The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis
Open accessAbstract
The pluripotency-promoting proteins Lin28a and Lin28b act as post-transcriptional repressors of let-7 miRNA biogenesis in undifferentiated embryonic stem cells. The levels of mature let-7a differ substantially in cells lacking Lin28 expression, indicating the existence of additional mechanism(s) of post-transcriptional regulation. Here, we present evidence supporting a role for heteronuclear ribonucleoprotein A1 (hnRNP A1) as a negative regulator of let-7a. HnRNP A1 binds the conserved terminal loop of pri-let-7a-1 and inhibits its processing by Drosha. Levels of mature let-7a negatively correlate with hnRNP A1 levels in somatic cell lines. Furthermore, hnRNP A1 depletion increased pri-let-7a-1 processing by cell extracts, whereas its ectopic expression decreased let-7a production in vivo. Finally, hnRNP A1 binding to let-7a interferes with the binding of KSRP, which is known to promote let-7a biogenesis. We propose that hnRNP A1 and KSRP have antagonistic roles in the post-transcriptional regulation of let-7a expression.
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Self-citationLin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells
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Metadata
- Authors
- Michlewski, G., & Cáceres, J. F.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2010-07-18
- Volume
- 17
- Issue
- 8
- Pages
- 1011-1018
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2165178850
- Cited by
- 269
- References
- 6
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- green
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