Hippocampal awake replay in fear memory retrieval
Open accessAbstract
Hippocampal place cells are key to episodic memories. How these cells participate in memory retrieval remains unclear. After rats acquired a fear memory by receiving mild footshocks in a shock zone on a track, we analyzed place cells when the animals were placed on the track again and displayed an apparent memory retrieval behavior: avoidance of the shock zone. We found that place cells representing the shock zone were reactivated, despite the fact that the animals did not enter the shock zone. This reactivation occurred in ripple-associated awake replay of place cell sequences encoding the paths from the animal's current positions to the shock zone but not in place cell sequences within individual cycles of theta oscillation. The result reveals a specific place-cell pattern underlying inhibitory avoidance behavior and provides strong evidence for the involvement of awake replay in fear memory retrieval.
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In rats, after a single mild shock experience in a shock-zone in a track, place cells representing that zone were activated when the rats merely approached it, causing them to avoid the zone.
“when rats received a singular experience of a mild shock upon entering a ‘shock-zone’ in a track, the place cells representing this zone were activated when the rats merely approached it, causing them to avoid the zone [157].”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [157]
When showing avoidance behaviour, the rat is representing the likely occurrence of an event associated with the context of a specific spatial location (the shock), critically based on only a single experience.
“This suggests that when showing the avoidance behaviour, the rat is representing the likely occurrence of an event associated with the context of a specific spatial location (the shock), critically based on only a single experience.”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [157]
Reactivation of place cells relating to the shock zone experience occurred in a sequence representing the path from the rat's current position to the shock zone.
“reactivation of place cells relating to the shock zone experience [157] occurred in a sequence representing the path from the rat’s current position to the shock zone”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [157]
This replay raises the possibility that replay allows for future planning.
“raising the possibility that replay allows for future planning.”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [157]
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- Authors
- Wu, C.-T., Haggerty, D., Kemere, C., & Ji, D.
- Affiliations
- Baylor College of Medicine (US)
- Rice University (US)
- Corresponding author
- Ji, Daoyun
- Venue
- Nature Neuroscience
- Published
- 2017-02-20
- Volume
- 20
- Issue
- 4
- Pages
- 571-580
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC5373994
- OpenAlex
- W2589540435
- Cited by
- 210
- References
- 51
- Citations by year
- 2026: 11 · 2025: 25 · 2024: 26 · 2023: 26 · 2022: 18 · 2021: 28 · 2020: 19 · 2019: 15 · 2018: 23 · 2017: 18
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rice Research Repository (Rice University) (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH106552)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- place cells, fear memory retrieval, ripple oscillations, passive avoidance, shock avoidance, theta oscillations, memory reactivation
- MeSH terms
- Place Cells, Animals, Avoidance Learning, Electric Stimulation, Fear, Hippocampus, Male, Memory, Mental Recall, Theta Rhythm, Wakefulness, Rats
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