Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches

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Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

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STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

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cGAS surveillance of micronuclei links genome instability to innate immunity

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DAXX / ATRX , MEN1 , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

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CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING.

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Chromosomal instability drives metastasis through a cytosolic DNA response

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STING is a direct innate immune sensor of cyclic di-GMP

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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

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The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

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Mitotic progression following DNA damage enables pattern recognition within micronuclei

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Cytoplasmic chromatin triggers inflammation in senescence and cancer

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STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

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STING: infection, inflammation and cancer.

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The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

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DNA breaks and chromosome pulverization from errors in mitosis

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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

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Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

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Altered Telomeres in Tumors with <i>ATRX</i> and <i>DAXX</i> Mutations

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Type I interferon is selectively required by dendritic cells for immune rejection of tumors

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cGAS is essential for cellular senescence

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Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

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Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

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Structural mechanism of cytosolic DNA sensing by cGAS

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

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ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties

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The innate immune DNA Sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.

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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

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Cancer immunotherapies targeting the PD-1 signaling pathway

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Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

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Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

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cGAS is essential for the antitumor effect of immune checkpoint blockade

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TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

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Role of telomeres and telomerase in cancer

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STING manifests self DNA-dependent inflammatory disease

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Homologous Recombination Generates T-Loop-Sized Deletions at Human Telomeres

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Signalling strength determines proapoptotic functions of STING

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STING and the innate immune response to nucleic acids in the cytosol

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DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

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T-loops and the origin of telomeres

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MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

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Inflammation-driven carcinogenesis is mediated through STING

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Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

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The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

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Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis

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Into the clinic: Talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy

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STING-dependent cytosolic DNA sensing pathways

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STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation

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Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

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Systemic Armed Oncolytic and Immunologic Therapy for Cancer with JX-594, a Targeted Poxvirus Expressing GM-CSF

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Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

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MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

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Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides

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Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

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Anti–CTLA-4 Antibody Therapy: Immune Monitoring During Clinical Development of a Novel Immunotherapy

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STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer

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Decreased expression of STING predicts poor prognosis in patients with gastric cancer

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The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells

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Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

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Control of telomere length by a trimming mechanism that involves generation of t‐circles

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Telomeric Strategies: Means to an End

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Anticancer Flavonoids Are Mouse-Selective STING Agonists

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