The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
A discrete organoplatinum(II) metallacage as a multimodality theranostic platform for cancer photochemotherapy
Open accessAbstract
Photodynamic therapy is an effective alternative to traditional treatments due to its minimally invasive nature, negligible systemic toxicity, fewer side effects, and avoidance of drug resistance. However, it is still challenging to design photosensitizers with high singlet oxygen (1 O 2) quantum yields (QY) due to severe aggregation of the hydrophobic photosensitizers. Herein, we developed a discrete organoplatinum(II) metallacage using therapeutic cis-(PEt 3)2 Pt(OTf)2 as the building block to improve the 1 O 2 QY, thus achieving synergistic anticancer efficacy. The metallacage-loaded nanoparticles (MNPs) with tri-modality imaging capability allow precise diagnosis of tumor and real-time monitoring the delivery, biodistribution, and excretion of the MNPs. MNPs exhibited excellent anti-metastatic effect and superior anti-tumor performance against U87MG, drug resistant A2780CIS, and orthotopic tumor models, ablating the tumors without recurrence after a single treatment. Gene chip analyses confirmed the contribution of different therapeutic modalities to the tumor abrogation. This supramolecular platform holds potential in precise cancer theranostics.
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Cited by
Supramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
Self-citationRecent advances of multi-dimensional porphyrin-based functional materials in photodynamic therapy
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Gong, Z., & Dai, Z. (2021) · Advanced Science · doi:10.1002/advs.202002178 · Cited by 320
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Ferroptosis promotes sonodynamic therapy: a platinum( ii )–indocyanine sonosensitizer
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Metadata
- Authors
- Yu, G., Yu, S., Saha, M. L., Zhou, J., Cook, T. R., Yung, B. C., Chen, J., Mao, Z., Zhang, F., Zhou, Z., Liu, Y., Shao, L., Wang, S., Gao, C., Huang, F., Stang, P. J., & Chen, X.
- Venue
- Nature Communications
- Published
- 2018-10-18
- Volume
- 9
- Issue
- 1
- Pages
- 4335-4335
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2896706456
- Cited by
- 255
- References
- 10
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Yu, G., Yu, S., Saha, M. L., Zhou, J., Cook, T. R., Yung, B. C., Chen, J., Mao, Z., Zhang, F., Zhou, Z., Liu, Y., Shao, L., Wang, S., Gao, C., Huang, F., Stang, P. J., & Chen, X. (2018). A discrete organoplatinum(II) metallacage as a multimodality theranostic platform for cancer photochemotherapy. Nature Communications. https://doi.org/10.1038/s41467-018-06574-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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