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Cited by 25Single-cell and spatial transcriptomicsAdvanced Neuroimaging Techniques and ApplicationsGenetics and Neurodevelopmental Disorders

Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys

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Bo, Tingting, Li, Jie, Hu, Ganlu, Zhang, Ge, Wang, Wei, Lv, Qian, Zhao, Shaoling, Ma, Junjie +5 more·2023·Nature Communications
DOI 10.1038/s41467-023-37246-wPMC PMC10023667
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Abstract

Integrative analyses of transcriptomic and neuroimaging data have generated a wealth of information about biological pathways underlying regional variability in imaging-derived brain phenotypes in humans, but rarely in nonhuman primates due to the lack of a comprehensive anatomically-defined atlas of brain transcriptomics. Here we generate complementary bulk RNA-sequencing dataset of 819 samples from 110 brain regions and single-nucleus RNA-sequencing dataset, and neuroimaging data from 162 cynomolgus macaques, to examine the link between brain-wide gene expression and regional variation in morphometry. We not only observe global/regional expression profiles of macaque brain comparable to human but unravel a dorsolateral-ventromedial gradient of gene assemblies within the primate frontal lobe. Furthermore, we identify a set of 971 protein-coding and 34 non-coding genes consistently associated with cortical thickness, specially enriched for neurons and oligodendrocytes. These data provide a unique resource to investigate nonhuman primate models of human diseases and probe cross-species evolutionary mechanisms.

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  • A macaque brain atlas integrating MRI-derived cortical thickness with bulk and single-nucleus transcriptomic data revealed a mitochondrial oxidative phosphorylation module whose expression gradient mirrors prefrontal cortical thinning.

    “Complementary research in non-human primates has produced a macaque brain atlas integrating MRI-derived cortical thickness with bulk and single-nucleus transcriptomic data. This work revealed a mitochondrial oxidative phosphorylation module whose expression gradient mirrors prefrontal cortical thinning, highlighting metabolic vulnerability as a regional determinant of atrophy359.”

    From Artificial intelligence-driven multi-omics approaches in Alzheimer's disease: Progress, challenges, and future directions (2025) · cites this paper as [359]

    The Introduction describes an atlas combining macaque structural MRI with bulk and single-nucleus RNA sequencing. The Results (‘Genetic topography in macaque brain’; page unavailable) identify a frontal-lobe expression gradient and report that module M4, enriched in dorsal prefrontal cortex, is associated with oxidative phosphorylation. They do not show that this module’s gradient mirrors prefrontal cortical thinning or establish metabolic vulnerability as a determinant of atrophy. (LLM, conf=0.88)

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Authors
Bo, T., Li, J., Hu, G., Zhang, G., Wang, W., Lv, Q., Zhao, S., Ma, J., Qin, M., Yao, X., Wang, M., Wang, G.-Z., & Wang, Z.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Shanghai Institute of Nutrition and Health (CN)
  • ShanghaiTech University (CN)
  • Zhengzhou University (CN)
  • McGovern Institute for Brain Research (US)
  • Chinese Academy of Sciences (CN)
  • Beijing University of Chemical Technology (CN)
  • Harbin Engineering University (CN)
Corresponding author
  • Wang, Meiyun
  • Wang, Guang-Zhong
  • Wang, Zheng
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2023-03-17
Volume
14
Issue
1
Pages
1499-1499
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-023-37246-w
PMC
PMC10023667
OpenAlex
W4327744356
Cited by
25
References
8
Citations by year
2026: 6 · 2025: 8 · 2024: 9 · 2023: 2
FWCI
2.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (82171483, 81827901, 32170567)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
cortical morphology, cortical thickness, single-nucleus RNA sequencing, bulk RNA-seq, non-coding genes, oligodendrocytes, neurons, nonhuman primate model, cynomolgus macaques
MeSH terms
Animals, Brain, Humans, Macaca fascicularis, Magnetic Resonance Imaging, Primates, RNA, Transcriptome

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