Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients
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The cytokine storm induced by excessive T-cell responses has been shown to accentuate the pathogenesis of COVID-19.
“The “cytokine storm” induced by excessive T-cell responses have been actually shown to accentuate the pathogenesis of COVID19 (18, 19).”
From Development of an inactivated vaccine candidate for SARS-CoV-2 (2020) · cites this paper as [19]
In the paper’s main text (page unavailable), the proposed direction is the reverse: virus-induced inflammatory storms can cause systemic T-cell responses. The authors also report no significant differences in the inflammatory cytokines they measured, so this paper does not show that excessive T-cell responses induce a cytokine storm that worsens COVID-19. (LLM, conf=0.87)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredSome studies found reduced CD4+ T cell effector functions, measured as IFNγ/IL-2/TNFα production, in severe COVID-19.
“Some studies have found reduced effector functions for CD4+ T cells, i.e. IFNγ/IL-2/TNFα production, in patients with severe disease141, while others have seen no differences142.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [141]
Other studies report opposite CD8+ T cell findings in severe COVID-19.
“For CD8+ T cells, there are reports of diminished CD8+ cytotoxicity and cytokine production in severe cases126,132, while others report the opposite141, and still others find no differences142.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [141]
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- Authors
- Zheng, H.-Y., Zhang, M., Yang, C.-X., Zhang, N., Wang, X.-C., Yang, X.-P., Dong, X.-Q., & Zheng, Y.-T.
- Affiliations
- Kunming Institute of Zoology (CN)
- Yunnan Provincial Infectious Disease Hospital (CN)
- Corresponding author
- Zheng, Yong-Tang
- Venue
- Cellular & Molecular Immunology
- Published
- 2020-03-17
- Volume
- 17
- Issue
- 5
- Pages
- 541-543
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- PMC
- PMC7091621
- OpenAlex
- W3011812996
- Cited by
- 940
- References
- 11
- Citations by year
- 2026: 10 · 2025: 34 · 2024: 62 · 2023: 106 · 2022: 171 · 2021: 265 · 2020: 291 · 2019: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cellular and Molecular Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- COVID-19 pandemic, SARS-CoV-2, T cell exhaustion, peripheral blood T cells, disease progression prediction, lymphopenia, cytokine release syndrome, immune homeostasis, severe pneumonia
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, China, Humans, Pneumonia, Viral, T-Lymphocytes, Coronavirus, Coronavirus Infections, Pandemics
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