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Full-length p53 tetramer bound to DNA and its quaternary dynamics
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“They are also consistent with long time scale molecular dynamics simulations of full-length p53 bound to p21 and Puma promoter sequences, in which K370, K372, K373, R379, K381, K382, and K386, located in the regions of the CTD that exhibit above average chemical shift changes (Figure 3), interact dynamically with DNA backbone atoms flanking the cognate recognition elements.65”
From Mapping Interactions of the Intrinsically Disordered C-Terminal Regions of Tetrameric p53 by Segmental Isotope Labeling and NMR (2022) · cites this paper as [65]
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“While the TET domain is expected to be positioned on the opposite side of the DNA relative to the four DBDs,65,66,68”
From Mapping Interactions of the Intrinsically Disordered C-Terminal Regions of Tetrameric p53 by Segmental Isotope Labeling and NMR (2022) · cites this paper as [65]
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Citations
Cites
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Cytoplasmic functions of the tumour suppressor p53
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Pang, Y.-P. (1999) · Journal of Molecular Modeling · doi:10.1007/s008940050119 · Cited by 161
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Cited by
Allosteric conformational ensembles have unlimited capacity for integrating information
Biddle, J. W., Martinez-Corral, R., Wong, F., & Gunawardena, J. (2021) · eLife · doi:10.7554/elife.65498 · Cited by 41
Krois, A. S., Park, S., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E. (2022) · Biochemistry · doi:10.1021/acs.biochem.2c00528 · Cited by 14
Metadata
- Authors
- Demir, Ö., Ieong, P. U., & Amaro, R. E.
- Venue
- Oncogene
- Published
- 2016-09-19
- Volume
- 36
- Issue
- 10
- Pages
- 1451-1460
- ISSN
- 0950-9232
- 1476-5594
- PMC
- PMC5344712
- Cited by
- 36
- References
- 5
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
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