Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works

DAMPs, PAMPs and alarmins: all we need to know about danger

Bianchi, M. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306164 · Cited by 2,794 · see citing works

Inflammation as a central mechanism in Alzheimer's disease

Kinney, J. W., Bemiller, S. M., Murtishaw, A. S., Leisgang, A. M., Salazar, A. M., & Lamb, B. T. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.06.014 · Cited by 2,253 · see citing works

Immune attack: the role of inflammation in Alzheimer disease

Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134 · see citing works

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

Hampel, H., Mesulam, M.-M., Cuello, A. C., Farlow, M. R., Giacobini, E., Grossberg, G. T., Khachaturian, A. S., Vergallo, A., Cavedo, E., Snyder, P. J., et al. (2018) · Brain · doi:10.1093/brain/awy132 · Cited by 1,918 · see citing works

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

Kurt-Jones, E., Popova, L., Kwinn, L. A., Haynes, L., Jones, L. P., Tripp, R., Walsh, E., Freeman, M., Golenbock, D., Anderson, L., et al. (2000) · Nature Immunology · doi:10.1038/80833 · Cited by 1,842 · see citing works

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

Moreno-Jiménez, E. P., Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0375-9 · Cited by 1,577 · see citing works

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426 · see citing works

A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species

Vaure, C., & Liu, Y. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00316 · Cited by 842 · see citing works

The Genetics of Alzheimer Disease: Back to the Future

Bertram, L., Lill, C. M., & Tanzi, R. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.013 · Cited by 834 · see citing works

HMGB1: Endogenous Danger Signaling

Klune, J. R., Dhupar, R., Cardinal, J., Billiar, T. R., & Tsung, A. (2008) · Molecular Medicine · doi:10.2119/2008-00034.klune · Cited by 762 · see citing works

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

Harris, H. E., Andersson, U., & Pisetsky, D. S. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.222 · Cited by 689 · see citing works

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

Deane, R., Singh, I., Sagare, A. P., Bell, R. D., Ross, N. T., LaRue, B., Love, R., Perry, S., Paquette, N., Deane, R. J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58642 · Cited by 619 · see citing works

HMGB proteins: Interactions with DNA and chromatin

Štros, M. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.09.008 · Cited by 605 · see citing works

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

Tobin, M. K., Musaraca, K., Disouky, A., Shetti, A., Bheri, A., Honer, W. G., Kim, N., Dawe, R. J., Bennett, D. A., Arfanakis, K., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.003 · Cited by 603 · see citing works

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation

Reed-Geaghan, E. G., Savage, J. C., Hise, A. G., & Landreth, G. E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3158-09.2009 · Cited by 591 · see citing works

The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins

Chavakis, T., Bierhaus, A., Al‐Fakhri, N., Schneider, D., Witte, S., Linn, T., Nagashima, M., Morser, J., Arnold, B., Preissner, K. T., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030800 · Cited by 583 · see citing works

Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease

Walter, S., Letiembre, M., Liu, Y., Heine, H., Penke, B., Hao, W., Bode, B., Manietta, N., Walter, J., Schulz-Schüffer, W., et al. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110455 · Cited by 543 · see citing works

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

Srikanth, V., Maczurek, A., Phan, T., Steele, M., Westcott, B., Juskiw, D., & Münch, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.016 · Cited by 524 · see citing works

RAGE, LRP-1, and amyloid-beta protein in Alzheimer’s disease

Donahue, J. E., Flaherty, S. L., Johanson, C. E., Duncan, J. A., Silverberg, G. D., Miller, M. C., Tavares, R., Yang, W., Wu, Q., Sabo, E., et al. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0115-3 · Cited by 519 · see citing works

Targeting RAGE Signaling in Inflammatory Disease

Hudson, B. I., & Lippman, M. E. (2017) · Annual Review of Medicine · doi:10.1146/annurev-med-041316-085215 · Cited by 511 · see citing works

Role of toll-like receptor signalling in A uptake and clearance

Tahara, K., Kim, H.-D., Jin, J.-J., Maxwell, J. A., Li, L., & Fukuchi, K.-I. (2006) · Brain · doi:10.1093/brain/awl249 · Cited by 493 · see citing works

Inflammation, autotoxicity and Alzheimer disease

McGeer, P. L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00289-5 · Cited by 474 · see citing works

Involvement of Microglial Receptor for Advanced Glycation Endproducts (RAGE) in Alzheimer's Disease: Identification of a Cellular Activation Mechanism

Lue, L.-F., Walker, D. G., Brachova, L., Beach, T. G., Rogers, J., Schmidt, A. M., Stern, D. M., & Yan, S. D. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7732 · Cited by 439 · see citing works

Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APP Sw,Ind ) mice

Jin, K., Galván, V., Xie, L., Mao, X. O., Gorostiza, O. F., Bredesen, D. E., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403678101 · Cited by 433 · see citing works

Neuroinflammatory processes in Alzheimer’s disease

Heneka, M. T., O’Banion, M. K., Terwel, D., & Kummer, M. P. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0438-z · Cited by 433 · see citing works

Resveratrol Mitigates Lipopolysaccharide- and Aβ-Mediated Microglial Inflammation by Inhibiting the TLR4/NF-Κb/STAT Signaling cascade

Capiralla, H., Vingtdeux, V., Zhao, H., Sankowski, R., Al‐Abed, Y., Davies, P., & Marambaud, P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07594.x · Cited by 426 · see citing works

HMGB1 loves company

Bianchi, M. E. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008585 · Cited by 415 · see citing works

The macrophage response towards LPS and its control through the p38MAPK–STAT3 axis

Bode, J. G., Ehlting, C., & Häussinger, D. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.018 · Cited by 392 · see citing works

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

Sheng, J. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00069-x · Cited by 388 · see citing works

Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing NLRP 3 inflammasomes and TLR 4/ NF ‐κB signaling pathway

Jin, X., Liu, M., Zhang, D., Zhong, X., Du, K., Qian, P., Yao, W., Gao, H., & Wei, M. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13086 · Cited by 385 · see citing works

High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule

Yang, H., Wang, H., Chavan, S. S., & Andersson, U. (2015) · Molecular Medicine · doi:10.2119/molmed.2015.00087 · Cited by 360 · see citing works

The Role of HMGB1 in the Pathogenesis of Inflammatory and Autoimmune Diseases

Magna, M., & Pisetsky, D. S. (2014) · Molecular Medicine · doi:10.2119/molmed.2013.00164 · Cited by 358 · see citing works

Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease

Donovan, M. H., Yazdani, U., Norris, R. D., Games, D., German, D. C., & Eisch, A. J. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20840 · Cited by 350 · see citing works

Tau and neuroinflammation: what impact for Alzheimer's disease and tauopathies?

Laurent, C., Buée, L., & Blum, D. (2018) · Biomedical Journal · doi:10.1016/j.bj.2018.01.003 · Cited by 348 · see citing works

RAGE‐dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease

Fang, F., Lue, L.-F., Yan, S., Xu, H., Luddy, J. S., Chen, D., Walker, D. G., Stern, D. M., Yan, S., Schmidt, A. M., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-139634 · Cited by 335 · see citing works

An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies

Musumeci, D., Roviello, G. N., & Montesarchio, D. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.11.001 · Cited by 334 · see citing works

Structural Biology of the Toll-Like Receptor Family

Kang, J. Y., & Lee, J. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052909-141507 · Cited by 331 · see citing works

RAGE potentiates Aβ‐induced perturbation of neuronal function in transgenic mice

Arancio, O., Zhang, H. P., Chen, X., Lin, C., Trinchese, F., Puzzo, D., Liu, S., Hegde, A. N., Yan, S. F., Stern, A., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600415 · Cited by 328 · see citing works

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

Salomone, S., Caraci, F., Leggio, G. M., Fedotova, J., & Drago, F. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.04134.x · Cited by 322 · see citing works

Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

Hu, J., Akama, K. T., Krafft, G. A., Chromy, B. A., & Eldik, L. J. V. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01318-8 · Cited by 313 · see citing works

High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells

Andersson, U., Yang, H., & Harris, H. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.02.011 · Cited by 309 · see citing works

Extracellular HMGB1 as a therapeutic target in inflammatory diseases

Andersson, U., Yang, H., & Harris, H. E. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1439924 · Cited by 287 · see citing works

Role of RAGE in Alzheimer’s Disease

Cai, Z., Liu, N., Wang, C., Qin, B., Zhou, Y., Xiao, M., Chang, L., Yan, L., & Zhao, B. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0233-3 · Cited by 286 · see citing works

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

Song, M., Jin, J., Lim, J.-E., Kou, J., Pattanayak, A., Rehman, J. A., Kim, H.-D., Tahara, K., Lalonde, R., & Fukuchi, K.-I. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-92 · Cited by 273 · see citing works

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

Jin, J.-J., Kim, H.-D., Maxwell, J. A., Li, L., & Fukuchi, K. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-23 · Cited by 272 · see citing works

Genetics of familial and sporadic Alzheimer s disease

Piaceri, I. (2013) · Frontiers in Bioscience · doi:10.2741/e605 · Cited by 256 · see citing works

Local Neuroinflammation and the Progression of Alzheimer's Disease

McGeer, P. L., & McGeer, E. G. (2002) · Journal of NeuroVirology · doi:10.1080/13550280290100969 · Cited by 255 · see citing works

Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer’s disease

Sasaki, N., Toki, S., Chowei, H., Saito, T., Nakano, N., Hayashi, Y., Takeuchi, M., & Makita, Z. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03075-4 · Cited by 253 · see citing works

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology

Michaud, J.-P., Hallé, M., Lampron, A., Thériault, P., Préfontaine, P., Filali, M., Tribout-Jover, P., Lanteigne, A.-M., Jodoin, R., Cluff, C. W., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215165110 · Cited by 251 · see citing works

The roles of inflammation and immune mechanisms in Alzheimer's disease

Eldik, L. J. V., Carrillo, M. C., Cole, P. E., Feuerbach, D., Greenberg, B., Hendrix, J. A., Kennedy, M. E., Kozauer, N., Margolin, R. A., Molinuevo, J. L., et al. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.05.001 · Cited by 226 · see citing works

TREM2 and the neuroimmunology of Alzheimer's disease

Hickman, S. E., & El Khoury, J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.11.021 · Cited by 221 · see citing works

Circulating Levels of Soluble Receptor for Advanced Glycation End Products in Alzheimer Disease and Vascular Dementia

Emanuele, E., D’Angelo, A., Tomaino, C., Binetti, G. G., Ghidoni, R., Politi, P., Bernardi, L., Maletta, R., Bruni, A. C., & Geroldi, D. (2005) · Archives of Neurology · doi:10.1001/archneur.62.11.1734 · Cited by 220 · see citing works

HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease

Festoff, B. W., Sajja, R. K., van Dreden, P., & Cucullo, L. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0670-z · Cited by 214 · see citing works

CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)

Ritchie, C. W., Smailagic, N., Noel-Storr, A. H., Ukoumunne, O. C., Ladds, E. C., & Martin, S. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010803.pub2 · Cited by 208 · see citing works

Inflammatory biomarkers in Alzheimer's disease plasma

Morgan, A. R., Touchard, S., Leckey, C. A., O’Hagan, C., Nevado‐Holgado, A. J., Barkhof, F., Bertram, L., Blin, O. J., Bos, I., Dobričić, V., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.03.007 · Cited by 207 · see citing works

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

Chi, W., Chen, H., Li, F., Zhu, Y., Yin, W. H., & Zhuo, Y. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0360-2 · Cited by 205 · see citing works

Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells

Dumitriu, I. E., Baruah, P., Bianchi, M. E., Manfredi, A. A., & Rovere, P. Q. (2005) · European Journal of Immunology · doi:10.1002/eji.200526066 · Cited by 203 · see citing works

Hippocampal RAGE immunoreactivity in early and advanced Alzheimer’s disease

Miller, M. C., Tavares, R., Johanson, C. E., Hovanesian, V., Donahue, J. E., Gonzalez, L., Silverberg, G. D., & Stopa, E. G. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.124 · Cited by 194 · see citing works

Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model

Ikram, M. A., Muhammad, T., Rehman, S. U., Khan, A., Jo, M. G., Ali, T., & Kim, M. O. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1512-7 · Cited by 194 · see citing works

HMGB1 in Development and Diseases of the Central Nervous System

Fang, P., Schachner, M., & Shen, Y.-Q. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8264-y · Cited by 193 · see citing works

Clinical trial of an inhibitor of RAGE-Aβ interactions in Alzheimer disease

Galasko, D. R., Bell, J. S., Mancuso, J. Y., Kupiec, J. W., Sabbagh, M. N., van Dyck, C. H., Thomas, R. G., Aisen, P. S. S., & Study, F. T. A. D. C. (2014) · Neurology · doi:10.1212/wnl.0000000000000364 · Cited by 187 · see citing works

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

Dionisio-Santos, D. A., Olschowka, J. A., & O’Banion, M. K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1453-0 · Cited by 184 · see citing works

Role of microglia in senile plaque formation

Mackenzie, I. R. A., Hao, C., & Munoz, D. G. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00092-s · Cited by 183 · see citing works

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

Mazarati, A. M., Maroso, M., Iori, V., Vezzani, A., & Carli, M. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.012 · Cited by 182 · see citing works

RAGE and Alzheimer's Disease: A Progression Factor for Amyloid-β-Induced Cellular Perturbation?

Yan, S. D., Bierhaus, A., Nawroth, P. P., & Stern, D. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1030 · Cited by 179 · see citing works

Enlightening the role of high mobility group box 1 (HMGB1) in inflammation: Updates on receptor signalling

Paudel, Y. N., Angelopoulou, E., Piperi, C., Balasubramaniam, V. R. M. T., Othman, I., & Shaikh, M. F. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172487 · Cited by 178 · see citing works

Toll‐like receptors 2 and 4 mediate Aβ(1–42) activation of the innate immune response in a human monocytic cell line

Udan, M. L. D., Ajit, D., Crouse, N. R., & Nichols, M. R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05001.x · Cited by 175 · see citing works

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

Ito, H., & Hamerman, J. A. (2012) · European Journal of Immunology · doi:10.1002/eji.201141679 · Cited by 173 · see citing works

PF-04494700, an Oral Inhibitor of Receptor for Advanced Glycation End Products (RAGE), in Alzheimer Disease

Sabbagh, M. N., Agro, A., Bell, J. S., Aisen, P. S. S., Schweizer, E. E., & Galasko, D. R. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318204b550 · Cited by 161 · see citing works

HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease

Fujita, K., Motoki, K., Tagawa, K., Chen, X., Hama, H., Nakajima, K., Homma, H., Tamura, T., Watanabe, H., Katsuno, M., et al. (2016) · Scientific Reports · doi:10.1038/srep31895 · Cited by 160 · see citing works

Role of the peripheral innate immune system in the development of Alzheimer's disease

Page, A. Y. L., Dupuis, G., Frost, E. H., Larbi, A., Pawelec, G., Witkowski, J. M., & Fülöp, T. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.019 · Cited by 158 · see citing works

Alzheimer’s Disease as Proteolytic Disorders: Anabolism and Catabolism of β-Amyloid

Saido, T. C. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00033-5 · Cited by 140 · see citing works

Imbalance of microglial TLR4/TREM2 in LPS-treated APP/PS1 transgenic mice: a potential Link between Alzheimer's disease and systemic inflammation

Zhou, J., Yu, W., Zhang, M., Tian, X., Li, Y., & Lü, Y. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02748-x · Cited by 139 · see citing works

The Role of Neuroinflammation in Dementias

Pasqualetti, G., Brooks, D. J., & Edison, P. (2015) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-015-0531-7 · Cited by 133 · see citing works

Regulation of Posttranslational Modifications of HMGB1 During Immune Responses

Tang, Y., Zhao, X. S., Antoine, D. J., Xiao, X., Wang, H., Andersson, U., Billiar, T. R., Tracey, K. J., & Lü, B. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6409 · Cited by 132 · see citing works

Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1–RAGE interaction

Okuma, Y., Liu, K., Wake, H., Liu, R., Nishimura, Y., Hui, Z., Teshigawara, K., Haruma, J., Yamamoto, Y., Yamamoto, H., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.007 · Cited by 121 · see citing works

In vivo molecular imaging of neuroinflammation in Alzheimer's disease

Chaney, A. M., Williams, S. R., & Boutin, H. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14615 · Cited by 116 · see citing works

Autoimmunity in Alzheimer’s disease: increased levels of circulating IgGs binding Aβ and RAGE peptides

Mruthinti, S., Buccafusco, J. J., Hill, W., Waller, J. L., Jackson, T. W., ZAMRINI, E. Y., & Schade, R. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.001 · Cited by 113 · see citing works

RAGE and amyloid beta interactions: Atomic force microscopy and molecular modeling

Chaney, M. O., Stine, W. B., Kokjohn, T. A., Kuo, Y., Esh, C. L., Rahman, A., Luehrs, D. C., Schmidt, A. M., Stern, D. M., Yan, S. D., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.03.014 · Cited by 109 · see citing works

In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin

Santoro, M., Maetzler, W., Stathakos, P., Martin, H. L., Hobert, M. A., Rattay, T. W., Gasser, T., Forrester, J. V., Berg, D., Tracey, K. J., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.02.018 · Cited by 107 · see citing works

Anti-HMGB1 monoclonal antibody therapy for a wide range of CNS and PNS diseases

Nishibori, M., Mori, S., & Takahashi, H. K. (2019) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2019.04.006 · Cited by 106 · see citing works

Potential Neuroprotective Effect of the HMGB1 Inhibitor Glycyrrhizin in Neurological Disorders

Paudel, Y. N., Angelopoulou, E., Semple, B. D., Piperi, C., Othman, I., & Shaikh, M. F. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00640 · Cited by 105 · see citing works

Pathogenesis and Disease-modifying Therapy in Alzheimer's Disease: The Flat Line of Progress

Castellani, R. J., & Perry, G. L. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.09.009 · Cited by 103 · see citing works

RAGE mediates Aβ accumulation in a mouse model of Alzheimer’s disease via modulation of β- and γ-secretase activity

Fang, F., Yu, Q., Arancio, O., Chen, D., Gore, S. S., Yan, S. S., & Yan, S. F. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy017 · Cited by 103 · see citing works

Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling

Hong, Y., & An, Z. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0662-z · Cited by 101 · see citing works

Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis.

Jeynes, B., & Provias, J. (2008) · Current Alzheimer Research · doi:10.2174/156720508785908937 · Cited by 99 · see citing works

The Oral Pretreatment of Glycyrrhizin Prevents Surgery-Induced Cognitive Impairment in Aged Mice by Reducing Neuroinflammation and Alzheimer’s-Related Pathology via HMGB1 Inhibition

Kong, Z.-H., Chen, X., Hua, H.-P., Liang, L., & Liu, L.-J. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0989-7 · Cited by 99 · see citing works

Gx‐50 reduces β‐amyloid‐induced TNF‐α, IL‐1β, NO, and PGE2 expression and inhibits NF‐κB signaling in a mouse model of Alzheimer's disease

Shi, S., Liang, D., Chen, Y., Xie, Y., Wang, Y., Wang, L., Wang, Z., & Qiao, Z. (2015) · European Journal of Immunology · doi:10.1002/eji.201545855 · Cited by 93 · see citing works

Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis

Takata, K., Kitamura, Y., Kakimura, J., Shibagaki, K., Tsuchiya, D., Taniguchi, T., Smith, M. A., Perry, G. L., & Shimohama, S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00024-x · Cited by 92 · see citing works

Blockade of RAGE Suppresses Alloimmune Reactions In Vitro and Delays Allograft Rejection in Murine Heart Transplantation

Moser, B., Szabolcs, M., Ankersmit, H. J., Lu, Y. F., Qu, W., Weinberg, A. D., Herold, K., & Schmidt, A. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01617.x · Cited by 91 · see citing works

Stimulation of TLR4 Attenuates Alzheimer’s Disease–Related Symptoms and Pathology in Tau-Transgenic Mice

Qin, Y., Liu, Y., Hao, W., Decker, Y., Tomic, I., Menger, M. D., Liu, C., & Fassbender, K. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600873 · Cited by 90 · see citing works

Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of TLR4 signaling in disease progression

Go, M., Kou, J., Lim, J.-E., Yang, J., & Fukuchi, K.-I. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.073 · Cited by 87 · see citing works

S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease

Cirillo, C., Capoccia, E., Iuvone, T., Cuomo, R., Sarnelli, G., Steardo, L., & Esposito, G. (2015) · BioMed Research International · doi:10.1155/2015/508342 · Cited by 86 · see citing works

Glycyrrhizin Alleviates Neuroinflammation and Memory Deficit Induced by Systemic Lipopolysaccharide Treatment in Mice

Song, J., Lee, J.-W., Shim, B., Lee, C., Choi, S., Kang, C., Sohn, N., & Shin, J.-W. (2013) · Molecules · doi:10.3390/molecules181215788 · Cited by 86 · see citing works

High mobility group box protein‐1 inhibits microglial Aβ clearance and enhances Aβ neurotoxicity

Takata, K., Kitamura, Y., Tsuchiya, D., Kawasaki, T., Taniguchi, T., & Shimohama, S. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20340 · Cited by 81 · see citing works

High-Mobility Group Box-1 Protein and β-Amyloid Oligomers Promote Neuronal Differentiation of Adult Hippocampal Neural Progenitors via Receptor for Advanced Glycation End Products/Nuclear Factor-κB Axis: Relevance for Alzheimer's Disease

Meneghini, V., Bortolotto, V., Francese, M. T., Dellarole, A., Carraro, L., Terzieva, S., & Grilli, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2052-12.2013 · Cited by 79 · see citing works

Expression of Concern: The functions of HMGB 1 depend on molecular localization and post‐translational modifications

Andersson, J., Antoine, D. J., & Tracey, K. J. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12309 · Cited by 78 · see citing works

Is Alzheimer’s Disease a Neurogenesis Disorder?

Choi, S. H., & Tanzi, R. E. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.06.001 · Cited by 78 · see citing works

Increased expressions of TLR2 and TLR4 on peripheral blood mononuclear cells from patients with Alzheimer's disease

Zhang, W., Wang, L., Yu, J., Zhao-fu, C., & Tan, L. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.11.032 · Cited by 77 · see citing works

Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer’s disease mouse model

Criscuolo, C., Fontebasso, V., Middei, S., Stazi, M., Ammassari‐Teule, M., Yan, S. S., & Origlia, N. (2017) · Scientific Reports · doi:10.1038/srep42370 · Cited by 75 · see citing works

RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes

Daffu, G. K., Shen, X., Senatus, L. M., Thiagarajan, D., Abedini, A., del Pozo, C. H., Rosario, R., Song, F., Friedman, R. A., Ramasamy, R., et al. (2015) · Diabetes · doi:10.2337/db15-0575 · Cited by 75 · see citing works

Receptor for advanced glycation end-products in neurodegenerative diseases

Juranek, J. K., Ray, R., Banach, M. D., & Rai, V. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0003 · Cited by 74 · see citing works

18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures

Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6494 · Cited by 72 · see citing works

The innate immune system in Alzheimer's disease

Boutajangout, A., & Wisniewski, T. (2013) · International Journal of Cell Biology · doi:10.1155/2013/576383 · Cited by 69 · see citing works

TLR4 Gene Expression and Pro-Inflammatory Cytokines in Alzheimer’s Disease and in Response to Hippocampal Deafferentation in Rodents

Miron, J., Picard, C., Frappier, J., Dea, D., Théroux, L., & Poirier, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171160 · Cited by 69 · see citing works

The Receptor for Advanced Glycation End Products (RAGE) and DIAPH1: Implications for vascular and neuroinflammatory dysfunction in disorders of the central nervous system

MacLean, M., Derk, J., Ruiz, H. H., Juranek, J. K., Ramasamy, R., & Schmidt, A. M. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.03.012 · Cited by 69 · see citing works

Early minor stimulation of microglial TLR2 and TLR4 receptors attenuates Alzheimer's disease–related cognitive deficit in rats: behavioral, molecular, and electrophysiological evidence

Pourbadie, H. G., Sayyah, M., Khoshkholgh-Sima, B., Choopani, S., Nategh, M., Motamedi, F., & Shokrgozar, M. A. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.06.020 · Cited by 68 · see citing works

Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimers Disease

Balistreri, C. R., Grimaldi, M., Chiappelli, M., Licastro, F., Castiglia, L., Listı̀, F., Vasto, S., Lio, D., Caruso, C., & Candore, G. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786264089 · Cited by 65 · see citing works

Hippocampal neurogenesis in the APP/PS1/nestin-GFP triple transgenic mouse model of Alzheimer’s disease

Zeng, Q., Zheng, M., Zhang, T., & He, G. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.054 · Cited by 64 · see citing works

MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo

Guan, F., Zhou, X.-K., Li, P., Wang, Y.-P., Liu, M., Li, F.-F., Cui, Y.-B., Huang, T.-J., Yao, M.-H., Zhang, Y.-T., et al. (2019) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109684 · Cited by 63 · see citing works

Can inflammation be resolved in Alzheimer’s disease?

Zhu, M., Wang, X., Sun, L., Schultzberg, M., & Hjorth, E. (2018) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286418791107 · Cited by 62 · see citing works

HMGB1 gene silencing inhibits neuroinflammation via down-regulation of NF-κB signaling in primary hippocampal neurons induced by Aβ25–35

Nan, K., Han, Y., Fang, Q., Huang, C., Yu, L., Ge, W., Xiang, F., Tao, Y.-X., Cao, H., & Li, J. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.027 · Cited by 62 · see citing works

Novel targets in Alzheimer’s disease: A special focus on microglia

Balducci, C., & Forloni, G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.017 · Cited by 61 · see citing works

RAB10: an Alzheimer’s disease resilience locus and potential drug target

Tavana, J. P., Rosene, M. J., Jensen, N. O., Ridge, P. G., Kauwe, J. S. K., & Karch, C. M. M. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s159148 · Cited by 60 · see citing works

The AD-CSF-Index Discriminates Alzheimer's Disease Patients from Healthy Controls: A Validation Study

Molinuevo, J. L., Gispert, J. D., Dubois, B., Heneka, M. T., Lleó, A., Engelborghs, S., Pujol, J., de Souza, L. C., Alcolea, D. A., Jessen, F., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130203 · Cited by 59 · see citing works

Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus

Li, Y., Wang, L., Zhang, B., Gao, F., & Yang, C.-M. (2018) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13040 · Cited by 59 · see citing works

Microglial Amyloid- β 1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer’s Disease

Takata, K., Takada, T., Ito, A., Asai, M., Tawa, M., Saito, Y., Ashihara, E., Tomimoto, H., Kitamura, Y., & Shimohama, S. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/685739 · Cited by 58 · see citing works

A Novel, Multi-Target Natural Drug Candidate, Matrine, Improves Cognitive Deficits in Alzheimer’s Disease Transgenic Mice by Inhibiting Aβ Aggregation and Blocking the RAGE/Aβ Axis

Cui, L., Cai, Y., Cheng, W., Liu, G., Zhao, J., Cao, H., Tao, H., Wang, Y., Yin, M., Liu, T., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9783-8 · Cited by 57 · see citing works

RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes

Avalos, A. M., Kiefer, K., Tian, J. Y., et al. (2009) · Autoimmunity · doi:10.3109/08916930903384591 · Cited by 56 · see citing works

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Webster, K. M., Shultz, S. R., Öztürk, E., Dill, L. K., Sun, M., Casillas-Espinosa, P. M., Jones, N. C., Crack, P. J., O'Brien, T. J., & Semple, B. D. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112979 · Cited by 55 · see citing works

TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling

Long, H., Zhong, G., Wang, C., Zhang, J., Zhang, Y., Luo, J., & Shi, S. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02817-1 · Cited by 54 · see citing works

Biomarkers for Alzheimer’s disease beyond amyloid and tau

Zetterberg, H., & Schott, J. M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0348-z · Cited by 53 · see citing works

The role of biomarkers and imaging in the clinical diagnosis of dementia

Bayer, A. J. (2018) · Age and Ageing · doi:10.1093/ageing/afy004 · Cited by 45 · see citing works

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation

Falcão, A. S., Carvalho, L. A. R., Lidónio, G. M. D. C., Vaz, A. R., Lucas, S. D., Moreira, R., & Brites, D. M. T. O. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00250 · Cited by 38 · see citing works

Plasma levels of soluble receptor for advanced glycation end products in Alzheimer's disease

Xu, X., Deng, C., Wang, J., Deng, X., Xiao, Q., Li, Y., He, Q., Fan, W.-H., Quan, F., Zhu, Y.-P., et al. (2016) · International Journal of Neuroscience · doi:10.1080/00207454.2016.1193861 · Cited by 35 · see citing works

sRAGE prolonged stem cell survival and suppressed RAGE-related inflammatory cell and T lymphocyte accumulations in an Alzheimer's disease model

Oh, S., Son, M., Choi, J., Lee, S., & Byun, K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.035 · Cited by 35 · see citing works

Suppressive effect of glycyrrhizic acid against lipopolysaccharide-induced neuroinflammation and cognitive impairment in C57 mice via toll-like receptor 4 signaling pathway

Liu, W., Huang, S., Li, Y., Zhang, K., & Zheng, X. (2019) · Food & Nutrition Research · doi:10.29219/fnr.v63.1516 · Cited by 35 · see citing works

With a little help from my friends: modulation of phagocytosis through TLR activation

Tricker, E. M., & Cheng, G. (2008) · Cell Research · doi:10.1038/cr.2008.78 · Cited by 32 · see citing works

Prestimulation of Microglia Through TLR4 Pathway Promotes Interferon Beta Expression in a Rat Model of Alzheimer’s Disease

Yousefi, N., Sotoodehnejadnematalahi, F., Heshmati-Fakhr, N., Sayyah, M., Hoseini, M., Ghassemi, S., Aliakbari, S., & Pourbadie, H. G. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1249-1 · Cited by 28 · see citing works

Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia

Kılıç, Ü., Elibol, B., Uysal, Ö., Kılıç, E., Yuluğ, B., Şakul, A., & Yıldız, G. B. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.07.018 · Cited by 27 · see citing works

p35 Deficiency Accelerates HMGB-1-mediated Neuronal Death in the Early Stages of an Alzheimer’s disease Mouse Model

Jang, A., Liew, H., Kim, Y., Choi, H., Kim, S., Lee, S. K., Ohshima, T., Mikoshiba, K., & Suh, Y. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990135 · Cited by 24 · see citing works

Effect of Linguizhugan decoction on neuroinflammation and expression disorder of the amyloid β‑related transporters RAGE and LRP‑1 in a rat model of Alzheimer's disease

Hu, Q., Yu, B., Chen, Q., Wang, Y., Ling, Y., Sun, S., Shi, Y., & Zhou, C. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7983 · Cited by 20 · see citing works

Lessons from Alzheimer's Disease (AD) Clinical Trials: Instead of “A-Drug”, AD-D prevention to Avert AD

Lahiri, D. K. (2019) · Current Alzheimer Research · doi:10.2174/156720501604190424114752 · Cited by 5 · see citing works

P3‐032: EFFICACY OF RAGE ANTAGONISTS IN MURINE MODEL OF ALZHEIMER'S DISEASE

Kostura, M. J., Kindy, M. S., Burstein, A. H., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.05.1119 · Cited by 4 · see citing works

Microglia in the Neuroinflammatory Pathogenesis of Alzheimer’s Disease and Related Therapeutic Targets

Cai, Y., Liu, J., Wang, B., Sun, M., & Yang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.856376 · Cited by 351 · see citing works

Imaging Techniques in Alzheimer’s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring

van Oostveen, W. M., & de Lange, E. C. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042110 · Cited by 297 · see citing works

Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer’s disease and frontotemporal dementia

Gaikwad, S., Puangmalai, N., Bittar, A., Montalbano, M., Garcia, S., McAllen, S., Bhatt, N., Sonawane, M., Sengupta, U., & Kayed, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109419 · Cited by 234 · see citing works

Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies

Gaikwad, S., Senapati, S., Haque, M. A., & Kayed, R. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13490 · Cited by 117 · see citing works

Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances

Deng, Q., Wu, C., Parker, E., Liu, T. C.-Y., Duan, R., & Yang, L. (2023) · Aging and disease · doi:10.14336/ad.2023.0907 · Cited by 102 · see citing works

Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage, and cell survival in Alzheimer’s disease

Islam, R., Choudhary, H. H., Zhang, F., Mehta, H., Yoshida, J., Thomas, A. J., & Hanafy, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-96456-y · Cited by 22 · see citing works

Possible Role of the HMGB1 and RAGE inflammatory pathway in primary sclerosing cholangitis

Sander, J., Kihm, L., Sauer, P., et al. (2018) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0037-1612665

The role of HMGB1-RAGE axis in migration and invasion of hepatocellular carcinoma cell lines

Chen, R.-C., Yi, P.-P., Zhou, R.-R., Xiao, M.-F., Huang, Z.-B., Tang, D., Huang, Y., & Fan, X. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-1978-6 · Cited by 109 · see citing works

Down Regulation of HMGB1‐RAGE pathway by Ethyl Pyruvate

Mun, S., & Yang, C. (2020) · The FASEB Journal · doi:10.1096/fasebj.2020.34.s1.03848 · Cited by 2 · see citing works

High-mobility group box protein1 increases tumor necrosis factor α expression in human bronchial epithelial cells

Yu, L. (2014) · Shiyong yixue zazhi

Receptor For Advanced Glycation End Products (RAGE) And High Mobility Group Box 1 (HMGB1) Mediate Pulmonary Ischemia-Reperfusion Injury

Sharma, A. K., LaPar, D. J., Fernández, L. G., et al. (2011) · doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5292