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Giant tortoise genomes provide insights into longevity and age-related disease

Quesada, Víctor, Freitas-Rodríguez, Sandra, Miller, Joshua, Pérez-Silva, José G., Jiang, Zi-Feng, Tapia, Washington, Santiago-Fernández, Olaya, Campos-Iglesias, Diana, Kuderna, Lukas F. K., Quinzin, Maud, Álvarez, Miguel G., Carrero, Dido, Beheregaray, Luciano B., Gibbs, James P., Chiari, Ylenia, Glaberman, Scott, Ciofi, Claudio, Araujo-Voces, Miguel, Mayoral, Pablo, Arango, Javier R., Tamargo-Gómez, Isaac, Roiz-Valle, David, Pascual-Torner, María, Evans, Benjamin R., Edwards, Danielle L., Garrick, Ryan C., Russello, Michael A., Poulakakis, Nikos, Gaughran, Stephen J., Rueda, Danny O., Bretones, Gabriel, Marquès-Bonet, Tomàs, White, Kevin P., Caccone, Adalgisa, López-Otín, Carlos·2018·Nature Ecology & Evolution
DOI 10.1038/s41559-018-0733-xPMC PMC6314442
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Abstract

Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic and molecular evolutionary information on giant tortoises is scarce. Here, we describe a global analysis of the genomes of Lonesome George—the iconic last member of Chelonoidis abingdonii—and the Aldabra giant tortoise (Aldabrachelys gigantea). Comparison of these genomes with those of related species, using both unsupervised and supervised analyses, led us to detect lineage-specific variants affecting DNA repair genes, inflammatory mediators and genes related to cancer development. Our study also hints at specific evolutionary strategies linked to increased lifespan, and expands our understanding of the genomic determinants of ageing. These new genome sequences also provide important resources to help the efforts for restoration of giant tortoise populations.

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Metadata

Authors
Quesada, V., Freitas-Rodríguez, S., Miller, J., Pérez-Silva, J. G., Jiang, Z.-F., Tapia, W., Santiago-Fernández, O., Campos-Iglesias, D., Kuderna, L. F. K., Quinzin, M., Álvarez, M. G., Carrero, D., Beheregaray, L. B., Gibbs, J. P., Chiari, Y., Glaberman, S., Ciofi, C., Araujo-Voces, M., Mayoral, P., Arango, J. R., Tamargo-Gómez, I., Roiz-Valle, D., Pascual-Torner, M., Evans, B. R., Edwards, D. L., Garrick, R. C., Russello, M. A., Poulakakis, N., Gaughran, S. J., Rueda, D. O., Bretones, G., Marquès-Bonet, T., White, K. P., Caccone, A., & López-Otín, C.
ORCID
Venue
Nature Ecology & Evolution
Publisher
Springer Science and Business Media LLC
Published
2018-12-03
Volume
3
Issue
1
Pages
87-95
ISSN
2397-334X
DOI
10.1038/s41559-018-0733-x
PMC
PMC6314442
Cited by
114
References
9
Language
en
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