Cited by 676SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesAnimal Virus Infections Studies

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

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Lee, Wen Shi, Wheatley, Adam K., Kent, Stephen J., DeKosky, Brandon J.·2020·Nature Microbiology

Abstract

Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data from the study of SARS-CoV and other respiratory viruses suggest that anti-SARS-CoV-2 antibodies could exacerbate COVID-19 through antibody-dependent enhancement (ADE). Previous respiratory syncytial virus and dengue virus vaccine studies revealed human clinical safety risks related to ADE, resulting in failed vaccine trials. Here, we describe key ADE mechanisms and discuss mitigation strategies for SARS-CoV-2 vaccines and therapies in development. We also outline recently published data to evaluate the risks and opportunities for antibody-based protection against SARS-CoV-2.

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Research works printed but not linked: 2

  1. [59]Quinlan BD The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement. bioRxiv, 2020.2004.2010.036418 (2020).
  2. [78]Pei S Convalescent Plasma to Treat COVID-19: Chinese Strategy and Experiences. medRxiv, 2020.2004.2007.20056440 (2020).

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Authors
Lee, W. S., Wheatley, A. K., Kent, S. J., & DeKosky, B. J.
Affiliations
  • The University of Melbourne (AU)
  • University of Kansas (US)
Corresponding author
  • Kent, Stephen J.
  • DeKosky, Brandon J.
Venue
Nature Microbiology
Published
2020-09-09
Volume
5
Issue
10
Pages
1185-1191
ISSN
2058-5276 (ISSN-L)
OpenAlex
W3083773456
Cited by
676
References
104
Citations by year
2026: 21 · 2025: 41 · 2024: 45 · 2023: 88 · 2022: 160 · 2021: 282 · 2020: 39
FWCI
6.72
Type
journal article
Language
en
Open access
Locations
  • Nature Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Fast Grants
  • State Government of Victoria
  • National Institutes of Health (DP5OD023118, COVID-19)
  • Medical Research Council (COVID-19)
  • National Health and Medical Research Council (1149990, 1162760)
  • National Institute of Allergy and Infectious Diseases (R21AI143407)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Keywords
antibody-dependent enhancement, SARS-CoV-2, COVID-19 vaccines, antibody-based therapy, vaccine safety, respiratory syncytial virus, dengue virus, SARS-CoV, neutralizing antibodies
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Vaccines, COVID-19 Drug Treatment, COVID-19 Serotherapy, Animals, Antibodies, Monoclonal, Antibodies, Viral, Humans, Immunization, Passive, Pneumonia, Viral, Respiratory Tract Diseases, Risk Factors, Safety, Viral Vaccines, Coronavirus Infections, Models, Immunological, Antibody-Dependent Enhancement, Antibodies, Neutralizing, Pandemics, In Vitro Techniques

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