The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients
Open accessAbstract
Wearable non-invasive biosensors for the continuous monitoring of metabolites in sweat can detect a few analytes at sufficiently high concentrations, typically during vigorous exercise so as to generate sufficient quantity of the biofluid. Here we report the design and performance of a wearable electrochemical biosensor for the continuous analysis, in sweat during physical exercise and at rest, of trace levels of multiple metabolites and nutrients, including all essential amino acids and vitamins. The biosensor consists of graphene electrodes that can be repeatedly regenerated in situ, functionalized with metabolite-specific antibody-like molecularly imprinted polymers and redox-active reporter nanoparticles, and integrated with modules for iontophoresis-based sweat induction, microfluidic sweat sampling, signal processing and calibration, and wireless communication. In volunteers, the biosensor enabled the real-time monitoring of the intake of amino acids and their levels during physical exercise, as well as the assessment of the risk of metabolic syndrome (by correlating amino acid levels in serum and sweat). The monitoring of metabolites for the early identification of abnormal health conditions could facilitate applications in precision nutrition. A wearable electrochemical biosensor can continuously detect, in sweat during physical exercise and at rest, trace levels of multiple metabolites and nutrients, including all essential amino acids and vitamins.
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Self-citationWearable biosensors for healthcare monitoring
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Self-citationA soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat
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Wearable chemical sensors for biomarker discovery in the omics era
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A wearable aptamer nanobiosensor for non-invasive female hormone monitoring
Ye, C., Wang, M., Min, J., Tay, R. Y., Lukas, H., Sempionatto, J. R., Li, J., Xu, C., & Gao, W. (2024) · Nature Nanotechnology · doi:10.1038/s41565-023-01513-0 · Cited by 466
Self-citationShirzaei Sani, E., Xu, C., Wang, C., Song, Y., Min, J., Tu, J., Solomon, S. A., Li, J., Banks, J. L., Armstrong, D. G., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf7388 · Cited by 405
Self-citationA physicochemical-sensing electronic skin for stress response monitoring
Xu, C., Song, Y., Sempionatto, J. R., Solomon, S. A., Yu, Y., Nyein, H. Y. Y., Tay, R. Y., Li, J., Heng, W., Min, J., et al. (2024) · Nature Electronics · doi:10.1038/s41928-023-01116-6 · Cited by 399
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Metadata
- Authors
- Wang, M., Yang, Y., Min, J., Song, Y., Tu, J., Mukasa, D., Ye, C., Xu, C., Heflin, N., McCune, J. S., Hsiai, T. K., Li, Z., & Gao, W.
- Venue
- Nature Biomedical Engineering
- Published
- 2022-08-15
- Volume
- 6
- Issue
- 11
- Pages
- 1225-1235
- ISSN
- 2157-846X (ISSN-L)
- OpenAlex
- W4291624534
- Cited by
- 896
- References
- 22
- FWCI
- 47.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, M., Yang, Y., Min, J., Song, Y., Tu, J., Mukasa, D., Ye, C., Xu, C., Heflin, N., McCune, J. S., Hsiai, T. K., Li, Z., & Gao, W. (2022). A wearable electrochemical biosensor for the monitoring of metabolites and nutrients. Nature Biomedical Engineering. https://doi.org/10.1038/s41551-022-00916-z
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