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Gut Microbiota-Derived Short-Chain Fatty Acids: Impact on Cancer Treatment Response and Toxicities

Al-Qadami, Ghanyah H., Secombe, Kate R., Subramaniam, Courtney B., Wardill, Hannah R., Bowen, Joanne M.·2022·Microorganisms
DOI 10.3390/microorganisms10102048PMC PMC9612155
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Abstract

The gut microbiota has emerged as a key modulator of cancer treatment responses in terms of both efficacy and toxicity. This effect is clearly mediated by processes impacting the activation and modulation of immune responses. More recently, the ability to regulate chemotherapeutic drug metabolism has also emerged as a key driver of response, although the direct mechanisms have yet to be fully elucidated. Through fermentation, the gut microbiota can produce several types of metabolites, including short-chain fatty acids (SCFAs). SCFAs play an important role in maintaining epithelial barrier functions and intestinal homeostasis, with recent work suggesting that SCFAs can modulate response to cancer treatments and influence both anti-tumor immune response and inflammatory-related side effects. In this review, we will discuss the importance of SCFAs and their implications for cancer treatment response and toxicities.

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Metadata

Authors
Al-Qadami, G. H., Secombe, K. R., Subramaniam, C. B., Wardill, H. R., & Bowen, J. M.
Venue
Microorganisms
Publisher
MDPI AG
Published
2022-10-17
Volume
10
Issue
10
Pages
2048
ISSN
2076-2607
DOI
10.3390/microorganisms10102048
PMC
PMC9612155
Cited by
162
References
22
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Hospital Research Foundation Group

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