A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination
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Abstract
The adaptive regulation of fear memories is a crucial neural function that prevents inappropriate fear expression. Fear memories can be acquired through contextual fear conditioning (CFC) which relies on the hippocampus. The thalamic nucleus reuniens (NR) is necessary to extinguish contextual fear and innervates hippocampal CA1. However, the role of the NR-CA1 pathway in contextual fear is unknown. We developed a head-restrained virtual reality CFC paradigm, and demonstrate that mice can acquire and extinguish context-dependent fear responses. We found that inhibiting the NR-CA1 pathway following CFC lengthens the duration of fearful freezing epochs, increases fear generalization, and delays fear extinction. Using in vivo imaging, we recorded NR-axons innervating CA1 and found that NR-axons become tuned to fearful freezing following CFC. We conclude that the NR-CA1 pathway actively suppresses fear by disrupting contextual fear memory retrieval in CA1 during fearful freezing behavior, a process that also reduces fear generalization and accelerates extinction.
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These ROIs have been previously associated with fear memory and align with work at the circuit level.
“These ROIs have been previously associated with fear memory56,59-66 and align with work at the circuit level62.”
From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [62]
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A Preprocessing Toolbox for 2-Photon Subcellular Calcium Imaging
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Diencephalic modulation of the hippocampus in affective and cognitive behavior
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SAME: Topology-flexible transforms enable robust integration of multimodal spatial omicsPreprint
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ApoE Isoform-Dependent Effects on Extinction of Contextual Fear Memory and Passive Avoidance Memory
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A contextual fear conditioning paradigm in head-fixed mice exploring virtual realityPreprint
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- Authors
- Ratigan, H. C., Krishnan, S., Smith, S., & Sheffield, M. E. J.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Sheffield, Mark E. J.
- Venue
- Nature Communications
- Published
- 2023-10-24
- Volume
- 14
- Issue
- 1
- Pages
- 6758-6758
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC10598272
- OpenAlex
- W4387903600
- Cited by
- 60
- References
- 92
- Citations by year
- 2026: 12 · 2025: 28 · 2024: 17 · 2023: 3
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by)
- Knowledge@UChicago (University of Chicago) (submittedVersion, cc-by-nc-nd)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Chicago (cc-by)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (1DP2NS111657-01)
- Whitehall Foundation
- U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (T32DA043469)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- nucleus reuniens, hippocampal CA1, contextual fear conditioning, fear extinction, fear generalization, fear memory retrieval, fear discrimination, mice
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