Cited by 87Muscle Physiology and DisordersMitochondrial Function and PathologyNutrition and Health in Aging

Mitochondrial dynamics in cancer-induced cachexia

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van der Ende, Miranda, Grefte, Sander, Plas, Rogier, Meijerink, Jocelijn, Witkamp, Renger F., Keijer, Jaap, van Norren, Klaske·2018·Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Abstract

Cancer-induced cachexia has a negative impact on quality of life and adversely affects therapeutic outcomes and survival rates. It is characterized by, often severe, loss of muscle, with or without loss of fat mass. Insight in the pathophysiology of this complex metabolic syndrome and direct treatment options are still limited, which creates a research demand. Results from recent studies point towards a significant involvement of muscle mitochondrial networks. However, data are scattered and a comprehensive overview is lacking. This paper aims to fill existing knowledge gaps by integrating published data sets on muscle protein or gene expression from cancer-induced cachexia animal models. To this end, a database was compiled from 94 research papers, comprising 11 different rodent models. This was combined with four genome-wide transcriptome datasets of cancer-induced cachexia rodent models. Analysis showed that the expression of genes involved in mitochondrial fusion, fission, ATP production and mitochondrial density is decreased, while that of genes involved ROS detoxification and mitophagy is increased. Our results underline the relevance of including post-translational modifications of key proteins involved in mitochondrial functioning in future studies on cancer-induced cachexia.

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Crossref · 10.1016/j.bbcan.2018.07.008

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  • Muscle loss in aging sarcopenia, cancer cachexia, chemotherapy-induced cachexia, and in a model of myasthenia gravis is characterized by the decline of both fusion and fission machinery.

    “Muscle loss in aging sarcopenia [185, 187, 215], cancer cachexia, chemotherapy-induced cachexia [157–159], and in a model of myasthenia gravis [216], is characterized by the decline of both fusion and fission machinery.”
  • The concomitant decrease of Opa1 and Drp1 also occurs in cancer cachexia and chemotherapy-induced cachexia as well as a model of myasthenia gravis.

    “Moreover, the concomitant decrease of Opa1 and Drp1 also occurs in cancer cachexia and chemotherapy-induced cachexia [15,16,17] as well as a model of myasthenia gravis [18].”
  • Muscle loss in aging sarcopenia, cancer cachexia, and myasthenia gravis is characterized by the decline of both fusion machinery and fission machinery.

    “However, muscle loss in aging sarcopenia, cancer cachexia, and myasthenia gravis are characterized by the decline of both fusion machinery and fission machinery [6,11,12,15,16,17,18].”

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Authors
van der Ende, M., Grefte, S., Plas, R., Meijerink, J., Witkamp, R. F., Keijer, J., & van Norren, K.
Affiliations
Wageningen University & Research (NL)
Venue
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Publisher
Elsevier BV
Published
2018-12
Volume
1870
Issue
2
Pages
137-150
ISSN
0304-419X (ISSN-L)
OpenAlex
W2884365126
Cited by
87
References
219
Citations by year
2026: 6 · 2025: 16 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 14 · 2019: 12 · 2018: 2
FWCI
0.96
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion, cc-by-nc-nd)
  • Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
Funders
Graduate School VLAG (11_17_VLAG)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
cancer cachexia, mitochondrial dynamics, mitochondrial fusion, mitochondrial fission, muscle atrophy, fat loss, mitochondrial density, ATP production, reactive oxygen species scavenging, mitophagy, gene expression, transcriptome, post-translational modification
MeSH terms
Animals, Cachexia, Disease Models, Animal, Mitochondria, Neoplasms, Rodentia, Transcriptome, Mitochondrial Dynamics

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