POLYRETINA restores light responses in vivo in blind Göttingen minipigs
Open accessAbstract
Retinal prostheses hold the potential for artificial vision in blind people affected by incurable diseases of the outer retinal layer. Available technologies provide only a small field of view: a significant limitation for totally blind people. To overcome this problem, we recently proposed a large and high-density photovoltaic epiretinal device, known as POLYRETINA. Here, we report the in vivo assessment of POLYRETINA. First, we characterise a model of chemically-induced blindness in Göttingen minipigs. Then, we develop and test a minimally invasive injection procedure to insert the large epiretinal implant into the eye. Last, we show that POLYRETINA restores light-evoked cortical responses in blind animals at safe irradiance levels. These results indicate that POLYRETINA holds the potential for artificial vision in totally blind patients affected by retinitis pigmentosa.
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POLYRETINA is a high-density wide-field epiretinal prosthesis containing 10,498 photovoltaic pixels distributed over an active area of approximately 43°.
“POLYRETINA is a high-density wide-field epiretinal prosthesis containing 10 498 photovoltaic pixels distributed over an active area of approximately 43 • [38,39,131,132].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [39]
POLYRETINA is a foldable and injectable photovoltaic epiretinal prosthesis that can be safely delivered with a 6 mm size cut through the sclera and conform better to the curvature of the eye.
“To overcome this issue, POLYRETINA is a foldable and injectable photovoltaic epiretinal prosthesis that can be safely delivered with a 6 mm size cut through the sclera and conform better to the curvature of the eye [39,38].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [39]
New developments in organic bioelectronics and photovoltaics showed superior features in conformability, flexibility and stretchability compared to silicon-based technology.
“In particular, new developments in organic bioelectronics and photovoltaics showed superior features in conformability, flexibility and stretchability [38,39] compared to silicon-based technology.”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [39]
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Emerging Biomaterials for Retinal Implants
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- Authors
- Vagni, P., Airaghi Leccardi, M. J. I., Vila, C.-H., Zollinger, E. G., Sherafatipour, G., Wolfensberger, T. J., & Ghezzi, D.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Hôpital Ophtalmique Jules-Gonin (CH)
- Corresponding author
- Ghezzi, Diego
- ORCID
- Venue
- Nature Communications
- Published
- 2022-06-27
- Volume
- 13
- Issue
- 1
- Pages
- 3678-3678
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC9237028
- OpenAlex
- W4283584388
- Cited by
- 62
- References
- 42
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 17 · 2023: 13 · 2022: 3
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, cc-by)
- IRIS (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Velux Stiftung (1102)
- Gebert Rüf Stiftung (GRS-035/17)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Keywords
- retinal prosthesis, epiretinal implants, retinitis pigmentosa, Göttingen minipig, vision restoration, artificial vision
- MeSH terms
- Animals, Blindness, Humans, Retinitis Pigmentosa, Swine, Swine, Miniature, Visually Impaired Persons, Persons with Visual Disabilities, Visual Prosthesis
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