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Deogharia, M., Venegas-Zamora, L., Agrawal, A., Shi, M., Jain, A. K., McHugh, K. J., Altamirano, F. J., Marian, A. J., & Gurha, P. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae014 · Cited by 35 · see citing works

PANoptosis is a prominent feature of desmoplakin cardiomyopathy

Olcum, M., Rouhi, L., Fan, S., Gonzales, M. M., Jeong, H.-H., Zhao, Z., Gurha, P., & Marian, A. J. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.34 · Cited by 34 · see citing works

Deletion of the Lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype

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The structure and function of lamin A/C: Special focus on cardiomyopathy and therapeutic interventions

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BRD4: an effective target for organ fibrosis

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Comprehensive review on gene mutations contributing to dilated cardiomyopathy

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LMNA-related cardiomyopathy: From molecular pathology to cardiac gene therapy

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Loss of function of the nuclear envelope protein LEMD2 causes DNA damage–dependent cardiomyopathy

Caravia, X. M., Ramirez-Martinez, A., Gan, P., Wang, F., McAnally, J., Xu, L., Bassel‐Duby, R., Liu, N., & Olson, E. N. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158897 · Cited by 24 · see citing works

Epigenetic Drivers of Atrial Fibrillation: Mechanisms, Biomarkers, and Therapeutic Targets

Karakasis, P., Theofilis, P., Milaras, N., Vlachakis, P. K., Patoulias, D., Karamitsos, T. D., Antoniadis, A. P., & Fragakis, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115253 · Cited by 26 · see citing works

Protein acetylation in cardiac aging

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The LMNA p.R541C mutation causes dilated cardiomyopathy in human and mice

Yang, L., Sun, J., Chen, Z., Liu, L., Sun, Y., Lin, J., Hu, X., Zhao, M., Ma, Y., Lü, D., et al. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.06.038 · Cited by 19 · see citing works

Genetic inactivation of β-catenin is salubrious, whereas its activation is deleterious in desmoplakin cardiomyopathy

Olcum, M., Fan, S., Rouhi, L., Cheedipudi, S. M., Cathcart, B., Jeong, H.-H., Zhao, Z., Gurha, P., & Marian, A. J. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad137 · Cited by 20 · see citing works

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Tan, C. Y., Chan, P. S., Tan, H., Tan, S. W., Lee, C. J. M., Wang, J., Ye, S., Werner, H., Loh, Y. J., Lee, Y. L., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04542-4 · Cited by 18 · see citing works

Effects of tamoxifen inducible MerCreMer on gene expression in cardiac myocytes in mice

Rouhi, L., Fan, S., Cheedipudi, S. M., Olcum, M., Jeong, H.-H., Zhao, Z., Gurha, P., & Marian, A. J. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2021.30 · Cited by 17 · see citing works

NLRP3 Inflammasome Targeting Offers a Novel Therapeutic Paradigm for Sepsis-Induced Myocardial Injury

Jin, Y., Fleishman, J. S., Ma, Y., Jing, X., Guo, Q., Shang, W., & Wang, H. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s506537 · Cited by 16 · see citing works

DNA double-stranded breaks, a hallmark of aging, defined at the nucleotide resolution, are increased and associated with transcription in the cardiac myocytes in LMNA-cardiomyopathy

Cathcart, B., Cheedipudi, S. M., Rouhi, L., Zhao, Z., Gurha, P., & Marian, A. J. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae063 · Cited by 14 · see citing works

BET Protein-Mediated Transcriptional Regulation in Heart Failure

Ijaz, T., & Burke, M. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116059 · Cited by 14 · see citing works

Preclinical Advances of Therapies for Laminopathies

Benarroch, L., Cohen, E., Atalaia, A., Yaou, R. B., Bonne, G., & Bertrand, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10214834 · Cited by 15 · see citing works

Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure PathogenesisPreprint

Alexanian, M., Padmanabhan, A., Nishino, T., Travers, J. G., Ye, L., Lee, C. Y., Sadagopan, N., Huang, Y., Pelonero, A., Auclair, K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.06.522937 · Cited by 14 · see citing works

(+)-JQ-1 alleviates cardiac injury in myocardial infarction by inhibiting ferroptosis through the NAMPT/SIRT1 pathway

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Targeting Epigenetics and Non-coding RNAs in Myocardial Infarction: From Mechanisms to Therapeutics

Chen, J., Liu, Z., Ma, L., Gao, S., Fu, H., Wang, C., Lu, A., Wang, B., & Gu, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.780649 · Cited by 13 · see citing works

The WNT/β-catenin pathway regulates expression of the genes involved in cell cycle progression and mitochondrial oxidative phosphorylation in the postmitotic cardiac myocytes

Olcum, M., Cheedipudi, S. M., Rouhi, L., Fan, S., Jeong, H.-H., Zhao, Z., Gurha, P., & Marian, A. J. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2021.35 · Cited by 12 · see citing works

Molecular signature of RV cardiac remodeling associated with Polymerase Gamma mutation

Gorr, M. W., Francois, A., Marcho, L. M., Saldaña, T., McGrail, E., Sun, N., & Stratton, M. S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120469 · Cited by 13 · see citing works

Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy

Luo, X., Jia, H., Wang, F., Mo, H., Kang, Y., Zhang, N., Zhao, L., Xu, L., Yang, Z., Yang, Q., et al. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.11.002 · Cited by 11 · see citing works

BRD4 as a therapeutic target for atrial fibrosis and atrial fibrillation

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Pharmacological suppression of the WNT signaling pathway attenuates age-dependent expression of the phenotype in a mouse model of arrhythmogenic cardiomyopathy

Cheedipudi, S. M., Fan, S., Rouhi, L., & Marian, A. J. (2021) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2021.04 · Cited by 9 · see citing works

Epigenetic regulation of heart failure

Deogharia, M., & Gurha, P. (2024) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000001150 · Cited by 9 · see citing works

Targeting BRD4 with PROTAC degrader ameliorates LPS-induced acute lung injury by inhibiting M1 alveolar macrophage polarization

Li, D., Deng, Y., Wen, G., Wang, L., Shi, X., Chen, S., & Chen, R. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111991 · Cited by 7 · see citing works

Nuclear envelope rupture in cardiomyocytes orchestrates early transcriptomic changes and immune activation in LMNA -related dilated cardiomyopathy that are reversed by LINC complex disruptionPreprint

Zuela-Sopilniak, N., Morival, J. L. P., Ntekas, I., Elpers, M. A., Agarwal, R., Henretta, S. J., Odell, J. D., Vlaminck, I. D., & Lammerding, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.11.598511 · Cited by 7 · see citing works

Lamin A/C Expression in Hematopoietic Cells Declines During Human Aging and Constrains Atherosclerosis in Mice

Amorós-Pérez, M., Monte-Monge, A. D., Gonzalo, P., Andrés‐Manzano, M. J., Rius, C., Fanjul, V., González‐Gómez, C., Moreno, G., Benguría, A., Dopazo, A., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.322893 · Cited by 6 · see citing works

Risk Assessment and Personalized Treatment Options in Inherited Dilated Cardiomyopathies: A Narrative Review

Arnăutu, D.-A., Cozma, D. C., Lala, I.-R., Arnăutu, S.-F., Tomescu, M., & Andor, M. (2024) · Biomedicines · doi:10.3390/biomedicines12081643 · Cited by 6 · see citing works

Lamin A K97E leads to NF‐κB‐mediated dysfunction of inflammatory responses in dilated cardiomyopathy

Sengupta, D., & Sengupta, K. (2024) · Biology of the Cell · doi:10.1111/boc.202300094 · Cited by 5 · see citing works

Genome organization in cardiomyocytes expressing mutated A-type lamins

Kervella, M., Jahier, M., Méli, A. C., & Muchir, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1030950 · Cited by 5 · see citing works

Non-Cell-Autonomous Cardiomyocyte Regulation Complicates Gene Supplementation Therapy for Lmna-Associated Cardiac Defects in Mice

Sun, Y., Guo, C., Chen, Z., Lin, J., Yang, L., Zhang, Y., Wu, C., Zhao, D., Jardin, B. D., Pu, W. T., et al. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.06.004 · Cited by 5 · see citing works

Cardiomyocyte cytosolic nuclear self-DNA contributes to the pathogenesis of desmoplakin cardiomyopathy

Wang, W., Cathcart, B., Nguyen, Q. D., Lao, L. Q., Bryans, A., Coleman, S. E., Rouhi, L., Gurha, P., & Marian, A. J. (2025) · JCI Insight · doi:10.1172/jci.insight.192283 · Cited by 4 · see citing works

An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary dilated cardiomyopathy: genetics and bioinfomatics exploration

Chang, L., Huang, R., Chen, J., Li, G., Shi, G., Xu, B., & Wang, L. Y. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01661-1 · Cited by 4 · see citing works

CD146/MCAM links doxorubicin-induced epigenetic dysregulation to the impaired fatty acid transportation in H9c2 cardiomyoblasts

Hasan, A. U., Obara, M., Sato, S., Kondo, Y., & Taira, E. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149370 · Cited by 4 · see citing works

Phenotypic diversity of the LMNA mutations

Marian, A. J. (2025) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000001205 · Cited by 3 · see citing works

Discovery of drugs to treat cytokine storm-induced cardiac dysfunction using human cardiac organoidsPreprint

Mills, R. J., Humphrey, S. J., Fortuna, P. R. J., Quaife-Ryan, G. A., Mehdiabadi, N. R., Devilée, L., Voges, H. K., Reynolds, L., Krumeich, S., Mathieson, E., et al. (2020) · The Sydney eScholarship Repository (The University of Sydney) · doi:10.1101/2020.08.23.258574 · Cited by 2 · see citing works

Knowledge, attitudes, and practices regarding heart failure among Chinese patients: a cross-sectional study

Jin, P., Shu, Z., Cui, K., Ou, Z., Li, H., & Luo, Y. (2025) · BMC Public Health · doi:10.1186/s12889-025-23860-4 · Cited by 2 · see citing works

BET Inhibitor JQ1 Attenuates Atrial Fibrillation Through Modulation of Fibrosis, Calcium Homeostasis, and Mitochondrial Function in a Murine Model

Song, Z., Murakoshi, N., Xu, D., Xi, B., Murakata, Y., Aonuma, K., Tajiri, K., & Ishizu, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110363 · Cited by 2 · see citing works

The cardiac 4D nucleome: nuclear and chromatin dynamics across development, disease and ageing

Wang, Y., & Dobreva, G. D. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-026-01322-7 · Cited by 2 · see citing works

Lamin A/C Ablation Restricted to Vascular Smooth Muscle Cells, Cardiomyocytes, and Cardiac Fibroblasts Causes Cardiac and Vascular Dysfunction

Monte-Monge, A. D., de Lara, Í. R.-P., Gonzalo, P., Espinós‐Estévez, C., González‐Amor, M., de la Fuente‐Pérez, M., Andrés‐Manzano, M. J., Fanjul, V., Gimeno, J. R., Villa, R. B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311172 · Cited by 2 · see citing works

Cardiac phenotypes in LMNA mutations

Rouhi, L. (2025) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000001209 · Cited by 2 · see citing works

BETs that cover the spread from acquired to heritable heart failure

Alexanian, M., & Haldar, S. M. (2020) · Journal of Clinical Investigation · doi:10.1172/jci140304 · Cited by 2 · see citing works

Lamin: guardian against DNA damage by transcription stress

Jahng, J. W. S., & Wu, J. C. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae122 · Cited by 2 · see citing works

Cardiac fibroblasts counterbalance cardiomyocytes in LMNA cardiomyopathy pathogenesisPreprint

Sikder, K., Phillips, E., Bouhrira, N., Mothy, D., Wang, N., Bonne, G., Margulies, K. B., & Choi, J. C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.05.657412 · Cited by 2 · see citing works

BET inhibitors in cardiovascular diseases: from atherosclerosis to heart failure

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Targeting BRD4 to reverse organ fibrosis: Epigenetic regulation, cellular plasticity, and therapeutic potential

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Histone Demethylase KDM5A Is Activated and Pathogenic in a Mouse Model of LMNA-Cardiomyopathy

Deogharia, M., Reddy, C. L., Chaudhuri, R., Chirasani, M. S., Jain, A. K., Rouhi, L., Marian, A. J., & Gurha, P. (2026) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2026.101714 · Cited by 1 · see citing works

Bromodomain and Extra-Terminal Family Protein Inhibitors: A Potentially New Therapy for Heart Disease

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Genetic Inactivation of β-Catenin Attenuates and Its Activation Aggravates Desmoplakin CardiomyopathyPreprint

Olcum, M., Fan, S., Rouhi, L., Cheedipudi, S. M., Cathcart, B., Jeong, H.-H., Zhao, Z., Gurha, P., & Marian, A. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.02.530831 · Cited by 1 · see citing works

Non-cell autonomous cardiomyocyte regulation complicates gene supplementation therapy for LMNA cardiomyopathyPreprint

Sun, Y., Guo, C., Chen, Z., Lin, J., Yang, L., Zhang, Y., Wu, C., Zhao, D., Jardin, B. D., Pu, W. T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.18.549413 · Cited by 1 · see citing works

Patients’ Knowledge, Attitude, and Practice of Heart Failure: A web-based cross-sectional studyPreprint

Jin, P., Shu, Z., Cui, K., Ou, Z., Li, H., & Luo, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-4694592/v1

Perinuclear organelle trauma at the nexus of cardiomyopathy pathogenesis arising from loss of function LMNA mutation

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Lamin variants cause cardiac arrhythmogenicity in Drosophila

van Wijk, S. W., Vree, P., Huiskes, F. G., van der Palen, R. L., Liutkute, A., Voigt, N., Wallrath, L. L., & Brundel, B. J. J. M. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052424

Epigenetic Therapeutics in Human Heart Failure

Leon, S., Liu, C., & Tang, W. H. W. (2025) · Heart Failure Clinics · doi:10.1016/j.hfc.2025.08.003

Additional file 2 of Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Tan, C. Y., Chan, P. S., Tan, H., Tan, S. W., Lee, C. J. M., Wang, J.-W., Ye, S., Werner, H., Loh, Y. J., Lee, Y. L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24312982

Additional file 1 of Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Tan, C. Y., Chan, P. S., Tan, H., Tan, S. W., Lee, C. J. M., Wang, J.-W., Ye, S., Werner, H., Loh, Y. J., Lee, Y. L., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24312939

Additional file 1 of An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary dilated cardiomyopathy: genetics and bioinfomatics exploration

Chang, L., Huang, R., Chen, J., Li, G., Shi, G., Xu, B., & Wang, L. (2023) · Figshare · doi:10.6084/m9.figshare.24234157

The Epigenetic Regulator Histone Demethylase KDM5A is Activated and Pathogenic in a Mouse Model of Heart FailurePreprint

Deogharia, M., Reddy, C. L., Chaudhuri, R., Chirasani, M. S., Jain, A. K., Rouhi, L., Marian, A. J., & Gurha, P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.05.697798

Lmna deficiency promotes EPHX2 nuclear translocation to ameliorate cardiac dysfunction in micePreprint

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Association of the LMNA c.929A > G Mutation with Dilated Cardiomyopathy

韩, 子. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.162590

Epigenetic regulation of cardiac physiology and pathophysiology: biological sex matters

Tavakoli‐Rouzbehani, O. M., Szulik, M. W., Gwynn, C., Stephens, S. L., Porter, R. W., Cobo, I., Rosa‐Garrido, M., Franklin, S., & Boudina, S. (2026) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2025.36

An Epi(c) Path to LMNA Cardiomyopathy

Wang, Y., & Rau, C. (2026) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2026.101716

LMNA cardiomyopathy: cell biology and genetics meet clinical medicine

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Abstract 232: NFkB1 Pathway is a Major Dysregulated Biological Pathway in Cardiac Myocytes in Myocyte-Specific Lamin A/C Deficient Mice

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Cardiomyocyte lamin A re-expression via AAV-Lmna/DJ8 ameliorates cardiac dysfunction in Lmna−/− mice

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‘State-of-the-heart’ of cardiac laminopathies

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Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Tan, C. Y., Chan, P. S., Tan, H., Tan, S. W., Lee, C. J. M., Wang, J., Ye, S., Werner, H., Loh, Y. J., Lee, Y. L., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04542-4 · Cited by 18 · see citing works