Cited by 106Fibromyalgia and Chronic Fatigue Syndrome ResearchPsychosomatic Disorders and Their TreatmentsPediatric Pain Management Techniques

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Juvenile fibromyalgia: current status of research and future developments

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Kashikar-Zuck, Susmita, Ting, Tracy V.·2014·Nature Reviews Rheumatology

DOI 10.1038/nrrheum.2013.177PMC PMC4470499

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Abstract

Juvenile-onset fibromyalgia (JFM) is a poorly understood chronic pain condition most commonly affecting adolescent girls. The condition is characterized by widespread musculoskeletal pain and other associated symptoms, including fatigue, nonrestorative sleep, headaches, irritable bowel symptoms, dysautonomia and mood disorders such as anxiety and/or depression. In the past few years, there has been a greater focus on understanding JFM in adolescents. Research studies have provided insight into the clinical characteristics of this condition and its effect on both short-term and long-term psychosocial and physical functioning. The importance of early and effective intervention is being recognized, as research has shown that symptoms of JFM tend to persist and do not resolve over time as was previously believed. Efforts to improve treatments for JFM are underway, and new evidence strongly points to the potential benefits of cognitive-behavioural therapy on improving mood and daily functioning. Research into pharmacotherapy and other nonpharmacological options is in progress. Advancements in the understanding of adult fibromyalgia have paved the way for future studies on diagnosis, assessment and management of JFM. This Review focuses on our current knowledge of the condition, provides an update of the latest research advances, and highlights areas for further study.

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See all 106

Authors: Kashikar-Zuck, S., & Ting, T. V.
Affiliations: Cincinnati Children's Hospital Medical Center (US)
ORCID: Ting, Tracy V.
Venue: Nature Reviews Rheumatology
Publisher: Springer Science and Business Media LLC
Published: 2013-11-26
Volume: 10
Issue: 2
Pages: 89-96
ISSN: 1759-4790 (ISSN-L)
1759-4804
DOI: 10.1038/nrrheum.2013.177
PMC: PMC4470499
OpenAlex: W2047802536
Cited by: 106
References: 119
Citations by year: 2026: 8 · 2025: 6 · 2024: 22 · 2023: 8 · 2022: 10 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 5 · 2014: 6
FWCI: 0.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Rheumatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000077)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (K24AR056687)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
Keywords: chronic pain, adolescents, chronic widespread pain, fatigue, non-restorative sleep, autonomic dysfunction, mood disorders, cognitive behavioral therapy, pharmacotherapy, non-pharmacological treatment, pathophysiology, prognosis, psychosocial functioning, early intervention
MeSH terms: Adolescent, Drug Therapy, Exercise Therapy, Female, Fibromyalgia, Humans, Male, Self Care, Cognitive Behavioral Therapy, Biomedical Research

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