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Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research
Open accessAbstract
Prostate cancer is a global cancer burden and considerable effort has been made through the years to identify biomarkers for the disease. Approximately a decade ago, the potential of analysing extracellular vesicles in liquid biopsies started to be envisaged. This was the beginning of a new exciting area of research investigating the rich molecular treasure found in extracellular vesicles to identify biomarkers for a variety of diseases. Vesicles released from prostate cancer cells and cells of the tumour microenvironment carry molecular information about the disease that can be analysed in several biological fluids. Numerous studies document the interest of researchers in this field of research. However, methodological issues such as the isolation of vesicles have been challenging. Remarkably, novel technologies, including those based on nanotechnology, show promise for the further development and clinical use of extracellular vesicles as liquid biomarkers. Development of biomarkers is a long and complicated process, and there are still not many biomarkers based on extracellular vesicles in clinical use. However, the knowledge acquired during the last decade constitutes a solid basis for the future development of liquid biopsy tests for prostate cancer. These are urgently needed to bring prostate cancer treatment to the next level in precision medicine.
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Cites
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099
Self-citationShedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186
Biological properties of extracellular vesicles and their physiological functions
Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926
Self-citationIsolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,894
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444
Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931 · cited 1×
“Although initially considered to be a waste-disposal mechanism [42], it is now clear that both EVs generated by living or apoptotic cells can be taken up by recipient cells and are important mediators of intercellular communication [37, 43].”
BackgroundLiquid biopsies come of age: Towards implementation of circulating tumour DNA
Wan, J. C. M., Massie, C., Garcia-Corbacho, J., Mouliere, F., Brenton, J. D., Caldas, C., Pacey, S., Baird, R., & Rosenfeld, N. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.7 · Cited by 2,809
Witwer, K. W., Buzás, E. I., Bemis, L., Bora, A., Lässer, C., Lötvall, J. O., Hoen, E. N. M. N., Piper, M. G., Sivaraman, S., Skog, J., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20360 · Cited by 2,513
Current knowledge on exosome biogenesis and release
Hessvik, N. P., & Llorente, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2595-9 · Cited by 2,362
Self-citationLiquid Biopsies: Genotyping Circulating Tumor DNA
Diaz, L. A., & Bardelli, A. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2011 · Cited by 2,210
Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
Al-Nedawi, K. N. I., Meehan, B., Micallef, J., Lhotak, V., May, L. L., Guha, A., & Rak, J. W. (2008) · Nature Cell Biology · doi:10.1038/ncb1725 · Cited by 2,037
Progress in Exosome Isolation Techniques
Li, P., Kaslan, M., Lee, S. H., Yao, J. D., & Gao, Z. (2017) · Theranostics · doi:10.7150/thno.18133 · Cited by 2,019
The exosome journey: from biogenesis to uptake and intracellular signalling
Gurung, S., Perocheau, D. P. B., Touramanidou, L., & Baruteau, J. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00730-1 · Cited by 1,912
Pre-metastatic niches: organ-specific homes for metastases
Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889
Age-related mutations associated with clonal hematopoietic expansion and malignancies
Xie, M., Lu, C., Wang, J., McLellan, M. D., Johnson, K. J., Wendl, M. C., McMichael, J. F., Schmidt, H. K., Yellapantula, V., Miller, C. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3733 · Cited by 1,874
RNA delivery by extracellular vesicles in mammalian cells and its applications
O’Brien, K., Breyne, K., Ughetto, S., Laurent, L. C., & Breakefield, X. O. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0251-y · Cited by 1,811
Biomarker definitions and their applications
Califf, R. M. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370217750088 · Cited by 1,694
Phases of Biomarker Development for Early Detection of Cancer
Pepe, M. S., Etzioni, R., Feng, Z., Potter, J. D., Thompson, M. L., Thornquist, M., Winget, M., & Yasui, Y. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.14.1054 · Cited by 1,686
Zhang, H., Freitas, D. P., Kim, H. S., Fabijanic, K. I., Li, Z., Chen, H., Mark, M. T., Molina, H., Benito‐Martín, A., Bojmar, L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0040-4 · Cited by 1,666
Isolation of Extracellular Vesicles: General Methodologies and Latest Trends
Konoshenko, M. Y., Lekchnov, E. A., Vlassov, A. V., & Laktionov, P. P. (2018) · BioMed Research International · doi:10.1155/2018/8545347 · Cited by 1,302
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
EV-TRACK Consortium, Van Deun, J., Mestdagh, P., Agostinis, P., Akay, Ö., Anand, S., Anckaert, J., Martinez, Z. A., Baetens, T., Beghein, E., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4185 · Cited by 1,284
Gardiner, C., Vizio, D. D., Sahoo, S., Théry, C., Witwer, K. W., Wauben, M. H. M., & Hill, A. F. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.32945 · Cited by 1,113
Liquid biopsy and minimal residual disease - latest advances and implications for cure
Pantel, K., & Alix-Panabières, C. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0187-3 · Cited by 1,110
Methodological Guidelines to Study Extracellular Vesicles
Coumans, F. A. W., Brisson, A. R., Buzás, E. I., Dignat‐George, F., Drees, E. E. E., Andaloussi, S. E., Emanueli, C., Gąsecka, A., Hendrix, A., Hill, A. F., et al. (2017) · Circulation Research · doi:10.1161/circresaha.117.309417 · Cited by 1,052
Liquid Biopsy: From Discovery to Clinical Application
Alix‐Panabières, C., & Pantel, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1311 · Cited by 1,006
The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling
Deun, J. V., Mestdagh, P., Sormunen, R. T., Cocquyt, V., Vermaelen, K., Vandesompele, J., Bracke, M., Wever, O. D., & Hendrix, A. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24858 · Cited by 987
Exosome-based liquid biopsies in cancer: opportunities and challenges
Wang, Y., Hurley, J. D., Roberts, D., Chakrabortty, S. K., Enderle, D., Noerholm, M., Breakefield, X. O., & Skog, J. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2021.01.074 · Cited by 882
Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
Nilsson, J. A., Skog, J., Nordstrand, A., Baranov, V. I., Mincheva‐Nilsson, L., Breakefield, X. O., & Widmark, A. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605058 · Cited by 786
Mateescu, B., Kowal, E. J. K., van Balkom, B. W. M., Bartel, S., Bhattacharyya, S. N., Buzás, E. I., Buck, A. H., de Candia, P., Chow, F. W., Das, S., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1286095 · Cited by 757
Changes in circulating microRNA levels associated with prostate cancer
Bryant, R. J., Pawlowski, T. L., Catto, J. W. F., Marsden, G. L., Vessella, R. L., Rhees, B. K., Kuslich, C. D., Visakorpi, T., & Hamdy, F. C. (2012) · British Journal of Cancer · doi:10.1038/bjc.2011.595 · Cited by 716
Zhao, Z., Yang, Y., Zeng, Y., & He, M. (2015) · Lab on a Chip · doi:10.1039/c5lc01117e · Cited by 695
A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy
McKiernan, J., Donovan, M. J., O’Neill, V., Bentink, S., Noerholm, M., Belzer, S. K., Skog, J., Kattan, M. W., Partin, A. W., Andriole, G. L., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.0097 · Cited by 691
Kanwar, S. S., Dunlay, C. J., Simeone, D. M., & Nagrath, S. (2014) · Lab on a Chip · doi:10.1039/c4lc00136b · Cited by 682
Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer
Huang, X., Yuan, T., Liang, M., Du, M., Xia, S., Dittmar, R. L., Wang, D., See, W. A., Costello, B. A., Quevedo, F., et al. (2014) · European Urology · doi:10.1016/j.eururo.2014.07.035 · Cited by 681
Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins
Karimi, N., Cvjetkovic, A., Jang, S. C., Crescitelli, R., Feizi, M. A. H., Nieuwland, R., Lötvall, J. O., & Lässer, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2773-4 · Cited by 613
Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20 nm
Wunsch, B. H., Smith, J. T., Gifford, S. M., Wang, C., Brink, M., Bruce, R. L., Austin, R. H., Stolovitzky, G. A., & Astier, Y. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.134 · Cited by 597
An emerging focus on lipids in extracellular vesicles
Skotland, T., Sagini, K., Sandvig, K., & Llorente, A. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.03.002 · Cited by 585
Self-citationGutman, A. B., & GUTMAN, E. B. (1938) · Journal of Clinical Investigation · doi:10.1172/jci100974 · Cited by 555
The evolving translational potential of small extracellular vesicles in cancer
Möller, A., & Lobb, R. J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00299-w · Cited by 550
Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris
Caruso, S., & Poon, I. K. H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01486 · Cited by 541
Liquid Biopsies in Cancer Diagnosis, Monitoring, and Prognosis
Rubis, G. D., Krishnan, S. R., & Bebawy, M. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.01.006 · Cited by 533
Modern isolation and separation techniques for extracellular vesicles
Liangsupree, T., Multia, E., & Riekkola, M. (2020) · Journal of Chromatography A · doi:10.1016/j.chroma.2020.461773 · Cited by 520
Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip
Zhang, P., Zhou, X., He, M., Shang, Y., Tetlow, A. L., Godwin, A., & Zeng, Y. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0356-9 · Cited by 505
Technologies and Standardization in Research on Extracellular Vesicles
Gandham, S. K., Su, X., Wood, J., Nocera, A. L., Alli, S. C., Milane, L. S., Zimmerman, A. J., Amiji, M. M., & Ivanov, A. R. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.05.012 · Cited by 505
Extracellular vesicles and viruses: Are they close relatives?
Hoen, E. N. M. N., Cremer, T., Gallo, R. C., & Margolis, L. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605146113 · Cited by 497
Role of Androgen Receptor in Prostate Cancer: A Review
Fujita, K., & Nonomura, N. (2019) · The World Journal of Men's Health · doi:10.5534/wjmh.180040 · Cited by 483
Beyond PSA: The Next Generation of Prostate Cancer Biomarkers
Prensner, J. R., Rubin, M. A., Wei, J. T., & Chinnaiyan, A. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003180 · Cited by 479
Field-Free Isolation of Exosomes from Extracellular Vesicles by Microfluidic Viscoelastic Flows
Liu, C., Guo, J., Tian, F., Yang, N., Yan, F., Ding, Y., Wei, J., Hu, G., Nie, G., & Sun, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b02277 · Cited by 477
Integrated Magneto–Electrochemical Sensor for Exosome Analysis
Jeong, S., Park, J., Pathania, D., Castro, C. M., Weissleder, R., & Lee, H. (2016) · ACS Nano · doi:10.1021/acsnano.5b07584 · Cited by 473
Tauro, B. J., Greening, D. W., Mathias, R. A., Mathivanan, S., Ji, H. L., & Simpson, R. J. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.021303 · Cited by 457
Exosome Biochemistry and Advanced Nanotechnology for Next‐Generation Theranostic Platforms
Yang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201802896 · Cited by 435
Translation of proteomic biomarkers into FDA approved cancer diagnostics: issues and challenges
Füzéry, A. K., Levin, J. D., Chan, M. M., & Chan, D. W. (2013) · Clinical Proteomics · doi:10.1186/1559-0275-10-13 · Cited by 428
Erdbrügger, U., Blijdorp, C. J., Bijnsdorp, I. V., Borràs, F. E., Burger, D. E., Bussolati, B., Byrd, J. B., Clayton, A., Dear, J. W., Falcón‐Pérez, J. M., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12093 · Cited by 422
Self-citationMinciacchi, V. R., You, S., Spinelli, C., Morley, S., Zandian, M., Aspuria, P.-J. P., Cavallini, L., Ciardiello, C., Reis-Sobreiro, M., Morello, M., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3598 · Cited by 419
Lacroix, R., Judicone, C., PONCELET, P., Robert, S., ARNAUD, L., Sampol, J., & Dignat‐George, F. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04610.x · Cited by 401
The prostasome: its secretion and function in man
Ronquist, G., & Brody, I. (1985) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(85)90008-5 · Cited by 400
Zhang, P., He, M., & Zeng, Y. (2016) · Lab on a Chip · doi:10.1039/c6lc00279j · Cited by 398
Royo, F., Théry, C., Falcón‐Pérez, J. M., Nieuwland, R., & Witwer, K. W. (2020) · Cells · doi:10.3390/cells9091955 · Cited by 389
Vagner, T., Spinelli, C., Minciacchi, V. R., Balaj, L., Zandian, M., Conley, A., Zijlstra, A., Freeman, M. R., Demichelis, F., De, S., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1505403 · Cited by 386
How liquid biopsies can change clinical practice in oncology
Siravegna, G., Mussolin, B., Venesio, T., Marsoni, S., Seoane, J., Dive, C., Papadopoulos, N., Kopetz, S., Corcoran, R. B., Siu, L. L., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz227 · Cited by 376
Apoptotic cell-derived exosomes: messages from dying cells
Kakarla, R., Hur, J., Kim, Y. J., Kim, J., & Chwae, Y. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0362-8 · Cited by 371
Lin, S., Yu, Z., Chen, D., Wang, Z., Miao, J., Li, Q., Zhang, D., Song, J., & Cui, D. (2019) · Small · doi:10.1002/smll.201903916 · Cited by 357
D'Amico, A. V., Whittington, R., Malkowicz, S. B., Cote, K., Loffredo, M. J., Schultz, D., Chen, M., Tomaszewski, J. E., Renshaw, A. A., Wein, A. J., et al. (2002) · Cancer · doi:10.1002/cncr.10657 · Cited by 357
Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers
Skotland, T., Ekroos, K., Kauhanen, D., Simolin, H., Seierstad, T., Berge, V., Sandvig, K., & Llorente, A. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.10.011 · Cited by 350
Self-citationInvestigation of miR-21, miR-141, and miR-221 in blood circulation of patients with prostate cancer
Ağaoğlu, F., Kovancilar, M., Dizdar, Y., Darendeliler, E., Holdenrieder, S., Dalay, N., & Deligezer, U. (2011) · Tumor Biology · doi:10.1007/s13277-011-0154-9 · Cited by 341
Plasma-Derived Exosomal Survivin, a Plausible Biomarker for Early Detection of Prostate Cancer
Khan, S., Jutzy, J. M. S., Valenzuela, M. M. A., Turay, D., Aspe, J. R., Ashok, A., Mirshahidi, S., Mercola, D., Lilly, M. B., & Wall, N. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046737 · Cited by 331
Zhang, H., Yang, L., Zhu, Y., Yao, X., Zhang, S., Dai, B., Zhu, Y., Shen, Y., Shi, G., & Ye, D. (2010) · The Prostate · doi:10.1002/pros.21246 · Cited by 324
Can urinary exosomes act as treatment response markers in prostate cancer?
Mitchell, P., Welton, J. L., Staffurth, J. N., Court, J., Mason, M. D., Tabi, Z., & Clayton, A. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-4 · Cited by 312
Murillo, O. D., Thistlethwaite, W., Rozowsky, J. S., Subramanian, S. L., Lucero, R., Shah, N., Jackson, A. R., Srinivasan, S., Chung, A. Y., Laurent, C. D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.018 · Cited by 308
Lázaro‐Ibáñez, E., Sanz-García, A., Visakorpi, T., Escobedo‐Lucea, C., Siljander, P. R. M., Ayuso‐Sacido, Á., & Yliperttula, M. L. (2014) · The Prostate · doi:10.1002/pros.22853 · Cited by 293
Re, M. D., Biasco, E., Crucitta, S., Derosa, L., Rofi, E., Orlandini, C., Miccoli, M., Galli, L., Falcone, A., Jenster, G. W., et al. (2016) · European Urology · doi:10.1016/j.eururo.2016.08.012 · Cited by 293
Tamm-Horsfall protein and urinary exosome isolation
Fernández-Llama, P., Khositseth, S., Gonzales, P. A., Star, R. A., Pisitkun, T., & Knepper, M. A. (2010) · Kidney International · doi:10.1038/ki.2009.550 · Cited by 290
Liang, L.-G., Kong, M., Zhou, S. X., Sheng, Y.-F., Wang, P., Yu, T., İnci, F., Kuo, W. P., Li, L., Demirci, U., et al. (2017) · Scientific Reports · doi:10.1038/srep46224 · Cited by 286
McKiernan, J., Donovan, M. J., Margolis, E., Partin, A. W., Carter, B., Brown, G. A., Torkler, P., Noerholm, M., Skog, J., Shore, N. D., et al. (2018) · European Urology · doi:10.1016/j.eururo.2018.08.019 · Cited by 286
microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer
Bhagirath, D., Yang, T. L., Bucay, N., Sekhon, K., Majid, S., Shahryari, V., Dahiya, R., Tanaka, Y., & Saini, S. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2069 · Cited by 283
Exosomes as Biomarker Treasure Chests for Prostate Cancer
Duijvesz, D., Luider, T. M., Bangma, C. H., & Jenster, G. W. (2010) · European Urology · doi:10.1016/j.eururo.2010.12.031 · Cited by 282
Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery
van Dongen, H. M., Masoumi, N., Witwer, K. W., & Pegtel, D. M. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00063-15 · Cited by 271
Endzeliņš, E., Berger, A., Melne, V., Bajo-Santos, C., Soboļevska, K., Ābols, A., Rodríguez, M., Šantare, D., Rudņickiha, A., Lietuvietis, V., et al. (2017) · BMC Cancer · doi:10.1186/s12885-017-3737-z · Cited by 270
Self-citationGlycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives
Williams, C., Royo, F., Aizpurua‐Olaizola, O., Pazos, R., Boons, G., Reichardt, N., & Falcón‐Pérez, J. M. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1442985 · Cited by 269
Neural stem cells traffic functional mitochondria via extracellular vesicles
Peruzzotti-Jametti, L., Bernstock, J. D., Willis, C. M., Manferrari, G., Rogall, R., Fernandez-Vizarra, E., Williamson, J. C., Braga, A., van den Bosch, A., Leonardi, T., et al. (2021) · PLOS Biology · doi:10.1371/journal.pbio.3001166 · Cited by 263
Rodríguez, M., Bajo-Santos, C., Hessvik, N. P., Lorenz, S., Fromm, B., Berge, V., Sandvig, K., Linē, A., & Llorente, A. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0726-4 · Cited by 255
Self-citationThe role of the prostate in male fertility, health and disease
Verze, P., Cai, T., & Lorenzetti, S. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.89 · Cited by 255
Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer
Tavoosidana, G., Ronquist, G., Darmanis, S., Yan, J., Carlsson, L. M. S., Wu, D., Conze, T., Ek, P., Semjonow, A., Eltze, E., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019330108 · Cited by 244
Increased PSA expression on prostate cancer exosomes in in vitro condition and in cancer patients
Logozzi, M., Angelini, D. F., Iessi, E., Mizzoni, D., Raimo, R. D., Federici, C., Lugini, L., Borsellino, G., Gentilucci, A., Pierella, F., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.06.036 · Cited by 242
Puhka, M., Takatalo, M. S., Nordberg, M.-E., Valkonen, S., Nandania, J., Aatonen, M. T., Yliperttula, M. L., Laitinen, S., Velagapudi, V., Mirtti, T. K., et al. (2017) · Theranostics · doi:10.7150/thno.19890 · Cited by 237
Identification of prostate cancer biomarkers in urinary exosomes
Øverbye, A., Skotland, T., Koehler, C. J., Thiede, B., Seierstad, T., Berge, V., Sandvig, K., & Llorente, A. (2015) · Oncotarget · doi:10.18632/oncotarget.4851 · Cited by 231
Self-citationUnveiling massive numbers of cancer-related urinary-microRNA candidates via nanowires
Yasui, T., Yanagida, T., Ito, S., Konakade, Y., Takeshita, D., Naganawa, T., Nagashima, K., Shimada, T., Kaji, N., Nakamura, Y., et al. (2017) · Science Advances · doi:10.1126/sciadv.1701133 · Cited by 224
Egevad, L., Delahunt, B., Srigley, J. R., & Samaratunga, H. (2016) · Apmis · doi:10.1111/apm.12533 · Cited by 224
Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases
Sahoo, S., Adamiak, M., Mathiyalagan, P., Kenneweg, F., Kafert-Kasting, S., & Thum, T. (2021) · Circulation · doi:10.1161/circulationaha.120.049254 · Cited by 218
Stenman, U., Leinonen, J., Zhang, W., & Finne, P. (1999) · Seminars in Cancer Biology · doi:10.1006/scbi.1998.0086 · Cited by 213
Smartphone‐based clinical diagnostics: towards democratization of evidence‐based health care
Hernández-Neuta, I., Neumann, F., Brightmeyer, J., Tis, T. B., Madaboosi, N., Wei, Q., Özcan, A., & Nilsson, M. F. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12820 · Cited by 207
Microfluidics‐based on‐a‐chip systems for isolating and analysing extracellular vesicles
Guo, S., Tao, S., & Dawn, H. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1508271 · Cited by 206
Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease
Işın, M., Uysaler, E., Özgür, E., KöseoÄŸlu, H., Åžanlı, Ã., Yücel, Ã. B., Deligezer, U., & Dalay, N. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00168 · Cited by 204
Emerging methods in biomarker identification for extracellular vesicle‐based liquid biopsy
Liang, Y., Lehrich, B. M., Zheng, S., & Lu, M. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12090 · Cited by 201
Smith, J. T., Wunsch, B. H., Dogra, N., Ahsen, M. E., Lee, K., Yadav, K. K., Weil, R., Pereira, M. A., Patel, J. V., Duch, E. A., et al. (2018) · Lab on a Chip · doi:10.1039/c8lc01017j · Cited by 195
Exosomal microRNA-141 is upregulated in the serum of prostate cancer patients
Hao, X., Li, Z., Ma, Y., Wang, J., Zeng, X., Li, R., & Kang, W. (2015) · OncoTargets and Therapy · doi:10.2147/ott.s95565 · Cited by 192
Lunavat, T. R., Cheng, L., Kim, D., Bhadury, J., Jang, S. C., Lässer, C., Sharples, R. A., López, M. D., Nilsson, J. A., Gho, Y. S., et al. (2015) · RNA Biology · doi:10.1080/15476286.2015.1056975 · Cited by 190
Samsonov, R. B., Shtam, T. A., Burdakov, V. S., Glotov, A. S., Tsyrlina, E. V., Berstein, L. M., Носов, А. К., Евтушенко, В. И., Filatov, M. V., & Malek, A. V. (2015) · The Prostate · doi:10.1002/pros.23101 · Cited by 183
Lehmann, S., Guadagni, F., Moore, H. A., Ashton, G., Barnes, M., Benson, E. E., Clements, J. A., Koppandi, I., Coppola, D., Nussbeck, S. Y., et al. (2012) · Biopreservation and Biobanking · doi:10.1089/bio.2012.0012 · Cited by 182
Tutrone, R. F., Jr., Donovan, M. J., Torkler, P., Tadigotla, V. R., McLain, T., Noerholm, M., Skog, J., & McKiernan, J. (2020) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-020-0237-z · Cited by 180
Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer
Fujita, K., Kume, H., Matsuzaki, K., Kawashima, A., Ujike, T., Nagahara, A., Uemura, M., Miyagawa, Y., Tomonaga, T., & Nonomura, N. (2017) · Scientific Reports · doi:10.1038/srep42961 · Cited by 176
Exosomal and Non-Exosomal Urinary miRNAs in Prostate Cancer Detection and Prognosis
Foj, L., Ferrer, F., Serra, M., Arévalo, A., Gavagnach, M., Giménez, N., & Filella, X. (2016) · The Prostate · doi:10.1002/pros.23295 · Cited by 175
Donovan, M. J., Noerholm, M., Bentink, S., Belzer, S. K., Skog, J., O’Neill, V., Cochran, J. S., & Brown, G. A. (2015) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2015.40 · Cited by 172
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
Principe, S., Jones, E., Kim, Y., Sinha, A., Nyalwidhe, J., Brooks, J. L., Semmes, O., Troyer, D., Lance, R., Kislinger, T., et al. (2013) · Proteomics · doi:10.1002/pmic.201200561 · Cited by 170
Bijnsdorp, I. V., Geldof, A. A., Lavaei, M., Piersma, S. R., van Moorselaar, R. J. A., & Jiménez, C. R. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.22097 · Cited by 170
Möhrmann, L., Huang, H. J., Hong, D. S., Tsimberidou, A. M., Fu, S., Piha-Paul, S. A., Subbiah, V., Karp, D. D., Naing, A., Krug, A., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2007 · Cited by 168
Prevalence and patterns of polyomavirus urinary excretion in immunocompetent adults and children
Polo, C., Pérez, J. L., Mielnichuck, A., Fedele, C. G., Niubó, J., & Tenório, A. (2004) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2004.00882.x · Cited by 168
Human Urinary Exosomes as Innate Immune Effectors
Hiemstra, T. F., Charles, P. D., Gracia, T., Hester, S., Gatto, L., Al‐Lamki, R. S., Floto, R. A., Su, Y., Skepper, J. N., Lilley, K. S., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013101066 · Cited by 167
Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT)
Wang, Z., Hill, S., Luther, J. M., Hachey, D. L., & Schey, K. L. (2011) · PROTEOMICS · doi:10.1002/pmic.201100477 · Cited by 167
Clos‐Garcia, M., Loizaga‐Iriarte, A., Zúñiga-García, P., Sánchez‐Mosquera, P., Cortázar, A. R., González, E., Torrano, V., Alonso, C., Pérez-Cormenzana, M., Ugalde‐Olano, A., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1470442 · Cited by 164
Recent advances and challenges in the recovery and purification of cellular exosomes
Ayala‐Mar, S., Donoso‐Quezada, J., Gallo‐Villanueva, R. C., Pérez‐González, V. H., & González‐Valdez, J. (2019) · Electrophoresis · doi:10.1002/elps.201800526 · Cited by 162
Immuno‐based detection of extracellular vesicles in urine as diagnostic marker for prostate cancer
Duijvesz, D., Versluis, C. Y. L., van der Fels, C. A. M., den Berg, M. S. V., Leivo, J., Peltola, M. T., Bangma, C. H., Pettersson, K. S. I., & Jenster, G. W. (2015) · International Journal of Cancer · doi:10.1002/ijc.29664 · Cited by 162
Dhondt, B., Geeurickx, E., Tulkens, J., Deun, J. V., Vergauwen, G., Lippens, L., Miinalainen, I., Rappu, P., Heino, J., Ost, P., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1736935 · Cited by 159
An Mg2+ and Ca2+-Stimulated Adenosine Triphosphatase in Human Prostatic Fluid: Part I
Ronquist, G. K., Brody, I., Gottfries, A., & Stegmayr, B. G. (2009) · Andrologia · doi:10.1111/j.1439-0272.1978.tb03030.x · Cited by 158
Vasconcelos, M. H., Caires, H. R., Ābols, A., Xavier, C. P. R., & Linē, A. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100647 · Cited by 150
The Long Journey of Cancer Biomarkers from the Bench to the Clinic
Pavlou, M. P., Diamandis, E. P., & Blasutig, I. M. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.184614 · Cited by 149
Royo, F., Zúñiga-García, P., Sánchez‐Mosquera, P., Egia, A., Perez, A., Loizaga‐Iriarte, A., Arceo, R., Viscasillas, I. L., Ferreiro, A. R., Arrieta, E., et al. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.29497 · Cited by 148
Clayton, A., Boilard, É., Buzás, E. I., Cheng, L., Falcón‐Pérez, J. M., Gardiner, C., Gustafson, D., Gualerzi, A., Hendrix, A., Hoffman, A. M., et al. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1647027 · Cited by 143
Self-citationLässer, C., Shelke, G. V., Yeri, A., Kim, D., Crescitelli, R., Raimondo, S., Sjöstrand, M., Gho, Y. S., Jensen, K., & Lötvall, J. O. (2016) · RNA Biology · doi:10.1080/15476286.2016.1249092 · Cited by 142
Broggi, M. A. S., Maillat, L., Clement, C. C., Bordry, N., Corthésy, P., Auger, A., Matter, M., Hamelin, R., Potin, L., Demurtas, D., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181618 · Cited by 141
Semen miRNAs Contained in Exosomes as Non-Invasive Biomarkers for Prostate Cancer Diagnosis
Barceló, M., Castells, M., Bassas, L., Vigués, F., & Larriba, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-50172-6 · Cited by 138
Extracellular Vesicles in Prostate Cancer Carcinogenesis, Diagnosis, and Management
Vlaeminck‐Guillem, V. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00222 · Cited by 136
Koppers‐Lalic, D., Hackenberg, M., de Menezes, R., Mišovic, B., Wąchalska, M., Geldof, A. A., Zini, N., de Reijke, T. M., Wurdinger, T. D., Vis, A. N., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8124 · Cited by 135
Garcı́a-Silva, S., Benito‐Martín, A., Sánchez‐Redondo, S., Hernández‐Barranco, A., Ximénez‐Embún, P., Nogués, L., Mazariegos, M. S., Brinkmann, K., López, A. A., Meyer, L., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181522 · Cited by 135
Microfluidic Raman biochip detection of exosomes: a promising tool for prostate cancer diagnosis
Wang, Y., Li, Q., Shi, H., Tang, K., Qiao, L., Yu, G., Ding, C., & Yu, S. (2020) · Lab on a Chip · doi:10.1039/d0lc00677g · Cited by 135
Regulation of the Tumor Suppressor PTEN through Exosomes: A Diagnostic Potential for Prostate Cancer
Gabriel, K., Ingram, A. J., Austin, R. C., Kapoor, A., Tang, D., Majeed, F., Qureshi, T. M., & Al-Nedawi, K. N. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070047 · Cited by 129
Circulating Tumor Cell Clusters: United We Stand Divided We Fall
Amintas, S., Bedel, A., Moreau‐Gaudry, F., Boutin, J., Buscail, L., Merlio, J., Vendrely, V., Dabernat, S., & Buscail, É. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072653 · Cited by 129
Ultrastructural Localization of the Prostasome - an Organelle in Human Seminal Plasma
Brody, I., Ronquist, G., & Gottfries, A. (1983) · Upsala Journal of Medical Sciences · doi:10.3109/03009738309178440 · Cited by 121
Logozzi, M., Angelini, D. F., Giuliani, A., Mizzoni, D., Raimo, R. D., Maggi, M., Gentilucci, A., Marzio, V., Salciccia, S., Borsellino, G., et al. (2019) · Cancers · doi:10.3390/cancers11101449 · Cited by 120
Improved circulating microparticle analysis in acid-citrate dextrose (ACD) anticoagulant tube
György, B., Pálóczi, K., Kovács, A., Barabás, E., Bekő, G., Várnai, K., Pállinger, É., Szabó-Taylor, K., Szabó, T. G., Kiss, A., et al. (2013) · Thrombosis Research · doi:10.1016/j.thromres.2013.11.010 · Cited by 118
Sequeiros, T., Rigau, M., Chiva, C., Montes, M., Garcia-Grau, I., García, M., Díaz, S., Celma, A., Bijnsdorp, I. V., Campos, A. R., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13634 · Cited by 113
Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer
Kawakami, K., Fujita, Y., Matsuda, Y., Arai, T., Horie, K., Kameyama, K., Kato, T., Masunaga, K., Kasuya, Y., Tanaka, M., et al. (2017) · BMC Cancer · doi:10.1186/s12885-017-3301-x · Cited by 113
Macías, M., Rebmann, V., Mateos, B., Varo, N., Perez‐Gracia, J. L., Alegre, E., & González, Á. (2019) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2018-1297 · Cited by 111
Prostate Cancer Biomarker Profiles in Urinary Sediments and Exosomes
Dijkstra, S., Birker, I. L., Smit, F. P., Leyten, G. H. J. M., de Reijke, T. M., van Oort, I. M., Mulders, P., Jannink, S. A., & Schalken, J. A. (2013) · The Journal of Urology · doi:10.1016/j.juro.2013.11.001 · Cited by 110
Baskaran, S., Selvam, M. K. P., & Agarwal, A. K. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.08.004 · Cited by 110
Wan, Y., Liu, B., Lei, H., Zhang, B., Wang, Y., Huang, H. J., Chen, S., Feng, Y., Zhu, L., Gu, Y., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy458 · Cited by 107
Extracellular vesicles in urological malignancies: an update
Linxweiler, J., & Junker, K. (2019) · Nature Reviews Urology · doi:10.1038/s41585-019-0261-8 · Cited by 107
Advances in liquid biopsy approaches for early detection and monitoring of cancer
Babayan, A., & Pantel, K. (2018) · Genome Medicine · doi:10.1186/s13073-018-0533-6 · Cited by 104
Xu, Y., Qin, S., An, T., Tang, Y., Huang, Y., & Zheng, L. (2017) · The Prostate · doi:10.1002/pros.23376 · Cited by 103
Oscillatory Viscoelastic Microfluidics for Efficient Focusing and Separation of Nanoscale Species
Asghari, M. H., Cao, X., Mateescu, B., van Leeuwen, D., Aslan, M. K., Stavrakis, S., & deMello, A. J. (2019) · ACS Nano · doi:10.1021/acsnano.9b06123 · Cited by 102
Zonneveld, M. I., van Herwijnen, M. J. C., Fernandez-Gutierrez, M. M., Giovanazzi, A., de Groot, A. M., Kleinjan, M., van Capel, T. M. M., Sijts, A. J. A. M., Taams, L. S., Garssen, J., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12071 · Cited by 101
Tumor-Derived Exosomal Long Noncoding RNAs as Promising Diagnostic Biomarkers for Prostate Cancer
Wang, Y.-H., Ji, J., Wang, B., Chen, H., Yang, Z., Wang, K., Luo, C., Zhang, W.-W., Wang, F., & Zhang, X. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000488620 · Cited by 101
Latest advances in extracellular vesicles: from bench to bedside
Yamamoto, T., Kosaka, N., & Ochiya, T. (2019) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2019.1629835 · Cited by 100
Clinical requirements for extracellular vesicle assays
Ayers, L., Pink, R. C., Carter, D. R. F., & Nieuwland, R. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1593755 · Cited by 99
The role of caveolin-1 in prostate cancer: clinical implications
Thompson, T. C., Tahir, S. A., Li, L., Watanabe, M., Naruishi, K., Yang, G., Kadmon, D., Logothetis, C. J., Troncoso, P., Ren, C., et al. (2009) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2009.29 · Cited by 96
Comparing Approaches to Normalize, Quantify, and Characterize Urinary Extracellular Vesicles
Blijdorp, C. J., Tutakhel, O. A. Z., Hartjes, T. A., van den Bosch, T. P. P., van Heugten, M. H., Rigalli, J. P., Willemsen, R., Musterd‐Bhaggoe, U. M., Barros, E., Carles-Fontana, R., et al. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020081142 · Cited by 95
From laboratory to clinic: Translation of extracellular vesicle based cancer biomarkers
Yekula, A., Muralidharan, K., Kang, K. M., Wang, L., Balaj, L., & Carter, B. S. (2020) · Methods · doi:10.1016/j.ymeth.2020.02.003 · Cited by 94
Extracellular vesicles for liquid biopsy in prostate cancer: where are we and where are we headed?
Minciacchi, V. R., Zijlstra, A., Rubin, M. A., & Vizio, D. D. (2017) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2017.7 · Cited by 93
Wang, L., Skotland, T., Berge, V., Sandvig, K., & Llorente, A. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.09.023 · Cited by 93
Self-citationLi, M., Rai, A. J., DeCastro, G. J., Zeringer, E., Barta, T. J., Magdaleno, S. M., Setterquist, R. A., & Vlassov, A. V. (2015) · Methods · doi:10.1016/j.ymeth.2015.03.009 · Cited by 91
Biggs, C. N., Siddiqui, K. M., Al‐Zahrani, A. A., Pardhan, S., Brett, S. I., Guo, Q., Yang, J., Wolf, P., Power, N. E., Durfee, P. N., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6983 · Cited by 89
Generating human prostate cancer organoids from leukapheresis enriched circulating tumour cells
Mout, L., van Dessel, L. F., Kraan, J., de Jong, A. C., Neves, R. P., Erkens‐Schulze, S., Beaufort, C. M., Sieuwerts, A. M., van Riet, J., Woo, T. L. C., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.03.023 · Cited by 87
Protocol for serum exosomal miRNAs analysis in prostate cancer patients treated with radiotherapy
Malla, B., Aebersold, D. M., & Pra, A. D. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1592-6 · Cited by 87
Development of an immunoassay for serum caveolin-1: a novel biomarker for prostate cancer.
Tahir, S. A., Ren, C., Timme, T. L., Gdor, Y., Hoogeveen, R. C., Morrisett, J. D., Frolov, A., Ayala, G., Wheeler, T. M., & Thompson, T. C. (2003) · PubMed · Cited by 86
Zavridou, M., Strati, A. D., Bournakis, E., Smilkou, S., Tserpeli, V., & Lianidou, E. S. (2021) · Cancers · doi:10.3390/cancers13040780 · Cited by 86
Krafft, C., Wilhelm, K., Eremin, A., Nestel, S., von Bubnoff, N. C. C., Schultze‐Seemann, W., Popp, J., & Nazarenko, I. A. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.11.016 · Cited by 86
Woo, H., Park, J., Ku, J. Y., Lee, C. H., Sunkara, V., Ha, H. K., & Cho, Y. (2018) · Lab on a Chip · doi:10.1039/c8lc01185k · Cited by 85
Nanou, A., Miller, M. C., Zeune, L. L., de Wit, S., Punt, C. J. A., Groen, H. J. M., Hayes, D. F., Bono, J. S. D., & Terstappen, L. W. M. M. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0726-9 · Cited by 85
Biochemical and Physical Characterisation of Urinary Nanovesicles following CHAPS Treatment
Musante, L., Saraswat, M., Duriez, E., Byrne, B. J., Ravidà, A., Domon, B., & Holthöfer, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037279 · Cited by 84
Profiling of circulating microRNAs for prostate cancer biomarker discovery
Haldrup, C., Kosaka, N., Ochiya, T., Borre, M., Høyer, S., Orntoft, T. F., & Sorensen, K. D. (2014) · Drug Delivery and Translational Research · doi:10.1007/s13346-013-0169-4 · Cited by 83
Ronquist, G. K., & Nilsson, B. O. (2004) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4500684 · Cited by 80
Bhagirath, D., Yang, T. L., Tabatabai, Z. L., Majid, S., Dahiya, R., Tanaka, Y., & Saini, S. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0498 · Cited by 80
Characteristics of human prostasomes isolated from three different sources
Carlsson, L. M. S., Nilsson, O. R., Larsson, A. O., Stridsberg, M., Sahlén, G., & Ronquist, G. (2003) · The Prostate · doi:10.1002/pros.10189 · Cited by 80
Plasma extracellular vesicles as phenotypic biomarkers in prostate cancer patients
Joncas, F., Lucien, F., Rouleau, M., Morin, F., Leong, H. S., Pouliot, F., Fradet, Y., Gilbert, C., & Toren, P. (2019) · The Prostate · doi:10.1002/pros.23901 · Cited by 79
Meyer, C. P., Pantel, K., Tennstedt, P., Strölin, P., Schlomm, T., Hans Heinzer, A., Riethdorf, S., & Steuber, T. P. (2016) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2015.12.003 · Cited by 78
Smartphone-enabled optofluidic exosome diagnostic for concussion recovery
Ko, J., Hemphill, M. A., Gabrieli, D. J., Wu, L., Yelleswarapu, V. R., Lawrence, G. G., Pennycooke, W., Singh, A. K., Meaney, D. F., & Issadore, D. (2016) · Scientific Reports · doi:10.1038/srep31215 · Cited by 77
The Value of Liquid Biopsies for Guiding Therapy Decisions in Non-small Cell Lung Cancer
Saarenheimo, J., Eigėlienė, N., Andersén, H., Tiirola, M., & Jekunen, A. P. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00129 · Cited by 76
Nanou, A., Coumans, F. A. W., van Dalum, G., Zeune, L. L., Dolling, D. I., Onstenk, W., Crespo, M., Fontes, M. S., Rescigno, P., Fowler, G., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25019 · Cited by 75
Urinary-exosomal miR-2909: A novel pathognomonic trait of prostate cancer severity
Wani, S., Kaul, D., Mavuduru, R. S., Kakkar, N., & Bhatia, A. (2017) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2017.07.029 · Cited by 73
Henrich, S. E., McMahon, K. M., Plebanek, M. P., Calvert, A. E., Feliciano, T. J., Parrish, S., Tavora, F., Mega, A. E., Souza, A. O., Carneiro, B. A., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12042 · Cited by 72
In-Depth Proteomic Analyses of Direct Expressed Prostatic Secretions
Drake, R. R., Elschenbroich, S., Lopez-Perez, O., Kim, Y., Ignatchenko, V., Ignatchenko, A., Nyalwidhe, J. O., Basu, G., Wilkins, C. E., Gjurich, B. N., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr1001498 · Cited by 72
Royo, F., Zúñiga-García, P., Torrano, V., Loizaga‐Iriarte, A., Sánchez‐Mosquera, P., Ugalde‐Olano, A., González, E., Cortázar, A. R., Palomo, L., Fernández‐Ruiz, S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6899 · Cited by 71
Soekmadji, C., Riches, J. D., Russell, P. J., Ruelcke, J. E., McPherson, S. J., Wang, C., Hovens, C. M., Corcoran, N. M., Hill, M. M. C., & Nelson, C. C. (2016) · Oncotarget · doi:10.18632/oncotarget.11111 · Cited by 70
Self-citationClayton, A., Buschmann, D., Byrd, J. B., Carter, D. R. F., Cheng, L., Compton, C. C., Daaboul, G. G., Devitt, A., Falcón‐Pérez, J. M., Gardiner, C., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1473707 · Cited by 70
Self-citationEmerging Role of Exosomes in Liquid Biopsy for Monitoring Prostate Cancer Invasion and Metastasis
Gao, Z., Pang, B., Li, J., Gao, N., Fan, T., & Li, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.679527 · Cited by 70
The proteomics of prostate cancer exosomes
Drake, R. R., & Kislinger, T. (2014) · Expert Review of Proteomics · doi:10.1586/14789450.2014.890894 · Cited by 69
Nimir, M., Ma, Y., Jeffreys, S. A., Opperman, T., Young, F., Khan, T., Ding, P. N., Chua, W. M., Balakrishnar, B., Cooper, A. J., et al. (2019) · Cells · doi:10.3390/cells8070688 · Cited by 69
Yoo, J. Y., Rho, M., You, Y., Kwon, E. J., Kim, M., Kym, S., Jee, Y., Kim, Y.-K., & Kim, Y. J. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.110 · Cited by 68
Splice variant transcripts of the anterior gradient 2 gene as a marker of prostate cancer
Neeb, A., Hefele, S., Bormann, S., Parson, W., Adams, F., Wolf, P., Miernik, A. J., Schoenthaler, M., Krönig, M., Wilhelm, K., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2365 · Cited by 68
Lee, Y., Park, J. Y., Lee, E. H., Yang, J., Jeong, B.-R., Kim, Y., Seoh, J., Lee, S., Han, P., & Kim, E. (2017) · Experimental Neurobiology · doi:10.5607/en.2017.26.5.307 · Cited by 67
Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies
Martín-Gracia, B., Martín‐Barreiro, A., Cuestas-Ayllón, C., Grazú, V., Linē, A., Llorente, A., de la Fuente, J. M., & Moros, M. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00861c · Cited by 67
Self-citationPlasma exosomal miR-125a-5p and miR-141-5p as non-invasive biomarkers for prostate cancer
LI, W., Dong, Y., Wang, K., DENG, Z., Zhang, W., & SHEN, H. F. (2020) · Neoplasma · doi:10.4149/neo_2020_191130n1234 · Cited by 67
Mullier, F., Bailly, N., Chatelain, C., Châtelain, B., & Dogné, J.-M. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12171 · Cited by 66
Hendriks, R. J., Dijkstra, S., Jannink, S. A., Steffens, M. G., van Oort, I. M., Mulders, P., & Schalken, J. A. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2015-0599 · Cited by 66
Identification of Urinary Exosomal miRNAs for the Non-Invasive Diagnosis of Prostate Cancer
Li, Z., Li, L.-X., Diao, Y., Wang, J., Ye, Y., & Hao, X. (2021) · Cancer Management and Research · doi:10.2147/cmar.s272140 · Cited by 64
Tegegn, T. Z., Paoli, S. H. D., Orečná, M., Elhelu, O. K., Woodle, S. A., Tarandovskiy, I. D., Ovanesov, M. V., & Šimák, J. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.30422 · Cited by 63
Tahir, S. A., Frolov, A., Hayes, T. G., Mims, M. P., Miles, B. J., Lerner, S. P., Wheeler, T. M., Ayala, G., Thompson, T. C., & Kadmon, D. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0417 · Cited by 63
Urine Exosomes for Non-Invasive Assessment of Gene Expression and Mutations of Prostate Cancer
Motamedinia, P., Scott, A., Bate, K., Sadeghi, N., Salazar, G., Shapiro, E. Y., Ahn, J. J., Lipsky, M., Lin, J. S., Hruby, G. W., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154507 · Cited by 62
Exosomal ephrinA2 derived from serum as a potential biomarker for prostate cancer
Li, S., Zhao, Y., Chen, W., Yin, L., Zhu, J., Zhang, H., Cai, C., Li, P., Huang, L., & Ma, P. (2018) · Journal of Cancer · doi:10.7150/jca.25201 · Cited by 61
Dhondt, B., Deun, J. V., Vermaerke, S., de Marco, A., Lumen, N., Wever, O. D., & Hendrix, A. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.04.009 · Cited by 60
Mercadal, M., Herrero, C., López‐Rodrigo, O., Castells, M., la Fuente, A. D., Vigués, F., Bassas, L., & Larriba, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175949 · Cited by 60
Tripisciano, C., Weiss, R., George, S. K., Fischer, M. B., & Weber, V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00298 · Cited by 60
Functional Implication of Exosomal miR-217 and miR-23b-3p in the Progression of Prostate Cancer
Zhou, C., Chen, Y., He, X., Zheng, Z., & Xue, D. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s272869 · Cited by 58
Qi, Y., Li, P., Weng, M., Wu, S., Zhang, Y., Chen, X., Zhang, Q. H., Shen, G., Ding, X., & Fu, S. (2018) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2018.2503 · Cited by 58
Research works printed but not linked: 1
- De Angelis G, Rittenhouse HG, Mikolajczyk SD. Blair Shamel, L., Semjonow, A. Twenty years of PSA: from prostate antigen to tumor marker. Rev Urol. 2007;9:113–23.
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Connal, S., Cameron, J. M., Sala, A., Brennan, P. M., Palmer, D. S., Palmer, J. D., Perlow, H. K., & Baker, M. J. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03960-8 · Cited by 403
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Metadata
- Authors
- Ramirez-Garrastacho, M., Bajo-Santos, C., Line, A., Martens-Uzunova, E. S., de la Fuente, J. M., Moros, M., Soekmadji, C., Tasken, K. A., & Llorente, A.
- Affiliations
- Latvian Biomedical Research and Study Centre (LV)
- The University of Queensland (AU)
- Oslo University Hospital (NO)
- Corresponding author
- Llorente, Alicia
- Venue
- British Journal of Cancer
- Published
- 2021-11-22
- Volume
- 126
- Issue
- 3
- Pages
- 331-350
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC8810769
- OpenAlex
- W3217233110
- Cited by
- 130
- References
- 243
- Citations by year
- 2026: 27 · 2025: 25 · 2024: 36 · 2023: 29 · 2022: 13
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- British Journal of Cancer (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- Zaguan (Universidad de Zaragoza) (submittedVersion, cc-by)
- Funders
- Latvijas Zinātnes Padome
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Keywords
- extracellular vesicles, prostate cancer, liquid biopsy, tumor markers, vesicle isolation, tumor microenvironment, precision medicine
- MeSH terms
- Extracellular Vesicles, Cell-Free Nucleic Acids, Liquid Biopsy, Animals, Humans, Male, Neoplastic Cells, Circulating, Prostatic Neoplasms, Biomarkers, Tumor, Early Detection of Cancer, Precision Medicine
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