Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics

Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis

Ramachandran, P., Matchett, K. P., Dobie, R., Wilson-Kanamori, J. R., & Henderson, N. C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0304-x · Cited by 253

Metabolic reprogramming in the tumor microenvironment of liver cancer

Lin, J., Rao, D., Zhang, M., & Gao, Q. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01527-8 · Cited by 251

C–Jun–N–Terminal Kinase Drives Cyclin D1 Expression and Proliferation During Liver Regeneration

Schwabe, R. F., Bradham, C. A., Uehara, T., Hatano, E., Bennett, B. L., Schoonhoven, R., & Brenner, D. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50135 · Cited by 251

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Zhu, C., Kim, K., Wang, X., Bartolome, A., Salomao, M., Dongiovanni, P., Meroni, M., Graham, M. J., Yates, K. P., Diehl, A. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0344 · Cited by 250

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome

Hofmann, J. J., Zovein, A. C., Koh, H., Radtke, F., Weinmaster, G., & Iruela‐Arispe, M. L. (2010) · Development · doi:10.1242/dev.052118 · Cited by 249

Glycogen metabolism regulates macrophage-mediated acute inflammatory responses

Ma, J., Wei, K., Liu, J., Tang, K., Zhang, H., Zhu, L., Chen, J., Li, F., Xu, P., Chen, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15636-8 · Cited by 248

Regeneration of Liver After Extreme Hepatocyte Loss Occurs Mainly via Biliary Transdifferentiation in Zebrafish

He, J., Lu, H., Zou, Q., & Luo, L. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.045 · Cited by 247

EFFECTS OF INSULIN, GLUCAGON, AND INSULIN/GLUCAGON INFUSIONS ON LIVER MORPHOLOGY AND CELL DIVISION AFTER COMPLETE PORTACAVAL SHUNT IN DOGS

Starzl, T. E., Porter, K. A., Watanabe, K., & Putnam, C. W. (1976) · The Lancet · doi:10.1016/s0140-6736(76)90477-3 · Cited by 247

Extensive Conversion of Hepatic Biliary Epithelial Cells to Hepatocytes After Near Total Loss of Hepatocytes in Zebrafish

Choi, T., Ninov, N., Stainier, D. Y. R., & Shin, D. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.10.019 · Cited by 244

Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!

Yang, J., Mowry, L. E., Nejak‐Bowen, K. N., Okabe, H., Diegel, C. R., Lang, R. A., Williams, B. O., & Monga, S. P. (2014) · Hepatology · doi:10.1002/hep.27082 · Cited by 244

Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration

Huang, Z., Chen, C., Zeng, Z., Yang, H., Oh, J., Chen, L., & Lu, S. C.-L. (2000) · The FASEB Journal · doi:10.1096/fj.00-0445fje · Cited by 244

Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

Meiser, J., Krämer, L., Sapcariu, S. C., Battello, N., Ghelfi, J., D'Herouel, A. F., Skupin, A., & Hiller, K. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.676817 · Cited by 243

Spatially resolved single-cell genomics and transcriptomics by imaging

Zhuang, X. (2021) · Nature Methods · doi:10.1038/s41592-020-01037-8 · Cited by 243

In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression

Park, O., Wang, H., Weng, H., Feigenbaum, L., Li, H., Yin, S., Ki, S. H., Yoo, S. H., Dooley, S., Wang, F., et al. (2011) · Hepatology · doi:10.1002/hep.24339 · Cited by 242

Pathophysiologic Observations and Histopathologic Recognition of the Portal Hyperperfusion or Small-for-Size Syndrome

Demetris, A. J., Kelly, D. M., Eghtesad, B., Fontes, P., Marsh, J. W., Tom, K. B., Tan, H. P., Shaw-Stiffel, T. A., Boig, L., Novelli, P. M., et al. (2006) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200608000-00009 · Cited by 241

FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2

Rao, J., Wang, H., Ni, M., Wang, Z., Wang, Z., Wei, S., Liu, M., Wang, P., Qiu, J., Zhang, L., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-325150 · Cited by 241

The role of notch signaling in the development of intrahepatic bile ducts

Kodama, Y., Hijikata, M., Kageyama, R., Shimotohno, K., & Chiba, T. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.004 · Cited by 240

The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

Zhang, X., Qiao, Y., Wu, Q., Chen, Y., Zou, S., Liu, X., Zhu, G., Zhao, Y., Chen, Y., Yu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms15280 · Cited by 237

Sinusoidal remodeling and angiogenesis: A new function for the liver-specific pericyte?

Lee, J. S., Semela, D., Iredale, J. P., & Shah, V. H. (2007) · Hepatology · doi:10.1002/hep.21564 · Cited by 236

The Hippo Pathway in Liver Homeostasis and Pathophysiology

Driskill, J. H., & Pan, D. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-030420-105050 · Cited by 236

Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options

Grander, C., Grabherr, F., & Tilg, H. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad095 · Cited by 236

Disruption of Hepatic Adipogenesis Is Associated With Impaired Liver Regeneration in Mice

Shteyer, E., Liao, Y., Muglia, L. J., Hruz, P. W., & Rudnick, D. A. (2004) · Hepatology · doi:10.1002/hep.20462 · Cited by 234

Tissue Repair: An Important Determinant of Final Outcome of Toxicant-Induced Injury

Mehendale, H. M. (2005) · Toxicologic Pathology · doi:10.1080/01926230590881808 · Cited by 233

TNF in the liver: targeting a central player in inflammation

Tiegs, G., & Horst, A. K. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00910-2 · Cited by 231

Cancer stem cell metabolism: a potential target for cancer therapy

Deshmukh, A. P., Deshpande, K. S., Arfuso, F., Newsholme, P., & Dharmarajan, A. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0555-x · Cited by 229

Granulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis: A Randomized Pilot Study

Singh, V., Sharma, A. K., Narasimhan, L. R., Bhalla, A., Sharma, N., & Sharma, R. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.154 · Cited by 228

Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice

Altomonte, J., Richter, A. M., Harbaran, S., Suriawinata, J., Nakae, J., Thung, S. N., Meseck, M. L., Accili, D., & Dong, H. H. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00156.2003 · Cited by 228

In vivo response of hepatocytes to growth factors requires an initial priming stimulus

Webber, E. M., Godowski, P. J., & Fausto, N. (1994) · Hepatology · doi:10.1002/hep.1840190230 · Cited by 227

CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization

Li, M., Sun, X., Zhao, J., Xia, L., Li, J., Xu, M., Wang, B., Guo, H., Yu, C., Gao, Y., et al. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-019-0279-0 · Cited by 225

The spatiotemporal program of zonal liver regeneration following acute injury

Ben-Moshe, S., Veg, T., Manco, R., Dan, S., Papinutti, D., Lifshitz, A., Kolodziejczyk, A. A., Bahar Halpern, K., Elinav, E., & Itzkovitz, S. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.04.008 · Cited by 224

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

Carmona‐Cuenca, I., Roncero, C., Sancho, P., Caja, L., Fausto, N., Fernández, M., & Fabregat, I. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.07.021 · Cited by 224

Clonal Tracing of Sox9+ Liver Progenitors in Mouse Oval Cell Injury

Tarlow, B., Finegold, M. J., & Grompe, M. (2014) · Hepatology · doi:10.1002/hep.27084 · Cited by 224

Aging and liver regeneration

Timchenko, N. A. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.01.005 · Cited by 222

Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease

Ebrahimkhani, M. R., Oakley, F., Murphy, L. B., Mann, J., Moles, A., Perugorria, M. J., Ellis, E., Lakey, A. F., Burt, A. D., Douglass, A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2490 · Cited by 221

Granulocyte‐colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis

Spahr, L., Lambert, J., Rubbia‐Brandt, L., Chalandon, Y., Frossard, J., Giostra, E., & Hadengue, A. (2008) · Hepatology · doi:10.1002/hep.22317 · Cited by 221

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

Planas-Paz, L., Sun, T., Pikiolek, M., Cochran, N. R., Bergling, S., Orsini, V., Yang, Z., Sigoillot, F., Jetzer, J., Syed, M., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.005 · Cited by 216

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition

Honda, A., Miyazaki, T., Iwamoto, J., Hirayama, T. T., Morishita, Y., Monma, T., Ueda, H., Mizuno, S., Sugiyama, F., Takahashi, S., et al. (2019) · Journal of Lipid Research · doi:10.1194/jlr.ra119000395 · Cited by 215

Hepatic fibrogenesis requires sympathetic neurotransmitters

Oben, J. A., Roskams, T., Yang, S., Lin, H., Sinelli, N., Torbenson, M., Smedh, U., Moran, T. H., Li, Z., Huang, J., et al. (2004) · Gut · doi:10.1136/gut.2003.026658 · Cited by 215

Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury

Wang, S., Wang, X., Tan, Z., Su, Y., Liu, J., Chang, M., Yan, F., Chen, J., Chen, T., Li, C., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0242-8 · Cited by 214

Osteopontin Takes Center Stage in Chronic Liver Disease

Song, Z., Chen, W., Athavale, D., Ge, X., Désert, R., Das, S., Han, H., & Nieto, N. (2020) · Hepatology · doi:10.1002/hep.31582 · Cited by 213

FXR signaling in metabolic disease

Zhang, Y., & Edwards, P. A. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.015 · Cited by 212

The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes.

Valdés, F., Alvarez, A. M., Locascio, A., Vega, S., Herrera, B. M., Fernández, M., Benito, M., Nieto, M. A., & Fabregat, I. (2002) · PubMed · Cited by 211

Hippo signalling in the liver: role in development, regeneration and disease

Russell, J. O., & Camargo, F. D. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00571-w · Cited by 211

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations

Chen, Q., Kirk, K., Shurubor, Y. I., Zhao, D., Arreguin, A. J., Shahi, I., Valsecchi, F., Primiano, G., Calder, E. L., Carelli, V., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.002 · Cited by 210

Alternatively activated macrophages promote resolution of necrosis following acute liver injury

Starkey Lewis, P., Campana, L., Aleksieva, N., Cartwright, J. A., Mackinnon, A., O'Duibhir, E., Kendall, T., Vermeren, M., Thomson, A., Gadd, V., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.02.031 · Cited by 209

Metabolite sensing and signaling in cell metabolism

Wang, Y.-P., & Lei, Q. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-018-0024-7 · Cited by 208

Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

Goldring, C. E., Kitteringham, N. R., Elsby, R., Randle, L. E., Clement, Y. N., Williams, D. P., McMahon, M. J., Hayes, J. D., Itoh, K., Yamamoto, M. P., et al. (2004) · Hepatology · doi:10.1002/hep.20183 · Cited by 207

Alcohol Use in Patients with Chronic Liver Disease

Fuster, D., & Samet, J. H. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1715733 · Cited by 207

A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook

Kramvis, A., Chang, K., Dandri, M., Farci, P., Glebe, D., Hu, J., Janssen, H. L. A., Lau, D., Pénicaud, C., Pollicino, T., et al. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00649-z · Cited by 207

Role of hepatic resident and infiltrating macrophages in liver repair after acute injury

You, Q., Holt, M. R., Yin, H., Li, G., Hu, C., & Ju, C. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.006 · Cited by 205

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

Liang, N., Zhang, C., Dill, P., Panasyuk, G., Pion, D., Koka, V., Gallazzini, M., Olson, E. N., Lam, H., Henske, E. P., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20140341 · Cited by 205

Pro-Regenerative Signaling after Acetaminophen-Induced Acute Liver Injury in Mice Identified Using a Novel Incremental Dose Model

Bhushan, B., Walesky, C. M., Manley, M. W., Gallagher, T., Borude, P. C., Edwards, G., Monga, S. P., & Apte, U. M. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.07.019 · Cited by 204

Animal models of drug-induced liver injury

McGill, M. R., & Jaeschke, H. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.037 · Cited by 202

Toxicity and adverse effects of Tamoxifen and other anti-estrogen drugs

Yang, G., Nowsheen, S., Aziz, K., & Georgakilas, A. G. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.05.005 · Cited by 200

Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

Jiang, X., Charlat, O., Zamponi, R., Yang, Y., & Cong, F. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.015 · Cited by 199

Trimethylamine N-Oxide: A Link among Diet, Gut Microbiota, Gene Regulation of Liver and Intestine Cholesterol Homeostasis and HDL Function

Canyelles, M., Tondo, M., Cedó, L., Farràs, M., Escolá‐Gil, J. C., & Blanco‐Vaca, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103228 · Cited by 197

Spatiotemporal control of CRISPR/Cas9 gene editing

Zhuo, C., Zhang, J., Lee, J., Jiao, J., Cheng, D., Liu, L., Kim, H., Tao, Y., & Li, M. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00645-w · Cited by 196

Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH

Xu, F., Guo, M., Huang, W., Feng, L., Zhu, J., Luo, K., Gao, J., Zheng, B., Kong, L.-D., Pang, T., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101634 · Cited by 196

Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration

Köhler, C. N., Bell, A. W., Bowen, W. C., Monga, S. P., Fleig, W. E., & Michalopoulos, G. K. (2004) · Hepatology · doi:10.1002/hep.20156 · Cited by 195

Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1

Averous, J., Fonseca, B. D., & Proud, C. G. (2008) · Oncogene · doi:10.1038/sj.onc.1210715 · Cited by 194

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

Pajvani, U. B., Shawber, C. J., Samuel, V. T., Birkenfeld, A. L., Shulman, G. I., Kitajewski, J., & Accili, D. (2011) · Nature Medicine · doi:10.1038/nm.2378 · Cited by 193

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

Péan, N., Doignon, I., Garcin, I., Besnard, A., Julien, B., Liu, B., Branchereau, S., Spraul, A., Guettier, C., Humbert, L., et al. (2013) · Hepatology · doi:10.1002/hep.26463 · Cited by 193

Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice

Bonzo, J. A., Ferry, C. H., Matsubara, T., Kim, J.-H., & Gonzalez, F. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.334599 · Cited by 193

Comparative Effectiveness of Pharmacological Interventions for Severe Alcoholic Hepatitis: A Systematic Review and Network Meta-analysis

Singh, S., Murad, M. H., Chandar, A. K., Bongiorno, C. M., Singal, A. K., Atkinson, S. R., Thursz, M. R., Loomba, R. S., & Shah, V. H. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.06.006 · Cited by 192

Kupffer cell depletion by CI2MDP‐liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy

Meijer, C., Wiezer, M. J., Diehl, A. M., Yang, S., Schouten, H. J., Meijer, S., van Rooijen, N., van Lambalgen, A. A., Dijkstra, C. D., & van Leeuwen, P. A. M. (2000) · Liver International · doi:10.1034/j.1600-0676.2000.020001066.x · Cited by 192

Liver Regeneration after Hepatectomy and Partial Liver Transplantation

Yagi, S., Hirata, M., Miyachi, Y., & Uemoto, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218414 · Cited by 192

Transplanting organs from pigs to humans

Sykes, M., & Sachs, D. H. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau6298 · Cited by 191

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b -deficient mice

Nishio, M., Sugimachi, K., Goto, H., Wang, J. H., Morikawa, T., Miyachi, Y., Takano, Y., Hikasa, H., Itoh, T., Suzuki, S. O., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517188113 · Cited by 190

An Unbalance Between von Willebrand Factor and ADAMTS13 in Acute Liver Failure: Implications for Hemostasis and Clinical Outcome

Hugenholtz, G. C. G., Adelmeijer, J., Meijers, J. C. M., Porte, R. J., Stravitz, R. T., & Lisman, T. (2013) · Hepatology · doi:10.1002/hep.26372 · Cited by 190

The biliary epithelium gives rise to liver progenitor cells

Rodrigo-Torres, D., Affò, S., Coll, M., Morales-Ibanez, O., Millán, C., Blaya, D., Alvarez-Guaita, A., Rentero, C., José Lozano, J., Maestro, M. A., et al. (2014) · Hepatology · doi:10.1002/hep.27078 · Cited by 189

The evolving role of liver sinusoidal endothelial cells in liver health and disease

McConnell, M. J., Kostallari, E., Ibrahim, S. H., & Iwakiri, Y. (2023) · Hepatology · doi:10.1097/hep.0000000000000207 · Cited by 189

Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-γ)

Sun, R., & Gao, B. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.055 · Cited by 187

Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

Ramirez, T., Li, Y.-M., Yin, S., Xu, M.-J., Feng, D., Zhou, Z., Zang, M., Mukhopadhyay, P., Varga, Z. V., Pacher, P., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.11.004 · Cited by 186

SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis

Fang, L., Teng, H., Wang, Y., Liao, G., Weng, L., Li, Y., Wang, X., Jin, J., Jiao, C., Chen, L., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.06.002 · Cited by 185

Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis

Dubuquoy, L., Louvet, A., Lassailly, G., Truant, S., Boleslawski, E., Artru, F., Maggiotto, F., Gantier, E., Buob, D., Leteurtre, E., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-308410 · Cited by 183

Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism

Lin, L., Ding, Y., Wang, Y., Wang, Z., Yin, X., Yan, G., Zhang, L., Yang, P., & Shen, H. (2017) · Hepatology · doi:10.1002/hep.29033 · Cited by 181

Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH

Ioannou, G. N., Subramanian, S., Chait, A., Haigh, W. G., Yeh, M. M., Farrell, G. C., Lee, S. P., & Savard, C. E. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m072454 · Cited by 180

Reactive oxygen species‐induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging

Seo, E., Kang, H., Choi, H., Choi, W., & Jun, H. (2019) · Aging Cell · doi:10.1111/acel.12895 · Cited by 180

Beta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury

Apte, U. M., Singh, S., Zeng, G., Cieply, B. W., Virji, M. A., Wu, T., & Monga, S. P. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080976 · Cited by 179

Liver Regeneration after Acetaminophen Hepatotoxicity

Bhushan, B., & Apte, U. (2019) · The American Journal of Pathology · doi:10.1016/j.ajpath.2018.12.006 · Cited by 179

Metabolic reprogramming in cholangiocarcinoma

Raggi, C., Taddei, M. L., Rae, C. J., Braconi, C., & Marra, F. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.04.038 · Cited by 179

The Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration

Zheng, Z., & Wang, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.775526 · Cited by 178

Gut microbiota promote liver regeneration through hepatic membrane phospholipid biosynthesis

Yin, Y., Sichler, A., Ecker, J., Laschinger, M., Liebisch, G., Höring, M., Basic, M., Bleich, A., Zhang, X.-J., Kuebelsbeck, L. A., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2022.12.028 · Cited by 178

Depressed Liver Regeneration After Partial Hepatectomy of Germ–Free, Athymic and Lipopolysaccharide–Resistant Mice

Cornell, R. P., Liljequist, B. L., & Bartizal, K. F. (1990) · Hepatology · doi:10.1002/hep.1840110603 · Cited by 178

Contribution of Toll‐like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration†

Seki, E., Tsutsui, H., Iimuro, Y., Naka, T., Son, G., Akira, S., Kishimoto, T., Nakanishi, K., & Fujimoto, J. (2005) · Hepatology · doi:10.1002/hep.20603 · Cited by 176

Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer

Jeong, S., Kim, H.-B., Kim, M., Lee, J.-M., Lee, J. H., Kim, J., Kim, J. W., Park, W., Kim, S., Kim, J. B., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95802 · Cited by 176

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling

Liu, Y., Gupta, V. K., Patwardhan, G. A., Bhinge, K. N., Zhao, Y., Bao, J. R., Mehendale, H. M., Cabot, M. C., Li, Y., & Jazwinski, S. M. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-145 · Cited by 174

Pivotal role of glutamine synthetase in ammonia detoxification

Hakvoort, T. B. M., He, Y., Kulik, W., Vermeulen, J. L. M., Duijst, S., Ruijter, J. M., Runge, J. H., Deutz, N. E. P., Koehler, S. E., & Lamers, W. H. (2017) · Hepatology · doi:10.1002/hep.28852 · Cited by 173

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