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The DNA-binding domain mediates both nuclear and cytosolic functions of p53
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“In a structural model of BCL-xL/p53 characterized by nuclear magnetic resonance (NMR) spectroscopy and determined using the HADDOCK docking method based on 1:1 stoichiometry, the BCL-xL binding surface of p53-DBD largely overlaps with the DNA-binding surface and encompasses helix H1 and the Zn2+-coordination site309 (Fig. 7f).”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [309]
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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
Chipuk, J. E., Kuwana, T., Bouchier-Hayes, L., Droin, N. M., Newmeyer, D. D., Schuler, M., & Green, D. R. (2004) · Science · doi:10.1126/science.1092734 · Cited by 2,108
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Green, D. R., & Kroemer, G. (2009) · Nature · doi:10.1038/nature07986 · Cited by 1,106
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Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease
Lee, J., Kim, Y., Liu, T., Hwang, Y. J., Hyeon, S. J., Im, H., Lee, K., Alvarez, V. E., McKee, A. C., Um, S., et al. (2018) · Aging Cell · doi:10.1111/acel.12679 · Cited by 213
Regulation of apoptosis by an intrinsically disordered region of Bcl-xL
Follis, A. V., Llambi, F., Kalkavan, H., Yao, Y., Phillips, A. H., Park, C.-G., Marassi, F. M., Green, D. R., & Kriwacki, R. W. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0011-x · Cited by 47
Self-citation
Metadata
- Authors
- Follis, A. V., Llambi, F., Ou, L., Baran, K., Green, D. R., & Kriwacki, R. W.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2014-05-11
- Volume
- 21
- Issue
- 6
- Pages
- 535-543
- ISSN
- 1545-9993
- 1545-9985
- Cited by
- 80
- References
- 9
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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