Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369

Circulating microRNAs as stable blood-based markers for cancer detection

Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186

Biological properties of extracellular vesicles and their physiological functions

Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,894

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12404 · Cited by 4,663

Liquid biopsies: the future of cancer early detection

Connal, S., Cameron, J. M., Sala, A., Brennan, P. M., Palmer, D. S., Palmer, J. D., Perlow, H. K., & Baker, M. J. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03960-8 · Cited by 403

Extracellular Vesicles for Clinical Diagnostics: From Bulk Measurements to Single-Vesicle Analysis

Tran, H. L., Zheng, W., Issadore, D., Im, H., Cho, Y., Zhang, Y., Liu, D., Liu, Y., Li, B., Liu, F., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c00706 · Cited by 117

Cancer diagnosis using label-free SERS-based exosome analysis

Liu, Y., Li, M., Liu, H., Kang, C., & Wang, C. (2024) · Theranostics · doi:10.7150/thno.92621 · Cited by 107

Extracellular vesicles as personalized medicine

Beetler, D. J., Di Florio, D. N., Bruno, K. A., Ikezu, T., March, K. L., Cooper, L. T., Wolfram, J., & Fairweather, D. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101155 · Cited by 101

Liquid Biopsy in the Clinical Management of Cancers

Ho, H.-Y., Chung, K.-S., Kan, C.-M., & Wong, S. C. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168594 · Cited by 87

Advances in Platelet Rich Plasma-Derived Extracellular Vesicles for Regenerative Medicine: A Systematic-Narrative Review

Anitua, E., Troya, M., Falcón‐Pérez, J. M., López-Sarrio, S., González, E., & Alkhraisat, M. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713043 · Cited by 69

Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease

Amin, S., Massoumi, H., Tewari, D., Roy, A. K., Chaudhuri, M., Jazayerli, C., Krishan, A., Singh, M., Soleimani, M., Karaca, E. E., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052730 · Cited by 66

Extracellular vesicles transport RNA between cells: Unraveling their dual role in diagnostics and therapeutics

Payandeh, Z., Tangruksa, B., Synnergren, J., Heydarkhan‐Hagvall, S., Nordin, J. Z., Andaloussi, S. E., Borén, J., Wiseman, J., Bohlooly‐Y, M., Lindfors, L., et al. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101302 · Cited by 70

Glycosylation in extracellular vesicles: Isolation, characterization, composition, analysis and clinical applications

Vrablova, V., Košútová, N., Blšáková, A., Bertóková, A., Kasák, P., Bertók, T., & Tkáč, J. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108196 · Cited by 62

The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis

Guo, S., Huang, J., Li, G., Chen, W., Li, Z., & Lei, J. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01909-5 · Cited by 65

Cancer-Associated Fibroblast Heterogeneity, Activation and Function: Implications for Prostate Cancer

Owen, J. S., Clayton, A., & Pearson, H. B. (2022) · Biomolecules · doi:10.3390/biom13010067 · Cited by 60

All-in-One Nanowire Assay System for Capture and Analysis of Extracellular Vesicles from an ex Vivo Brain Tumor Model

Chattrairat, K., Yasui, T., Suzuki, S., Natsume, A., Nagashima, K., Iida, M., Zhang, M., Shimada, T., Kato, A., Aoki, K., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c08526 · Cited by 52

Nanomechanical Signatures of Extracellular Vesicles from Hematologic Cancer Patients Unraveled by Atomic Force Microscopy for Liquid Biopsy

Feng, Y., Liu, M., Li, X., Li, M., Xing, X., & Liu, L. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c00093 · Cited by 46

Prostate cancer theragnostics biomarkers: An update

Kumar, S., Rajan, P., Alkhamees, M. A., Holley, M., & Lakshmanan, V. (2024) · Korean journal of urology · doi:10.4111/icu.20240229 · Cited by 39

Heat shock protein A2 is a novel extracellular vesicle-associated protein

Sojka, D. R., Abramowicz, A., Adamiec‐Organiściok, M., Karnas, E., Mielańczyk, Ł., Kania, D., Blamek, S., Telka, E., & Ścieglińska, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-31962-5 · Cited by 37

Prospects and Current Challenges of Extracellular Vesicle-Based Biomarkers in Cancer

Lawrence, S. R., & Shah, K. M. (2024) · Biology · doi:10.3390/biology13090694 · Cited by 39

Optical Imaging of Single Extracellular Vesicles: Recent Progress and Prospects

Ma, B., Li, L., Bao, Y., Yuan, L., Liu, S., Qi, L., Tong, S., Xiao, Y., Qi, L., Fang, X., et al. (2023) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.3c00095 · Cited by 35

Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies

Bajo-Santos, C., Brokāne, A., Zayakin, P., Endzeliņš, E., Soboļevska, K., Belovs, A., Jansons, J., Sperga, M., Llorente, A., Radoviča-Spalviņa, I., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.980433 · Cited by 31

On the dilemma of using single EV analysis for liquid biopsy: the challenge of low abundance of tumor EVs in blood

Imanbekova, M., Sharma, M., & Wachsmann‐Hogiu, S. (2025) · Theranostics · doi:10.7150/thno.115131 · Cited by 37

CRISPR/Cas detection with nanodevices: moving deeper into liquid biopsy

Kong, H., Yi, K., Mintz, R. L., Wang, B., Xu, Y., Lao, Y., Tao, Y., & Li, M. (2024) · Chemical Communications · doi:10.1039/d3cc05375j · Cited by 28

Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26

The Role of Extracellular Vesicles in the Pathogenesis of Hematological Malignancies: Interaction with Tumor Microenvironment; a Potential Biomarker and Targeted Therapy

Das, K., Mukherjee, T., & Shankar, P. (2023) · Biomolecules · doi:10.3390/biom13060897 · Cited by 27

Advancements in Biomarkers of Prostate Cancer: A Review

Agbetuyi-Tayo, P. T., Gbadebo, M., Rotimi, O. A., & Rotimi, S. O. (2024) · Technology in Cancer Research & Treatment · doi:10.1177/15330338241290029 · Cited by 25

Identification and detection of plasma extracellular vesicles-derived biomarkers for esophageal squamous cell carcinoma diagnosis

Zhu, Q., Xu, H., Huang, L., Luo, J., Li, H., Yang, R., Liu, X., & Liu, F. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115088 · Cited by 25

Cancer and Aging Biomarkers: Classification, Early Detection Technologies and Emerging Research Trends

Ki, M., Kim, D. H., Abdelhamid, M. A. A., & Pack, S. P. (2025) · Biosensors · doi:10.3390/bios15110737 · Cited by 33

Unlocking the power of extracellular vesicles: multi-omics integration for cancer biomarker discovery

Ansermino, C., Pavlović, R., Braccia, C., Drago, D., Anelli, C., & Andolfo, A. (2026) · Biomarker Research · doi:10.1186/s40364-025-00889-6 · Cited by 24

In Search of Ideal Solutions for Cancer Diagnosis: From Conventional Methods to Protein Biomarkers in Liquid Biopsy

Neagu, A.-N., Bruno, P. S., Josan, C.-L., Waterman, N., Morrissiey, H., Njoku, V. T., & Darie, C. C. (2025) · Proteomes · doi:10.3390/proteomes13040047 · Cited by 25

Patients With “Gray Zone” PSA Levels: Application of Prostate MRI and MRS in the Diagnosis of Prostate Cancer

Li, X., Li, C., & Chen, M. (2022) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28505 · Cited by 23

Transcending frontiers in prostate cancer: the role of oncometabolites on epigenetic regulation, CSCs, and tumor microenvironment to identify new therapeutic strategies

Ambrosini, G., Cordani, M., Zarrabi, A., Alcón-Rodríguez, S., Sainz, R. M., Velasco, G., González‐Menéndez, P., & Dando, I. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01462-0 · Cited by 25

Extracellular vesicles as source for the identification of minimally invasive molecular signatures in glioblastoma

Rackles, E., Lopez, P. H., & Falcón‐Pérez, J. M. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.11.004 · Cited by 22

Separation and isolation of CD9-positive extracellular vesicles from plasma using flow cytometry

Khanna, K., Salmond, N., Halvaei, S., Johnson, A., & Williams, K. C. (2023) · Nanoscale Advances · doi:10.1039/d3na00081h · Cited by 22

Extracellular Vesicles Isolation from Large Volume Samples Using a Polydimethylsiloxane-Free Microfluidic Device

Bajo-Santos, C., Priedols, M., Kauķis, P., Paidere, G., Gerulis-Bergmanis, R., Mozoļevskis, G., Ābols, A., & Rimša, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097971 · Cited by 20

Exploration of Extracellular Vesicle miRNAs, Targeted mRNAs and Pathways in Prostate Cancer: Relation to Disease Status and Progression

Puhka, M., Thierens, L., Nicorici, D., Forsman, T., Mirtti, T. K., af Hällström, T., Serkkola, E., & Rannikko, A. S. (2022) · Cancers · doi:10.3390/cancers14030532 · Cited by 18

Unraveling the Role of EV-Derived miR-150-5p in Prostate Cancer Metastasis and Its Association with High-Grade Gleason Scores: Implications for Diagnosis

Cruz-Burgos, M., Cortés-Ramírez, S. A., Losada-García, A., Morales-Pacheco, M., Martínez‐Martínez, E., Morales-Montor, J. G., Haddad-Servín, A., Izquierdo-Luna, J. S., Martinez, G. R., Ramos‐Godínez, M. D. P., et al. (2023) · Cancers · doi:10.3390/cancers15164148 · Cited by 17

Progress and application of intelligent nanomedicine in urinary system tumors

Xiao, Y., Zhong, L., Liu, J., Chen, L., Wu, Y. G., & Li, G. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.100964 · Cited by 17

The Potential of Extracellular Matrix- and Integrin Adhesion Complex-Related Molecules for Prostate Cancer Biomarker Discovery

Samaržija, I. (2023) · Biomedicines · doi:10.3390/biomedicines12010079 · Cited by 15

Machine learning diagnosis by immunoglobulinN‐glycan signatures for precision diagnosis of urological diseases

Iwamura, H., Mizuno, K., Akamatsu, S., Hatakeyama, S., Tobisawa, Y., Narita, S., Narita, T., Yamashita, S., Kawamura, S., Sakurai, T., et al. (2022) · Cancer Science · doi:10.1111/cas.15395 · Cited by 15

A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation

Capozza, M., Stefanìa, R., Dinatale, V., Bitonto, V., Conti, L., Grange, C., Škovroňová, R., & Terreno, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112878 · Cited by 15

Hydrogen Peroxide Promotes the Production of Radiation-Derived EVs Containing Mitochondrial Proteins

Miller, C. E., Xu, F., Zhao, Y., Luo, W., Zhong, W., Meyer, K. K., Jayswal, R. D., Weiss, H. L., Clair, W. H. S., Clair, D. K. S., et al. (2022) · Antioxidants · doi:10.3390/antiox11112119 · Cited by 15

Validation of potential RNA biomarkers for prostate cancer diagnosis and monitoring in plasma and urinary extracellular vesicles

Brokāne, A., Bajo-Santos, C., Zayakin, P., Belovs, A., Jansons, J., Lietuvietis, V., Martens‐Uzunova, E. S., Jenster, G. W., & Linē, A. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1279854 · Cited by 14

Air Pollution and Lung Cancer: Contributions of Extracellular Vesicles as Pathogenic Mechanisms and Clinical Utility

González-Ruíz, J., Baccarelli, A., de León, D. F. C., & Prada, D. (2023) · Current Environmental Health Reports · doi:10.1007/s40572-023-00421-8 · Cited by 16

Snorkel‐tag based affinity chromatography for recombinant extracellular vesicle purification

Bobbili, M. R., Görgens, A., Yan, Y., Vogt, S., Gupta, D., Corso, G., Barbaria, S., Patrioli, C., Weilner, S., Pultar, M., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12523 · Cited by 14

Toward Identification of Markers for Brain‐Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large‐Scale, Unbiased Analysis Using Proximity Extension Assays

Norman, M., Shah, A. S., D'Amaddio, S., Travis, B. G., Ter‐Ovanesyan, D., Dougan, T. J., & Walt, D. R. (2025) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70052 · Cited by 14

Affinity‐Based Isolation and One‐Pot Analysis of Extracellular Vesicles from Biofluids Using Phase Separated Zwitterionic Coacervates

Torrini, F., Frigerio, R., Garlipp, J., Lenzen, P. S., Normak, K., Paganini, C., Cretich, M., Gori, A., & Arosio, P. (2025) · Advanced Science · doi:10.1002/advs.202411653 · Cited by 12

Extracellular vesicles from biological fluids as potential markers in castration resistant prostate cancer

Choi, W. W. Y., Sánchez, C., Li, J. J., Dinarvand, M., Adomat, H. H., Ghaffari, M., Khoja, L., Vafaee, F., Joshua, A. M., Chi, K. N., et al. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04391-6 · Cited by 12

Extracellular vesicle isolation, purification and evaluation in cancer diagnosis

Mortezaee, K., Majidpoor, J., & Fathi, F. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.34 · Cited by 12

Circulating Tumor DNA Biomarkers for Response Assessment in Prostate Cancer

Sartor, O. A. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-1043 · Cited by 13

Small extracellular vesicles: crucial mediators for prostate cancer

Tang, S., Cheng, H., Zang, X., Tian, J., Ling, Z., Wang, L., Xu, W., & Jiang, J. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03326-w · Cited by 11

Extracellular vesicles for precision medicine in prostate cancer – Is it ready for clinical translation?

Robinson, H., Roberts, M. J., Gardiner, R. A., & Hill, M. M. C. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.01.003 · Cited by 10

Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics

Zhang, G., Ding, Y., Zhang, H., Wei, D., Liu, Y., Sun, J., Xie, Z., Tao, W. A., & Zhu, Y. (2024) · The Analyst · doi:10.1039/d4an00296b · Cited by 9

Applications of Urinary Extracellular Vesicles in the Diagnosis and Active Surveillance of Prostate Cancer

Smith, S. F., Brewer, D. S., Hurst, R., & Cooper, C. S. (2024) · Cancers · doi:10.3390/cancers16091717 · Cited by 9

Blood-based liquid biopsy in advanced prostate cancer

Giunta, E. F., Malapelle, U., Russo, A. D., & Giorgi, U. D. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104241 · Cited by 9

Liver-derived Exosomal miRNA in NAFLD: Mechanisms of Action, Biomarkers, and Therapeutic Applications

Yang, J., Xiaolei, T., Chen, L., Hu, J., Li, S., Yuan, M., Tian, X., & Qiu, Z. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673276581231210170332 · Cited by 8

Prospects and challenges of targeted extracellular vesicles drug delivery for cancer treatment

Maher, F., Samadi, A., Asadi, P., & Jodoin, I. (2024) · Extracellular Vesicle · doi:10.1016/j.vesic.2024.100059 · Cited by 8

Extracellular Vesicles: Tiny Messengers for Mighty RNA Delivery

Das, A. (2024) · Biologics · doi:10.3390/biologics4010007 · Cited by 8

Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression

Nturubika, B. D., Guardia, C. M. A., Gershlick, D. C., Logan, J. M., Martini, C., Heatlie, J. K., Łaźniewska, J., Moore, C. R., Lam, G. T., Li, K. L., et al. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02829-x · Cited by 7

AI for BPH Surgical Decision-Making: Cost Effectiveness and Outcomes

Lama, J., Winograd, J., Codelia-Anjum, A. J., Bhojani, N., Elterman, D., Zorn, K. C., & Chughtai, B. I. (2024) · Current Urology Reports · doi:10.1007/s11934-024-01240-6 · Cited by 7

Characterization of proteins, mRNAs, and miRNAs of circulating extracellular vesicles from prostate cancer patients compared to healthy subjects

Chisholm, J., Haas‐Neill, S., Margetts, P. J., & Al-Nedawi, K. N. I. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.895555 · Cited by 7

Transcript Markers from Urinary Extracellular Vesicles for Predicting Risk Reclassification of Prostate Cancer Patients on Active Surveillance

Erdmann, K., Distler, F. A., Gräfe, S., Kwe, J., Erb, H. H. H., Fuessel, S., Pahernik, S. A., Thomas, C., & Borkowetz, A. (2024) · Cancers · doi:10.3390/cancers16132453 · Cited by 6

Label-Free Refractive-Index-Based Detection of Breast, Leukemia, and Prostate Cancer Cells Using a Tetra-Core PCF SPR Biosensor

Shakya, A. K., & Grigalavicius, M. (2026) · Biosensors · doi:10.3390/bios16090463 · Cited by 6

The biological function of extracellular vesicles in prostate cancer and their clinical application as diagnostic and prognostic biomarkers

Limonta, P., Marchesi, S., Giannitti, G., Casati, L., & Fontana, F. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-024-10210-w · Cited by 6

Unlocking the potential of extracellular vesicles: one stimulus away from clinical implementation

Silva, R. M., Azevedo, A. M., Bonifácio, V. D. B., Fernandez-Becerra, C., & Pinto, S. N. (2025) · Biomaterials Science · doi:10.1039/d5bm01091h · Cited by 7

Differentiation of high risk prostate cancer with a facile urinary exosome detection workflow

Qiu, S., Li, Y., Zhang, Z., Li, C., Wang, H., Chen, A., Yan, Z., Liu, Y., Li, Z., Huang, H., et al. (2025) · iScience · doi:10.1016/j.isci.2025.111896 · Cited by 4

Knowledge mapping of exosomes in prostate cancer from 2003 to 2022: a bibliometric analysis

Li, Y., Ma, L., Chen, H., Jin, Z., Yang, W., Qiao, Y., Ji, Z., & Liu, G. (2024) · Discover Oncology · doi:10.1007/s12672-024-01183-x · Cited by 4

Roles of gastric cancer-derived exosomes in the occurrence of metastatic hepatocellular carcinoma

Zhou, J., Gou, Y.-K., Guo, D. S., Wang, M., & Liu, P. (2025) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2025.01.005 · Cited by 4

Extracellular Vesicles as a Source of Biomarkers for Cancer Diagnosis

Ovchinnikova, L. A., & Lomakin, Y. A. (2025) · Acta Naturae · doi:10.32607/actanaturae.27591 · Cited by 5

Proteomic Profiling of Extracellular Vesicles Distinguishes Prostate Cancer Molecular Subtypes

Ludwig, M., Arafa, A. T., Vinoo, S., Jones, J. C., Day, A., Bergom, H. E., Sychev, Z. E., Horrmann, A., Levinson, N. M., Dehm, S. M., et al. (2025) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70176 · Cited by 4

Catecholate Dye-Assisted Decoration of Ag on TiO2 Nanoparticles for Detection of Cancer-Related MicroRNA Biomarkers on a Multiplexed Photoelectrochemical Platform

Sakib, S., Maclachlan, R., Gao, Y., Mascher, P., Knights, A. P., Soleymani, L., & Zhitomirsky, I. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c04438 · Cited by 4

Novel Blood-Based Biomarkers for HCC

Pai, S., & Parikh, N. D. (2024) · Current Hepatology Reports · doi:10.1007/s11901-023-00626-3 · Cited by 4

Towards Understanding the Role of the Glycosylation of Proteins Present in Extracellular Vesicles in Urinary Tract Diseases: Contributions to Cancer and Beyond

Wilczak, M., Surman, M., & Przybyło, M. (2024) · Molecules · doi:10.3390/molecules29225241 · Cited by 4

Multiplexed quantitative proteomics in prostate cancer biomarker development

Gao, Y., Kim, H., Kitata, R. B., Lin, T., Swensen, A., Shi, T., & Liu, T. (2024) · Advances in cancer research · doi:10.1016/bs.acr.2024.04.003 · Cited by 3

Liquid Biopsy and its significance on the Early Detection of Breast Cancer

Hasannejad, F., Fazilat, A., & Majidzadeh‐A, K. (2024) · Journal of Breast Disease · doi:10.61186/ijbd.17.3.55 · Cited by 3

Liquid biopsy to personalize treatment for metastatic prostate cancer

López-Valcárcel, M. (2024) · American Journal of Translational Research · doi:10.62347/dicu9510 · Cited by 3

Constructing and Validating Models for Predicting Gleason Grade Group Upgrading following Radical Prostatectomy in Localized Prostate Cancer: A Comparison between Machine Learning Algorithms and Conventional Logistic Regression

Gui, Q., Wang, X., Wu, D., & Guo, Y. (2025) · Oncology · doi:10.1159/000543492 · Cited by 3

Small extracellular vesicles: Roles and clinical application in prostate cancer

Smack, C., Johnson, B., Nyalwidhe, J. O., Semmes, O. J., & Yang, L. (2024) · Advances in cancer research · doi:10.1016/bs.acr.2024.05.008 · Cited by 2

Novel Bronchoscopy Method for Molecular Profiling of Lung Cancer: Targeted Washing Technique

Kim, M., Seong, H., Jang, H., Kim, S., Yoo, W., Kim, S. H., Mok, J., Lee, K., Kim, K. U., Lee, M. K., et al. (2025) · Cancer Research and Treatment · doi:10.4143/crt.2024.1128 · Cited by 2

Integration of exosome-related genes and differential expression analysis reveals potential biomarkers for prostate cancer

Huang, S., Hu, C., Guo, Z., Zhang, X., Wu, T., Zeng, Y., Qing, C., & Cheng, S. (2025) · Discover Oncology · doi:10.1007/s12672-025-03861-w · Cited by 2

Extracellular vesicles from tumor-associated macrophages: implications for tumor progression and emerging therapeutic strategies

Amorim, C. S., Moraes, J. A., Renovato‐Martins, M., & Motta, J. M. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114855 · Cited by 2

Focusing on Prostate-Specific Membrane Antigen in Precision Diagnosis and Treatment of Prostate Cancer

Ren, X., Zhang, L., An, R., Song, H., Shi, M., & Wang, Z. (2026) · Biomedicines · doi:10.3390/biomedicines14020482 · Cited by 2

Understanding tumor heterogeneity: Implications for precision oncology and therapeutic strategies

Lv, Y., He, C., Xie, Q., Long, F., & Fan, C. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189617 · Cited by 3

Exosomes, the Key Players in Cell-To-Cell Communication as the Universal Nano-Sized Disease Sensors of the Future

Mohammadi, K., Bǎdilescu, S., Ghosh, A., & Packirisamy, M. (2023) · ECS Sensors Plus · doi:10.1149/2754-2726/ace981 · Cited by 2

Urinary miRNAs: Technical Updates

Raveendran, S., Massih, A. A., Hashmi, M. A., Saeed, A., Al-Azwani, I. K., Mathew, R., & Tomei, S. (2024) · MicroRNA · doi:10.2174/0122115366305985240502094814 · Cited by 2

In silico analysis of prognostic and diagnostic significance of target genes from prostate cancer cell lines derived exomicroRNAs

Altuna-Coy, A., Ruiz-Plazas, X., Arreaza‐Gil, V., Tomás, J. S., & Chacón, M. R. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03123-1 · Cited by 2

Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3

Lee, K. Y., Beatson, E. L., Knechel, M. A., Sommer, E. R., Napoli, G. C., Risdon, E. N., Leon, A. F., Depaz, R. D., Strope, J. D., Price, D. K., et al. (2023) · Journal of Cancer · doi:10.7150/jca.90836 · Cited by 2

Current understanding of prostate cancer biomarkers

Popov, S. V., Guseynov, R. G., Vasin, A. V., Сивак, К. В., Помешкин, Е. В., Perepelitsa, V. V., Bunenkov, N. S., & Lelyavina, Т. А. (2023) · Cancer Urology · doi:10.17650/1726-9776-2023-19-4-148-157 · Cited by 1

Advances in metastatic prostate cancer circulating tumor cell enrichment technologies and clinical studies

Abou-Ghali, N. E., & Giannakakou, P. (2024) · International review of cytology · doi:10.1016/bs.ircmb.2024.06.005 · Cited by 1

New Challenges and Opportunities: Extracellular Vesicles in Biological and Biochemical Processes

Giusti, I., & Bavisotto, C. C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073395 · Cited by 1

Efficient capture and proteomics analysis of urinary extracellular vesicles by affinity purification

Zhang, G., Zhen, Z. H. A. N., Tao, W. A., & Zhang, H. (2025) · Chinese Journal of Chromatography · doi:10.3724/sp.j.1123.2024.11013 · Cited by 1

The role of circulating tumor DNA in gynecological cancer management

Gao, M., Yu, P.-Y., Li, R.-X., Chen, C., Cong, X., & Liu, Z. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2025.1664172 · Cited by 1

Research advances in extracellular vesicles for diagnosis and treatment of genitourinary cancers

Zhao, M., Huang, W., Yang, C., Lu, L., Chen, L., Wang, J., Yang, H., Guo, Q., Qin, T., & Huang, D. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1793573 · Cited by 1

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Werner, S., Tennstedt, P., Pose, R., Müller, C., Besler, K., Schneegans, S., Alawi, M., Roesch, M. C., Peine, S., Bonci, D., et al. (2026) · Molecular Oncology · doi:10.1002/1878-0261.70244 · Cited by 1

A multi-gene urinary extracellular vesicle mRNA panel as a non-invasive biomarkers for prostate cancer detection

Patnam, S., Koppula, A., Kumar, S. K., Thalakanti, S., Bendre, R. V., Addla, S. K., & Manda, S. V. (2026) · Scientific Reports · doi:10.1038/s41598-026-47999-1 · Cited by 1

Potential Value and Application of Liquid Biopsy in Tumor, Neurodegeneration, and Muscle Degenerative Diseases

Chen, L., Yang, J., Xu, G., & Wu, Y. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3346-5_22 · Cited by 1

Research and development of emerging technologies for exosome-based cancer diagnostics and therapeutics

Ayala‐Mar, S., & González‐Valdez, J. (2023) · LACCEI International Multi-Conference for Engineering, Education and Technology (LACCEI) · doi:10.18687/laccei2023.1.1.1656 · Cited by 1

Extracellular vesicles derived-microRNAs predicting enzalutamide-resistance in 3D spheroid prostate Cancer model

Tavares, I., Morais, M., Dias, F., Ferreira, M., Martins, G., Fernandes, R., Bidarra, S. J., Medeiros, R., & Teixeira, A. L. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137993 · Cited by 1

A liquid biopsy algorithm exploiting local exosome heterogeneity

Kim, T., Choi, D.-Y., Kwon, S., Park, S. E., Kim, J., Lee, Y., Choi, S., & Paek, S.-H. (2025) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2025.100585 · Cited by 1

Oncogenic KRAS regulates secretion of extracellular vesicles and surface membrane charge via regulation of phosphatidylserine in pancreatic cancerPreprint

Kapoor, K. S., Luo, X., Church, K. A., Bell, M. M., Fan, B., Kong, S., Ramirez, E. V., Chen, Y., Kugeratski, F. G., Biswal, S. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.21.677641 · Cited by 1

All-in-One Nanowire Assay System for Extracellular Vesicle Capture and Analysis from Ex Vivo Brain Tumor ModelPreprint

Chattrairat, K., Yasui, T., Suzuki, S., Natsume, A., Nagashima, K., Iida, M., Shimada, T., Aoki, K., Ohka, F., Yamazaki, S., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4142409

Extracellular vesicles from biological fluids as potential biomarkers for prostate cancerPreprint

Choi, W. Y., Sánchez, C., Li, J. J., Dinarvand, M., Adomat, H. H., Ghaffari, M., Khoja, L., Vafaee, F., Joshua, A. M., Chi, K. N., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1948091/v1

Extracellular vesicle-derived biomarkers in prostate cancer care: Opportunities and challenges

Wang, X., Zhang, L., Zhang, L., Wang, Y., Li, M., Yu, J., Ma, Z., Ho, P. C., Sethi, G., Chen, X., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217184 · Cited by 13

Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis

Pang, B., Zhu, Y., Ni, J., Thompson, J. E., Malouf, D. J., Bucci, J. A., Graham, P., & Li, Y. (2020) · Theranostics · doi:10.7150/thno.39486 · Cited by 221

Extracellular vesicles for liquid biopsy in prostate cancer: where are we and where are we headed?

Minciacchi, V. R., Zijlstra, A., Rubin, M. A., & Vizio, D. D. (2017) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2017.7 · Cited by 93

Extracellular vesicles in prostate cancer: a narrative review

Hatano, K., & Fujita, K. (2021) · Translational Andrology and Urology · doi:10.21037/tau-20-1210 · Cited by 31

Liquid biopsy of extracellular vesicle biomarkers for prostate cancer personalized treatment decision

Han, M., Pang, B.-R., Zhou, C., Li, X., Wang, Q., Jiang, J.-H., & Li, Y. (2022) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2021.20 · Cited by 14