A pan-cancer dye for solid-tumour screening, resection and wound monitoring via short-wave and near-infrared fluorescence imaging
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Abstract
The efficacy of fluorescence-guided surgery in facilitating the real-time delineation of tumours depends on the optical contrast of tumour tissue over healthy tissue. Here we show that CJ215-a commercially available, renally cleared carbocyanine dye sensitive to apoptosis, and with an absorption and emission spectra suitable for near-infrared fluorescence imaging (wavelengths of 650-900 nm) and shortwave infrared (SWIR) fluorescence imaging (900-1,700 nm)-can facilitate fluorescence-guided tumour screening, tumour resection and the assessment of wound healing. In tumour models of either murine or human-derived breast, prostate and colon cancers and of fibrosarcoma, and in a model of intraperitoneal carcinomatosis, imaging of CJ215 with ambient light allowed for the delineation of nearly all tumours within 24 h after intravenous injection of the dye, which was minimally taken up by healthy organs. At later timepoints, CJ215 provided tumour-to-muscle contrast ratios up to 100 and tumour-to-liver contrast ratios up to 18. SWIR fluorescence imaging with the dye also allowed for quantifiable non-contact wound monitoring through commercial bandages. CJ215 may be compatible with existing and emerging clinical solutions.
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- Authors
- Mc Larney, B. E., Sonay, A. Y., Apfelbaum, E., Mostafa, N., Monette, S., Goerzen, D., Aguirre, N., Exner, R. M., Habjan, C., Isaac, E., Phung, N. B., Skubal, M., Kim, M., Ogirala, A., Veach, D., Heller, D. A., & Grimm, J.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Georgia Institute of Technology (US)
- Weill Cornell Medicine (US)
- Corresponding author
- Grimm, Jan
- ORCID
- Venue
- Nature Biomedical Engineering
- Published
- 2024-09-09
- Volume
- 8
- Issue
- 9
- Pages
- 1092-1108
- ISSN
- 2157-846X (ISSN-L)
- PMC
- PMC11699565
- OpenAlex
- W4402372164
- Cited by
- 28
- References
- 87
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 1
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- green
- dx.doi.org
- Licence
- Locations
- Nature Biomedical Engineering (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (R56 EB030512, R00-EB033580, R01-EB033651)
- U.S. Department of Health & Human Services | NIH | National Cancer Institute (P30 CA008748, R01-CA215719)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Keywords
- carbocyanine dyes, fluorescence-guided surgery, tumor resection, tumor delineation, near-infrared fluorescence imaging, wound healing monitoring, breast cancer, prostate cancer, colon cancer, fibrosarcoma, peritoneal carcinomatosis, renal clearance
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