Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract
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The vanguard deconjugation reaction acts as a gatekeeper for subsequent BA transformations that turn primary BAs into secondary BAs.
“This vanguard reaction acts as a ‘gatekeeper’ for subsequent BA transformations that turn primary BAs into secondary BAs”
From Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut (2023) · cites this paper as [1]
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- Authors
- Foley, M. H., O’Flaherty, S., Barrangou, R., & Theriot, C. M.
- Affiliations
- North Carolina State University (US)
- Corresponding author
- Theriot, Casey M.
- Venue
- PLOS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2019-03-07
- Volume
- 15
- Issue
- 3
- Pages
- e1007581
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC6405046
- OpenAlex
- W2922056291
- Cited by
- 271
- References
- 40
- Citations by year
- 2026: 43 · 2025: 37 · 2024: 38 · 2023: 38 · 2022: 41 · 2021: 37 · 2020: 30 · 2019: 7
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R35GM119438)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- bile salt hydrolase, bile acid metabolism, host-microbiome interactions, gut microbiota, bile acid synthesis
- MeSH terms
- Gastrointestinal Microbiome, Host Microbial Interactions, Amidohydrolases, Bile Acids and Salts, Humans, Gastrointestinal Tract
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