The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Microbial metabolite sensor GPR43 controls severity of experimental GVHD
Open accessAbstract
Microbiome-derived metabolites influence intestinal homeostasis and regulate graft-versus-host disease (GVHD), but the molecular mechanisms remain unknown. Here we show the metabolite sensor G-protein-coupled receptor 43 (GPR43) is important for attenuation of gastrointestinal GVHD in multiple clinically relevant murine models. GPR43 is critical for the protective effects of short-chain fatty acids (SCFAs), butyrate and propionate. Increased severity of GVHD in the absence of GPR43 is not due to baseline differences in the endogenous microbiota of the hosts. We confirm the ability of microbiome-derived metabolites to reduce GVHD by several methods, including co-housing, antibiotic treatment, and administration of exogenous SCFAs. The GVHD protective effect of SCFAs requires GPR43-mediated ERK phosphorylation and activation of the NLRP3 inflammasome in non-hematopoietic target tissues of the host. These data provide insight into mechanisms of microbial metabolite-mediated protection of target tissues from the damage caused allogeneic T cells.
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Cites
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Cited by
Short-chain fatty acids: Linking diet, the microbiome and immunity
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Free Fatty Acid Receptors in Health and Disease
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Mining the microbiota for microbial and metabolite-based immunotherapies
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Gut Microbiota-Derived Short-Chain Fatty Acids: Impact on Cancer Treatment Response and Toxicities
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Roles of the intestinal microbiota and microbial metabolites in acute GVHD
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Metadata
- Authors
- Fujiwara, H., Docampo, M. D., Riwes, M., Peltier, D., Toubai, T., Henig, I., Wu, S. J., Kim, S., Taylor, A., Brabbs, S., Liu, C., Zajac, C., Oravecz-Wilson, K., Sun, Y., Núñez, G., Levine, J. E., van den Brink, M. R. M., Ferrara, J. L. M., & Reddy, P.
- Venue
- Nature Communications
- Published
- 2018-09-10
- Volume
- 9
- Issue
- 1
- Pages
- 3674-3674
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2890880346
- Cited by
- 161
- References
- 14
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- gold
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- Fujiwara, H., Docampo, M. D., Riwes, M., Peltier, D., Toubai, T., Henig, I., Wu, S. J., Kim, S., Taylor, A., Brabbs, S., Liu, C., Zajac, C., Oravecz-Wilson, K., Sun, Y., Núñez, G., Levine, J. E., van den Brink, M. R. M., Ferrara, J. L. M., & Reddy, P. (2018). Microbial metabolite sensor GPR43 controls severity of experimental GVHD. Nature Communications. https://doi.org/10.1038/s41467-018-06048-w
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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