișan, T. O., Netea, M. G., & Joosten, L. A. B. (2016) · European Journal of Immunology · doi:10.1002/eji.201545497 · Cited by 118

Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to G Alert

Lee, G., Santo, A. I. E., Zwingenberger, S., Cai, L. X., Vogl, T., Feldmann, M., Horwood, N. J., Chan, J. K.-K., & Nanchahal, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802893115 · Cited by 112

Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy

Lin, H., Xiong, W. G., Fu, L., Yi, J., & Yang, J. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00305-3 · Cited by 137

Clear and present danger? Engineered nanoparticles and the immune system

Fadeel, B. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13609 · Cited by 116

Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice.

Liu, Z., Wu, B., Guo, Y., Zhou, Y., Fu, Z., Xu, B.-Q., Li, J., Jing, L., Jiang, J., Tang, J., et al. (2015) · Europe PMC (PubMed Central) · Cited by 105

Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1

Lian, Y., Gong, H., Wu, T., Su, W., Zhang, Y., Yang, Y., Wei, P., Zhang, T., Zhou, J., Jiang, C., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.017 · Cited by 105

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High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction

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Oxidative Stress Elicits Platelet/Leukocyte Inflammatory Interactions via HMGB1: A Candidate for Microvessel Injury in Sytemic Sclerosis

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Mechanical Ventilation Induces Neutrophil Extracellular Trap Formation

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HMGB1 released from nociceptors mediates inflammation

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Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells

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Emerging role of HMGB 1 in fibrotic diseases

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The role of HMGB1 in the pathogenesis of rheumatic disease

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High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

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