Mitochondrial dynamics in cancer-induced cachexia
Open accessAbstract
Cancer-induced cachexia has a negative impact on quality of life and adversely affects therapeutic outcomes and survival rates. It is characterized by, often severe, loss of muscle, with or without loss of fat mass. Insight in the pathophysiology of this complex metabolic syndrome and direct treatment options are still limited, which creates a research demand. Results from recent studies point towards a significant involvement of muscle mitochondrial networks. However, data are scattered and a comprehensive overview is lacking. This paper aims to fill existing knowledge gaps by integrating published data sets on muscle protein or gene expression from cancer-induced cachexia animal models. To this end, a database was compiled from 94 research papers, comprising 11 different rodent models. This was combined with four genome-wide transcriptome datasets of cancer-induced cachexia rodent models. Analysis showed that the expression of genes involved in mitochondrial fusion, fission, ATP production and mitochondrial density is decreased, while that of genes involved ROS detoxification and mitophagy is increased. Our results underline the relevance of including post-translational modifications of key proteins involved in mitochondrial functioning in future studies on cancer-induced cachexia.
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Muscle loss in aging sarcopenia, cancer cachexia, chemotherapy-induced cachexia, and in a model of myasthenia gravis is characterized by the decline of both fusion and fission machinery.
“Muscle loss in aging sarcopenia [185, 187, 215], cancer cachexia, chemotherapy-induced cachexia [157–159], and in a model of myasthenia gravis [216], is characterized by the decline of both fusion and fission machinery.”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [158]
The concomitant decrease of Opa1 and Drp1 also occurs in cancer cachexia and chemotherapy-induced cachexia as well as a model of myasthenia gravis.
“Moreover, the concomitant decrease of Opa1 and Drp1 also occurs in cancer cachexia and chemotherapy-induced cachexia [15,16,17] as well as a model of myasthenia gravis [18].”
From Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles (2019) · cites this paper as [17]
Muscle loss in aging sarcopenia, cancer cachexia, and myasthenia gravis is characterized by the decline of both fusion machinery and fission machinery.
“However, muscle loss in aging sarcopenia, cancer cachexia, and myasthenia gravis are characterized by the decline of both fusion machinery and fission machinery [6,11,12,15,16,17,18].”
From Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles (2019) · cites this paper as [17]
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Rowe, G. C., Jang, C., Patten, I. S., & Arany, Z. P. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00681.2010 · Cited by 53 · see citing works
Assi, M., Derbré, F., Lefeuvre‐Orfila, L., & Rébillard, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.019 · Cited by 53 · see citing works
Toth, M. J., Callahan, D. M., Miller, M. S., Tourville, T. W., Hackett, S. B., Couch, M. E., & Dittus, K. L. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.02.016 · Cited by 53 · see citing works
Cachectic skeletal muscle response to a novel bout of low-frequency stimulation
Puppa, M., Murphy, E. A., Fayad, R., Hand, G. A., & Carson, J. A. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01270.2013 · Cited by 52 · see citing works
Dwarkasing, J. T., Boekschoten, M. V., Argilés, J. M. A., van Dijk, M., Busquets, S., Penna, F., Toledo, M., Laviano, A., Witkamp, R. F., & van Norren, K. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12008 · Cited by 52 · see citing works
Self-citationChacón-Cabrera, A., Mateu-Jiménez, M., Langohr, K., Fermoselle, C., García-Arumí, E., Andreu, A., Yélamos, J., & Barreiro, E. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25851 · Cited by 52 · see citing works
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TFAM forces mtDNA to make a U-turn
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Sun, R., Zhang, S., Hu, W., Lü, X. Q., Lou, N., Zhen-de, Y., Chen, S., Zhang, X., & Yang, H. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00344.2015 · Cited by 49 · see citing works
The therapeutic potential of exercise to treat cachexia
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Increased hypothalamic serotonin turnover in inflammation-induced anorexia
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C26 Cancer-Induced Muscle Wasting Is IKKβ-Dependent and NF-kappaB-Independent
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Hypothalamic inflammation and food intake regulation during chronic illness
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Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
Favaro, G., Romanello, V., Varanita, T., Andrea Desbats, M., Morbidoni, V., Tezze, C., Albiero, M., Canato, M., Gherardi, G., De Stefani, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10226-9 · Cited by 398 · see citing works
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Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles
Romanello, V., Scalabrin, M., Albiero, M., Blaauw, B., Scorrano, L., & Sandri, M. (2019) · Cells · doi:10.3390/cells8060597 · Cited by 91 · see citing works
- Authors
- van der Ende, M., Grefte, S., Plas, R., Meijerink, J., Witkamp, R. F., Keijer, J., & van Norren, K.
- Affiliations
- Wageningen University & Research (NL)
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 1870
- Issue
- 2
- Pages
- 137-150
- ISSN
- 0304-419X (ISSN-L)
- OpenAlex
- W2884365126
- Cited by
- 87
- References
- 219
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 14 · 2019: 12 · 2018: 2
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
- Funders
- Graduate School VLAG (11_17_VLAG)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- cancer cachexia, mitochondrial dynamics, mitochondrial fusion, mitochondrial fission, muscle atrophy, fat loss, mitochondrial density, ATP production, reactive oxygen species scavenging, mitophagy, gene expression, transcriptome, post-translational modification
- MeSH terms
- Animals, Cachexia, Disease Models, Animal, Mitochondria, Neoplasms, Rodentia, Transcriptome, Mitochondrial Dynamics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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