The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates
Open accessAbstract
Persisters are transiently antibiotic-tolerant cells that complicate the treatment of bacterial infections. Both theory and experiments have suggested that persisters facilitate genetic resistance by constituting an evolutionary reservoir of viable cells. Here, we provide evidence for a strong positive correlation between persistence and the likelihood to become genetically resistant in natural and lab strains of E. coli. This correlation can be partly attributed to the increased availability of viable cells associated with persistence. However, our data additionally show that persistence is pleiotropically linked with mutation rates. Our theoretical model further demonstrates that increased survival and mutation rates jointly affect the likelihood of evolving clinical resistance. Overall, these results suggest that the battle against antibiotic resistance will benefit from incorporating anti-persister therapies.
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Cites
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Cited by
Antibiotic resistance and persistence—implications for human health and treatment perspectives
Huemer, M., Mairpady Shambat, S., Brugger, S. D., & Zinkernagel, A. S. (2020) · The EMBO Reports · doi:10.15252/embr.202051034 · Cited by 850
Distribution of antibiotic resistance genes in the environment
Zhuang, M., Achmon, Y., Cao, Y., Liang, X., Chen, L., Wang, H., Siame, B. A., & Leung, K. Y. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117402 · Cited by 422
Arastehfar, A., Daneshnia, F., Cabrera, N., Penalva-Lopez, S., Sarathy, J., Zimmerman, M., Shor, E., & Perlin, D. S. (2023) · Nature Communications · doi:10.1038/s41467-023-36882-6 · Cited by 58
Impact of bacterial persisters on their host
Moldoveanu, A. L., Rycroft, J. A., & Helaine, S. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.07.006 · Cited by 44
Fungicide-tolerant persister formation during cryptococcal pulmonary infection
Ke, W., Xie, Y., Chen, Y., Ding, H., Ye, L., Qiu, H., Li, H., Zhang, L., Chen, L., Tian, X., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2023.12.012 · Cited by 45
Metadata
- Authors
- Windels, E. M., Michiels, J. E., Fauvart, M., Wenseleers, T., Van den Bergh, B., & Michiels, J.
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-01-15
- Volume
- 13
- Issue
- 5
- Pages
- 1239-1251
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- OpenAlex
- W2910584283
- Cited by
- 367
- References
- 81
- FWCI
- 21.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Windels, E. M., Michiels, J. E., Fauvart, M., Wenseleers, T., Van den Bergh, B., & Michiels, J. (2019). Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates. The ISME Journal. https://doi.org/10.1038/s41396-019-0344-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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